Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

1.945

P-Index

This Author published in this journals

All Journal Jurnal Sains Dasar Pendas : Jurnah Ilmiah Pendidikan Dasar Jurnal Farmasi Indonesia Jurnal Biomedika Berkala Ilmiah Mahasiswa Farmasi Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Multidisiplin Madani (MUDIMA) Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan Strada Jurnal Ilmiah Kesehatan (SJIK)

Ismi Rahmawati

Unknown Affiliation

Author-ID : 435123

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 12 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

Uji Mekanisme Kerja Antibakteri Senyawa 1,5-difuril-1,4-pentadien-3-on ANALOG Kurkumin terhadap Beberapa Bakteri Dwiningsih Dwiningsih; Vivin Nopiyanti; Ismi Rahmawati; Marlia Singgih Wibowo; Daryono Hadi Tjahjono
Biomedika Vol 9 No 1 (2016): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Senyawa monokarbonil analog kurkumin yang sudah berhasil disintesis yaitu senyawa 1,5-difuril-1,4-pentadien-3-on, mempunyai aktivitas sebagai antioksidan, anti inflamasi dan antibakteri. Penelitian ini bertujuan untuk mengetahui mekanisme kerja senyawa analog kurkumin 1,5-difuril-1,4-pentadien-3-on terhadap bakteri Klebsiella pneumonia ATCC 10031, Shigella dysenteriae ATCC 9361, Pseudomonas aeruginosaATCC 27853 dan Bacillus subtilis ATCC 6633 yang teraktif. Senyawa 1,5-difuril-1,4-pentadien-3-on merupakan hasil sintesis yang dinyatakan murni dan memiliki hasil elusidasi struktur yang sesuai. Senyawa hasil sintesis diuji aktivitas antibakteri dengan menggunakan metode difusi dengan pelarut DMSO serta kontrol positif amoksilin dilanjutkan dengan metode dilusi. Senyawa 1,5-difuril-1,4-pentadien-3- on dibuat dengan konsentrasi 1500 ppm. Suspensi bakteri disetarakan dengan Mc Farlan 0,5. Hasil aktivitas dengan metode dilusi ditentukan hasil KBM (Konsentrasi Bunuh Minimal) untuk dilakukan kajian mekanisme kerja dengan melihat kebocoran membran dan rusaknya dinding sel bakteri. Hasil menunjukkan senyawa 1,5-difuril-1,4-pentadien-3-on memiliki aktivitas terhadap bakteri K. pneumonia ATCC 10031, S. dysenteriae ATCC 9361, P. aeruginosa ATCC 27853 dan B.subtilis ATCC 6633 dengan diameter daya hambat rata-rata berturutan adalah 16mm; 18,6mm; 21,2mm dan 19mm. Senyawa1,5-difuril-1,4-pentadien-3-on merupakan senyawa teraktif terhadap bakteri P. aeruginosa ATCC 27853. Uji aktivitas antibakteri dilanjutkan dengan metode dilusi untuk mendapatkan nilai KBM (Konsentrasi Bunuh Minimal). Hasil KBM senyawa 1,5-difuril-1,4-pentadien-3-on adalah 187,5 ppm. Uji mekanisme kerja dilakukan dengan pengujian kebocoran membran dan kerusakan dinding sel yang dilihat dengan AAS. Hasil menunjukkan adanya kerusakan dinding sel bakteri karena terjadinya peningkatan konsentrasi Mg2+ pada perlakuan.

Uji Aktivitas Antijamur Fraksi n-Heksana, Kloroform dan Air dari Ekstrak Etanolik Daun Zodia (Evodia sauveolens, Scheff) terhadap Candida albicans ATCC 10231 Ismi Rahmawati; Ratno Agung Samsumaharto; Patricius Prima Dimas Putranto
Biomedika Vol 9 No 1 (2016): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Daun zodia (Evodia sauveolens, Scheff) adalah tanaman yang secara empiris berkhasiat sebagai antimikroba. Kandungan kimia daun zodia adalah minyak atsiri, flavonoid, alkaloid, saponin dan zodia. Penelitian ini dilakukan untuk untukmengetahuiaktivitasfraksin-heksan,kloroform, air dari ekstraketanolikdaun zodia (Evodia sauveolens, Scheff) sebagai antijamur terhadap Candida albicans ATCC 10231. Metode yang digunakan dalam penelitian ini adalah metode maserasi dengan pelarut etanol 96% dilanjutkan dengan pelarut n-heksan, kloroform dan air. Uji aktivitas antijamur dilakukan dengan metode dilusi. Konsentrasi ekstrak etanolik dan fraksi yang digunakan 50%; 25%; 12,5%; 6,2%; 3,1%; 1,5%; 0,7%; 0,3%; 0,1%; 0,09%. Hasil penelitian menunjukkan bahwa ekstrak etanolik dan fraksi air memiliki konsentrasi bunuh minimum sebesar 25% terhadapCandida albicans ATCC 10231. Fraksi air dari ekstrak etanolik dari daun zodia memiliki aktivitas antijamur paling aktif dibandingkan dengan fraksi n-heksan dan fraksi kloroform.

