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All Journal Jurnal Gizi Kerja dan Produktivitas Proceeding of Mulawarman Pharmaceuticals Conferences Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan

Vita Olivia Siregar

Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 5557455

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Uji Toksisitas Ekstrak Berbasis Nades dari Daun Kadamba (Mitragyna Speciosa Korth) terhadap Mencit (Mus Musculus): Toxicity of Nades-Based Extract From Kadamba Leaf (Mitragyna Speciosa Korth) on Mice (Mus Musculus) Fauzan Afandi; Vita Olivia Siregar; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Traditionally, kadamba leaves have benefits for treating diarrhea, diabetes, pain, rheumatism, gout and have been scientifically proven to be antinociceptive and inhibit T47D breast cancer cells. This study aims to determine the toxicity of NADES-based extract from kadamba leaves by looking at the LD50 value and its effect on body weight and behavior of mice. The 15 mice used were divided into 5 groups with 3 mice in each group. The NADES-based extract from kadamba leaves was given orally with various doses of 4000 mg/KgBB, 8000 mg/KgBB, 16000 mg/KgBB, and 32000 mg/KgBB and one group was given a solvent. Each group was observed for 30, 60, 120, 180, and 240 minutes after administration of the extract and the observations were continued for 14 days to observe toxic symptoms, changes in body weight and death. Based on the results of the study, no deaths were found in the solvent group, 4000 mg/KgBB, and 8000 mg/KgBB. For the group with a dose of 16000 mg/KgBW, 2 mice died and the group with a dose of 32000 mg/KgBW found the death of 3 mice, so the LD50 value obtained was 14.256 g/KgBW which was included in the practically non-toxic category.

Pola Penggunaan Antimalaria pada Pasien Malaria di Instalasi Rawat Inap RSUD Jayapura Periode Januari–Desember 2020: Pattern of Antimalarial Drug in Malaria Patients in the Jayapura Hospital Inpatient Installation During January – Desember 2020 Kornelius Yustico Trimedya Purba; Vita Olivia Siregar; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The Jayapura city is one of the endemic areas of malaria in the province of Papua. The use of antimalarial medicine in hospitals has adjusted to a pattern of successful therapy in previous years. The study aims to know the pattern of antimalarial use in malarial patients at the jayapura hospital installation in January - December 2020. The method of research used is a non-experimental study with a descriptive design from the retrospective data that sources the data of the treatment records of malaria patients. Studies show that the age of 17-25 became the most common age to develop malaria by 38 patients (38%). The male group became dominant compared with the female population of 60 (60%). Students are the primary target of malaria with 38 patients (38%). Tropical malaria is the most common of 62 patients (62%). Combination of primaquine + artesunate therapy reaches (66%). For precise indications and precise intervals of time entering into the precision of the treatment of malaria with accuracy (100%) while for right the medicine has a percentage (92%) and the right dosage has a percentage (99%) so it can be maximized in the future.

Pengaruh Pemberian Kombinasi Jus Belimbing Manis (Averrhoa carambola) dan Labu Siam (Sechium edule) terhadap Pemeliharaan Tekanan Darah: The Effect of Combination of Starfruit (Averrhoa carambola) and Chayote (Sechium edule) Juice on Blood Pressure Maintenance Nugrahiwulan Oktaviani; Riski Sulistiarini; Vita Olivia Siregar
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Starfruit (Averrhoa carambola) and chayote (Sechium edule) contain potassium which can balance blood pressure. This study aims to determine the characteristics of the respondents including gender, age, education, occupation, physical activity, and regular exercise, to determine the blood pressure profile of the respondents, and to determine the effect of giving a combination of starfruit juice and chayote in the Samarinda Ulu District. The method used is a quasi-experimental method by measuring pre and post treatment for 5 days. Data collected on the characteristics of respondents obtained the highest percentage of women 95%, ages 18-30 years 95%, high school education 95%, college student job 95%, low physical activity 95%, and not doing regular exercise 70% . The respondent's blood pressure profile for 14 days every 3 days shows the Mean Artery Pressure value in the normal and high normal categories. The results of the combination of starfruit juice and chayote can maintain blood pressure, with a mean decrease in systolic and diastolic 12.2 ± 7.97 mmHg and 6.5 ± 3.60 mmHg for the treatment group. Based on the results, it can be concluded that the combination of sweet star fruit juice and chayote can maintain blood pressure in normotensive respondents.

