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All Journal Bioma : Berkala Ilmiah Biologi JURNAL ANATOMI FISIOLOGI Biosaintifika: Journal of Biology & Biology Education Bioedukasi: Jurnal Pendidikan Biologi
Enny Yusuf Wachidah Yuniwarti
Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology

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The Histomorphometry of Liver and Kidney of Hyperglycemic Albino Rats after Treatment with Tithonia diversifolia Leaf Extract Yuneldi, Rizki Fitrawan; Saraswati, Tyas Rini; Yuniwarti, Enny Yusuf Wachidah
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 2 (2021): August 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i2.29459

Abstract

Tithonia diversifolia can be used as an antidiabetic, so it is necessary to study the safety of its use, especially the side effects on the liver and kidneys. This study aimed to determine the effect of using T. diversifolia leaf extract through histomorphometry observations of the liver and kidneys of hyperglycemic albino rats. The study design used a completely randomized design (CRD). This study used 20 male albino rats which were divided into five treatment groups, there were T0 (rat normal/control), T1 (hyperglycemic rat without T. diversifolia leaf extract), T2 (hyperglycemic rat administered with Glibenclamide 10 mg/kg BW), T3 (hyperglycemic rat administered with T. diversifolia leaf extract 150 mg/kg BW), T4 (hyperglycemic rat administered with T. diversifolia leaf extract 300 mg/kg BW). Every treatment was repeated four times. The damage of hepatocyte and the glomerular cell was observed through histological structure observation by histomorphometry method using a photomicrography microscope (Olympus BX51). The results indicate that there were significant differences (P < 0.05) in the variable of hepatocytes diameter and there was no significant different (P > 0.05) result on glomerular diameter, as well as kidney and liver weight. It was concluded that T. diversifolia leaf extract of 150 mg/kg BW and 300 mg/kg BW are safe to be used as antidiabetic. It does not cause any side effects on the liver and kidneys of hyperglycemic albino rats. Thereby T. diversifolia leaf extract can be further tested as preparation of biopharmaca which can be used as herbal medicines for diabetics.
The Effects of Kersen Juice (Mutingia calabura L.) and Lakum Leaf Extract (Cayratia trifolia L.) on Lipid Profile of White Rats (Rattus norvegicus L.) Hyperlipidemia Sopandi, Didin; Saraswati, Tyas Rini; Yuniwarti, Enny Yusuf Wachidah
Bioedukasi: Jurnal Pendidikan Biologi Vol 12, No 2 (2019): Bioedukasi: Jurnal Pendidikan Biologi
Publisher : Department of Biology Education Faculty of Teacher Training and Education Sebelas Maret Un

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/bioedukasi-uns.v12i2.34236

Abstract

Kersen fruit and Lakum leaf contain substances that are potential as an antihyperlipidemic. This study aimed to analyze The Effects of Kersen Juice (Mutingia calabura L.) with dosage 0.2 ml/200 g BW and Lakum Leaf Extract (Cayratia trifolia L.) with dosage 40 mg/200 g BW on Lipid Profile of White Rats (Rattus norvegicus L.) Hyperlipidemia. This study used a complete randomized design (CRD). Twenty adult male Wistar rats were divided into five groups, P0 as a control group, P1 as a HFD control group, P2 as a HFD group treated with Kersen juice with dosage 0.2 ml/200 g BW, P3 as a HFD group treated with Lakum leaf extract with dosage 40 mg/200 g BW and P4 as a HFD group treated by simvastatin. The treatments were given orally for 28 days. The parameters of this study were cholesterol level, HDL, LDL, triglyceride, body weight, and food consumption. One way ANOVA test was performed to determine the significant differences p<0.05 between groups followed by Duncan test with a 95% significant level. The results showed that compared to Kersen juice with dosage 0.2 ml/200 g BW, administration of Lakum leaf extract with dosage 40 mg/200 g BW was more effective in lowering cholesterol level, triglyceride and increasing HDL level, however, they were not effective in lowering LDL in rats with hyperlipidemia
Co-Authors Baehaqi, Ibnu Kio, Albertina Dhiu Kumala, Amelia Setya Nur Muhammad Anwar Djaelani Nuke Nur Hidayati, Nuke Nur Sari, Anisa Rachma Sopandi, Didin Sri Isdadiyanto Suhartatik, S Tyas Rini Saraswati Yuneldi, Rizki Fitrawan Yuneldi, Rizki Fitrawan