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Khing S. Ong
Director Allergy and Immunology Division, Department of Pediatrics, University of California Irvine. 1978-1985, USA
Health Professions Medicine & Pharmacology Public Health

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A Review of Gene Editing/Therapy and CRISPR Technology Khing S. Ong; Zack S.T. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 46, No 6 (2019): Diabetes Mellitus
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i6.470

Abstract

This review will discuss the gene editing or manipulation in general, including various methods and tools currently available, including CRISPR. Some encouraging results of clinical applications of gene-therapy will also be discussed. With its diverse and far reaching effect on biomedical field, we will also discuss CRISPR technology beyond its gene-editing functions. We also review the cost for performing a gene-therapy.Ulasan ini membahas penyuntingan atau manipulasi gen umumnya, berbagai cara dan alat yang kini tersedia, termasuk teknologi CRISPR. Akan disajikan pula hasil-hasil percobaan klinik yang memberi harapan. Mengingat pengaruhnya yang luas di bidang biomedis , akan dibahas pula pemanfaatannya di bidang lain. Akhirnya, akan dibicarakan juga hal-hal terkait biaya pengeditan terapi gen yang sangat tinggi, dengan harapan bisa ditekan di masa yang akan datang dengan teknologi yang lebih canggih.
Anti-aging Interventions : Caloric Restriction and Beyond Khing S. Ong; Zack S.T. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45, No 9 (2018): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i9.614

Abstract

Aging is the biggest risk factor for most of the age-related chronic diseases, which carried a heavy health-care costs burden worldwide. These age-related diseases, such as cardiovascular diseases, neurodegenerative diseases, cancers, type2 diabetes and osteoarthritis shared common mechanisms that associate with aging, such as chronic sterile low grade inflammation, cellular senescence, DNA damages and stem cells dysfunctions. In this review, we will first discussed the dietary manipulation, such as caloric restriction as the mean of delaying aging, and we will also review nutraceuticals or natural compounds, and pharmaceutical drugs as the mean for intervention of aging.Proses menua dikaitkan dengan berbagai penyakit kronis terkait-usia. Penyakit-penyakit tersebut, seperti penyakit kardiovaskuler, penyakit neurodegeneratif, kanker, diabetes tipe 2 dan osteoarthritis mempunyai gambaran umum serupa yaitu inflamasi steril kronis kadar rendah, penuaan sel,kerusakan DNA dan disfungsi sel punca. Tinjauan ini berkenaan dengan manipulasi diet berupa restriksi kalori, juga nutraceuticals serta senyawa alami, juga sediaan faramakologis untuk tujuan mengintervensi proses penuaan. 
Cancer Immunotherapy and CAR T Cells Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45, No 12 (2018): Farmakologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i12.551

Abstract

Within the past decade, radical changes of idea emerged from the works of research scientists, medical experts and oncologists. Instead of treating cancers with man-made chemicals or chemotherapy and radiotherapy, or surgically remove the tumor, we should unleash the power of our own body immune system. Indeed, such approach has borne fruits and benefited at least for some cancer patients. This review described various types of immunotherapy known to date, with its beneficial effects, albeit some with serious harmful effects. To understand how immunotherapies worked, we also review some biologic characteristic of cancer cell that let them evade attacks from our immune system; cancer microenvironment that works in favor or protecting the growth of cancer against our immune system will also be discussed.Hanya dalam jangka 10 tahun terakhir, telah terjadi perubahan radikal hasil penelitian penyakit kanker. Di samping cara klasik penyembuhan kanker seperti obat-obat kimia sintetik, kemoterapi dan radiologi atau pembedahan, kini para ahli telah menggunakan sistim imunitas tubuh penderita sendiri. Cara ini telah terbukti dalam pengobatan beberapa pasien kanker. Dalam ulasan ini kami akan memaparkan beberapa immunoterapi saat ini dengan hasil baik meskipun masih terdapat beberapa kesalahan dan efek samping. Akan diulas dan dijelaskan sifat-sifat biologi sel kanker, dan bagaimana kanker sel bisa menghindari serangan sistim imun; dan lingkungan mikrokanker (cancer microenviroment) yang melindungi kanker dari sistim imun. 
Senolytics: A Potential Fountain of Youth. Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 46, No 2 (2019): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i2.524