Activity test of 2,6-bis-(2-furilidine) sikloheksanonecompound antibacterial towards resistence Staphyloccus aureus bacteria Ismi Rahmawati; Iswandi Iswandi; Sardjiman Sardjiman
Jurnal Sains Dasar Vol 3, No 2 (2014): October 2014
Publisher : Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta

The data that have been obtained in Indonesia by using samples of clinical material from the hospital, Staphylocccus aureusis proved to be resistant to penicilin and methicillin, tetracyclin, oxacilin, gentamicin, erytromycin, chloramphenicol, and trimethrophrim-sulfemethoxazole. The high resistant inStaphylocccus aureus bacteria encourage efforts to find drugs that have antibacterial activity. Furfural and its derivates are known to have antibacterial activity. The purpose of this study was to obtain derivate of furfural compound 2,6-bis-(2’-furilidyn)-sikloheksanone, which is expected to have antibacterial activity against drug resistant bacteria Methicillin resistant Stapylococcus aureus (MRSA). 2,6-bis-(2’-furilidyn)-sikloheksanone synthesis was done with starting materials ofcyclohexanone (0,0121 mol)and furfural (0,0121 mol), using KOH 7,5% as catalys in the aquadest solvent. The purity test were carried out with melting distance test, thin layer chromatography, and gas chromatography. Structure elucidation was performed with mass spectrometer analysis, IR, and spectrophotometer, H1-NMR. The syntesis result is then tested for its antibacterial activity againts MRSA bacteria with diffusion method to determine the inhibition diameter. The result of this study showed that 2,6-bis-(2’-furilidyn)-cyclohexanone has been successfully synthesized with an average yield of 73,60% ±0,204. Re-crystallization resulting in pure compound base on its melting range (1,90C), TLC (one spot Rf= 0,33), and GC (100% area). The results of the chemical structure elucidation by mass spectrometry, IR spectrophotometerand H-NMR spectrometer line with the target compound. The synthesis result has antibacterial activity with average of inhibition diameter at a concentration of 3,959mM/ml= 27 mm. Keywords:synthesis, analog of curcumin, antibacterial

STUDI LITERATUR RASIONALITAS, DAN POLA SENSITIVITAS TERHADAP ANTIBIOTIK PADA BAKTERI STAPHYLOCOCCUS AUREUS PENYEBAB INFEKSI GANGREN DIABETES MELITUS Aprilia rina wati; ismi rahmawati; Inaratul Rizkhy Hanifah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.78

Introduction: Diabetic gangrene can be treated with antibiotics. The use of antibiotics must be done rationally. Antibiotic sensitivity patterns know which antibiotics have become resistant. The purpose of this literature study is to determine the relationship between rationality and patterns of antibiotic sensitivity in bacteria that cause gangrene infection. Methods: The research was conducted using a literature study method using journals obtained through journal sites such as search engines Scopus, Google Scholar, ScienceDirect, NCBI, PubMed, Oxford Academics, Cambridge, and Sprinkle link published between 2009-2021, obtained journals as many as 13 journals extracted from 99 existing journals. This literature study was carried out in several stages, namely, formulating problems, collecting data, extracting data, synthesizing data, and compiling a thesis. Result: The results of the literature study rationality of antibiotic use is precise indication, appropriate drug and appropriate patient. Antibiotics that are resistant in several hospitals in Indonesia are ceftriaxone, cotrimoxazole, benzylpenicillin erythromycin, ampicillin, cloramfenicol, cefoperazone, meropenem, cefixime, gentamicin, ceftazidime, ciprofloxacin, streptomycin, lincomycin, and cefotaxime. The mechanism that bacteria have in developing resistance is by enzymatic modification, changes in PBP structure, pump protein production, and changes in antibiotic targets

Analisis Perencanaan dan Pengendalian Obat Kategori A dengan Metode ABC-VEN dan EOQ di IFRS RSIS Mojokerto Mustika Wati; Ismi Rahmawati; Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1178