Perbandingan Efektivitas Teh Daun Kecombrang (Etlingera elatior) dan Teh Bunga Kecombrang (Etlingera elatior) terhadap Penurunan Kadar Glukosa Darah pada Mencit (Mus musculus) yang Diinduksi Aloksan: Comparison of The Effectiveness of Kecombrang Leaf Tea (Etlingera elatior) and Kecombrang Flower Tea (Etlingera elatior) to Decreased Blood Glucose Levels in Mice (Mus musculus) Induced Alloxan Winchy Putri Cantika; Vita Olivia Siregar; Riski Sulistiarini
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.641

Efek Toksik Pemberian Ekstrak Etanol Daun Mekai (Albertisia papuana Becc.) Terhadap Mencit: Toxic Effects of Mekai (Albertisia papuana Becc.) Leaf Ethanol Extract on Mice Febrianto Ubang; Vita Olivia Siregar; Herman Herman
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 16 (2022): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v16i1.672

Daun mekai merupakan tanaman khas Kalimantan yang dimanfaatkan oleh masyarakat Dayak secara tradisional sebagai terapi untuk penyakit seperti hipertensi, stroke, kanker. Secara ilmiah daun mekai memiliki potensi sebagai anti plasmodium, antibakteri dan antifungi. Saat ini penelitian dan pengembangan daun mekai sebagai kandidat obat baru masih terus berlanjut. Penelitian ini bertujuan untuk mengetahui efek toksik pemberian ekstrak etanol daun mekai berdasarkan kematian, tanda toksisitas, perubahan berat badan, dan indeks organ. Mencit dikelompokkan menjadi 5 kelompok yang terdiri dari 1 kelompok kontrol (NaCMC) dan 4 kelompok dosis ekstrak etanol daun mekai (5000, 10000, 15000, dan 30000 mg/KgBB). Masing-masing diamati dalam rentang waktu 30, 60, 120, 180, dan 240 menit setelah pemberian ekstrak etanol daun mekai. Pengamatan dilanjutkan hingga 14 hari untuk mengamati gejala toksik, perubahan berat badan dan kematian serta mencit dibedah setelah 14 hari untuk diamati organnya. Berdasarkan hasil penelitian efek toksik pemberian ekstrak etanol daun mekai memberikan pengaruh pada mencit uji berdasarkan tanda toksisitas, indeks organ dan kematian dengan nilai LD50 31,5723 g/KgBB namun tidak memberikan pengaruh terhadap berat badan mencit.

Identifikasi Metabolit Sekunder Minyak Atsiri Kulit Jeruk Manis Pontianak (Citrus nobilis Lour.) Menggunakan Metode Ekstraksi Microwave Hydrodistillation: Identification of Secondary Metabolites of Essential Oil Sweet Orange Pontianak Peel (Citrus nobilis Lour.) Using Microwave Hydrodistillation Extraction Method Dinda Hariyanti; Fajar Prasetya; Vita Olivia Siregar
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 17 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v17i1.686

