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Khing S. Ong
Director Allergy and Immunology Division, Department of Pediatrics, University of California Irvine. 1978-1985, USA
Health Professions Medicine & Pharmacology Public Health

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Senolytics : A Potential Fountain of Youth. Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 46 No 2 (2019): Interna
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i2.511

Abstract

Senolytics are groups of natural compounds, small molecules drugs and methods that eliminate senescent cells in the body of an organism. This review illustrate the pathogenesis or factors that lead to cellular senescence. As cellular senescence is the main culprit for age-associated diseases, the development of various classes of senolytics is of paramount importance in maintaining or even extending our health-span. Different classes of senolytics with some perspective of its potential for clinical applications will also be discussed. Senolyitcs merupakan kelompok senyawa alami, obat dan metode yang melenyapkan sel-sel tua dari tubuh. Tinjauan ini membahas patogenesis dan faktor-faktor yang menyebabkan proses penuaan sel. Mengingat penuaan sel merupakan penyebab utama penyakit-penyakit akibat penuaan, pengembangan berbagai jenis senolytics sangat penting dalam upaya mempertahankan dan memperpanjang harapan hidup. Akan dibicarakan pula beberapa kelas senolytics beserta potensi klinisnya
Anti-aging Interventions: Caloric Restriction and Beyond Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45 No 9 (2018): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.726

Abstract

Aging is the biggest risk factor for most of the age-related chronic diseases, which carried a heavy health-care costs burden worldwide. These age-related diseases, such as cardiovascular diseases, neurodegenerative diseases, cancers, type 2 diabetes, and osteoarthritis, shared common mechanisms that associate with aging, such as chronic sterile low grade inflammation, cellular senescence, DNA damages, and stem cells dysfunctions. In this review, we will first discussed the dietary manipulation, such as caloric restriction as the mean of delaying aging, and we will also review nutraceuticals or natural compounds, and pharmaceutical drugs as the mean for intervention of aging. Proses menua dikaitkan dengan berbagai penyakit kronis terkait-usia, yang mengakibatkan beban biaya perawatan kesehatan yang besar di seluruh dunia. Penyakit-penyakit tersebut meliputi penyakit kardiovaskuler, penyakit neurodegeneratif, kanker, diabetes tipe 2, dan osteoartritis, yang mempunyai gambaran umum serupa yaitu inflamasi steril kronis kadar rendah, penuaan sel, kerusakan DNA, dan disfungsi sel punca. Tinjauan ini berkenaan dengan manipulasi diet berupa restriksi kalori, dan nutraceuticals serta senyawa alami, juga sediaan farmakologis untuk tujuan mengintervensi proses penuaan
Co-Authors Boenjamin Setiawan Boenjamin Setiawan Boenjamin Setiawan Zack S.T. Liem Zack S.T. Lim Zack ST. Lim