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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal Orthopaedi and Traumatology Surabaya (JOINTS) SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Majalah Biomorfologi (Biomorphology Journal)
Airlangga, Primadenny Ariesa
Department Of Orthopaedic And Traumatology Surabaya, Faculty Of Medicine, Universitas Airlangga/ Dr. Soetomo General Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Neuroscience Public Health

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Collagen Type I and Type II Expression Evaluation on Cartilage Defect Regeneration Treated with Dwikora–Ferdiansyah–Lesmono–Purwati (DFLP) Scaffold Supplemented with Adipose–Derived Stem Cells (ASCs) or Secretome: An In-Vivo Study Adrianto Prasetyo Perbowo; Dwikora Novembri Utomo; Lukas Widhiyanto; Primadenny Ariesa Airlangga; Purwati Purwati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4377

Abstract

Abstract Cell-based therapies such as Scaffold, stem cells, and secretome, are one of the alternatives to enhance the regeneration of hyaline-like cartilage in cases of cartilage defects. This study is an in-vivo experiment using animal models, in which we apply a composite of DFLP (Dwikora-Ferdiansyah-Lesmono-Purwati) Scaffold and Adipose-Derived Stem Cells (ASCs) or Secretome to an injury model on the distal femoral trochlea of New Zealand White Rabbits. The animals were divided into four groups: (1) control (K); (2) Scaffold only (S); (3) Scaffold + ASCs (SA); (4) Scaffold + Secretome (SS). Animals were terminated in the 12th week, and an immunohistochemistry (IHC) evaluation for Collagen type I and II were done. Statistical analysis shows that collagen type I IHC between groups shows no significant difference (p = 0.546). Collagen type II IHC shows significant difference between groups (p = 0,016). The findings in this study showed that Scaffold + ASCs group and Scaffold + Secretome have better collagen type II expression compared to the control group. DFLP Scaffold composite with ASCs or Secretome shows potential for cartilage regeneration therapy by increasing type II collagen expression as in hyaline-like cartilage which may be used for regenerative therapy for cartilage defects. Keywords             : DFLP Scaffold; Adipose-Derived Stem Cells (ASCs); Secretome; Collagen Type I; Collagen Type IICorrespondence    : ianperbowo@me.com
Studi Epidemiologi Fraktur Vertebra di RSUD Dr.Soetomo Surabaya Pada Tahun 2013-2017 Lukas Widhiyanto; I Ketut Martiana; Primadenny Ariesa Airlangga; Donny Permana
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 1 (2019)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.446 KB) | DOI: 10.30651/jqm.v3i1.2191

Abstract

 AbstractThe incidence of spinal trauma in the world is 0.019-0.088% per year. However, the epidemiological data from each country varies according to the specificities of each country. Until now, there have been no reports of epidemiological research for vertebral trauma in Indonesia. This research is a descriptive analytic study. The sample of this study were all patients with vertebral fractures who entered the Dr. Soetomo Hospital in 2013-2017. The data were obtained through medical records and electronic data in hospital databases. The data are displayed in tables and graphs and comparative analysis of variables is carried out. Based on data from 2014-2017, there were a total of 442 patients with vertebral fractures, with male and female ratio of 3.3: 1. The mean age of patients was 43.6 year. The causes of vertebral fractures are due to fall from altitude (38%), traffic accidents (34%), and direct impact / hit burden (10%). Based on fracture level, most fractures were at the lumbar level (153 patients, 34,6%). At the lumbar level, the most fracture subtypes were type A with a percentage of 91.5% and the most mechanism of injury was due to falling from a height. Based on the fracture subtype, type A (compression or burst) fracture is the most common type of fracture. Lumbar vertebral fracture is the most fractured in vertebral fractures. The most common cause of fracture in the vertebrae is trauma with great energy due to falling from a height.Keywords: Epidemiology, vertebral fractures, spinal traumaCorrespondence to : dr.donnypermana@gmail.com Abstrak Insiden trauma spinal di dunia tercatat sebesar 0,019% hingga 0,088% per tahun, namun data epidemiologi dari masing-masing negara adalah berbeda-beda, sesuai dengan kekhususan dari masing-masing negara. Hingga saat ini, belum terdapat laporan penelitian epidemiologi untuk trauma vertebra di Indonesia. Penelitian ini merupakan penelitian deskriptif analitik. Sampel penelitian ini adalah seluruh pasien dengan fraktur vertebra yang masuk di RS Dr. Soetomo Surabaya pada tahun 2013-2017. Data penelitian ini didapatkan melalui data berkas rekam medis dan database elektronik rumah sakit. Data ditampilkan dalam bentuk tabel dan grafik serta dilakukan analisa komparasi dari variabel. Berdasarkan data tahun 2014-2017 didapatkan total 442 pasien dengan fraktur vertebra, dengan perbandingan laki-laki dan perempuan sebesar 3,3:1.  Rerata usia pasien adalah 43,6 tahun. Penyebab fraktur vertebra adalah akibat jatuh dari ketinggian (38%), kecelakaan lalu lintas (34%), dan benturan langsung/ tertimpa beban (10%). Berdasarkan level fraktur, fraktur terbanyak sejumlah 153 pasien (34,6%) pada level lumbal. Pada level lumbal didapatkan subtIpe fraktur terbanyak adalah tipe A dengan persentase 91,5% dan mechanism of injury terbanyak adalah akibat jatuh dari ketinggian. Berdasarkan subtipe frakturnya, fraktur tipe A (kompresi atau burst) merupakan jenis fraktur yang paling banyak terjadi. Fraktur vertebra lumbal adalah fraktur terbanyak pada kasus fraktur pada vertebra. Penyebab terbanyak fraktur pada vertebra adalah trauma dengan energi besar akibat jatuh dari ketinggian. Laki-laki 3 kali lebih banyak mengalami fraktur vertebra dibanding perempuan.Kata kunci: Epidemiologi, fraktur vertebra, trauma spinalKorespondensi  : dr.donnypermana@gmail.com
KARAKTERISTIK PASIEN TUBERKULOSIS TULANG BELAKANG DI RSUD DR. SOETOMO SURABAYA Amy Rosalie Sukamto; Primadenny Ariesa Airlangga; Tri Hartini Yuliawati
Majalah Biomorfologi Vol. 29 No. 1 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.077 KB) | DOI: 10.20473/mbiom.v29i1.2019.1-6

