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All Journal Majalah Kedokteran Bandung Jurnal Penelitian Kesehatan Suara Forikes Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal Ners Science Midwifery Jurnal Ilmu Kesehatan Indonesia (JIKSI) Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmiah

Nita Afriani

Universitas Andalas

Author-ID : 4165845

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Ramipril Terhadap Gambaran Histopatologis Otak Tikus Wistar yang Mengalami Edema Otak Rizka Fitria Husni; Nita Afriani; Aswiyanti Asri
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Background. Brain edema is excessive accumulation of fluid in the intracranial or extracellular space of the brain. It can be caused by head trauma, brain tumors, hypoxia, metabolic disorders, or acute hypertension. Acute myocardial infraction is damage to the myocard that occurs due to lack oxygen. When acute myocardial infarction occurs, there will be disruption of blood flow in the form of stasis which allows emboli and decreased Cardiac Output which will cause a decrease in Cerebral Blood Flow. There will be a state of ischemia and hypoxia so that the hemostatic mechanism is disturbed which will trigger brain edema. Objective. This research was conducted to see the effect of giving ramipril to histopathological of the brain of wistar rat with brain edema. Methods. This research is an experimental study. We used 32 animals which were divided into 4 groups (K-, K +, P1, and P2). P1 was given 3 mg/kgBW ramipril for 7 consecutive days. P2 was given 4 mg/kgBW ramipril for 7 consecutive days. On days 8 and 9, P1, P2, and K+ induced isoproterenol 85 mg/kgBW for 2 consecutive days to induce brain edema through the mechanism of acute myocardial infarction. Data analysis was performed using One Way Anova test and Post Hoc Bonferroni test. Results. The mean area of brain edema in the K-, K +, P1, and P2 groups respectively were 20.76%, 34.69%, 22.70%, and 21.90%. Conclusion. There was a significant effect of giving ramipril to histopathological of the brain of wistar rat with brain edema

Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak Muhammad Arief Ansyar; Nita Afriani; Aisyah Ellyanti
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 2 (2021): Juni 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Background. Brain edema is swelling in the brain due to excessive accumulation of fluid in the brain. This condition is triggered by a decrease in cerebral blood flow (CBF) due to heart damage or isoproterenol administraion. A decrease in CBF results in brain edema which triggers damage to neuron cells. This study uses isoproterenol to induce brain edema. This damage is prevented by giving ramipril with the aim of improving cardiac and brain perfusion. Objective. To see the effect of giving ramipril to the microscopic assessment of mouses brain neuron cells with brain edema which was induced by isoproterenol. Methods. This research is an experimental study which was used 21 experimental animals which were divided into 3 groups (K-, K +, and P). The treatment group (P) was given ramipril at a dose of 3 mg/KgBW for 7 days. On the 8th and 9th day K+ and P groups were injected by isoproterenol 85 mg/KgBW to induce brain edema through AMI. Data analysis was performed using the Kruskal-Wallis Test and Mann Whitney U Test (MWUT). Results. The average number of neuron cell damage in the K -, K +, and P group, respectively, 6.2, 26.3 and 17.33. Significant differences were obtained for each group with a value of p = 0.001 (p <0.05). Conclusion. There is a significant effect of giving ramipril to the microscopic assessment of mouses brain neuron cells with brain edema which was induced by isoproterenol.

Gambaran Motivasi Belajar Mahasiswa Kedokteran Universitas Andalas selama Pandemi COVID-19 Muhamad Imamhamda Muttaqien; Y Yulistini; Nita Afriani
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 3 (2021): September 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v2i3.349

