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All Journal Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Journal of Community Empowerment for Health Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Setyo Purwono
Department of Pharmacology and Therapy, Faculty of Medicine, University of Gadjah Mada, Yogyakarta, Indonesia
Computer Science & IT Education Engineering Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats Pusmarani, Jastria; Putri, Risky Juliansyah; Dewi, Citra; Fitriani, Difa; Purwono, Setyo; Ikawati, Zullies
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27639

Abstract

Banana (Musa paradiasiaca var. sapientum) is the world's most popular fruit-bearing crop, with rising consumption and waste. This study aimed to measure the metabolite compound and evaluate the gastroprotective properties of a banana peel-purified methanol extract. Animals test used in this study were divided into six groups: Group One received NaCMC 0.5%, Group Two received sucralfate, Group Three received aspirin 1000 mg/kg body weight, and groups four, five, and six received PBP at doses of 200 mg/kg body weight, 400 mg/kg body weight, and 600 mg/kg body weight, respectively, for seven days. Except for group 1, all groups were induced with aspirin at 1000 mg/kg body weight on the eighth day. The result of this study exhibited banana peel containing total phenolic, flavonoid, and tannin compounds with concentrations of 33.45 mg GAE/g, 19.92 mg QE/g, and 0.16 %, respectively. The results showed that pure extract of Musa paradiasiaca var. sapientum fruit peel can reduce the incidence of gastric ulcers by decreasing the ulcer index (p<0.05).. The results suggested that Musa paradisiaca var. sapientum peel has a gastroprotective effect against aspirin-induced gastric ulceration.
Effects of Yacon Leaf Extract on MCP-1 and IL-10 Expressions and Macrophage Phenotypes in CKD Mouse Model Sofyana, Meida; Wasityastuti, Widya; Ihsana, Nuni; Purwono, Setyo; Arfian, Nur
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3605

Abstract

Macrophages are essential in tissue homeostasis and immunity, but also contribute to disease development and progression. Chronic kidney disease (CKD) is characterized by interstitial infiltration of macrophages, the density of which correlates inversely with kidney survival. Studies have shown that yacon (Smallanthus sonchifolius) has beneficial effects on CKD. Therefore, this study aimed to investigate the effects of yacon leaf extract on mice with subtotal nephrectomy by evaluating the M1 and M2 macrophage counts and mRNA expressions of monocyte chemoattractant protein-1 (MCP-1 and IL-10. The mice were randomly divided into five groups: SO (negative control: underwent sham operation), SN (positive control: underwent subtotal nephrectomy), and yacon-treated groups: YK1, YK2, and YK3 (underwent subtotal nephrectomy, given peroral yacon leaf extract for 14 days with doses of 24,5 mg/kgBW/day, 49 mg/kgBW/day, and 98 mg/kgBW/day, respectively). The macrophage subtypes were assessed using immunohistochemistry anti-CD68 for M1 and anti-Arginase I for M2. MCP-1 and IL-10 mRNA expressions were analyzed using semi-quantitative PCR. Results showed that yacon leaf extract could significantly lower the M2 macrophage count (p<0.001) and the mRNA expressions of MCP-1 and IL-10 in all yacon-treated groups when compared to the SN group. However, the M1 macrophage count was only lower in the YK2 group (p=0.009). In conclusion, the administration of yacon leaf extract could attenuate kidney injury by lowering the macrophage count and the expression of MCP-1 and IL-10.
Non Specific and Specific Parameter Standardization of Banana Peel (Musa paradisciata Sapientum) and Andrographis Paniculata Pusmarani, Jastria; Putri, Risky Juliansyah; Dewi, Citra; Purwono, Setyo; Ikawati, Zullies
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1439

Abstract

Purpose: The aim of this study is to standardize the methanol extract of banana peel (Musa paradisciata sapientum) and ethanolic extract of Andrographis Paniculata and Phytochemical screening of banana peel extract and Andrographis PaniculataMethodology: Standardization of the extract conducting with two parameters, they are specific and nonspecific parameters.Results: Content of water solvent of banana peel as many as 47.8% and as many as 35.79% in Andrographis Paniculata. Phytochemical screening result reveals that banana peel extract contains saponin, polyphenol, tannin, flavonoid, and terpenoid. Andrographis Paniculata extract contains alkaloid, steroid, terpenoid, flavonoid and saponin. Non-specific parameter can be observed based on water content, total ash content, non-soluble acid ash content and drying losses. Water content of methanol extract of banana peel as many as 8.47% and Andrographis Paniculata leaves as many as 7.91%. The result of total ash content of banana peel as many as 17.99% and Andrographis Paniculata leaves as many as 17.23%. Ash content of insoluble acid of banana peel as many as 3.15% and Andrographis Paniculata leaves as many as 5.10%. The result of drying loss determination of the extract of plantain peel is 9.37% and sambiloto leaves is8.82%.Applications/Originality/Value: Based on specific and non-specific standardization parameter assay which consist of methanol extract of banana peel and Andrographis Paniculata leaves meet the standardization of quality.
Improving literacy about the cultivation and utilization of family medicinal plants in Blunyahrejo Village, Yogyakarta City Wahyuningsih, Mae Sri Hartati; Najiyati, Ifa; Wastutiningsih, Sri Peni; Purwono, Setyo; Padmawati, Retna Siwi
Journal of Community Empowerment for Health Vol 8, No 2 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.82763

Abstract

Introduction: During the COVID-19 pandemic, Indonesian society used family medicinal plants to prevent infection by enhancing immunity. Consumption of medicinal plants as herbal medicine should have scientific consideration so that the benefits can be proven and do not cause harmful side effects. Cultivation of medicinal plants is necessary to meet the needs of the family's medicinal plants independently.Methods: We designed a community-based education to improve literacy about the cultivation and utilization of family medicinal plants to farmer groups at Blunyahrejo, Yogyakarta. The study used a quasi-experimental research design with one group pre-post-test design. The group received an intervention in the form of training on the use and cultivation of medicinal plants. Community literacy was measured before and after participants attended the training. The 1st post-test has been conducted right after the training and the 2nd post-test was carried out after 3 months of intervention. The data were analyzed by a paired t-test.Results: The total number of participants who participated was 28 people. Observations have also been done during and after the training. The study showed that there was an increase in knowledge about the cultivation and utilization of family medicinal plants between the pre-test and 1st post-test, 1st post-test and 2nd post-test, and the pre-test and 2nd post-test (9.96%; 1.98%; 12.04%).Conclusion: The training improved the literacy about the cultivation and utilization of family medicinal plants of the farmer group in Blunyahrejo, Yogyakarta. Although the number of participants was quite small, participants showed a positive response during and after the training. Community leaders often reported the activities of farmer groups that showed enthusiasm for maintaining and continuing the cultivation of medicinal plants after the training.
Co-Authors Citra Dewi Fitriani, Difa Ihsana, Nuni Lisma Evareny, Mohammad Hakimi, Retna Siwi Padmawati Mae Sri Hartati Wahyuningsih Najiyati, Ifa Nur Arfian, Nur Pusmarani, Jastria Putri, Risky Juliansyah Sofyana, Meida Sri Peni Wastutiningsih Widya Wasityastuti