Abstract

Background: Spine tuberculosis or spondylitis TB is one of the most common found extrapulmonary form of Mycobacterium tuberculosis infection that can be rapidly transmitted. However, people’s alertness are still to be increased and this disease is still rarely investigated. Objective: To study the characteristics of spondylitis tuberculosis patients to enhance the understanding of the disease and improve alertness to its signs and symptoms. Material and method: This study was conducted by assessing patients’ medical records based on particularly the epidemiology, signs and symptoms, radiology and laboratory tests. Collected data were assessed retrospectively and analyzed descriptively. Results: Of 35 patients, most come from early adult age group which is ranged from 26 to 35 years old (25.72%), and 57.14% of the patients were female. Sorted from the most to least common found signs and symptoms are back pain (85.71%), formation of abscess (74.29%), formation of gibbus (54.29%), fever (37.14%), and significant weight loss (34.29%). In radiologic evaluation, spine destruction were found on 82.86% of the patients. Erythrocyte sedimentation rate (ESR) was evaluated from 30 patients, 90% of which had increased ESR to >30 mm/hour. The leukocyte count was based from 35 patients, which result was 71.43% of them had normal count. Conclusions: Spondylitis TB is mostly found in adult females with back pain as the most common symptom. Most patients had spine destruction. Largely had elevated ESR while their leukocyte count mostly remains within normal range.
UNSTABLE LUMBAR FRACTURE-DISLOCATION TREATED BY LONG SEGMENT POSTERIOR PEDICLE SCREW INSTRUMENTATION Ferdiansyah Danang; Primadenny Ariesa Airlangga
Journal Orthopaedi and Traumatology Surabaya Vol. 9 No. 2 (2020): October 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v9i2.2020.71-76

Abstract

Background: Among all the thoracolumbar fractures, 50-60% affects the thoracolumbar transitional zone, and 51% AO Type C Fractures has a neurological deficit. We experienced treating a case of unstable lumbar fracture-dislocation treated with long segment pedicle screw instrumentation.Case: A 26-year-old man came to the ER after his back hit by a canopy while working 2 hours before admission. The motoric function was diminished from the L2-S1 level and hypoesthesia at the T12 level. Plain X-Ray showed Fracture-Dislocation Lumbar Vertebral 1-2 Denis Classification Flexion Rotation (AO Type C) ASIA A. The patient underwent reduction, decompression, and long-segment posterior pedicle screw instrumentation.Discussion: The surgery’s primary purpose is to restore alignment and stability to improve the patient’s quality of life by enabling daily activity in a wheelchair without significant pain. Short segment or long segment pedicle screw instrumentation remains a debate. In this case report, we apply long segment pedicle screw instrumentation for lumbar vertebral fracture-dislocation.Conclusion: Thoracolumbar fracture and dislocation fixation aim to restore alignment and stability, to reduce kyphotic deformity, and to decompress the spinal canal. The long segment pedicle screw instrumentation can resist the deforming force of thoracolumbar fractures and dislocations that will inevitably collapse into further kyphosis, resulting in a better outcome.
THORACIC SPINE CANAL STENOSIS WITH CAUDA EQUINE SYNDROME: CASE REPORT Primadenny Ariesa Airlangga; Arifin Arifin
Journal Orthopaedi and Traumatology Surabaya Vol. 8 No. 2 (2019): October 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v8i2.2019.86-92

