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Hajrah Hajrah

Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4295850

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Evaluasi Penggunaan Obat Antiemetik pada Penderita Kanker Payudara Pasca Kemoterapi: Evaluation of Antiemetic Drugs Use in Breast Cancer Patients After Chemotherapy Dhea Amanda Sabilla Fauzi; Hajrah Hajrah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Data from the Ministry of Health Republic Indonesia in 2018 showed 42,100 women had breast cancer. Chemotherapy is the main choice of treatment for treating cancer, but it has several side effects, such as nausea and vomiting. The aims of this research, to identify characteristics breast cancer patient, classification risk of chemotherapy induce of nausea and vomiting also appropriate use of antiemetic to prevent chemotherapy side effect. Observational research had been use for this study with retrospective data collection based on patient medical records in January-December 2020. The results showed that breast cancer patients were women with age range of 46-55 years with percentage 38.1% and 33.33% had Body Mass Index (BMI) Obesity I. Combination of Antibiotics and Taxanes is the most widely used by 71.45% and has the most common risk classification of moderate nausea and vomiting. The most widely used antiemetic is a combination of 5-Hydroxitryptamine-3, Antagonists Histamine 2, and Dexamethasone. 96.2% compliance with antiemetic use was achieved and 3.8% was not achieved.

Pengujian Maksimal Penggunaan Ulang Masker Kain dengan Berbagai Jenis Bahan Baku Masker: Maximum Testing of Cloth Mask Reuse with Different Types of Mask Materials Eni Ayu Putri; Hajrah Hajrah; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Cloth masks are used as personal protective equipment from exposure to foreign particles in the air, the use of cloth masks while can reduce the number of medical mask waste number. Cloth masks in use need to be washed repeatedly, so it is necessary to know the effect of washing on the effectiveness and maximum duration of use. The purpose of this study was to determine the effectiveness of the use of cloth masks after going through a repeated washing process by looking at their characteristics and filtration ability in filtering bacteria. The experimental research method was carried out by making 3 types of cloth masks from different masks raw materials, cloth masks were washed 10, 20, 30, 40, and 50 times. Then it is characterized by looking at water absorption, steam filtration, translucency, and ability to filter Streptococcus aureus bacteria. The results showed that the average absorption capacity of the mask in the 10th wash was >60 seconds, while in the 50th washing it was <60 seconds. The results of the steam filtration test are only 4.5% of the masks that have changed characteristics. The results of the translucency test in the 10th wash were 7.4 ±1.67 lux while in the 50th washing the average was 11.4 ±1, 94 lux. The results of the bacterial mask filtering test in the 10th washing were 5.3±5.57 colonies, while in the 50th washing the average was 1.9±2.2 colonies. Based on the characteristic test and bacterial filtering test, there was no significant change in the three types of cloth masks in each wash so that the three types of cloth masks were still effective until the 50th washing. The conclusion is that the cloth masks made have the potential to be used by the public as an effort to prevent the transmission of infectious diseases.

Uji Aktivitas Antikoagulan Ekstrak Daun Ciplukan (Physalis Angulata L) Secara Invitro: Anticoagulant Activity Test of Ciplukan Leaf Extract (Physalis Angulata L) Invitro Uswatun Khasanah Duri Putri; Hajrah Hajrah; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Ciplukan leaf (Physalis angulata L) is empirically used as a hypercoagulation drug. The content of flavonoid secondary metabolites has potential as an anticoagulant. This study aims to determine the yield of ciplukan leaf extract and fraction, the content of secondary metabolites, and its activity as an anticoagulant. The method used in testing anticoagulant activity is Lee White and blood smear. Ciplukan leaves was extracted by maceration method using 70% ethanol solvent. The test samples for the extract and fraction of ciplukan leaves were made in 3 variations of concentration, that is 0.1%; 0.5%; and 1%. The results of ciplukan leaf extract, n hexane fraction, ethyl acetate and distilled water fraction were 14.284%; 12.9%; 10%; and 19.5%. The results of the phytochemical screening test of 70% ethanol extract contain secondary metabolites of flavonoids, alkaloids, tannins, phenols, saponins, steroids, triterpenoids. n?hexane fraction contains alkaloids, steroids and triterpenoids. The ethyl acetate fraction contains flavonoids, phenols and tannins. While the distilled water fraction contains flavonoids, phenols, tannins and saponins. Based on the test results of the Lee White method, extracts and fractions of ciplukan leaves have anticoagulant activity where blood clots do not occur after 2 hours of observation. In the blood smear method, the blood cells are round and not clustered. The best test sample concentration is at a concentration of 1%. The anticoagulant activity of the positive control was better than that of the ciplukan leaf extract and fraction.

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