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All Journal MPI (Media Pharmaceutica Indonesiana) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA ad-Dawaa : Journal of Pharmaceutical Sciences Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Sains dan Kesehatan Jurnal Pengabdian Masyarakat Wadah Publikasi Cendekia

Mukti Priastomo

Universitas Mulawarman

Author-ID : 4295861

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Pengaruh Pemberian Madu dari Lebah Apis mellifera, Apis cerana, dan Trigona sp. terhadap Beberapa Parameter Biokimia pada Mencit yang Diuji dengan Metode WFST Mukti Priastomo; I Ketut Adnyana; Sukrasno Sukrasno; Kusnaedi Kusnaedi
MPI (Media Pharmaceutica Indonesiana) Vol. 3 No. 2 (2020): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v3i2.3042

Lebah madu merupakan golongan serangga yang dapat menghasilkan madu. Produk madu ini dihasilkan dari nectar yang diolah oleh lebah madu sebagai cadangan makanan bagi koloni lebah madu. Komposisi kimia yang terkandung pada madu menjadikan produk alam ini memiliki manfaat yang banyak. Salah satunya adalah manfaat untuk meningkatkan stamina. Peningkatan aktivitas dapat menurunkan stamina dan menimbulkan kelelahan. Penelitian ini bertujuan untuk melihat perbedaan efek anti lelah dari tiga jenis madu yang banyak digunakan di Indonesia, yaitu madu Apis mellifera, Apis cerana, dan Trigona sp. Pengujian anti lelah dilakukan dengan mengukur efek anti lelah secara fisik dan biokimia terhadap hewan coba mencit jantan dengan menggunakan metode Weight-loaded Forced Swimming Test (WFST). Madu digunakan pada pengujian dengan pemberian oral menggunakan dosis 10,40 g/kg yang dilanjutkan dengan pengamatan waktu aktivitas serta uji biokimia darah dengan parameter glukosa darah, asam laktat, serta glikogen pada otot dan hati. Hasil penelitian menunjukkan bahwa ketiga jenis madu yang diujikan dapat memberikan efek anti lelah dibanding kelompok kontrol, dimana madu Apis cerana menunjukkan hasil yang lebih baik dari dua kelompok sampel lainnya.

Uji Aktivitas Ekstrak Daun Sepat (Mitragyna speciosa) terhadap Penurunan Kadar Glukosa Darah Mencit (Mus musculus) Ayu Indah Cahyani; Mukti Priastomo; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 4 (2016): Proceeding of Mulawarman Pharmaceuticals Conferences (Prosiding Seminar Nasional Kefa
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Tumbuhan sepat merupakan tumbuhan dari famili rubiceae, yang biasa digunakan sebagai obat tradisional dalam menurunkan kadar glukosa darah. Daun sepat memiliki kandungan kimia alkaloid yang diduga memiliki efek dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun sepat, mengetahui dosis terbaik dan mengetahui potensinya dalam menurunkan kadar glukosa darah mencit (Mus musculus). Metode penelitian yang digunakan adalah secara in vivo dengan menggunakan hewan coba mencit jantan yang diberikan beban sukrosa 50 % secara oral. Hewan coba dibagi menjadi 5 kelompok yaitu kelompok 1 (diberi suspensi Na CMC 0,5 %), kelompok 2 (glibenklamid), kelompok 3 (ekstrak dosis 100 mg/kg bb), kelompok 4 (ekstrak dosis 200 mg/kg bb), kelompok 5 (ekstrak dosis 400 mg/kg bb). Kadar glukosa darah mencit didapatkan dari pengukuran menggunakan alat glukometer. Dari hasil pengujian diketahui bahwa ekstrak daun sepat memiliki aktivitas dalam menurunkan kadar glukosa darah mencit. Dosis efektif ekstrak daun sepat dalam menurunkan kadar glukosa darah yaitu dosis 200 mg/kg bb.