The high residualvalue of drug inventory at IFRS RSIS Mojokerto indicates that drug management has not been managed optimally. The priority scale of supervision and control at planning stage needs to be carried out using the ABC-VEN method analyzing and calculating the EOQ value in order to achieve the most economical ordering value to avoid overstock. The purpose of this study was to determine drug classificationusing the ABC-VEN method, planning control using with EQQ and measuringthe efficiency value at IFRS RSIS Mojokerto. The design of this research is descriptive quantitative. Retrieval of retrospective data from the January-October 2020 financial statement at IFRS RSIS Mojokerto. The data were analyzed by ABC-VEN to get categoryA drugs. Drug inventory control was calculated by calculating the value of EOQ,ROP, efficiency value by calculating ITOR. The results of drug classification using the ABC-VEN method obtained categoryA drugs absorbing 68.05% of the total investment value. Control of planning category A drug needs resulted in the value of the remaining inventory dropping from 48.4% to 36% of the total inventory value, ITOR increased from 2.0 to 4.1 times per month. The conclusion of the ABC-VEN, EOQ and ROP analysis can be used to determine the priority scale of procurement and control to avoid over-stocking of drug supplies in the hospital.

AKTIVITAS ANTIBIOFILM DAN ANTIBAKTERI DAUN BINAHONG (Anredera cordifolia (Ten) Steenis) TERHADAP Pseudomonas aeruginosa Fradine, Chossy; Ismi Rahmawati; Opstaria Saptarini
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1705

Plant in Indonesia that has antibacterial activity is binahong (Anredera cordifolia (Ten.) Stennis). Binahong leaf contains flavonoid, saponins, tannins and terpenoids compounds. The purpose of the study are determining the potential of extracts and fractions (n-hexane, ethyl acetate and water) in inhibiting the formation of biofilms, biofilm degradation and the value of P. aeruginosa bacterial MBC and to determining the working location of the most active binahong leaf fraction. Binahong leaf is extracted by using maceration method with ethanol as solvent. Then the viscous extract is fractionated with n-hexane, ethyl acetate and water. Antibiofilm activity test is carried out using a microplate and absorbance readings using a microplate reader at a wavelength of 595 nm. The antibacterial activity test uses the dilution method. The IC50 value of the biofilm inhibition test on the extract, water fraction, ethyl acetate and n-hexane for P.aeruginosa bacteria was 0,94; 1,21; 1,03; 0,78. The EC50 value of the biofilm degradation test on the extract, n-hexane, ethyl acetat, water e for P. aeruginosa bacteria is 10,95; 16,06; 12,35; 5,92. The minimum bactericidal concentration value of binahong leaf water fraction for P. aeruginosa is 512 mg/ml.

Pengaruh Rebusan Air Daun Sirsak (Annonamuricata) terhadap Penurunan Tekanan Darah pada Lansia Penderita Hipertensi di Wilayah Desa Sukawangi Kecamatan Warungkondang Kabupaten Cianjur Tahun 2023 Ismi Rahmawati; Sancka Stella G.S; Siti Kamillah
Jurnal Ventilator Vol. 2 No. 3 (2024): September : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v2i3.1307

Soursop is a traditional medicinal plant used as a therapy for hypertension. One of them is Flavonoids which work as ACE inhibitors which will inhibit the change of AIR into AIR thereby reducing the secretion of antidiuretic hormone (ADH ) thus causing a drop in blood pressure.This study aims to determine the effect of boiled soursop leaves on reducing blood pressure in elderly people with hypertension in the Sukawangi Village area, Warungkondang District, Cianjur Regency in 2023. This research uses a quantitative experimental research method using a quasi-experimental design with pre and post using a one group pre test and post test design. The population in this study was elderly people suffering from hypertension in the Sukawangi Village area, Warungkondang District, Cianjur Regency with a sample of 17 people. The analysis used is Univariate and Bivariate using the Paired Sample T test. The blood pressure of hypertensive patients before being given soursop leaf decoction treatment to obtain information on the Mean Arterial Preasure value) before being given the intervention, the mean MAP value was 124.09 mmHg from 17 respondents. After being given the intervention, the results obtained were an average MAP value of 95.24 mmHg.That there is an effect of boiled soursop leaves on reducing blood pressure in elderly people with hypertension in the Sukawangi Village area, Warungkondang District, Cianjur Regency in 2023. Should be more overcoming the problems of the Indonesian people due to the increase in patients with hypertension.

