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All Journal Jurnal Sains Dasar Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Penelitian Kesehatan Suara Forikes Journal of Dedicators Community JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Borneo Journal Of Pharmascientech Medfarm: Jurnal Farmasi dan Kesehatan Natural Sciences Engineering and Technology Journal JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Ilmiah Kesehatan (JIKA) Jurnal AFAMEDIS Medical Sains : Jurnal Ilmiah Kefarmasian Journal Borneo Jurnal Ilmiah Farmasi Akademi Farmasi Jember Hippocampus: Jurnal Pengabdian Kepada Masyarakat Serulingmas Health Journal (SHJ) Indonesian Journal of Pharmaceutical Research Medical Sains : Jurnal Ilmiah Kefarmasian

Iswandi Iswandi

Fakultas Farmasi, Universitas Setia Budi

Author-ID : 938070

Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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UJI AKTIVITAS ANTIOKSIDAN PADA EKSTRAK KULIT JERUK MANIS (Citrus x sinensis) DENGAN METODE SPF SECARA SPEKTROFOTOMETRI UV-Vis iswandi
AFAMEDIS Vol. 2 No. 2 (2021): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.571 KB)

ABSTRACT Sweet orange peel (Citrus x sinensis) has benefits as an antioxidant and Sun Protecting Factor (SPF). This study aims to determine the antioxidant activity of sweet orange peel extract with 70% and 90% ethanol solvent variations using the Sun Protecting Factor (SPF) method. Sweet orange peel (Citrus x sinensis) was extracted using maceration method with 70% ethanol and 90% ethanol as solvent variations. The extract was then concentrated using a water bath. The extracts obtained were tested for phytochemicals for alkaloids, flavonoids, tannins, saponins and triterpenoids. The antioxidant activity test was carried out by dissolving each extract in absolute alcohol with a concentration of 20% (w/v). Antioxidant activity test using Sun Protecting Factor (SPF) method using UV-Vis spectrophotometer. The data was processed using One-Way Anova test statistics. The phytochemical test results on sweet orange peel extract showed that the extract contained positive alkaloids, flavonoids, saponins, tannins and triterpenoids. The antioxidant activity test on sweet orange peel extract showed that 70% alcohol solvent had a higher SPF value of 20,95, while the extract with 90% alcohol solvent had a lower SPF value of 15,70. Keywords: Citrus x sinensis, extract, maceration, UV-Vis spectrophotometer, SPF.

Activity test of 2,6-bis-(2-furilidine) sikloheksanonecompound antibacterial towards resistence Staphyloccus aureus bacteria Ismi Rahmawati; Iswandi Iswandi; Sardjiman Sardjiman
Jurnal Sains Dasar Vol 3, No 2 (2014): October 2014
Publisher : Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta

The data that have been obtained in Indonesia by using samples of clinical material from the hospital, Staphylocccus aureusis proved to be resistant to penicilin and methicillin, tetracyclin, oxacilin, gentamicin, erytromycin, chloramphenicol, and trimethrophrim-sulfemethoxazole. The high resistant inStaphylocccus aureus bacteria encourage efforts to find drugs that have antibacterial activity. Furfural and its derivates are known to have antibacterial activity. The purpose of this study was to obtain derivate of furfural compound 2,6-bis-(2’-furilidyn)-sikloheksanone, which is expected to have antibacterial activity against drug resistant bacteria Methicillin resistant Stapylococcus aureus (MRSA). 2,6-bis-(2’-furilidyn)-sikloheksanone synthesis was done with starting materials ofcyclohexanone (0,0121 mol)and furfural (0,0121 mol), using KOH 7,5% as catalys in the aquadest solvent. The purity test were carried out with melting distance test, thin layer chromatography, and gas chromatography. Structure elucidation was performed with mass spectrometer analysis, IR, and spectrophotometer, H1-NMR. The syntesis result is then tested for its antibacterial activity againts MRSA bacteria with diffusion method to determine the inhibition diameter. The result of this study showed that 2,6-bis-(2’-furilidyn)-cyclohexanone has been successfully synthesized with an average yield of 73,60% ±0,204. Re-crystallization resulting in pure compound base on its melting range (1,90C), TLC (one spot Rf= 0,33), and GC (100% area). The results of the chemical structure elucidation by mass spectrometry, IR spectrophotometerand H-NMR spectrometer line with the target compound. The synthesis result has antibacterial activity with average of inhibition diameter at a concentration of 3,959mM/ml= 27 mm. Keywords:synthesis, analog of curcumin, antibacterial