Latar Belakang: Pandemi COVID-19 telah merubah cara pembelajaran di semua perguruan tinggi, termasuk pendidikan kedokteran, yakni dengan menggunakan metode pembelajaran jarak jauh (PJJ). Penelitian ini bertujuan mengetahui gambaran motivasi belajar mahasiswa tahap sarjana di Fakultas Kedokteran Universitas Andalas selama pandemi COVID-19. Metode: Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional study. Pengambilan sampel dengan teknik simple random sampling, didapatkan sampel sebanyak 309 responden yang merupakan mahasiswa angkatan 2017, 2018, dan 2019. Motivasi belajar diukur dengan menggunakan kuesioner Motivated Strategies for Learning Questionnaire (MSLQ). Hasil pengukuran disajikan dengan skala kategorik, yaitu motivasi tinggi, sedang, dan rendah. Hasil: Analisis univariat menunjukkan bahwa 79% mahasiswa kedokteran Universitas Andalas memiliki tingkat motivasi belajar tinggi dan tidak ditemukan mahasiswa yang memiliki tingkat motivasi belajar rendah. Angkatan 2019 memiliki tingkat motivasi belajar tertinggi pada saat pandemi, yaitu sebesar 88,9% diantara angkatan mahasiswa aktif lainnya. Kesimpulan: Mahasiswa kedokteran Universitas Andalas memiliki tingkat motivasi belajar sedang dan tinggi selama pandemi COVID-19, serta mahasiswa angkatan 2019 memiliki tingkat motivasi tinggi terbesar, yakni sebesar 88,9%.

Effect of High Fat Diet on Histopathological Appearance of Pregnant Wistar Rat’s Liver Desmawati Desmawati; Ruhilmi Nisa; Nita Afriani
Majalah Kedokteran Bandung Vol 54, No 3 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n3.2650

Indonesia is facing increased consumption of calorie-dense foods, such as fast food, among its society. Changes in diet and physical activities towards unhealthy ones can result in an imbalanced lifestyle, leading to various consequences, including hyperlipidemia. Pregnant women experience significant increases in plasma concentrations of lipids, lipoproteins, and apolipoproteins. Excessive cholesterol levels in pregnant women will result in the formation of fat in the liver. The purpose of this study was to determine the effect of a high-fat diet to pregnant Wistar rats (Rattus norvegicus) on the histopathological features of the liver. A true experimental with post test only control group design was applied in this study, which was conducted from August 2020 to November 2021. Fourteen (14) pregnant female rats were divided into two groups. The first group of rats was fed with a high-fat diet, while the second group, which was the control group, was given a standard diet. The high-fat diet used was 3 mL/rat/day beef brain. After the rats delivered their litters, the rats’ livers were retrieved, then examined histopathologically under a microscope. This research was conducted from No fatty liver was identified in the control group or the treatment group. Hence, a high-fat diet does not affect the liver histopathological features in pregnant Wistar rats.

Correlation of macronutrient intake and body fat precentage with menstrual cycle in famale students faculty of medicine Andalas University Nadya Khaira Nurdi; Desmawati; Nita Afriani
Science Midwifery Vol 10 No 6 (2023): February: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v10i6.1098

Indonesian Basic Health Research 2010 state that 13.7% of women in Indonesia with irregular menstrual cycles, 7,7% caused by lifestyle factors. West Sumatra is third highest province of irregular menstruation prevalence in Indonesia, which is 19.1%.The purpose of this research is to determine the relationship between macronutrient intake and body fat percentage with the menstrual cycle in female students Faculty of Medicine, Andalas University. This research type was an observational study with cross sectional research design. This research was conducted at the Faculty of Medicine, Andalas University in November 2021-September2022, with samples were 78 respondents. Sample techniques used systematic random sampling. Data were collected by physical examination and questionnaires. Bivariate analysis used independent sample t-test and multivariate analysis used logistic regression. The results of this research stated that the mean of macronutrient intake (calories, carbohydrates, fat, and protein) consumed by female students with irregular menstruation were 2839,87±229,32 kcal, 391,58±37,70 gram, 95,87±12,90 gram, 102,66±11,81 gram, and 42,71±4,42%. In addition, female students with normal menstruation were 2644,82±226,85 kcal, 369,31±40,40 gram, 86,69±14,32 gram, 96,85±10,95 gram, and 31,66±4,44%. This research showed that female students with irregular menstruation had higher of macronutrient intake and body fat percentage (p-value = <0.001, 0.016, 0.005, 0.028, and <0.001). The conclusion of this research is a significant relationship between macronutrient intake and body fat percentage with the menstrual cycle.