Abstract

Background: Cases of thoracic stenosis with cauda equina syndrome are rare. The thoracal canal is relatively narrow compared with cervical and lumbar, so the less pressure on the lower thoracal region is the thoracic vertebral height 11 which is the initial release of the cauda equine nerve root can cause complaints of cauda equina syndrome.Case: A 50-year-old male presented pain in both legs for 3 years, accompanied by weakness in the legs, numbness in the buttocks, and erectile dysfunction. Thoracal MRI examination shows severe spinal stenosis at 11th-12th thoracal vertebra with ligamentum flavum hypertrophy. Second patient, a 70-year-old man complained of weak legs since 1 week, accompanied by low back pain, numbness in the buttocks, and difficulty defecating. Thoracal MRI examination shows severe spinal stenosis in the 10th-11th thoracal vertebra. Both patients immediately underwent selective decompression surgery, laminotomy, and flavectomy at thoracal level showed satisfactory results based on improvement in clinical symptoms.Discussion: Leg weakness, hypoesthesia in the buttocks and pubic area, erectile dysfunction is the cauda equina syndrome. The exit of the first cauda equine nerve can be placed at 11th thoracic vertebra, so the presence of stenosis at that level and bellow can cause symptoms of the cauda equina syndrome. MRI examination is needed to ensure that there is severe spinal stenosis at the level of the thoracal-lumbar spine, according to the level of neurological disorders. The surgery of decompression is immediately carried out in the case of cauda equina syndrome because it is an emergency state.Conclusion. In cases with complaints of the cauda equina syndrome, thoracic stenosis can be the cause due to stenosis of the lower thoracic region which is the initial root of the cauda equina nerve. Confirm accurate diagnosis is with MRI.
Spinal Dural Arteriovenous Fistula in a Pediatric Patient with History of Endovascular Therapy Failure: A Case Report Primadenny Ariesa Airlangga, M.D, M.Sc; Rizal Alexander Lisan; Aries Rakhmat Hidayat
Surabaya Physical Medicine and Rehabilitation Journal Vol. 5 No. 2 (2023): SPMRJ, AUGUST 2023
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/spmrj.v5i2.41525

Abstract

Spinal Dural Arteriovenous Fistula (SDAVF) cases in children are extremely rare and pose a high risk for intraoperative hemorrhage. The clinical manifestation and imaging results may be vague and deceptive, frequently mistaken for other conditions such as demyelinating or spinal degenerative illnesses. SDAVF's cause is not well understood. Here, we present the case of a 10-year-old male patient with SDAVF who did not improve after endovascular therapy. The patient complained of weakness in the lower extremities, skin thickness, tingling sensations, and painful bowel movements and urination. The patient underwent endovascular embolization due to spinal AVF from the 9th thoracic vertebrae until the sacral vertebrae one month earlier. But no significant clinical improvement was found. The vital signs of the patient were within normal limits. An MRI showed a flow-void lesion with tortuosity in the dorsal spinal area at the 9th and 10th thoracic vertebrae. Because an embolization procedure was performed on the patient, which resulted in no significant improvement, it was planned for the patient to undergo an MRI and MRA evaluation. An MRI and MRA later showed the formation of an extramedullary intradural cyst at levels T9 to T10 of the thoracic vertebrae. Decompression surgery (left hemilaminectomy) and tumor extirpation were thereafter carried out on the patient after the routine laboratory test was performed. After the procedure, the patient showed improvement and could carry out everyday activities independently at 10 months post-operatively. The failure of endovascular therapy can be attributed to several factors, such as the surgeon's experience, tools, and embolization technique, and follow-up treatment by surgery.
Co-Authors Adrianto Prasetyo Perbowo Amy Rosalie Sukamto Aries Rakhmat Hidayat Arifin Arifin Donny Permana Dwikora Novembri Utomo Ferdiansyah Danang I Ketut Martiana Lukas Widhiyanto Purwati Purwati Rizal Alexander Lisan Tri Hartini Yuliawati