Aktivitas Antijamur Fraksi n-Heksana, Etil Asetat, dan Air dari Ekstrak Metanolik Daun Bunga Pukul Empat (Mirabilis jalapa L.) terhadap Pityrosporum ovale ATCCÂ® 3179 Agnes Christina Budiwati; Gunawan Pamudji Widodo; Iswandi Iswandi
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Leaves of Mirabilis jalapa L. can inhibit the growth of Staphylococcus aureus and Aspergillus sp. The study aimed to determine the antifungal activity of n-hexane, ethyl acetate, and water fractions from the methanolic extract of leaves of Mirabilis jalapa L. against Pityrosporum ovale fungi and to determine the most effective fraction in inhibiting the growth of Pityrosporum ovale. Antifungal activity assays using the diffusion method, in which the test solution of Mirabilis jalapa L. leaves made serial consentrations of 10%, 5%, 3% entered in wells that have been applied to SGA media fungal suspension test. The results was analyzed using two ways statistical analysis. The result showed that of n-hexane, ethyl acetate, and water fractions from methanolic extracts Mirabilis jalapa L. leaves have antifungal activity against Phytyrosporum ovale. Ethyl acetate fraction at a concentration of 10% had the highest antifungal activity was 25 mm.

Pengaruh Waktu Fermentasi Teh Kombucha terhadap Penurunan Kadar Glukosa Darah pada Tikus Putih Jantan Galur Wistar dengan Induksi Aloksan Nilam Kristianingtyas; Inaratul Rizkhy Hanifah; Iswandi Iswandi
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Diabetes mellitus is a group of metabolism disorders which is characteristic by the blood glucosa levels. Kombucha tea is a fermented product of sweet tea due o activity of yeast and bacteria.The research was aimed to determine the influence of various kombucha fermentation time on the decrease of glucose level in white male rats wistar. The tested animal is were inducted with aloksan and arranged into groups. Each group consisted of 5 white male rats. Group I as negative control was treated by aquadest. Group II, III dan IV were treated by 5,5 ml of 4, 8 and 12 days-fermentation kombucha tea, respectively. Group V, as positive control was treated by glibenclamide at 0,09 mg/200 g BB. The treatments were conducted for two weeks. Each group was observed for glucose levels an the firstand second week. The results were analyzed using one way ANOVA. The result showed that tea kombucha is able to decreaseglucose levels and the 12 days fermented kombucha tea has ability to decrease glucose levels better than 4 and 8 days fermented tea kombucha.

Pembinaan Teknik Bercocok Tanam Hidroponik Tanaman Obat di Perumahan Josroyo Ika Purwidyaningrum; Iswandi Iswandi; Meta Kartika Untari
Journal of Dedicators Community Vol 4, No 2 (2020)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v4i2.1056

The development of the Hydroponic Planting Technique for Medicinal Planting in the Central Java Josroyo Housing was carried out with the aim of improving the quality of health and the economy of the community. Pollution is a daily consumption for residents living in big cities and densely populated settlements. On free roads, motor vehicle fumes mixed with cigarette smoke are almost inevitable. Health research about cigarette smoke that causes lung cancer is not new and widely reported by researchers. Hydroponics is a method of planting that is positive for health. Consuming vegetables and medicinal plants hydroponics is better than conventional vegetables and free of pesticides so it is healthy. Vegetables and medicinal hydroponic drugs are fresher and tastier than similar products from the market or vegetable vendors. The durability of vegetables and hydroponic medicinal plants is recognized relatively longer than vegetables grown above ground. The advantages of hydroponic planting methods are saving land, saving water, without pesticides, free of weed disturbances, on-target nutrition as well as saving land and labor so as to answer the problem of planting in Josroyo housing

Development of a Simultaneous Sulfadiazine, Sulfamethoxazole, and Tetracycline Antibiotic Level Determination Method with High-Performance Liquid Chromatography Yanulia Handayani; Iswandi; Supriyadi
Natural Sciences Engineering and Technology Journal Vol. 3 No. 1 (2023): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v3i1.25

Sulfonamides and tetracyclines are a group of synthetic antibacterials that are widely used in veterinary practice for the treatment and prevention of infections in animals that can be consumed by humans. The purpose of this study was to determine the optimum conditions for High-Performance Liquid Chromatography for simultaneous analysis of sulfadiazine, sulfamethoxazole, and tetracycline and meet the validation requirements. The research method used is the HPLC method. The instruments used are Agilent 1220 Infinity II low-pressure dual-channel gradient valve, variable wavelength detector (VWD) BI detector, the column used is Agilent 5 TC-C18 (250 x 4.6 mm), motion phase A = acetic acid 0.08%: acetonitrile (9:1) and motion phase B = methanol with a flow rate gradient of 0.5 mL/minute and UV-VIS detector at wavelength 295 hm. The results showed that the method of determining the levels of sulfadiazine, sulfamethoxazole, and tetracycline met the requirements of selectivity, accuracy, precision, linearity, LOD, and LOQ and could be applied to fish samples. The accuracy parameter test obtained recovery results between 96.99%-103.16% at all sample concentration levels of 80%, 100%, and 120%. Testing the precision parameters showed that all sample concentrations were 100% repeated for 6 times replications, fulfilling the precision requirements, namely, the concentration of ≥10 ppm was < 7.3%. The linearity test showed that the correlation coefficient of sulfadiazine was 0.999, sulfamethoxazole was 0.999, and tetracycline was 0.998. LOD and LOQ values of sulfadiazine 1.15 ppm and 3.84 ppm, sulfamethoxazole LOD 2.51 ppm and LOQ 8.37 ppm, and tetracycline LOD 3.37 ppm and LOQ 11.22 ppm. Applications to fish samples were carried out by addition and obtained levels of 14.79 ppm sulfadiazine, 14.01 ppm sulfamethoxazole, and 45.05 ppm tetracycline.