Pengaruh Yodium terhadap Gambaran Histopatologi Kelenjar Tiroid Tikus yang Diinduksi Timbal Asetat Friska Marcelly; Miftah Irrahmah; Nita Afriani
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 1 (2023): Maret 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i1.886

Latar Belakang: Timbal adalah logam berat beracun yang mudah ditemui di lingkungan. Timbal menyebabkan stres oksidatif pada berbagai jaringan dan organ tubuh, termasuk kelenjar tiroid. Kerusakan akibat stres oksidatif akan dikompensasi oleh tubuh dengan antioksidan, salah satunya adalah yodium. Objektif: Penelitian ini bertujuan untuk melihat pengaruh pemberian larutan yodium terhadap gambaran histopatologi kelenjar tiroid tikus yang diinduksi dengan timbal asetat. Metode: Penelitian ini merupakan penelitian eksperimental menggunakan 18 ekor tikus rattus norvegicus yang dibagi dalam 3 kelompok, yaitu kelompok kontrol negatif yang hanya diberi pakan standar, kontrol positif yang diberi pakan standar dan timbal asetat 100mg/L, serta kelompok perlakuan yang diberi pakar standar, timbal asetat 100mg/L, dan larutan yodium 12,5mg selama 19 hari. Pada hari ke 20 tikus dimatikan dan dilakukan pengambilan organ tiroid untuk dibuatkan preparat dengan pulasan hematoxylin eosin. Preparat dibaca menggunakan mikroskop, dilihat kerusakannya, dan dianalisis lebih lanjut. Hasil: Penelitian menunjukkan pada kelompok kontrol negatif sel-sel terlihat normal, pada kontrol positif sel mengalami kerusakan disertai infiltrasi sel radang, sedangkan pada kelompok perlakuan terjadi penurunan jumlah kerusakan dan sel radang secara signifikan. Pada hasil analisis data didapatkan perbedaan yang bermakna tiap kelompok penelitian dengan nilai p<0,05. Kesimpulan: Penelitian ini adalah terdapat pengaruh pemberian larutan yodium dalam mencegah kerusakan tiroid tikus yang diinduksi timbal asetat.

APC-Pengaruh Pemberian Blastocystis sp. Terhadap Jumlah Leukosit Pada Tikus Febriyanti, Rizka; Nofita, Eka; Afriani, Nita; Adrial, Adrial; Asri, Aswiyanti; Almurdi, Almurdi
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 16, No 2 (2025): April-Juni 2025 (up coming)
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v16i2.3590

Blastocystis sp. are the most common intestinal protists in human and animal faeces. Blastocystis sp infection associated with inhibition of celluler immunity due to an increase in cytokines resulting in an increase in the number of leukocytes. This study was conducted to determine the correlation between Blastocystis sp infection and leukocyte count. This experimental study with a post test only control group design, used male Wistar white rats (Rattus norvegicus). Blastocystis sp infection in rats assessed by performing microscopic examination of rat faeces and culture. Leukocytes count examination was carried out using a counting chamber. Data analysis was carried out using the One Way Anova Test. The final results obtained were the mean number of leukocytes in treatment group 1 (P1), treatment 2 (P2) negative control (K-) respectively, 6171.43 cells/mm3, 6866.67 cells/mm3 , and 7742.86 cells/mm3 mm3. The p value of One Way Anova p = 0.7 (p > 0.05). The conclusion is the administration of Blastocystis sp. did not significantly influence the number of rat leukocytes.Keywords: blastocystis sp; leukocyte count; rattus norvegicus

