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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) Indonesian Andrology and Biomedical Journal

Tri Hartini Yuliawati

Departemen Anatomi Dan Histologi, Fakultas Kedokteran, Universitas Airlangga

Author-ID : 3484501

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Articles

Tulsi (Ocimum sanctum) Leaf Ethanol Extract Reduces Inflammatory Cell Infiltration in Aspirin-Induced Gastritis Rats Sari, Festi Artika; Sandhika, Willy; Yuliawati, Tri Hartini
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Gastritis is an inflammation of the gastric mucosa. Tulsi leaf extract has phenol, flavonoid and saponin compounds which are potential as antioxidant and increase defensive factors in the gastric. The purpose of this research was to find out the effect of tulsi (Ocimum sanctum) leaf extract in polymorphonuclear (PMN) inflammatory cell infiltration in gastric of aspirin-induced gastritis rat model. This study was laboratory experimental research using post-test only control group design. Randomly, 27 male rats were divided into 3 groups, the first group was not induced by aspirin and extract as negative control, the second group was induced by aspirin of 600 mg/kgBW as positive control, and the third group was induced by aspirin of 600 mg/kgBW and was given Ocimum sanctum extract at a dose of 400 mg/kgBW as treatment group. Gastric of the rats were taken on 16th day for histopathology evaluation using hematoxylin and eosin (HE) staining. Evaluation was done by calculating the PMN inflammatory cell infiltration in mucosal and submucosal layer. The results of the average number of PMN inflammatory cell in the gastric tissue of the treatment group showed a significant decrease compared to the positive and negative control groups with P-value <0.05. This study proved that Ocimum sanctum leaf extract administration with the dose of 400 mg/kgBW can decrease gastritis inflammation by reducing PMN inflammatory cell in gastric of aspirin-induced gastritis rat model.

KARAKTERISTIK PASIEN TUBERKULOSIS TULANG BELAKANG DI RSUD DR. SOETOMO SURABAYA Amy Rosalie Sukamto; Primadenny Ariesa Airlangga; Tri Hartini Yuliawati
Majalah Biomorfologi Vol. 29 No. 1 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Spine tuberculosis or spondylitis TB is one of the most common found extrapulmonary form of Mycobacterium tuberculosis infection that can be rapidly transmitted. However, people’s alertness are still to be increased and this disease is still rarely investigated. Objective: To study the characteristics of spondylitis tuberculosis patients to enhance the understanding of the disease and improve alertness to its signs and symptoms. Material and method: This study was conducted by assessing patients’ medical records based on particularly the epidemiology, signs and symptoms, radiology and laboratory tests. Collected data were assessed retrospectively and analyzed descriptively. Results: Of 35 patients, most come from early adult age group which is ranged from 26 to 35 years old (25.72%), and 57.14% of the patients were female. Sorted from the most to least common found signs and symptoms are back pain (85.71%), formation of abscess (74.29%), formation of gibbus (54.29%), fever (37.14%), and significant weight loss (34.29%). In radiologic evaluation, spine destruction were found on 82.86% of the patients. Erythrocyte sedimentation rate (ESR) was evaluated from 30 patients, 90% of which had increased ESR to >30 mm/hour. The leukocyte count was based from 35 patients, which result was 71.43% of them had normal count. Conclusions: Spondylitis TB is mostly found in adult females with back pain as the most common symptom. Most patients had spine destruction. Largely had elevated ESR while their leukocyte count mostly remains within normal range.

EFEK IBUPROFEN ORAL TERHADAP PERUBAHAN BERAT BADAN PADA MENCIT BETINA Anindya Marcha Angelina Djianto; Tri Hartini Yuliawati; Sri Ratna Dwiningsih; Widjiati Widjiati
Majalah Biomorfologi Vol. 29 No. 2 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Ibuprofen is one of the most used non-steroidal anti-inflammatory drugs (NSAID) due to its ease of access without the need of prescription. However, ibuprofen may cause side effects associated with gastrointestinal mucosal injury. The discomfort caused when eating may cause nausea and loss of appetite which leads to weight loss. Objective: This study was done to prove changes in body weight after treatment of oral ibuprofen using mice as test subjects. Material and method: This study used pre-test post-test control group design. 33 female BALB/c mice were grouped into 3 groups (P1, P2, P3). P1 is a control group which was given aquadest as placebo, P2 was given 52 mg/kg body weight of oral ibuprofen and P3 was given 104 mg/kg body weight of oral ibuprofen. Treatment lasted for 15 days. Results were analyzed using Kruskal-Wallis test and Mann-Whitney U test in IBM SPSS Statistics 22. Result: 80% of the mice had their body weights decreased with an average decrease of 0.91 g (±2.26) in group P1, average decrease of 2.2 g (±2.15) in P2, and average decreased of 4.11 g (±2.62) in P3. Statistical analysis showed that body weight changes of group P3 has significant difference (p = 0.009) compared to P1 and P2. Conclusion: It can be concluded that 104 mg/kg dose of oral ibuprofen caused a decrease in body weight of female mice.