PENGARUH SUHU TERHADAP PERURAIAN KADAR ASETOSAL PADA TABLET GENERIK DAN PATEN SECARA SPEKTROFOTOMETRI UV Iswandi Iswandi
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 1 (2022): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v11i1.92

Acetosal has many properties or broad therapeutic effects, including analgesic, antipyretic, non-steroidal anti-inflammatory, antifibrinolysis, inhibition of prostaglandin biosynthesis, pain relief, and cardiovascular disorders. The purpose of this study was to determine the effect of storage temperature on acetosal content and acetosal decomposition in generic and patent tablets. Acetosal tablets were stored at 250C, 500C and 750C, then weighed 50.0 mg and dissolved with 5.0 mL of ethanol and aquabidestilata to 100.0 mL, then diluted and read with the maximum wavelength. The results were calculated as percent acetosal content and percent decomposition and were analyzed using the Two Way Anova statistical test. The levels of generic acetosal tablets at 250C, 500C and 750C respectively yielded 94.3% (± 0.64) ; 91.53% (±1.19) ; 81.43% (± 0.73). Acetosal levels in patent tablets at temperatures of 250C, 500C and 750C respectively yielded 96.06% (± 0.68) ; 92.74% (±0.53) ; 87.15% (± 0.67). Acetosal decomposition results in generic tablets at temperatures of 250C, 500C and 750C respectively yielded 5.07% (± 0.64) ; 8.47 %(± 1.19); 18.57% (± 0.73). The levels of acetosal decomposition products in patent tablets at temperatures of 250C, 500C and 750C respectively yielded 3.94% (± 0.68) ; 7,26 %(± 0,53) ; 12.85% (± 0.67). The results of the two-way ANOVA showed that there was a significant difference in the levels of acetosal and decomposition products between generic tablets and patented tablets which were affected by storage temperature.

Karakterisasi Cocrystal Glibenklamida Dengan Variasi Pelarut dan Uji Stabilitas Termal Anang Kuncoro Rachmad Setiawan; Iswandi Iswandi; Dian Marlina
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 3 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i3.59893

Glibenklamida termasuk dalam Biopharmaceutical Classification System (BCS) kelas II yaitu kelarutannya rendah. Kelarutan dapat ditingkatkan dengan dengan mengubah glibenklamida menjadi bentuk cocrystal. Penelitian bertujuan mengetahui karakteristik kristal dan pengaruh termal terhadap cocrystal glibenklamida yang dibuat dengan variasi pelarut aceton, etanol dan pelarut acetonitril-aceton, dan untuk mengetahui peningkatan kelarutan cocrystal glibenklamida. Cofomer yang digunakan asam oksalat dalam perbandingan equivalensi molar 1:1 dibuat dengan metode solvent evaporasi, menggunakan variasi pelarut aceton (F1), etanol (F2) dan pelarut campuran acetonitril-aceton (F3). Karakteristik cocrystal menggunakan Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Fourier Transform Infrared (FTIR), Differential Thermal Analysis (DTA), Differential Scanning Calorimetry (DSC), Thermal Gravimetric Analysis (TGA) dan uji kelarutan. Hasil penelitian cocrystal yang dibuat dengan variasi pelarut aceton (F1), etanol (F2) dan pelarut campuran acetonitril-aceton (F3) pada difraktogram XRD memiliki intensitas kristalisasi sudut 2θ: (F1) 5230,55; (F2) 4115,12 dan (F3)3404,17. Hasil spektra FTIR cocrystal pada gugus NH (F1) 3398,72 cm-1 (F2) 3381,36 (F3) 3404,51, pada gugus C=O (F1)1641,42 cm-1; (F2) 1433,17 cm-1; (F3) 1437,64 cm-1. Analisis termal DTA menunjukan titik leleh pada suhu 141-169,90C. Nilai entalpi (ΔH) dari DSC glibenklamida murni -38,0044 J/g; (F1) -12,14874 J/g; (F2) -38,8612 J/g; (F3) -5,8400 J/g. Hasil uji kelarutan terjadi peningkatan pada F1 6,75-12,65%, F2 7,40-12,52% dan F3 5,46-10,75%. Kesimpulan dari penelitian ini, cocrystal glibenklamida yang dibuat dengan variasi pelarut F1, F2 dan F3 memiliki perbedaan karakteristik kristal dan karakteristik terhadap pengaruh termal, cocrystal yang dibuat dengan pelarut aceton mempunyai peningkatan kelarutan yang paling tinggi sebesar 12,65 % pada medium pelarut dapar pH 4,5.