Efek Perubahan Tekanan Darah Pada Manusia Dengan Pemberian Aroma dari Tanaman Kemangi (Ocimum basilicum L.) Delti Delaya Busa; Mukti Priastomo; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 6 (2017): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Tanaman kemangi (Ocimum basilicum L.) mengandung minyak atsiri yang dapat menghasilkan aroma khas. Aroma khas pada tanaman dapat mempengaruhi perubahan tekanan darah. Penelitian ini dilakukan untuk mengetahui perubahan tekanan darah pada manusia dengan pemberian aroma dari tanaman kemangi (Ocimum basilicum L.) Metode penelitian ini merupakan penelitian kuantitatif dengan menggunakan desain penelitian quasi eksperiment dengan rancangan one group pretest-posttest dengan jumlah sampel 5 orang. Hasil penelitian ini diketahui ada pengaruh pemberian aroma dari tanaman kemangi terhadap tekanan darah sistolik sebelum intervensi yaitu dengan rata-rata sebesar 112,4 mmHg dan setelah intervensi menjadi 107,26 mmHg, tekanan darah diastolik sebelum intervensi sebesar 74,46 mmHg dan setelah intervensi menjadi 76,13 mmHg, serta denyut jantung sebelum intervensi sebesar 83,53 kali/menit dan setelah intervensi menjadi 77,26 kali/menit. Hasil penelitian ini menunjukkan bahwa aroma tanaman kemangi terbukti dapat mempengaruhi perubahan tekanan darah yaitu menurunkan tekanan darah sistolik.

Studi Penggunaan Antibiotik pada Pasien Demam Tifoid di RS SMC Periode 2017 Khoirunnisa Hazimah; Mukti Priastomo; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 7 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Penyakit demam tifoid merupakan infeksi akut pada usus halus yang disebabkan oleh bakteri Salmonella typhi dengan gejala demam lebih dari satu minggu. Terapi utama pengobatan demam tifoid yaitu menggunakan antibiotik, yang dapat menyebabkan resistensi. Sehingga dibutuhkan studi terkait penggunaan antibiotik pada pasien demam tifoid. Penelitian dilakukan dengan pendekatan retrospektif pada 79 data pasien demam tifoid. Hasil penelitian menunjukkan bahwa penderita demam tifoid terbanyak adalah perempuan (53,16%) dengan usia kanak–kanak (6-11 tahun) dan masa dewasa awal (26-35 tahun) sebesar 17,72%. Penggunaan antibiotik terbanyak digunakan adalah adalah golongan sefalosporin (56,96 %) yakni seftriakson, dengan frekuensi pemberian yaitu sekali dalam sehari. Selain penggunaan antibiotik, diberikan pula terapi suportif seperti antipeuretik, H-2 bocker dan anti mual muntah.

Potensi Ekstrak Buah Libo (Ficus variegate, Blume ) Sebagai Hepatoprotektor pada Tikus (Rattus novergicus) Halimatu Sadiyah; Mukti Priastomo; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 9 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Buah libo (Ficus variegate, Blume) mengandung metabolit sekunder alkaloid, saponin, flavanoid dan polifenol dimana hal tersebut menunjukkan bahwa buah libo memiliki aktivitas antioksidan yang dapat berperan dalam pencegahan dan terapi berbagai penyakit termasuk kerusakan hepar. Penelitian ini bertujuan mengetahui potensi hepatoprotektor dan dosis efektif ekstrak buah libo pada tikus dibandingkan dengan curcumaÒ melalui indikator SGOT dan SGPT serta perubahan berat badan. Jenis penelitian ini eksperimental laboratorik. Subjek penelitian 12 ekor tikus dalam 4 kelompok perlakuan. Data dianalisis menggunakan uji One-Way Anova. Hasil yang diperoleh adalah terdapat perbedaan yang signifikan kadar SGOT dan SGPT.

Evaluasi Ketepatan Antipsikotik pada Pasien Skizofrenia di Instalasi Rawat Inap Rumah Sakit Jiwa Daerah Atma Husada Mahakam Samarinda Khofifah Nurwahidah Balqis; Mukti Priastomo; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Schizophrenia is a psychotic mental disorder that causes psychiatric symptoms, such as confusion in thinking, emotions, perceptions, and deviant behavior. The purpose of this study was to determine the characteristics, pattern of use of antipsychotic drugs, and evaluation of the accuracy of antipsychotics for schizophrenia patients in the inpatient installation of RSJD Atma Husada Mahakam Samarinda including the right indication, the right patient, the right drug selection, the right dose, the right frequency and the right duration. administration based on Pharmacotherapy Handbook Tenth Edition Algorithms and Formularium schizophrenia at RSJD Atma Husada Mahakam Samarinda. This type of research is observational. The data collection was done retrospectively with the sampling technique with total sampling on medical records at RSJD Atma Husada Mahakam Samarinda. The results of The most prescribed antipsychotics in schizophrenia patients was the administration of a single antipsychotic risperidone (21.51%), and the administration of a clozapine-risperidone combination antipsychotic (20.43%). Accuracy of antipiscotic use with precise parameters of indication, patient, drug selection, dose, frequency of administration and exact duration of administration based on the Pharmacotherapy Handbook Tenth Edition Algorithms and formulary at RSJD Atma Husada Mahakam Samarinda is 100% accurate from the 93 drug prescriptions studied.