Effect of Ashitaba Leaf as Antibiofilm Against Pseudomonas aeruginosa and Staphylococcus aureus Luluk Aniqoh Meliana Putri; Ismi Rahmawati; Opstaria Saptarini
STRADA : Jurnal Ilmiah Kesehatan Vol. 14 No. 1 (2025): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v14i1.1236

Infection is one of the serious health problems that will continue to grow in Indonesia. Indonesian people have used herbal medicines derived from plants such as ashitaba leaves which contain chemical compounds tannin, alkaloids, flavonoids and saponins to treat several diseases. This study aims to see the potential of extracts and fractions (n-hexane, water and ethyl acetate) to inhibit the formation, destroy biofilms against Pseudomonas aeruginosa and Staphylococcus aureus. The method used is antibacterial testing using the dilution method, observation of bacterial cell morphology using SEM. Results active ashitaba leaf fraction inhibits the formation and degrades Pseudomonas aeruginosa and Staphylococcus aureus biofilms is water. The location of the most active water fraction against Staphylococcus aureus bacteria is on the bacterial cell wall. The water fraction has antibacterial activity against Staphylococcus aureus with an MBC value of 12.5%, the location of the water fraction is on the bacterial cell wall.

Fraction Activities Rosella Flower (Hibiscus Sabdariffa L) as an Antibacterial and Antibiofilm Escherichia Coli ATCC 25922 Ratna Ika Yusuf; Ana Indrayati; Ismi Rahmawati
Jurnal Multidisiplin Madani Vol. 4 No. 8 (2024): August 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i8.11133

Rosella flowers (Hibiscus sabdariffa L) contain alkaloid, flavonoid, saponin and tannin compounds. The compounds contained in rosella flowers have activity as antibacterial and antibiofilm. Biofilm is the ability of microorganisms that stick to the surface of objects and form a matrix. This study aims to antibacterial and biofilm activity in the form of inhibition of biofilm formation and biofilm degradation of E.coli bacteria. Rosella flowers were extracted using maceration method with 96% ethanol solvent. The thick extract was then fractionated with n-hexane, ethyl acetate and water solvents. Antibacterial activity test using diffusion and dilution methods followed by observation of cell wall and membrane damage using SEM and ion leakage with AAS. Biofilm activity test was conducted using a microplate device and readings were taken at a wavelength of 595 nm. The absorbance results of the inhibition percentage to determine the IC50 and EC50 values. The average IC50 values of biofilm formation inhibition test on extract, n-hexane fraction, ethyl acetate fraction and water fraction against E. coli bacteria are 1.059; 1.070; 0.921; 0.863. The EC50 values of biofilm degradation test on extract, n-hexane fraction, ethyl The minimum killing concentration value of rosella flower water fraction against E. coli is 25 mg/ml. the effect of the active fraction of rosella flower on E. coli bacteria is on the cell wall and cell membrane

ANALISIS KEMAMPUAN PENGGUNAAN MEDIA PEMBELAJARAN DIGITAL INTERAKTIF DITINJAU DARI GURU PENGGERAK GUGUS 2 SDN SE-KECAMATAN DURENAN Ismi Rahmawati; Kukuh Andri Aka; Frans Aditia Wiguna
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 2 (2025): Volume 10 Nomor2, Juni 2025
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i2.26134

This study aims to determine the ability of driving teachers and non driving teachers of Cluster 2 elementary schools throughout Durenan District in using interactive digital learning media, as well as to determine the differences in the ability to use interactive digital learning media between driving teachers and non driving teachers of Cluster 2 elementary schools throughout Durenan. This study uses a quantitative approach with a comparative descriptive method. The instrument used was a questionnaire given to two groups of respondents, each consisting of 10 driving teachers and 10 non-driving teachers. Based on the results obtained, there is a difference in the ability to use interactive digital learning media between driving and non-driving teachers, seen from the results of the Mann-Whitney test, a significance value of 0.000 (> 0.05) was obtained, which indicates that there is a difference in the ability to use interactive digital media.

Co-Authors Ana Indrayati Aprilia rina wati Daryono Hadi Tjahjono Dwiningsih Dwiningsih Fradine, Chossy Frans Aditia Wiguna Gunawan Pamudji Widodo Ika Purwidyaningrum Inaratul Rizkhy Hanifah Iswandi Iswandi Kukuh Andri Aka Marlia Singgih Wibowo Mustika Wati Nafi’ah, Luthfiana Nurulin Naha Ndjurumbaha, Echa Malinda Opstaria saptarini Patricius Prima Dimas Putranto Putri, Luluk Aniqoh Meliana Ratna Ika Yusuf Ratno Agung Samsumaharto Sancka Stella G. Sihura Sardjiman Sardjiman Siti Kamillah Titik Sunarni Vivin Nopiyanti

Title

Found 12 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 12 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 12 Documents
Search