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All Journal Jurnal Kedokteran Brawijaya IJOEP : International Journal of Ecophysiology
Aldy Safruddin Rambe
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Agriculture, Biological Sciences & Forestry Medicine & Pharmacology

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Correlation between Chronic Kidney Disease Severity and Cognitive Function Epa Danisa Surbakti; Fasihah Irfani Fitri; Aldy Safruddin Rambe
Jurnal Kedokteran Brawijaya Vol. 31 No. 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.2

Abstract

Chronic kidney disease (CKD) is an independent risk factor for cognitive impairment in all domains, especially delayed memory and executive function. The purpose of this study was to determine the correlation between chronic kidney disease severity and cognitive function. This study used a cross-sectional design in stage III, IV, and V CKD patients in the Nephrology Polyclinic of Haji Adam Malik Central General Hospital. Cognitive function tests were performed using the Montreal Cognitive Assessment (MoCA INA), digit span, and Trail Making Test A & B. The Spearman test was used to analyze the correlation between CKD severity and cognitive function. This study involved 45 chronic kidney disease patients consisting of 28 (62.2%) males and 17 (37.8%) females with a mean age of 49.67±12.18 years. The results of statistical analysis showed that there was a significant positive correlation between CKD on the MoCA-INA examination (r=0.618, p=<0.001), FDS (r=0.414, p=0.005), there was a significant negative correlation on the TMT A time examination (r=-0.425, p=0.004), TMT A error (r=-0.497, p=0.001), TMT B time (r=-0.618, p=<0.001), TMT B error (r=-0.370, p=0.012). The results of this study prove a significant correlation between the severity of CKD and cognitive function.
The Role Of Serotonin In The Cognitive Function Of The Elderly : A Literature Review Rifqi Hamdani Pasaribu; Muhammad Ichwan; Aldy Safruddin Rambe; Ririe F. Malisie; Sry Suryani Widjaja
International Journal of Ecophysiology Vol. 5 No. 1 (2023): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v5i1.12313

Abstract

The last few decades have seen an increase in the number of elderly populations around the world. One consequence of an aging population is an increased incidence of impaired cognitive function. Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Alterations in serotonin (5-HT) function have been hypothesized to underlie a range of physiological, emotional, and cognitive changes in eldery. This paper provide reviews and references that a serotonin plays a role in the cognitive function of the elderly.
Co-Authors Epa Danisa Surbakti Fasihah Irfani Fitri Muhammad Ichwan Rifqi Hamdani Pasaribu Ririe F. Malisie Soufika Zamharira Rokan Widjaja, Sry Suryani