Jeruk manis pontianak (Citrus nobilis Lour.) merupakan salah satu komoditas unggulan tanaman holtikultura di Kalimantan Barat, Pontianak. Umumnya, kulit jeruk di Indonesia hanya dibuang begitu saja padahal kulit jeruk memiliki banyak khasiat terlebih jika diolah menjadi minyak atsiri. Senyawa yang terkandung dalam kulit jeruk bermanfaat dalam bidang kesehatan yaitu sebagai antibakteri, antijamur, antioksidan, antiaging, dan dapat menghambat pertumbuhan sel kanker. Tujuan dari penelitian ini adalah untuk mengetahui kandungan metabolit sekunder yang terdapat dalam minyak atsiri kulit jeruk manis pontianak yang diekstraksi dengan metode microwave hydrodistillation. Jenis penelitian ini adalah kualitatif deskriptif. Metode yang digunakan adalah analisis fitokimia. Minyak atsiri kulit jeruk manis pontianak diperoleh dengan ekstraksi microwave hydrodistillation. Minyak atsiri kulit jeruk manis pontianak yang dihasilkan kemudian dilakukan uji skrining fitokimia. Hasil uji skrining fitokimia didapatkan hasil bahwa minyak atsiri kulit jeruk manis pontianak positif mengandung senyawa flavonoid, saponin, terpenoid, dan alkaloid, sedangkan hasil negatif mengandung senyawa steroid

Aktivitas Imunoglobulin M (IgM) Ekstrak Etanol Kulit Buah Kakao (Theobroma cacao L.) terhadap Tikus Putih (Rattus norvegicus) Vita Olivia Siregar; Rolan Rusli; Arsyik Ibrahim
Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 5 (2014): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v2i5.74

The research of Immunoglobulin M (IgM) activity of Theobroma cacao peel extract has been done to 20 rats. The parameter is agglutination between serum of rats and antigen. Rats were grouped to 4 group, which are group of negative control and 3 groups as experiment groups those given by extract in 250, 500 and 700 mg doses of rats. On the first day was given SDMK 2% by Intraperitonial and after 5 day the serum taken and tested. The data of agglutination then analyzed by Anova. The experiment showed that Theobroma cacao peel extract has activity as immunostimulant in 500 mg doses of rats effective dose. Keywords: Theobroma cacao peel extract, agglutination, immunostimulant, Immunoglobulin M (IgM) ABSTRAK Penelitian Aktivitas Imunoglobulin M (IgM) Ekstrak Kulit Buah Kakao (Theobroma cacao L.) telah dilakukan terhadap 20 ekor tikus uji. Parameter yang diamati adalah terjadinya aglutinasi antara serum tikus yang telah diberi perlakuan dengan antigen. Tikus putih dikelompokkan menjadi 4 kelompok yaitu kelompok kontrol negatif diberi Na CMC 0,5%, serta 3 kelompok uji yang diberikan ekstrak dengan konsentrasi 250, 500 dan 700 mg/200 g BB Tikus. Perlakuan secara per oral diberikan selama 5 hari. Pada hari ke-1 diinjeksikan Sel Darah Merah Kambing (SDMK) 2% secara intraperitonial dan setelah perlakuan, yaitu hari ke-7 serum diambil dan dilakukan pengujian dengan metode titer antibodi. Data hasil pengamatan aglutinasi di analisis menggunakan Anova. Hasil penelitian menunjukkan bahwa ekstrak kulit buah Kakao memiliki aktivitas sebagai imunostimulan dengan dosis terbaik 500 mg/200 g BB tikus. Kata kunci: Ekstrak Kulit Buah Kakao, Theobroma cacao L., IgM tikus putih, Hemaglutinasi, Imunostimulan

Imunomodulator Activity of Three Types “Kayu Kuning” Borneo Dwi Hadi Setya Palupi; Riski Sulistiarini; Vita Olivia Siregar
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.375

The immune system is a system that plays a role in maintaining the integrity of the body against the dangers that various foreign objects can cause. Immunomodulators are substances or substances that can change/modify the immune system. Empirically, Kayu Kuning or Yellow Wood is used as a cleaner for post-partum conditions. Yellow wood in East Kalimantan is the name for three species, namely Arcangelisia Flava, Fibraurea tinctoria, and Coscinium fensteratum. With the approach of improving the immune system and metabolism, immunomodulatory tests carried out on three types of yellow wood found in Borneo Island. The immunomodulatory activity of Yellow wood steam extract in the non-specific immune response test used phagocytic index and organ index parameters where BALB/c female mice were randomly divided into 16 treatment groups which included a normal group, an immunostimulant comparison group (Levamisole 2.5 mg/kg body weight), an immunosuppressant comparison group (Methylprednisolone 40mg/kg BW), a test extract group with a dose of 100 mg/kg body weight, for the ethanolic extracts of A. Flava, F. tinctoria and C. fenestratum, respectively. Based on the study results, it means that the methanol extract of A. Flava methanol extract had immunostimulating activity, while the methanol extract of F. tinctoria and C. fenestratum showed an immunosuppressant effect