Abstract

Senolytics are groups of natural compounds, small molecules drugs and methods that eliminate senescent cells in the body of an organism. This review illustrate the pathogenesis or factors that lead to cellular senescence. As cellular senescence is the main culprit for age-associated diseases, the development of various classes of senolytics is of paramount importance in maintaining or even extending our health-span. Different classes of senolytics with some perspective of its potential for clinical applications will also be discussed.Senolyitcs merupakan kelompok senyawa alami, obat dan metode yang melenyapkan sel-sel tua dari tubuh. Tinjauan ini membahas patogenesis dan faktor-faktor yang menyebabkan proses penuaan sel. Mengingat penuaan sel merupakan penyebab utama penyakit-penyakit akibat penuaan, pengembangan berbagai jenis senolytics sangat penting dalam upaya mempertahankan dan memperpanjang harapan hidup. Akan dibicarakan pula beberapa kelas senolytics beserta potensi klinisnya.
A Review of Gene Editing/Therapy and CRISPR Technology Khing S. Ong; Zack S.T. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 46 No 6 (2019): Endokrinologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i6.441

Abstract

This review will discuss the gene editing or manipulation in general, including various methods and tools currently available, including CRISPR. Some encouraging results of clinical applications of gene-therapy will also be discussed. With its diverse and far reaching effect on biomedical field, we will also discuss CRISPR technology beyond its gene-editing functions. We also review the cost for performing a gene-therapy. Ulasan ini membahas penyuntingan atau manipulasi gen umumnya, berbagai cara dan alat yang kini tersedia, termasuk teknologi CRISPR. Akan disajikan pula hasil-hasil percobaan klinik yang memberi harapan. Mengingat pengaruhnya yang luas di bidang biomedis, akan dibahas pula pemanfaatannya di bidang lain. Akhirnya, akan dibicarakan juga hal-hal terkait biaya pengeditan terapi gen yang sangat tinggi, dengan harapan bisa ditekan di masa yang akan datang dengan teknologi yang lebih canggih.
Roles of Telomeres and Telomerase in Aging Khing S. Ong; Zack S.T. Liem; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol. 46 No. 4 (2019): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.483

Abstract

Telomeres are DNA structure that capped the end of linear eukaryotic chromosomes to protect the stability and integrity of the chromosomes. Attrition of telomeres has been known as one of the hallmark of aging. This review leads to huge interest in the biology of telomeres and the related enzyme in the aging and related fields. We attempt to review briefly the biology and functions of telomeres, factors, and mechanisms that control its length and its maintenance. Genetic and epigenetic related dysfunction of telomeres and telomerase will also be discussed. Finally, a list of disorders of telomeres and telomerase (telomeropathies) will be mentioned with potential therapeutic interventions for these disorders, and the potential for delaying cell senescence and health-span extension. Telomeres adalah bagian dari struktur DNA di ujung linier helix eukaryotic chromosome sebagai penutup/cap untuk menghindari dan melindungi bagian ujung kromosom dari kerusakan dan untuk menjaga kestabilannya. Telomeres akan mengalami erosi atau pemendekan yang merupakan tanda penuaan/aging. Proses ini mendapat perhatian besar sehubungan dengan peristiwa penuaan. Ulasan singkat ini tentang sifat-sifat biologi dan fungsi telomeres. Akan dibahas pula akibat pergeseran/disfungsi genetik dan epigenetik yang menyebabkan perubahan telomeres dan telomerase. Di akhir pembahasan, dicantumkan daftar telomeres dan telomerase (telomeropathies) yang dapat diintervensi dan dapat memperlambat proses penuaan, dengan kata lain memperpanjang usia.
Senolytics : A Potential Fountain of Youth. Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol. 46 No. 2 (2019): Interna
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i2.511

Abstract

Senolytics are groups of natural compounds, small molecules drugs and methods that eliminate senescent cells in the body of an organism. This review illustrate the pathogenesis or factors that lead to cellular senescence. As cellular senescence is the main culprit for age-associated diseases, the development of various classes of senolytics is of paramount importance in maintaining or even extending our health-span. Different classes of senolytics with some perspective of its potential for clinical applications will also be discussed. Senolyitcs merupakan kelompok senyawa alami, obat dan metode yang melenyapkan sel-sel tua dari tubuh. Tinjauan ini membahas patogenesis dan faktor-faktor yang menyebabkan proses penuaan sel. Mengingat penuaan sel merupakan penyebab utama penyakit-penyakit akibat penuaan, pengembangan berbagai jenis senolytics sangat penting dalam upaya mempertahankan dan memperpanjang harapan hidup. Akan dibicarakan pula beberapa kelas senolytics beserta potensi klinisnya
Anti-aging Interventions: Caloric Restriction and Beyond Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45 No 9 (2018): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.726