EFFECT OF SEX DIFFERENCE ON THE HISTOLOGICAL STRUCTURE OF BRONCHUS AND NASAL CAVITY IN ANIMAL ASTHMA MODEL Reinaldi Rachmadhianto; Tri Hartini Yuliawati; Gatot Soegiarto
Majalah Biomorfologi Vol. 30 No. 1 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: The prevalence of asthma in prepuberty women is more common than in puberty men. Even after puberty, to a certain age, women dominate more. It is still unclear whether sex hormones affect the histological structure of male and female airways. Objective: This study objective was to examine the effect of sex difference on the histological structure of bronchial and nasal cavity of mice model (Mus musculus) with ovalbumin exposure. Materials and Methods: This study used 24 mice in four groups (male control, female control, male asthma model, and female asthma model). At the sensitization phase in days 0 and 14, the mice were injected intraperitoneally with 100 μl of a mixture of 50 μl ovalbumin (200 μl/ml) and 50 μl alum. At the exposure phase in days 21 to 23, the mice were exposed to 1% ovalbumin (aerosol, 30 minutes/per day). The mice were sacrificed 48 hours after the last exposure. The data taken included four variables, bronchial epithelial thickness, bronchial smooth muscle thickness, nasal cavity goblet cells number, and nasal cavity mucosal thickness. Then, Shapiro-Wilk normality test and parametric t-test were conducted. Results: In animal asthma models, mice with male and female exposure did not cause differences in epithelial thickness and smooth muscle thickness in bronchus compared to the control group. However, there were significant differences in the number of goblet cells and mucosal thickness in nasal cavity of male and female mice compared to the control group (respectively, p= 0.002; p= 0.006 and p= 0.003; p = 0.005). There were no significant differences between groups of male and female mice on all variables. Conclusion: In animal asthma models of mice, ovalbumin exposure did not cause differences in the values of all variables between male and female groups.

THE PROFILE OF CHILDREN WITH CONGENITAL RUBELLA SYNDROME SUFFERING FROM HEARING DISORDERS IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA Raudhatuzzahra Kesuma; Haris Mayagung Ekorini; Tri Hartini Yuliawati
Majalah Biomorfologi Vol. 30 No. 2 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v30i2.2020.45-51

Background: Congenital Rubella Syndrome (CRS) is an infection that can cause hearing loss which is commonly found in infants in Indonesia. The hearing screening of otoacoustic emission (OAE) and automated auditory brainstem response (AABR) is essential as an early screening to prevent speech and language development disorders which may reduce the social function of the patient in the future. Objective: To analyze the profile of children with CRS who suffer from hearing loss in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2015-2017. Materials and Methods: This research employed a descriptive retrospective study by collecting 118 secondary data from the medical records. Results: CRS was mostly found in 0-3 months age group (76 patients), and was dominated by males (62 patients). The most common signs and symptoms were congenital heart disease (49 patients), followed by hearing loss (37 patients). The serological results were mostly dominated by negative IgM and positive IgG (40 patients). The most dominant results of hearing screening test were OAE and AABR bilateral refer (45 patients). Conclusion: The profile of children with CRS suffering from hearing loss is various, depending on which country the research is conducted.

GLUT 4 DI JARINGAN ADIPOSA (GLUT 4 in Adipose Tissue) Dewi Ratna Sari; Rimbun Rimbun; Tri Hartini Yuliawati; Joni Susanto; Ari Gunawan; Harjanto JM
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1263

The decreasing of glucose transporter 4 (GLUT 4) in adipose tissue of diabetic and obesity patients are associated withhyperinsulinaemia and insulin resistance. The adipose tissue can be used as therapeutic targets in the treatment of Diabetes Mellitus(DM). Visceral adipose tissue has different morphology and functional with subcutaneous adipose tissue and Vitamin D has been knownto have contributed in DM. The aim of this study is to know the role of cholecalciferol on the expression of GLUT 4 in subcutaneous andvisceral adiposity of diabetic rats by elucidated in those tissues. The subjects of the study consisted of nineteen male diabetic rats of Wistarstrain, which were divided into control group (K) and three (3) treatment groups (X1, X2 and X3). In order to induce the condition ofDM, the animals were fed with high fat diet for three (3) weeks and administered a single intraperitoneal injection of streptozotocin (35mg/kgBW) at the end of the second week. Cholecalciferol were administered with doses of 6.25 μg/kgBW in X1, 12.5 μg/kgBW in X2and 25 μg/kgBW in X3 per oral everyday within 14 days. The subcutaneous and visceral adipose tissues of the subjects were processedinto histological slides with immunohistochemistry staining. The data were analyzed by one way ANOVA test and paired t-test (α= 0.05,significance p<0.05). In this study was found the significance of GLUT 4 expression in subcutaneous adiposity (p=0.035) is differentbetween the groups, the differences were found between group K and groups X1, X2 and X3. Also there were found the significance differentof GLUT 4 expression in subcutaneous adiposities compared with visceral adiposities in all treatment groups (p>0.05). Based on thisstudy it can be concluded that cholecalciferol could increase the expression of GLUT 4 in the subcutaneous adiposity, but not in visceraladiposity of the diabetic rats.

