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All Journal MDJ (Makassar Dental Journal) Sriwijaya Journal of Dentistry
Ade Puspa Sari
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Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Public Health

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Tatalaksana oral lichen planus akibat stres pada diabetes melitus Management of oral lichen planus due to stress in diabetes mellitus Ade Puspa Sari; Nafi'ah .; Dwi Setianingtyas; Iwan Hernawan; Bagus Soebadi
Makassar Dental Journal Vol. 6 No. 3 (2017): Vol 6 No 3 Desember 2017
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1034.8 KB) | DOI: 10.35856/mdj.v6i3.31

Abstract

Pendahuluan: Oral lichen planus (OLP) merupakan penyakit inflamasi kronik pada membran mukosa mulut dengan karakteristik tanda klinis adanya retikuler papula berwarna putih yang dimediasi oleh sistem imun seluler ditandai oleh respon sel-T sitotoksik terhadap keratinosit basal dengan stres bisa sebagai faktor pemicu. Diagnosis OLP berdasarkan gambaran klinis yang khas ditunjang dengan pemeriksaan histopatologi. Tujuan: Melaporkan tata laksana kasus oral lichen planus dipicu stres pada pasien diabetes melitus. Kasus: Seorang wanita usia 68 tahun dengan keluhan nyeri, pasien sulit makan, sariawan yang persisten pada pipi kanan dan kiri sejak 4 tahun yang lalu, hilang kambuh. Pasien memiliki riwayat diabetes melitus. Kondisi pasien terlihat cemas pada saat anamnesis. Pemeriksaan klinis intra oral pada mukosa bukal bilateral terdapat papula putih berbentuk jala-jala (wickham’s striae) dan ulserasi. Tata laksana: Pasien diterapi dengan obat kumur anastetikum, kortikosteroid sistemik, deksametason elixir, obat kumur antiseptik dan multivitamin, menghindari makanan yang pedas dan berbumbu tajam serta pemeriksaan DASS 42. Pasien dirujuk untuk pemeriksaan darah lengkap dan glukosa sewaktu, glukosa 2 JPP, HbA1c, dan ke psikiater. Simpulan: Depresi sedang dengan gejala somatik dapat sebagai faktor predisposisi menyebabkan gangguan sistem imun yang memicu penyakit autoimun. Perawatan dengan mengelola stres serta terapi simtomatis dengan kortikoseroid sistemik dan topikal serta mempertahankan oral higiene.
Minimum Inhibitory and Fungicidal Concentration Tests Of Snakehead Fish (Channa Striata) Oil Extracts Against Candida Albicans: An In Vitro Study Nabila; Ade Puspa Sari; Trisnawaty K
Sriwijaya Journal of Dentistry Vol. 1 No. 2 (2020): Sriwijaya Journal of Dentistry
Publisher : Dentistry Study Program, Faculty of Medicine Universitas Sriwijaya 

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (421.468 KB) | DOI: 10.32539/sjd.v1i2.258

Abstract

Introduction: Candida albicans (C. Albicans) is an oral cavity commensal organism that can shift into a pathogenic form under certain conditions. Nowadays, natural substances used as an alternative for a new antifungal agent. Snakehead fish oil extracts have been reported to have antifungal effect i.e; unsaturated fatty acids such as Omega-3 and Omega-6. The purpose of this study was to investigate the antifungal activity of snakehead fish oil extracts against C. Albicans. Materials and Methods: An in vitro laboratory study with a posttest control group design was established. To produce the snakehead fish oil extracts, wet rendering method was used. The snakehead fish oil extracts then tested with microdilution method to determine Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) against C. Albicans. An 0,062-32 μl/ml concentrations used for the microdilution test and 2-32 μl/ml for the disc-diffusion test. Nystatin (100 μg/ml) was used as the positive control. Results: There were visible growths and no inhibition zone in all concentrations of snakehead fish oil extracts. Conclusion: 0.062-32 μl/ml concentrations of Snakehead fish oil extracts did not have the abilities to decrease the growth of C. albicans.
Acute Pseudomembran Candidiasis In A Patient With Osteogenic Sarcoma And Anemia Zara Alviometha; Ade Puspa Sari; Siti Rusdiana Puspa Dewi
Sriwijaya Journal of Dentistry Vol. 2 No. 1 (2021): Sriwijaya Journal of Dentistry
Publisher : Dentistry Study Program, Faculty of Medicine Universitas Sriwijaya 

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.341 KB) | DOI: 10.32539/sjd.v2i1.588

Abstract

Introduction: Acute pseudomembranous candidiasis is an opportunistic infection caused by the overgrowth of Candida spp. Candida spp can become pathogenic in a weak immune response. There is a clear relationship between oral candidiasis and patients with malignant disease (cancer) and hematological disorders, such as anemia. Anemia is a complication that often occurs in patients with malignancy. Purpose: This paper reports a case of acute pseudomembtane candidasis caused by osteogenic sarcoma and secondary anemia. Case presentation: A 12-year-old male patient was hospitalized for osteogenic sarcoma and anemia. Intraoral examination showed white plaque that could be wiped out on the tongue dorsum. Candida albicans was identified by oral microbial tests. Antifungal therapy was applied for 14 days and it showed improvement. Conclusion: The successful management of this patient involves control of predisposing factors, plaque control, and DHE.
Minimum Inhibitory And Fungicidal Concentrations For Combined Extracts Of Papaya Leaves And Garlic Siti Rusdiana Puspa Dewi; Pudji Handayani; Anita Nurmilasari; Rahmatullah Irfani; Tyas Hestiningsih; Ade Puspa Sari
Sriwijaya Journal of Dentistry Vol. 7 No. 1 (2026): Sriwijaya Journal of Dentistry
Publisher : Dentistry Study Program, Faculty of Medicine Universitas Sriwijaya 

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjd.v7i1.104

Abstract

Introduction: Oral Candidiasis is a common fungal infection caused by Candida albicans-a predominant cause of fungal infections in the oral cavity. Prolonged use of antifungal agents for oral candidiasis can be associated with side effects, indicating a need to consider alternative therapies. Natural resources such as papaya leaves and garlic have the effect of antifungal against Candida albicans that may serve as alternative therapies. In vitro study of  the minimum inhibition and fungicidal concentration of combined extracts, papaya leaves and garlic against Candida albicans need to be examined. Purpose: To determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of combined extracts of papaya leaves and garlic against Candida albicans. Methods: A laboratory experimental study with a post-test control group design was established. The minimum inhibitory concentration was tested using Kirby-bauer method and the minimum fungicidal concentration was tested with agar dilution method. The ratio of each extract in each concentration is 1: 1 which made into five concentrations; 5%, 10%, 15%, 20% and 25%. Results: This study showed the 5%, 10%, 15%, 20%, and 25% extracted of papaya leaves and garlic combination could not inhibit and eliminate Candida albicans colonies. Conclusion: No inhibitory and fungicidal effect of 5%, 10%, 15%, 20% and 25% papaya leaves and garlic extract combination. Higher concentration need to be considered.
Co-Authors Anita Nurmilasari Bagus Soebadi Dwi Setianingtyas Iwan Hernawan Nabila Nafi'ah . Pudji Handayani Rahmatullah Irfani Siti Rusdiana Puspa Dewi Siti Rusdiana Puspa Dewi Trisnawaty K Tyas Hestiningsih Zara Alviometha