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Linda Hevira
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Medicine & Pharmacology

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PEMBUATAN DAN KARAKTERISTIK MULTIKOMPONEN KRISTAL IBUPROFEN DAN ASAM SITRAT DENGAN METODE SOLVENT EVAPORATION Sonya Fiola; Rido Farnandi; Linda Hevira; Devahimer Harsep Rosi
Journal of Science and Clinical Pharmacy Research Vol. 1 No. 2 (2025): August 2025
Publisher : LPPM Universitas Mohammad Natsir Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1144/jscpr.v1i2.306

Abstract

Ibuprofen merupakan obat antiinflamasi non-steroid (NSAID) yang tergolong dalam Biopharmaceutical Classification System (BCS) kelas II, yaitu memiliki kelarutan rendah dan permeabilitas tinggi. Salah satu untuk meningkatkan kelarutan dan disolusi ibuprofen adalah melalui pembentukan multikomponen kristal dengan koformer yang sesuai. Penelitian ini bertujuan untuk membuktikan terbentuknya multikomponen kristal ibuprofen dengan asam sitrat melalui metode solvent evaporation serta mengevaluasi karakteristik fisikokimia dan profil disolusinya. Hasil FT-IR menunjukkan pergeseran bilangan gelombang yang mengindikasikan adanya interaksi intermolekul berupa ikatan hidrogen. Hasil XRD menunjukkan terbentuknya fase kristalin baru. Penetapan kadar ibuprofen dalam multikomponen kristal menunjukkan nilai 98,83%, yang sesuai dengan standar Farmakope Indonesia (97–103%). Uji disolusi dilakukan dalam medium dapar fosfat pH 7,2. Persentase zat terdisolusi ibuprofen pada menit ke-30 adalah 42,21%, sedangkan multikomponen kristal mencapai 88,27%. Rata-rata efisiensi disolusi (ED) ibuprofen sebesar 25,53%, sementara multikomponen kristal sebesar 84,25%, menunjukkan peningkatan yang signifikan. Uji statistik menggunakan independent t-test dengan SPSS versi 26 menunjukkan nilai signifikansi p < 0,05 untuk kedua sampel (ibuprofen dan multikomponen kristal), yang mengindikasikan adanya perbedaan yang signifikan antara keduanya dalam laju disolusi.
STUDI ADSORPSI CONGO RED PADA KITOSAN BERBASIS SELONGSONG PUPA BLACK SOLDIER FLY Linda Hevira
Journal of Science and Clinical Pharmacy Research Vol. 2 No. 1 (2026): February 2026
Publisher : LPPM Universitas Mohammad Natsir Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1144/jscpr.v2i1.530

Abstract

Pollution of liquid waste containing synthetic dyes is an environmental problem that is also relevant in the industrial and pharmaceutical laboratories. One of these dyes is Congo Red, which is stable, difficult to degrade, and has the potential to cause negative impacts on the aquatic environment. This study aims to produce the ability of chitosan which is generally synthesized from shrimp shells, this time synthesized from the pupa sheath of the Black Soldier Fly (Hermetia illucens). The adsorption test was carried out in batches with variations in pH, contact time, and initial concentration of the dye. Chitosan-BSF before and after absorbing Congo Red was characterized using FTIR and SEM-EDS. The results showed that the adsorption process was greatly influenced by the environmental pH and the pHPZC value of chitosan. The adsorption percentage increased at pH below pHPZC due to the electrostatic interaction between the chitosan surface which produces a positive signal and the Congo Red molecule which produces a negative signal. Contact time affected the rate of achieving adsorption equilibrium, while increasing the initial concentration tended to decrease the adsorption percentage. These results indicate that chitosan from Black Soldier Fly pupae casings has the potential to be an alternative adsorbent that has added value and is environmentally friendly and supports the principle of the desire for dye waste processing.
Co-Authors Azimatur Rahmi Devahimer Harsep Rosi Nadya Hardi Rido Farnandi Sonya Fiola