The Contribution of Sex Difference on Different Liver Histopathology Between Male and Female Mice After Oral Administration of Caffeine Muhammad Sholikhuddin Nafi’; Tri Hartini Yuliawati; Prijati Sri Irawati; Nurina Hasanatuludhhiyah
Indonesian Andrology and Biomedical Journal Vol. 2 No. 2 (2021): December
Publisher : Universitas Airlangga

Background: There are several studies reporting the effect of caffeine on liver histopathology, but it remains controversy. The laboratory animal used in those studies were predominantly male, whereas there is contribution of sex difference on different liver reaction to xenobiotic between male and female subject. Objective: It is necessary to conduct a study to explore the differences between the liver histopathology of male and female mice after oral administration of caffeine. Methods: This study used 36 mice (Mus musculus) that were divided into 4 groups: male & female untreated groups and male & female treated groups which were orally administered with caffeine 0.4 mg / 20 gramBW daily for 30 days. At the end of treatment, mice were euthanized and dissected. Histopathological examination was done to determine the percentage of liver cell death of each group. Results: The percentage of liver cell deathin female treated group was higher than male treated group (p = 0.0001). But there was no significant difference of liver cells death between male control and treated group and between female control and treated group. Conclusion: There was significant difference in liver histopathology between male and female mice after oral administration of caffeine.

Effect of Acute Exposure of Cigarette Smoke on Endometrium Thickness and Number of Ovarian Follicles in Rats Izdihar Ramadhanty Abiyasa Putri; R Haryanto Aswin; Tri Hartini Yuliawati
Indonesian Andrology and Biomedical Journal Vol. 2 No. 1 (2021): June
Publisher : Universitas Airlangga

Background: Cigarrete smoke has been ascociated with many health-related problems especially in long time use. One of many health problems that are affected is the reproductive system that give negative impact in fertility. However, there are limited studies about this in acute exposure of cigarette smoke. Objective: The aim of this study is to investigate the effect of acute exposure of cigarette smoke on endometrial thickness and number of ovarian follicles in rats. Methods: Thirty adult female rats were randomly divided into 3 groups: P0, P1 and P2. The P1 and P2 groups were exposed to cigarette smoke for 15 days with dose of 2 and 4 cigarettes daily, respectively. Vaginal swab was done twice, before and after the last treatment, to determine the proestrus phase of the animals. Histological slide of uterus and ovarium using Haematoxylin Eosin staining were observed under light microscop. Number of ovarian follicles were measured, and the thickness of endometrium was meassured using CellSens software version 2.3 (Olympus Life Science). Statistical analysis of data was performed using MANOVA in SPSS software version 23 for Windows. Results: There were no significant differences in both endometrial thickness and number of ovarian follicles between 3 groups (p>0.05). However, we found that there were a downward trend of some variables (endometrial thickness, number of primary follicles, de Graff follicles, and corpus luteum) from P0 to P2. Conclusion: We concluded that acute exposure of cigarette smoke not yet influenced the female reproductive organ, based on histological appearance of endemotrium and ovarium.

Co-Authors Airlangga, Primadenny Ariesa Amy Rosalie Sukamto Anindya Marcha Angelina Djianto Ari Gunawan Aswin, R. Haryanto Dewi Ratna Sari Dewi Ratna Sari Djoni Susanto Ekorini, Haris Mayagung Gatot Soegiarto Harjanto JM Izdihar Ramadhanty Abiyasa Putri Kusuma Eko Purwantari Muhammad Sholikhuddin Nafi’ Nur Aliya Nurina Hasanatuludhhiyah Prijati Sri Irawati Raudhatuzzahra Kesuma Reinaldi Rachmadhianto Rimbun Rimbun Rimbun Rimbun Sari, Festi Artika Sri Ratna Dwiningsih Sudibjo Sudibjo Widjiati Widjiati Willy Sandhika

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