Correlation of macronutrient intake and body fat precentage with menstrual cycle Nurdi, Nadya Khaira; Desmawati, Desmawati; Afriani, Nita
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 11 ISSUE 1, 2023
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2023.11(1).22-29

ABSTRAK Latar Belakang: Hasil Riset Kesehatan Dasar Tahun 2010 menyatakan bahwa terdapat sebanyak 13,7% wanita di Indonesia mengalami siklus menstruasi tidak teratur, 7,7% disebabkan oleh faktor pola hidup. Sumatera Barat merupakan provinsi tiga tertinggi gangguan siklus menstruasi di Indonesia, dengan prevalensi sebesar 19,1% (3).Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara jumlah asupan makronutrien dan kadar lemak tubuh dengan siklus menstruasi pada mahasiswi Fakultas Kedokteran Universitas Andalas.Metode: Penelitian ini merupakan penelitian observasional dengan desain penelitian cross sectional. Penelitian ini dilaksanakan di Fakultas Kedokteran Universitas Andalas pada bulan November 2021-September 2022, dengan jumlah sampel sebanyak 78 orang. Sampel diperoleh secara sistematis berdasarkan interval sampel. Pengumpulan data dilakukan secara langsung dengan cara pemeriksaan fisik dan pengisian kuesioner. Analisis bivariat dilakukan dengan uji t-independen dan analisis multivariat dilakukan dengan regresi logistik.Hasil: Hasil penelitian menyatakan bahwa 42,3% mahasiswi memiliki siklus menstruasi tidak normal, rerata jumlah asupan makronutrien (kalori total, karbohidrat, lemak, protein) dan kadar lemak tubuh mahasiswi adalah 2725,40±269,90 kkal, 378,86±40,70 gram, 90,58±14,40 gram, 98,54±11,36 gram, dan 36,19±7,02%. Uji T-independen menunjukkan bahwa terdapat hubungan yang bermakna antara jumlah asupan makronutrien (kalori total, karbohidrat, lemak, protein) dan kadar lemak tubuh dengan siklus menstruasi (p=0,000, 0,016, 0,005, 0,028, 0,000). Uji regresi logistik menunjukkan bahwa kadar lemak tubuh merupakan faktor yang paling dominan berhubungan dengan siklus menstruasi (p=0,000).Kesimpulan: Adanya hubungan yang bermakna antara jumlah asupan makonutrien dan kadar lemak tubuh dengan siklus mentruasi. Serta, kadar lemak tubuh merupakan faktor yang paling dominan berhubungan dengan siklus menstruasi. KATA KUNCI: asupan makronutrien; kadar lemak tubuh; siklus menstruasi ABSTRACTBackground: Indonesian Basic Health Research 2010 state that 13.7% of women in Indonesia with irregular menstrual cycles, 7,7% caused by lifestyle factors. West Sumatra is the third highest province of irregular menstruation prevalence in Indonesia, which is 19.1% (3).Objectives: The purpose of this research is to determine the relationship between macronutrient intake and body fat percentage with the menstrual cycle in female students Faculty of Medicine, Andalas University.Methods: This research type was an observational study with cross-sectional research design. This research was conducted at the Faculty of Medicine, Andalas University in November 2021-September 2022, with samples were 78 respondents. Samples were taken systematically based on sample intervals. Data were collected by physical examination and questionnaires. Bivariate analysis used an independent sample t-test and multivariate analysis used logistic regression.Results: The results of this research stated that 42,3% of respondents had irregular menstruation, the mean of macronutrient intake (calories, carbohydrate, fat, protein) and body fat percentage of respondents were 2725,40±269,90 kcal, 378,86±40,70 gram, 90,58±14,40 gram, 98,54±11,36 gram, and 36,19±7,02%. The independent sample T-test showed a significant relationship between of macronutrient intake (calories, carbohydrate, fat, protein) and body fat percentage with menstrual cycle (p=0,000, 0,016, 0.005, 0,028, and 0,000). The logistic regression test showed that body fat percentage as dominant factor of menstrual cycle (p=0,000).Conclusions: The conclusion of this research is a significant relationship between macronutrient intake and body fat percentage with the menstrual cycle. And also, body fat percentage as dominant factor of menstrual cycle. KEYWORD: body fat percentage; macronutrients intake; menstrual cycle