Pengaruh Pemberian Kombinasi Jus Buah Naga (Hylocereus polyrhizus) dan Air Rebusan Daun Kersen (Muntingia calabura) pada Penderita DM (Tipe 2): Effect of Combination of Dragon Fruit (Hylocereus polyrhizus) Juice and Kersen Leaf (Muntingia calabura) Boiled Water in DM (Type 2) Patients Aprilia Putri Firdaus; Mukti Priastomo; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetes mellitus is a disease characterized by an increase in blood glucose levels, which prevalence in East Kalimantan in 2018 is the third highest in Indonesia. Kersen leaves and dragon fruit are believed to regulate blood glucose levels in people with type 2 diabetes mellitus and can be used as a complementary therapy. This study aims to see the characteristics, determine the organoleptic assessment of the combination of dragon fruit juice with kersen leaves boiled water and its effect on blood glucose levels, blood pressure, heart rate, body weight, and the frequency of polyuria, polyphagia, and polydipsia in patients type 2 diabetes mellitus at Klinik Semoga Sehat Samarinda. The research method used was quasi experimental with pre-test and post-test procedures. The data obtained from the characteristics were 70% aged 50-59 years, 70% women, 50% diploma/bachelor, 60% housewives. For organoleptic assessment, it was found that 70% liked the taste, texture, aroma and color and 50% did not feel bitter. The combination of dragon fruit with kersen leaves boiled water had an effect on reducing blood glucose levels significantly (P 0.05) and there was a change in the frequency of polyuria, polyphagia, polydipsia by 80% did not urinate frequently and were not often thirsty and 90% were less hungry.

Penambatan Molekuler Senyawa Metabolit Sekunder Bawang Dayak (Eleutherine bulbosa) Sebagai Penghambat Dipeptidil Peptidase IV (DPP-4): Molecular Binding of Secondary Metabolite Compounds of Dayak Onion (Eleutherine bulbosa) As Dipeptidyl Peptidase IV (DPP-4) Inhibitors Nur Ainah; Mukti Priastomo; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetes is a frightening disease that threatens people's lives, because almost every 10 seconds in the world, people die from complications of this disease. A new DM treatment approach in the creatinase system that inhibits dipeptidyl peptidase IV (Dpp-4) has been developed, and has been shown to effectively increase insulin secretion, maintain pancreatic -integration, and slow gastric emptying. antidiabetic, namely inhibition of the -glucosidase enzyme in one of its compounds and has not been found to inhibit the Dpp-4 enzyme. This study aims to determine the potential of the compounds in Dayak onions as inhibitors of the Dpp-4 enzyme. The method used is molecular anchoring or in silico because the research time is short and the cost is cheaper than in vitro or in vivo. The software used is autodock which is a device that can attach ligand molecules to receptor macromolecules. Then visualized using discovery studio 2020 and other devices to support tethering such as chemdraw and chimera 1.4. vidagliptin as an antidiabetic which has activity against inhibiting Dpp-4 inhibitors was used as a standard. The grid is placed on natural ligands with a box size of 52? x 28? x 26? and a center of 40,926? x 50,522? x 35,031? with a spacing of 0.375?. Based on the docking that has been done, the secondary metabolite compounds in Dayak onions have a low bond energy value, with the lowest value being -8.46 kcal/mol and the highest -5.54 with different values of inhibition constant and bond form. Eleuthoside C has the lowest bond energy of -8.46 and has the most similar interaction with natural ligands. The bond that occurs is the type of hydrogen bonding at the residues of Phe357, Arg125, Arg358, Tyr666, Tyr662, and Glu205. With this, Dayak onions have antidiabetic activity but further docking still needs to be done to see other compounds in Dayak onions as Dpp-4 inhibitors.

