Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Proceeding of Mulawarman Pharmaceuticals Conferences
Hajrah Hajrah
Laboratorium Penelitian dan Pengembangan Kefarmasian ?Farmaka Tropis? Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Simulasi Docking Senyawa Napthoquinones Umbi Bawang Tiwai (Eleutherine americana Merr.) terhadap Bakteri Mycobacterium tuberculosis: Docking Simulation of Umbi Bawang Tiwai Napthoquinones Compound (Eleutherine americana Merr.) against Mycobacterium tuberculosis bacteria Irmayanti Irwan; Hajrah Hajrah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.969 KB) | DOI: 10.25026/mpc.v13i1.449

Abstract

Bawang tiwai (Eleutherine americana Mirr.) is a plant empirically used as an antituberculosis. This plant is thought to have potential because having a compound naphthoquinone potential antituberculosis seen from the average value of the MIC between 206,6 and 12.5 ?M. This study aims to examine a model of the interaction of compounds derived naphthoquinone of bawang tiwai against the side of the fastener from the bacterium Mycobacterium tuberculosis. The method used is docking molecular using AutoDock tools, and Biovia 2020, the prediction of physicochemical which refers to the law of the five Lipinski of using pkCSM online tool. The receptor proteins used were InhA (PDB: 2X23) and the test ligands of elecanacin, eleutherin, eleutherol, and isoeleutherin. The results show that the four compounds comply with Lipinski's five laws, and the docking analysis data is the value of free bond energy (?G) of the four compounds, respectively, -5.82, -4.80, - 5.06, -5.52. The ?G value is below the natural ligand, namely -8, 19, and no hydrogen bonding interaction. It can be concluded that the four naphthoquinone derivative compounds in bawang tiwai lack the potential to bind to the binding site of the Mycobacterium tuberculosis bacteria.
Pengaruh Pemberian Jus Daging Buah Jambu Biji (Psidium guajava) Terhadap Penurunan Kolesterol Pada Pasien Hiperkolesterolemia: The Administration Effect from Guava Fruit Juice (Psidium guajava) Towards Cholesterol Reduction on Hypercholesterolemia Patients Nadiyah Amalia Aprilliani; Hajrah Hajrah; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.591 KB) | DOI: 10.25026/mpc.v13i1.457

Abstract

Red guava (Psidium guajava) fruits contain lots of vitamin C with 183,5 mg/ 100g. Vitamin C has been researched to have an antioxidant activity that can lower total cholesterol levels. This study aims to analyze meat guava juice's effect in reducing total cholesterol levels in hypercholesterolemia patients in Samarinda. The research method is quasi-experimental, pre-test and post-test with control design, with purposive sampling as a sampling method. In the study research, as many as ten people were divided into two groups, group one was given a dose of 250 g once a day, and group two was given a dose of 125 g twice a day and both treatments were given 14-days. Cholesterol data is taken by strip-test method and data analysis using paired T-Test. The analysis results obtained a p-value for the treatment group one of 0.018, for treatment group two of 0,00, and the difference between groups one and two of 0,00. The analysis results showed p-value
Co-Authors Hadi Kuncoro Irmayanti Irwan Nadiyah Amalia Aprilliani Yurika Sastyarina