Hubungan Kadar Matrix Metalloproteinase-8 (MMP-8) pada Pasien Gingivitis Setelah Tindakan Scaling dan Root Planing Berdasarkan Gingival Index (GI) Thifla Rafifa Wirza; Nita Afriani; Nila Kasuma
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1419

This study aims to analyze the relationship between the Gingival Index (GI) and the levels of Matrix Metalloproteinase-8 (MMP-8) in the saliva of gingivitis patients after Scaling and Root Planing (SRP). A total of 36 gingivitis patients aged 15-24 years who underwent SRP in Padang City were included in the study. GI was assessed using the WHO probe, and saliva samples were collected on day 7 after SRP using the unstimulated saliva method. MMP-8 levels in the saliva were analyzed using an ELISA kit. The results showed higher average MMP-8 levels in the moderate and severe gingivitis groups compared to the mild group, but with considerable individual variation. The Kruskal-Wallis test revealed that the difference in MMP-8 levels among GI categories was not statistically significant (p = 0.584). Although there was a trend of increasing levels, these results suggest that MMP-8 cannot be used as a sole determinant of gingivitis severity and is better utilized as a supportive biomarker when combined with other clinical parameters.

GAMBARAN TINGKAT PENGETAHUAN MASYARAKAT TENTANG KEJADIAN IKUTAN PASCA IMUNISASI (KIPI) COVID-19 DI KOTA SOLOK Adhima Indriyani; Eryati Darwin; Syandrez Prima Putra; Nita Afriani; Firdawati Firdawati
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 6 (2026): SINERGI : Jurnal Riset Ilmiah, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i6.2677

Covid-19 is an infectious disease caused by SARS-CoV-2 virus. Many people are worried about getting vaccinated because they received false rumors about KIPI Covid-19 which can cause death by using several types of vaccines. Objective: This study aims to describe the level of public knowledge about Covid-19 Post-Immunization Follow-up Events (KIPI) in Solok City. Methode: This research is a quantitative descriptive study, which is to see a variable description of the level of public knowledge regarding KIPI Covid-19 based on the characteristics of respondents. Sampling using simple random sampling method on 100 respondents. Result: In this study, the results were obtained: only 36% of respondents had received the third dose of Covid-19 vaccination, 52% of respondents had insufficient knowledge regarding KIPI Covid-19, and 57% of respondents experienced Covid-19 Post Immunization Follow-Up Events (KIPI). There is no association between gender, age, education level, and employment status with knowledge of Covid-19 Post Immunization Follow-Up Events (KIPI). There is a significant association between vaccination status with knowledge of Covid-19 Post Immunization Follow-Up Events (KIPI). Conclusion: There were more respondents who have less knowledge (more than half of the respondents). When viewed from the vaccination status, more respondents with less knowledge got vaccinated up to the second dose.

Co-Authors Adhima Indriyani Adrial Adrial Aisyah Ellyanti Almurdi Almurdi Aswiyanti Asri Desmawati Desmawati DWI SURYANTO Eka Nofita Eryati Darwin Febriyanti, Rizka Firdawati Firdawati Friska Marcelly Miftah Irrahmah Muhamad Imamhamda Muttaqien Muhammad Arief Ansyar Nadya Khaira Nurdi Nila Kasuma Nurdi, Nadya Khaira Rizka Fitria Husni Ruhilmi Nisa Sakina Munira Syandrez Prima Putra Thifla Rafifa Wirza Yulistini, Yulistini Yusrawati Yusrawati

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