Abstract

Aging is the biggest risk factor for most of the age-related chronic diseases, which carried a heavy health-care costs burden worldwide. These age-related diseases, such as cardiovascular diseases, neurodegenerative diseases, cancers, type 2 diabetes, and osteoarthritis, shared common mechanisms that associate with aging, such as chronic sterile low grade inflammation, cellular senescence, DNA damages, and stem cells dysfunctions. In this review, we will first discussed the dietary manipulation, such as caloric restriction as the mean of delaying aging, and we will also review nutraceuticals or natural compounds, and pharmaceutical drugs as the mean for intervention of aging. Proses menua dikaitkan dengan berbagai penyakit kronis terkait-usia, yang mengakibatkan beban biaya perawatan kesehatan yang besar di seluruh dunia. Penyakit-penyakit tersebut meliputi penyakit kardiovaskuler, penyakit neurodegeneratif, kanker, diabetes tipe 2, dan osteoartritis, yang mempunyai gambaran umum serupa yaitu inflamasi steril kronis kadar rendah, penuaan sel, kerusakan DNA, dan disfungsi sel punca. Tinjauan ini berkenaan dengan manipulasi diet berupa restriksi kalori, dan nutraceuticals serta senyawa alami, juga sediaan farmakologis untuk tujuan mengintervensi proses penuaan
A Review of Gene Editing/Therapy and CRISPR Technology Khing S. Ong; Zack S.T. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 46 No 6 (2019): Endokrinologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i6.441

Abstract

This review will discuss the gene editing or manipulation in general, including various methods and tools currently available, including CRISPR. Some encouraging results of clinical applications of gene-therapy will also be discussed. With its diverse and far reaching effect on biomedical field, we will also discuss CRISPR technology beyond its gene-editing functions. We also review the cost for performing a gene-therapy. Ulasan ini membahas penyuntingan atau manipulasi gen umumnya, berbagai cara dan alat yang kini tersedia, termasuk teknologi CRISPR. Akan disajikan pula hasil-hasil percobaan klinik yang memberi harapan. Mengingat pengaruhnya yang luas di bidang biomedis, akan dibahas pula pemanfaatannya di bidang lain. Akhirnya, akan dibicarakan juga hal-hal terkait biaya pengeditan terapi gen yang sangat tinggi, dengan harapan bisa ditekan di masa yang akan datang dengan teknologi yang lebih canggih.
Roles of Telomeres and Telomerase in Aging Khing S. Ong; Zack S.T. Liem; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 46 No 4 (2019): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.483

Abstract

Telomeres are DNA structure that capped the end of linear eukaryotic chromosomes to protect the stability and integrity of the chromosomes. Attrition of telomeres has been known as one of the hallmark of aging. This review leads to huge interest in the biology of telomeres and the related enzyme in the aging and related fields. We attempt to review briefly the biology and functions of telomeres, factors, and mechanisms that control its length and its maintenance. Genetic and epigenetic related dysfunction of telomeres and telomerase will also be discussed. Finally, a list of disorders of telomeres and telomerase (telomeropathies) will be mentioned with potential therapeutic interventions for these disorders, and the potential for delaying cell senescence and health-span extension. Telomeres adalah bagian dari struktur DNA di ujung linier helix eukaryotic chromosome sebagai penutup/cap untuk menghindari dan melindungi bagian ujung kromosom dari kerusakan dan untuk menjaga kestabilannya. Telomeres akan mengalami erosi atau pemendekan yang merupakan tanda penuaan/aging. Proses ini mendapat perhatian besar sehubungan dengan peristiwa penuaan. Ulasan singkat ini tentang sifat-sifat biologi dan fungsi telomeres. Akan dibahas pula akibat pergeseran/disfungsi genetik dan epigenetik yang menyebabkan perubahan telomeres dan telomerase. Di akhir pembahasan, dicantumkan daftar telomeres dan telomerase (telomeropathies) yang dapat diintervensi dan dapat memperlambat proses penuaan, dengan kata lain memperpanjang usia.
Co-Authors Boenjamin Setiawan Boenjamin Setiawan Boenjamin Setiawan Zack S.T. Liem Zack S.T. Lim Zack ST. Lim