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All Journal Jurnal Sains Dasar Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Sardjiman Sardjiman
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Activity test of 2,6-bis-(2-furilidine) sikloheksanonecompound antibacterial towards resistence Staphyloccus aureus bacteria Ismi Rahmawati; Iswandi Iswandi; Sardjiman Sardjiman
Jurnal Sains Dasar Vol 3, No 2 (2014): October 2014
Publisher : Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3188.871 KB) | DOI: 10.21831/jsd.v3i2.4144

Abstract

The data that have been obtained in Indonesia by using samples of clinical material from the hospital, Staphylocccus aureusis proved to be resistant to penicilin and methicillin, tetracyclin, oxacilin, gentamicin, erytromycin, chloramphenicol, and trimethrophrim-sulfemethoxazole. The high resistant inStaphylocccus aureus bacteria encourage efforts to find drugs that have antibacterial activity. Furfural and its derivates are known to have antibacterial activity. The purpose of this study was to obtain derivate of furfural compound 2,6-bis-(2’-furilidyn)-sikloheksanone, which is expected to have antibacterial activity against drug resistant bacteria Methicillin resistant Stapylococcus aureus (MRSA). 2,6-bis-(2’-furilidyn)-sikloheksanone synthesis was done with starting materials ofcyclohexanone (0,0121 mol)and furfural (0,0121 mol), using KOH 7,5% as catalys in the aquadest solvent. The purity test were carried out with melting distance test, thin layer chromatography, and gas chromatography. Structure elucidation was performed with mass spectrometer analysis, IR, and spectrophotometer, H1-NMR. The syntesis result is then tested for its antibacterial activity againts MRSA bacteria with diffusion method to determine the inhibition diameter. The result of this study showed that 2,6-bis-(2’-furilidyn)-cyclohexanone has been successfully synthesized with an average yield of 73,60% ±0,204. Re-crystallization resulting in pure compound base on its melting range (1,90C), TLC (one spot Rf= 0,33), and GC (100% area). The results of the chemical structure elucidation by mass spectrometry, IR spectrophotometerand H-NMR spectrometer line with the target compound. The synthesis result has antibacterial activity with average of inhibition diameter at a concentration of 3,959mM/ml= 27 mm.   Keywords:synthesis, analog of curcumin, antibacterial
Hubungan Tingkat Pengetahuan Pasien Hiperkolesterolemia Dengan Ketepatan Penggunaan Obat Simvastatin Di Apotek Kecamatan Weru Sukoharjo Kania Istiqomah; Hanugrah Ardya Crisdian Saraswati; Sardjiman Sardjiman
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 3 (2024): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i3.284

Abstract

Hypercholesterolemia is an elevation of cholesterol levels exceeding 240 mg/dl. Simvastatin is a cholesterol-lowering drug classified as a statin. Improper medication use is often due to incomplete or incorrect information obtained by patients, which can impact their level of knowledge. The purpose of this research is to determine the relationship between patients' knowledge levels on hypercholesterolemia and the accuracy of simvastatin medication use at pharmacies in Weru Sub-District, Sukoharjo. The study was an analytical observational study with a cross-sectional research design. Sample selection used purposive sampling based on inclusion and exclusion criteria. The instrument for this research utilized a questionnaire distributed to 110 respondents. The research findings revealed a correlation coefficient value of 0.383 and a significant value (P Value) of 0.001<0.05, indicating that the alternative hypothesis was accepted. In conclusion, there was a significant correlation between the variables of patients' knowledge levels on hypercholesterolemia and the accuracy of simvastatin medication use at pharmacies in Weru Sub-District, Sukoharjo.
Hubungan Tingkat Pengetahuan Pasien Hiperkolesterolemia Dengan Ketepatan Penggunaan Obat Simvastatin Di Apotek Kecamatan Weru Sukoharjo Kania Istiqomah; Hanugrah Ardya Crisdian Saraswati; Sardjiman Sardjiman
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.584

Abstract

Hypercholesterolemia is an elevation of cholesterol levels exceeding 240 mg/dl. Simvastatin is a cholesterol-lowering drug classified as a statin. Improper medication use is often due to incomplete or incorrect information obtained by patients, which can impact their level of knowledge. The purpose of this research is to determine the relationship between patients' knowledge levels on hypercholesterolemia and the accuracy of simvastatin medication use at pharmacies in Weru Sub-District, Sukoharjo. The study was an analytical observational study with a cross-sectional research design. Sample selection used purposive sampling based on inclusion and exclusion criteria. The instrument for this research utilized a questionnaire distributed to 110 respondents. The research findings revealed a correlation coefficient value of 0.383 and a significant value (P Value) of 0.001<0.05, indicating that the alternative hypothesis was accepted. In conclusion, there was a significant correlation between the variables of patients' knowledge levels on hypercholesterolemia and the accuracy of simvastatin medication use at pharmacies in Weru Sub-District, Sukoharjo.
Co-Authors Hanugrah Ardya Crisdian Saraswati Ismi Rahmawati Iswandi Iswandi Kania Istiqomah