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All Journal Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation
Adelia Safira
Medical Staff
Decision Sciences, Operations Research & Management Neuroscience Physics

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The Effect of Yap Taz on Flexibility Exercise in Patient With Idiopathic Scoliosis Adelia Safira; Yenni Limyati; Grace Puspasari
Indonesian Journal of Physical Medicine & Rehabilitation Vol 10 No 01 (2021): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1536.847 KB) | DOI: 10.36803/ijpmr.v10i1.283

Abstract

ABSTRACTDuring the outbreak of Covid-19, the policy of working from home for employees and studying from home for students create a new problem. Employees and students mostly have to sit for long periods of time. This can affect body posture leading to lower back pain. Scoliosis is a postural disorder consistingof lateral curvature and rotation of the vertebrae. The etiology of idiopathic scoliosis remains unknown, and still present as theoretical hypothesis’s experts. One of non-surgical treatment that has been used for mild to moderate scoliosis is flexibility exercises. Flexibility exercises have been reported to reducethe degree of curvature in idiopathic scoliosis through the muscle hypertrophy mechanism. Muscle hypetrophy is regulated by Yes-associated protein (Yap) and transcriptional co-activator with PDZbinding motif protein (Taz) through three pathways, such as Hippo pathway signal, mechanosensorresponse, and mTOR signaling. The aim of this review is to examine more deeply the effect of Yap Taz protein on flexibility exercises in idiopathic scoliosis patien ts.Keywords: flexibility, hypertrophy, scoliosis, Taz, Yap.
The Effect of Yap Taz on Flexibility Exercise in Patient With Idiopathic Scoliosis Adelia Safira; Yenni Limyati; Grace Puspasari
Indonesian Journal of Physical Medicine & Rehabilitation Vol 10 No 01 (2021): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1536.847 KB) | DOI: 10.36803/ijpmr.v10i1.283

Abstract

ABSTRACTDuring the outbreak of Covid-19, the policy of working from home for employees and studying from home for students create a new problem. Employees and students mostly have to sit for long periods of time. This can affect body posture leading to lower back pain. Scoliosis is a postural disorder consistingof lateral curvature and rotation of the vertebrae. The etiology of idiopathic scoliosis remains unknown, and still present as theoretical hypothesis’s experts. One of non-surgical treatment that has been used for mild to moderate scoliosis is flexibility exercises. Flexibility exercises have been reported to reducethe degree of curvature in idiopathic scoliosis through the muscle hypertrophy mechanism. Muscle hypetrophy is regulated by Yes-associated protein (Yap) and transcriptional co-activator with PDZbinding motif protein (Taz) through three pathways, such as Hippo pathway signal, mechanosensorresponse, and mTOR signaling. The aim of this review is to examine more deeply the effect of Yap Taz protein on flexibility exercises in idiopathic scoliosis patien ts.Keywords: flexibility, hypertrophy, scoliosis, Taz, Yap.
Co-Authors Grace Puspasari, Grace Purwoko, Agus Yenni Limyati