Aktivitas Antioksidan dan Tabir Surya Ekstrak Etanol Tanaman Crassocephalum crepidioides (Benth.): Antioxidant and Sunscreen Activity of Ethanol Extract of Crassocephalum crepidioides (Benth.) Rolan Rusli; Ismah Nuri; Mahdyya Afiana Ramadani; Vita Olivia Siregar; Mukti Priastomo; Muhammad Faisal
Jurnal Sains dan Kesehatan Vol. 4 No. 3 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i3.1026

Crassocephalum crepidioides (sintrong) plant has secondary metabolites such as flavonoids, saponins, steroids, and tannins which are thought to have antioxidant and sunscreen activities. Antioxidant activity of the ethanol extract of the leaves and flowers of Sintrong was measured using Uv-Vis spectrophotometry obtained IC50 values of 23.558 ppm (flowers) and 0.62 ppm (leaves), and categories as very strong antioxidants. Based on %Te and %Tp values, ethanol extract of sintrong leaves was categories as sunblock, while ethanol extract of flowers of sintrong was categories as Fast Tanning (for %Te) and for %Tp was categories as suntan standard (for 200-300 ppm) and Extra Protection (for 400-600 ppm). The SPF of the ethanol extract of the leaves and flowers of sintrong is categories as minimal protection.

Efektivitas Pemberian Kombinasi Teh Daun Mint (Mentha piperita) dan Madu terhadap Intensitas Nyeri Haid (Dismenore): Effectiveness Giving a Combination of Mint Leaf Tea (Mentha piperita) and Honey Against Menstrual Pain Intensity (Dysmenorrhea) Nafara Aghnia Anfusufi; Adam M. Ramadhan; Vita Olivia Siregar
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2050

Dysmenorrhea or menstrual pain is still a major problem for most women. There are many ways to deal with menstrual pain or dysmenorrhea, one of which is by consuming herbal drinks. Mint leaves contain menthol compounds which can reduce contractions in the myometrium so that the pain of dysmenorrhea that is felt can be reduced. Flavonoids contained in honey can reduce pain by inhibiting the formation of prostaglandins through inhibition of the cyclooxygenase enzyme. So that the combination of the two can work synergistically in reducing the intensity of dysmenorrhea pain. This study aims to determine the effectiveness of giving mint leaf tea (Mentha piperita) and honey to reduce the intensity of menstrual pain (dysmenorrhea). The research method used was quasy experimental with purposive sampling and obtained 50 respondents divided into 2 groups. The results obtained in the two groups of respondents after giving the combination of mint leaf tea and honey for 2 days were a decrease between the pretest and posttest with a significance value of 0.000 (p

Co-Authors Adam M. Ramadhan Andi Tenri Kawareng Arsyik Ibrahim Dinda Hariyanti Dwi Hadi Setya Palupi Fahriani Istiqomah Jafar Fajar Prasetya Fauzan Afandi Febrianto Ubang Herman Herman Irfan Idris Islamudin Ahmad Ismah Nuri Kornelius Yustico Trimedya Purba Mahdyya Afiana Ramadani Muhammad Faisal Muhammad Faisal Mukti Priastomo Mukti Priastomo Nafara Aghnia Anfusufi Niken Indriyanti Noviyanty Indjar Gama Nugrahiwulan Oktaviani Nurhayana Sennang Putri Anggreini Rolan Rusli Satriani Badawi Sulistiarini, Riski Winchy Putri Cantika

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