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Anti-aging Interventions : Caloric Restriction and Beyond Khing S. Ong; Zack S.T. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45, No 9 (2018): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i9.614

Aging is the biggest risk factor for most of the age-related chronic diseases, which carried a heavy health-care costs burden worldwide. These age-related diseases, such as cardiovascular diseases, neurodegenerative diseases, cancers, type2 diabetes and osteoarthritis shared common mechanisms that associate with aging, such as chronic sterile low grade inflammation, cellular senescence, DNA damages and stem cells dysfunctions. In this review, we will first discussed the dietary manipulation, such as caloric restriction as the mean of delaying aging, and we will also review nutraceuticals or natural compounds, and pharmaceutical drugs as the mean for intervention of aging.Proses menua dikaitkan dengan berbagai penyakit kronis terkait-usia. Penyakit-penyakit tersebut, seperti penyakit kardiovaskuler, penyakit neurodegeneratif, kanker, diabetes tipe 2 dan osteoarthritis mempunyai gambaran umum serupa yaitu inflamasi steril kronis kadar rendah, penuaan sel,kerusakan DNA dan disfungsi sel punca. Tinjauan ini berkenaan dengan manipulasi diet berupa restriksi kalori, juga nutraceuticals serta senyawa alami, juga sediaan faramakologis untuk tujuan mengintervensi proses penuaan.

Cancer Immunotherapy and CAR T Cells Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45, No 12 (2018): Farmakologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i12.551

Within the past decade, radical changes of idea emerged from the works of research scientists, medical experts and oncologists. Instead of treating cancers with man-made chemicals or chemotherapy and radiotherapy, or surgically remove the tumor, we should unleash the power of our own body immune system. Indeed, such approach has borne fruits and benefited at least for some cancer patients. This review described various types of immunotherapy known to date, with its beneficial effects, albeit some with serious harmful effects. To understand how immunotherapies worked, we also review some biologic characteristic of cancer cell that let them evade attacks from our immune system; cancer microenvironment that works in favor or protecting the growth of cancer against our immune system will also be discussed.Hanya dalam jangka 10 tahun terakhir, telah terjadi perubahan radikal hasil penelitian penyakit kanker. Di samping cara klasik penyembuhan kanker seperti obat-obat kimia sintetik, kemoterapi dan radiologi atau pembedahan, kini para ahli telah menggunakan sistim imunitas tubuh penderita sendiri. Cara ini telah terbukti dalam pengobatan beberapa pasien kanker. Dalam ulasan ini kami akan memaparkan beberapa immunoterapi saat ini dengan hasil baik meskipun masih terdapat beberapa kesalahan dan efek samping. Akan diulas dan dijelaskan sifat-sifat biologi sel kanker, dan bagaimana kanker sel bisa menghindari serangan sistim imun; dan lingkungan mikrokanker (cancer microenviroment) yang melindungi kanker dari sistim imun.

Roles of Telomeres and Telomerase in Aging Khing S. Ong; Zack S.T. Liem; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 46, No 4 (2019): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.495

Telomeres are DNA structure that capped the end of linear eukaryotic chromosomes to protect the stability and integrity of the chromosomes. Attrition of telomeres has been known as one of the hallmark of aging. This lead to huge interest in the biology of telomeres and the related enzyme in the aging and related fields. We attempt to review briefly the biology and functions of telomeres, factors and mechanisms that control its length and its maintenance. Genetic and epigenetic related dysfunction of telomeres and telomerase will also be discussed. Finally, a list of disorders of telomeres and telomerase (telomeropathies) will be mentioned with potential therapeutic interventions for these disorders, and the potential for delaying cell senescence and health-span extension.Telomeres adalah bagian dari struktur DNA di ujung linier helix eukaryotic chromosome sebagai penutup/cap untuk menghindari dan melindungi bagian ujung khromosom dari kerusakan dan untuk kestabilannya. Telomeres akan mengalami erosi atau memendek yang merupakan tanda penuaan / aging. Proses ini mendapat perhatian besar sehubungan dengan peristiwa penuaan/aging. Ulasan singkat ini tentang sifat-sifat biologi dan fungsi telomeres. Akan dibahas pula akibat pergeseran/disfungsi genetik dan epigenetik yang menyebabkan perubahan telomeres dan telomerase. Di akhir pembahasan, dicantumkan daftar telomeres dan telomerase (telomeropathies) yang bisa diintervensi dan dapat memperlambat proses penuaan, dengan kata lain memperpanjang umur.

