Eka Saraswati
Jurusan Matematika Fakultas MIPA Universitas Brawijaya Malang, Indonesia

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Pengaruh Self Esteem, Self Efficacy, Kinerja Pegawai Terhadap Kepuasan Pegawai Pada Badan Pengelola Keuangan Dan Aset Daerah Kota Metro Suwarto, Suwarto; Yateno, Yateno; Saraswati, Eka
Jurnal Manajemen DIVERSIFIKASI Vol. 3 No. 4 (2023): Desember
Publisher : Universitas Muhammadiyah Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/diversifikasi.v3i4.2768

Abstract

The influence of globalization today will lead to increasingly global competition. Human resources, namely employees or employees have an important role in a company. The existence of competent and quality human resources will support the company's activities and are assets that must be guarded by the company to be managed and managed. This study aims to determine the relationship between slef esteem and employee satisfaction at BPKAD metro city. Knowing the effect of self efficacy on job satisfaction of employees at BPKAD metro city, knowing the effect of employee performance on job satisfaction at BPKAD in metro city, knowing the effect of slef esteem, slef efficacy of employee performance, on employee job satisfaction at BPKAD Metro city. The sample of respondents in this study were employees of the financial and asset management agency of the Kora metro area, totaling 60 people, using the accideal sampling technique. The quantitative method in this study used a quantitative approach. n comparative. The data were collected in questionnaire sheets and analyzed using multiple linear regression analysis. The results of this study showed that the self-esteem variable obtained a tcount value of 0.315 ttable <234 with a significant value of 0.754 <0.05, meaning that the quality of self-esteem has an effect on employee satisfaction. tcount 18.905 ttable <234 with a significant value of 0.00 <0.05, meaning that the quality of self-efficacy affects employee satisfaction. tcount -0.315 ttable <234 with a significant value of 0.754 <0.05, meaning that the quality of self-efficacy has no effect on employee satisfaction. While in the f-test (both test fcount 865.963 and ftable 2.77 that the independent variables jointly influence positive and significant employee satisfaction. This means that self-esteem (x1), self-efficacy (x2), employee performance (3), employee satisfaction (y) the independent variable is able to explain the independent variable of 98.1% while the remaining 1% is influenced by the variable which were not included in this study.
Mekanisme Kerja Obat Anti Diabetes Golongan Biguanid dan Sulfonilurea Tinjauan Kimia Medisinal Amin, Saeful; Saraswati, Eka; Ilhami, Dinda Ayu Dara; Muliadi, Prayoga; Anggraeni, Yuniar Dwi; Pratama, Andika
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.44627

Abstract

Diabetes melitus tipe 2 merupakan salah satu penyakit metabolik yang paling umum, ditandai oleh resistensi insulin dan gangguan sekresi insulin yang menyebabkan hiperglikemia kronis. Penanganan farmakologis umumnya dilakukan melalui pemberian obat hipoglikemik oral, di antaranya yang paling sering digunakan adalah golongan biguanid dan sulfonilurea. Dalam perspektif kimia medisinal, biguanid seperti metformin bekerja terutama dengan menjghambat glukoneogenesis di hati dan meningkatkan ambilan glukosa oleh jaringan perifer tanpa menstimulasi sekresi insulin. Mekanisme ini melibatkan aktivasi jalur AMP-activated protein kinase (AMPK). Tinjauan ini juga membahas struktur molekul kedua kelas obat, keterkaitan antara struktur kimia dan aktivitas biologisnya (SAR), serta profil farmakokinetik dan potensi efek samping. Tujuan literatur memberikan pemahaman mendalam terhadap aspek kimia dan mekanisme kerja obat ini penting untuk pengembangan terapi yang lebih selektif dan minim efek samping bagi pasien diabetes. Hasil kedua golongan obat ini sama-sama efektif dalam penanganan DMT2, tetapi pemilihan terapi harus dilakukan dengan mempertimbangkan mekanisme, potensi efek samping, serta kondisi pasien secara individu untuk memberikan penanganan terbaik dan meningkatkan kualitas hidup pasien diabetes.