Pengaruh Pelarut, Suhu, dan pH Terhadap Pigmen Antosianin dari Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus): Effect of Solvent, Temperature, and pH on Anthocyanin Pigments from Red Dragon Fruit Peel Extract (Hylocereus Polyrhizus) Gusti Alamsyah Abdil Almajid; Rolan Rusli; Mukti Priastomo
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Red dragon fruit peel (Hylocereus polyrhizus) is an agricultural waste that contains quite high natural anthocyanin pigments. The purpose of this study was to determine how the effect of solvent, temperature and pH on the total content and stability of anthocyanins from liquid extract of red dragon fruit peel. Extraction of anthocyanins from red dragon fruit peel using maceration method with solvent distilled water, distilled water: acetic acid 10% (1:6), and distilled water: citric acid 10% (1:6) and testing was carried out in the form of anthocyanin stability tests at pH 1, 2, 3, 4, 5 and temperatures 0°C, 10°C, 20°C, 30°C, 40°C, 50°C. The results obtained showed that the use of distilled water:citric acid 10% (1:6) as a solvent resulted in the highest total anthocyanin content with 18.034 mg/200 mg and the results of the anthocyanin stability test showed that it was stable at pH 1, 2, 3 and at temperatures of 10°C, 20°C, 30°C.

Efektivitas Jenis Bahan Masker Kain Berdasarkan Kemampuan Penyaringan Mikroba: Effectiveness of Fabric Mask Material Types Based on Microbial Filtration Capabilities Nilam Sari; Mukti Priastomo; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

A cloth mask is a mask that can be used repeatedly and is made of thicker fabric material. Cloth masks circulating in the community have not guaranteed quality. This study aims to find out the effectiveness of fabric mask materials based on microbial filtration capabilities as well as find out the optimal characteristics of the initial use of cloth mask materials and after washing 50 times. This study was conducted experimentally where the effectiveness of fabric mask material by spraying bacterial suspension, and testing the characteristics of fabric mask materials by conducting fiber observation, light intensity test, steam filtration test, water absorption test and water capillary on the fabric. The results of research on the effectiveness of fabric mask materials showed Asymp.Sig >0.05 so that there are significant differences from all types of fabric mask materials. Based on the results of characteristic testing, the fiber material of the initial cloth mask looks better than after 50 washes. Test the light intensity of the outer layer, inner layer, and filter layers p, f and s after washing there is an increase compared to the initial use. Steam filtration tests of outer layers, inner layers and filter layers p, f and s when the initial user takes time for steam to penetrate the fabric compared to 50 washes. The absorption test of the outer layer during initial use does not occur absorption above 60 seconds and after 50 washes begins absorption. The inner layer and filter layer at the initial use do not absorb above 60 seconds and after 50 washes there is absorption under 60 seconds. The p filter layer does not absorb during initial use and after 50 washes. Filter layer f during initial use and after 50 washes there is absorption under 60 seconds. Capillary test results for 60 seconds the outer layer and the p filter layer during initial use do not absorb while 50 times the washing occurs absorption. The inner layer, filter layer f and s increase after 50 washes. The conclusion of the study was that the effectiveness of the mask material was good enough for the inner and outer layers, the p filter layer was more effective than the f and s filter layers. The characteristic test results at initial use were very good, but after 50 washes there was a decrease.

Co-Authors Adam M. Ramadhan Aditya Fridayanti Adzimahtinur Pradawahyuningtyas Angga Cipta Narsa Aprilia Putri Firdaus Ayu Indah Cahyani Delti Delaya Busa Desy Aulia Rahmah Gusti Alamsyah Abdil Almajid Hadi Kuncoro Halimatu Sadiyah I Ketut Adnyana I Ketut Adyana Ismah Nuri Jaka Fadraersada Jaka Fadraersada Jessica Merry Irawan Khofifah Nurwahidah Balqis Khoirunnisa Wal Hazimah Kusnaedi, Kusnaedi Laode Rijai Mahdyya Afiana Ramadani Muhammad Faisal Niken Indriyanti Nilam Sari Novalinda Novalinda Nur Ainah Riska Putri Patila Sau Rolan Rusli S Sukrasno Sukrasno Sukrasno Vita Olivia Siregar Widya Suci Musfirah

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