Evaluasi Perbandingan Sistem Rantai Dingin Penyimpanan Vaksin Maelana Eka Dewi; Iswandi Iswandi; meta kartika
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16485

Vaccines are preparations of biological products that contain antigens or contain components of microorganisms that have been attenuated from genetic engineering. Defective vaccine quality can be caused by the time of the cold chain storage process that is not in procedure. This study aims to compare the vaccine cold chain system in the warehouse of the City Health Office and Salatiga City Health Center which is guided by the Indonesian Minister of Health Regulation Number 12 of 2017. This type of research uses a descriptive observational method. The data collected in the form of quantitative and qualitative. Collecting qualitative data obtained from interviews and observations. Qualitative data were obtained from vaccine storage data in 2021. The results of the study obtained that he cold chain compatibility system at the City Health Office and Salatiga City Health Center was in good category, with the percentage of the City Health Office 88.88%, Cebongan Health Center 77.77%, Mangunsari Health Center 70.37%, Kalicacing Health Center 85.18%, Tegalrejo Health Center 81.48%, Sidorejo Lor Health Center 81.48%, Sidorejo Kidul Health Center 77.77%. Supporting facilities for vaccine storage are in accordance with the guidelines of the Permenkes RI Nomor 12 tahun 2017, in good category. With the percentage of the City Health Office 99.64%, Cebongan Health Center 96.87%, Mangunsari Health Center 97.02%, Kalicacing Health Center 91.80%, Tegalrejo Health Center 94.11%, Sidorejo Lor Health Center 96.29%, Sidorejo Kidul Health Center 98,30%.

Evaluasi Penyaluran Vaksin Sesuai Standar CDOB (Cara Distribusi Obat yang Baik) Kintan Fahra Ningrum; Iswandi Iswandi; Meta Kartika Untari
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15644

Vaccines are biological products made using germs and then weekened. According to existing studies, 75% of vaccines in Indonesia are exposed to freezing temperatures during the distribution process, as a result, vaccines cannot be used anymore. The City Health Office has responsibility for the distribution of vaccines, especially in health centers, which must be evenly distributed and given regularly at the right time. The purpose of this study is the distribution of cold chain vaccines from the City Health Office to Salatiga Health Centers using the 2020 CDOB regulatory guidelines. This study uses an observational method that has a descriptive nature and evaluation using data collection techniques by interviewing with pharmacists or vaccine managers. The data will be based on the analysis of the result of data collection using an interview sheet, and the results will be stated with a percentation. The results of the study indicate that the distribution guidelines for the rantai dingin vaccine distribution system from the Health Office to the Salatiga City Health Center using the 2020 CDOB have a good category with a percentage of 72,72% and 84,21%. Then, there was a discrepancy in the distribution carried out by the Health Service to the Salatiga City Health Center but no deviation occurred, the vaccine distributed was not damaged or expired. Factors that may occur due to discrepancies are the lack of Human Resources (HR) for vaccine managers and vaccine warehouses that have not been maximized.

Co-Authors Agnes Christina Budiwati Anang Kuncoro Rachmad Setiawan Asmiyenti Djaliasrin Djalil Bangkit Riska Permata Cut Bidara Panita Umar Endang Sri Rejeki Eva Widhia Saprini Sipa Fatmawati Fatmawati Fitra Indah Wiratantri Gunawan Pamudji Gunawan Pamudji Widodo Ika Purwidyaningrum Inaratul Rizkhy Hanifah Ismi Rahmawati Khusnul Hotimah Kintan Fahra Ningrum M. Aisy Akbar Firdaus Firdaus Maelana Eka Dewi Marlina, Dian meta kartika Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Moh. Rivaldi Mappa Nilam Cahya Aprilia Nilam Kristianingtyas Nilawati, Anita Nur Anggreini Dwi Sasangka Pudiastuti Safira Prasita Dewanti Sardjiman Sardjiman Sasongko Roshinta Wulandari Sri Devi Rahma Suherman Sumaryana Sumaryana Sumaryana Sumaryana Supriyadi Supriyadi Supriyadi Susiyarti Susiyarti TN Saifullah Tri Nur Azizah Widyasti, Jena Hayu Yanulia Handayani

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