Roles of Telomeres and Telomerase in Aging Khing S. Ong; Zack S.T. Liem; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol. 46 No. 4 (2019): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.483

Telomeres are DNA structure that capped the end of linear eukaryotic chromosomes to protect the stability and integrity of the chromosomes. Attrition of telomeres has been known as one of the hallmark of aging. This review leads to huge interest in the biology of telomeres and the related enzyme in the aging and related fields. We attempt to review briefly the biology and functions of telomeres, factors, and mechanisms that control its length and its maintenance. Genetic and epigenetic related dysfunction of telomeres and telomerase will also be discussed. Finally, a list of disorders of telomeres and telomerase (telomeropathies) will be mentioned with potential therapeutic interventions for these disorders, and the potential for delaying cell senescence and health-span extension. Telomeres adalah bagian dari struktur DNA di ujung linier helix eukaryotic chromosome sebagai penutup/cap untuk menghindari dan melindungi bagian ujung kromosom dari kerusakan dan untuk menjaga kestabilannya. Telomeres akan mengalami erosi atau pemendekan yang merupakan tanda penuaan/aging. Proses ini mendapat perhatian besar sehubungan dengan peristiwa penuaan. Ulasan singkat ini tentang sifat-sifat biologi dan fungsi telomeres. Akan dibahas pula akibat pergeseran/disfungsi genetik dan epigenetik yang menyebabkan perubahan telomeres dan telomerase. Di akhir pembahasan, dicantumkan daftar telomeres dan telomerase (telomeropathies) yang dapat diintervensi dan dapat memperlambat proses penuaan, dengan kata lain memperpanjang usia.

Cancer Immunotherapy and CAR T Cells King S Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45 No 12 (2018): Interna
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i12.683

Within the past decade, radical changes of idea emerged from the works of research scientists, medical experts, and oncologists. Instead of treating cancers with man-made chemicals or chemotherapy and radiotherapy, or surgically remove the tumor, we should unleash the power of our own body immune system. Indeed, such approach has borne fruits and benefited at least for some cancer patients. This review describes various types of immunotherapy known to date, with its beneficial effects, albeit some with serious harmful effects. To understand how immunotherapies work, we also review some biologic characteristics of cancer cells that let them evade attacks from our immune system; cancer microenvironment that works in favor or protecting the growth of cancer against our immune system will also be discussed. Hanya dalam jangka 10 tahun terakhir, telah terjadi perubahan radikal hasil penelitian para ahli, ahli medis, dan ahli onkologi. Di samping cara klasik penyembuhan kanker seperti obat-obat kimia sintetik atau kemoterapi dan radioterapi atau pembedahan, kini para ahli telah menggunakan sistem imunitas tubuh penderita sendiri. Cara ini telah terbukti dalam pengobatan beberapa pasien kanker. Dalam ulasan ini kami akan memaparkan beberapa immunoterapi saat ini dengan hasil baik meskipun masih terdapat beberapa efek samping berbahaya. Untuk memahami bagaimana imunoterapi bekerja, akan diulas dan dijelaskan sifat-sifat biologi sel kanker, dan bagaimana kanker sel bisa menghindari serangan sistem imun; dan lingkungan mikrokanker (cancer microenviroment) yang melindungi kanker dari sistem imun.

Anti-aging Interventions: Caloric Restriction and Beyond Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45 No 9 (2018): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.726

Aging is the biggest risk factor for most of the age-related chronic diseases, which carried a heavy health-care costs burden worldwide. These age-related diseases, such as cardiovascular diseases, neurodegenerative diseases, cancers, type 2 diabetes, and osteoarthritis, shared common mechanisms that associate with aging, such as chronic sterile low grade inflammation, cellular senescence, DNA damages, and stem cells dysfunctions. In this review, we will first discussed the dietary manipulation, such as caloric restriction as the mean of delaying aging, and we will also review nutraceuticals or natural compounds, and pharmaceutical drugs as the mean for intervention of aging. Proses menua dikaitkan dengan berbagai penyakit kronis terkait-usia, yang mengakibatkan beban biaya perawatan kesehatan yang besar di seluruh dunia. Penyakit-penyakit tersebut meliputi penyakit kardiovaskuler, penyakit neurodegeneratif, kanker, diabetes tipe 2, dan osteoartritis, yang mempunyai gambaran umum serupa yaitu inflamasi steril kronis kadar rendah, penuaan sel, kerusakan DNA, dan disfungsi sel punca. Tinjauan ini berkenaan dengan manipulasi diet berupa restriksi kalori, dan nutraceuticals serta senyawa alami, juga sediaan farmakologis untuk tujuan mengintervensi proses penuaan

