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Upregulation of MRNA TNF-α in Skeletal Muscle Tissue of Streptozotocin-Induced Diabetic RAT Akbar Satria Fitriawan; Christin Wiyani; Endang Nurul Syafitri; Ririn Wahyu Widayati
Proceedings of the International Conference on Nursing and Health Sciences Vol 1 No 1 (2020): November 2020
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (794.02 KB)

Inflammation is a molecular mechanism that linking obesity and ageing with insulin resistance in type 2 diabetes mellitus (DM). Although type 1 DM is primarily caused by insulin deficiency, but insulin resistance also prominent feature in this disease. It is not fully understood whether inflammation also contribute in insulin resistance phenotype in type 1 DM. This study aimed to assess mRNA TNF-α expression in the skeletal muscle tissue of type 1 diabetes mellitus rat model.This in-vivo study used 18 adults male wistar rats. The study conducted at Department of Anatomy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada from July to October 2020. Male Wistar rats divided into control group (CDM, n=6), and diabetes mellitus group which is divided into 1-month DM group (DM1M, n=6), and 2-month DM group (DM2M, n=6). The DM model was conducted through single intraperitoneal injection of Streptozotocin 60 mg/kg Body Weight (BW). At the end of study, rats were sacrificed and the gastrocnemius muscle was harvested. The expression of mRNA TNF-α was measured by RT-PCR. Statistical analysis was conducted using One Way ANOVA test. Blood glucose level were significantly higher in DM groups compared to control group (p<0.05). The body weight of DM groups was significantly lower after 1 month and 2 months DM period compared to control group (p<0.05). DM groups demonstrated upregulation of mRNA TNF-α compared to control group (p<0.05). Type 1 diabetes mellitus model demonstrated upregulation of mRNA TNF-α in skeletal muscle tissue.

FACTORS THAT INFLUENCE THE COMPLIANCE OF ANTIRETROVIRAL THERAPY (ART) ON HIV / AIDS PATIENTS IN DR. SARDJITO YOGYAKARTA Akbar Satria Fitriawan; Khudazi Aulawi; Haryani Haryani
Journal of Nursing Science Update (JNSU) Vol. 7 No. 1 (2019)
Publisher : Department of Nursing, Faculty of Health Sciencce, Universitas Brawijaya

Antiretroviral therapy (HAART) is very important for patients with HIV/AIDS in order to prevent the appearance of AIDS symptoms, reduce hospitalizations and prevent mortality. But it required minimum of 95% adherence rate to prevent the occurrence of viral resistance to and AIDS development. Identification of the factors that influence adherence are needed to develop appropriate interventions to maintain patient adherence. The aimed of the study was to assess adherence rate with antiretroviral therapy in HIV-infected patients in Dr.Sardjito General Hospital and identify factors that influence it. Observational analytic study with cross sectional design was used in this study. The independent variable in this study is sociodemographic factors, social support, depression, self efficacy, quality of health care providerâ€™s communication and patient's CD4 count. Bivariate and logistic regression is used to determine the factors that affecting adherence. A total of 64 HIV/AIDS patients participated in this study. 36 patients (56.3%) had adherence <95% with an average adherence of 83.64% (SD = 21.25). Depression, social support, self efficacy, quality of health care providerâ€™s communication, age and employment status is associated with adherence (p <0.05). In multivariate analysis, low self-efficacy (PR = 12,94; p = 0,001) and low social support (PR = 5,47; p = 0,024) is a predictor of poor medication adherence. In conclusion self efficacy and social support is a predictor of adherence in HIV/AIDS patient. Interventions that focus on these factors is expected to improve patient adherence to medication.

Upregulation of MRNA TNF-α in Skeletal Muscle Tissue of Streptozotocin-Induced Diabetic RAT Akbar Satria Fitriawan; Christin Wiyani; Endang Nurul Syafitri; Ririn Wahyu Widayati
Proceedings of the International Conference on Nursing and Health Sciences Vol 1 No 1 (2020): July-December 2020
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar

Inflammation is a molecular mechanism that linking obesity and ageing with insulin resistance in type 2 diabetes mellitus (DM). Although type 1 DM is primarily caused by insulin deficiency, but insulin resistance also prominent feature in this disease. It is not fully understood whether inflammation also contribute in insulin resistance phenotype in type 1 DM. This study aimed to assess mRNA TNF-α expression in the skeletal muscle tissue of type 1 diabetes mellitus rat model.This in-vivo study used 18 adults male wistar rats. The study conducted at Department of Anatomy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada from July to October 2020. Male Wistar rats divided into control group (CDM, n=6), and diabetes mellitus group which is divided into 1-month DM group (DM1M, n=6), and 2-month DM group (DM2M, n=6). The DM model was conducted through single intraperitoneal injection of Streptozotocin 60 mg/kg Body Weight (BW). At the end of study, rats were sacrificed and the gastrocnemius muscle was harvested. The expression of mRNA TNF-α was measured by RT-PCR. Statistical analysis was conducted using One Way ANOVA test. Blood glucose level were significantly higher in DM groups compared to control group (p<0.05). The body weight of DM groups was significantly lower after 1 month and 2 months DM period compared to control group (p<0.05). DM groups demonstrated upregulation of mRNA TNF-α compared to control group (p<0.05). Type 1 diabetes mellitus model demonstrated upregulation of mRNA TNF-α in skeletal muscle tissue.

HOPELESSNESS AMONG NURSING STUDENTS DURING THE EARLY PHASE OF COVID-19 PANDEMIC : ONLINE CROSS SECTIONAL STUDY AT UNIVERSITAS RESPATI YOGYAKARTA Akbar Satria Fitriawan; Ririn Wahyu Widayati; Januar Rizqi; C.Riyan Alfrendo
Jurnal Keperawatan Respati Yogyakarta Vol 10 No 1 (2023): JANUARY 2023
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35842/jkry.v10i01.716

Background: Global pandemic of COVID-19 caused unprecedented effect in education sector due to the university closure and distance education, which could significantly affected students mental health and increased suicidality. Nursing students are vulnerable population due to already stressful academic activities coupled with pandemic loneliness and financial difficulties. Hopelessness, a negative view of the self in relation to the world and the future, identified as consistent predictor of suicidality. This study aimed to explore the prevalence of hopelessness among nursing students and association between sociodemographic characteristic and hopelessness. Methods: Online cross sectional study was conducted in Universitas Respati Yogyakarta between June until September 2020, and involved 232 nursing students that selected using consecutive sampling method. Sociodemographic questionnare and Beck Hopelessness Scale (BHS) were used to collect the data. Chi square test was used to analyze association between sociodemographic characteristic and hopelessness. Result: Our study elucidated that the prevalence of hopelessness among nursing students at Universitas Respati Yogyakarta during the early phase of COVID-19 pandemic is 9.5%. Chi square test revealed that there is no significant association between any sociodemographic characteristic and hopelessness (p>0.05). Conclusion: The prevalence of hopelessness among nursing students is low, and sociodemographic profiles is not determinant of hopelessness.

Pelatihan Dan Pendampingan Kader Kesehatan Tentang Pengukuran Kadar Glukosa Darah Sebagai Upaya Deteksi Dini Diabetes Melitus Januar Rizqi; Akbar Satria Fitriawan
JURNAL SUAKA INSAN MENGABDI (JSIM) Vol 2 No 2 (2020): Jurnal Suaka Insan Mengabdi (JSIM)
Publisher : STIKES Suaka Insan Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51143/jsim.v2i2.191

Diabetes mellitus (DM) Tipe 2 menjadi salah satu masalah kesehatan di Dunia dan Indonesia yang jumlahnya terus meningkat. Pendidikan kesehatan manajemen diri DM dianggap sebagai komponen integral dalam perawatan diabetes. Upaya deteksi dini dan monitor kadar gula darah bagi penderita DM melalui kader kesehatan diperlukan untuk mendeteksi dan megurangi risiko terjadinya komplikasi serta kematian akibat DM. Solusi yang ditawarkan adalah pelatihan dan pendampingan kader tentang pengukuran kadar glukosa darah. Metode pemecahan masalah dilakukan dengan 1) melakukan pendidikan kesehatan tentang diabetes mellitus kepada kader kesehatan, 2) melakukan pelatihan pengukuran kadar glukosa darah kepada kader kesehatan, 3) melakukan pendampingan kegiatan pengukuran kadar glukosa darah. Hasil: Terdapat 5 warga yang resiko tinggi diabetes, sedangkan 16 warga diantaranya dengan kategori prediabetes. Terdapat perubahan pengetahuan dan kepercayaan diri kader kesehatan untuk deteksi dini serta pencegahan penyakit diabetes setelah diberikan pelatihan. Kesimpulan: Kader kesehatan mengalami peningkatan pengetahuan tentang penyakit diabetes mellitus dan secara mandiri dapat melakukan pengukuran kadar glukosa darah kepada warga sebagai upaya deteksi dini diabetes mellitus.

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