Roles of Telomeres and Telomerase in Aging Khing S. Ong; Zack S.T. Liem; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 46 No 4 (2019): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.483

Telomeres are DNA structure that capped the end of linear eukaryotic chromosomes to protect the stability and integrity of the chromosomes. Attrition of telomeres has been known as one of the hallmark of aging. This review leads to huge interest in the biology of telomeres and the related enzyme in the aging and related fields. We attempt to review briefly the biology and functions of telomeres, factors, and mechanisms that control its length and its maintenance. Genetic and epigenetic related dysfunction of telomeres and telomerase will also be discussed. Finally, a list of disorders of telomeres and telomerase (telomeropathies) will be mentioned with potential therapeutic interventions for these disorders, and the potential for delaying cell senescence and health-span extension. Telomeres adalah bagian dari struktur DNA di ujung linier helix eukaryotic chromosome sebagai penutup/cap untuk menghindari dan melindungi bagian ujung kromosom dari kerusakan dan untuk menjaga kestabilannya. Telomeres akan mengalami erosi atau pemendekan yang merupakan tanda penuaan/aging. Proses ini mendapat perhatian besar sehubungan dengan peristiwa penuaan. Ulasan singkat ini tentang sifat-sifat biologi dan fungsi telomeres. Akan dibahas pula akibat pergeseran/disfungsi genetik dan epigenetik yang menyebabkan perubahan telomeres dan telomerase. Di akhir pembahasan, dicantumkan daftar telomeres dan telomerase (telomeropathies) yang dapat diintervensi dan dapat memperlambat proses penuaan, dengan kata lain memperpanjang usia.

Cancer Immunotherapy and CAR T Cells King S Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45 No 12 (2018): Interna
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i12.683

Within the past decade, radical changes of idea emerged from the works of research scientists, medical experts, and oncologists. Instead of treating cancers with man-made chemicals or chemotherapy and radiotherapy, or surgically remove the tumor, we should unleash the power of our own body immune system. Indeed, such approach has borne fruits and benefited at least for some cancer patients. This review describes various types of immunotherapy known to date, with its beneficial effects, albeit some with serious harmful effects. To understand how immunotherapies work, we also review some biologic characteristics of cancer cells that let them evade attacks from our immune system; cancer microenvironment that works in favor or protecting the growth of cancer against our immune system will also be discussed. Hanya dalam jangka 10 tahun terakhir, telah terjadi perubahan radikal hasil penelitian para ahli, ahli medis, dan ahli onkologi. Di samping cara klasik penyembuhan kanker seperti obat-obat kimia sintetik atau kemoterapi dan radioterapi atau pembedahan, kini para ahli telah menggunakan sistem imunitas tubuh penderita sendiri. Cara ini telah terbukti dalam pengobatan beberapa pasien kanker. Dalam ulasan ini kami akan memaparkan beberapa immunoterapi saat ini dengan hasil baik meskipun masih terdapat beberapa efek samping berbahaya. Untuk memahami bagaimana imunoterapi bekerja, akan diulas dan dijelaskan sifat-sifat biologi sel kanker, dan bagaimana kanker sel bisa menghindari serangan sistem imun; dan lingkungan mikrokanker (cancer microenviroment) yang melindungi kanker dari sistem imun.

Anti-aging Interventions: Caloric Restriction and Beyond Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45 No 9 (2018): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.726

Aging is the biggest risk factor for most of the age-related chronic diseases, which carried a heavy health-care costs burden worldwide. These age-related diseases, such as cardiovascular diseases, neurodegenerative diseases, cancers, type 2 diabetes, and osteoarthritis, shared common mechanisms that associate with aging, such as chronic sterile low grade inflammation, cellular senescence, DNA damages, and stem cells dysfunctions. In this review, we will first discussed the dietary manipulation, such as caloric restriction as the mean of delaying aging, and we will also review nutraceuticals or natural compounds, and pharmaceutical drugs as the mean for intervention of aging. Proses menua dikaitkan dengan berbagai penyakit kronis terkait-usia, yang mengakibatkan beban biaya perawatan kesehatan yang besar di seluruh dunia. Penyakit-penyakit tersebut meliputi penyakit kardiovaskuler, penyakit neurodegeneratif, kanker, diabetes tipe 2, dan osteoartritis, yang mempunyai gambaran umum serupa yaitu inflamasi steril kronis kadar rendah, penuaan sel, kerusakan DNA, dan disfungsi sel punca. Tinjauan ini berkenaan dengan manipulasi diet berupa restriksi kalori, dan nutraceuticals serta senyawa alami, juga sediaan farmakologis untuk tujuan mengintervensi proses penuaan

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