Article Per Year (5 Year)
p-Index From 2020 - 2025
0.817
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JPSCR : Journal of Pharmaceutical Science and Clinical Research Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Farmasi Sains dan Praktis
Lucia Hendriati
Department Of Pharmacy, Faculty Of Pharmacy, Universitas Katolik Widya Mandala Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Formulasi Sediaan Gel Rektal Ketoprofen dengan Peningkat Kelarutan Tween 80 Sulfia Imami; Lucia Hendriati; Teguh Widodo
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (352.184 KB) | DOI: 10.33508/jfst.v6i1.2012

Abstract

Ketoprofen is a non steroidal anti-inflammatory drugs,often used as a post operative analgesic for the patient which is oral drug delivery, so ketoprofen should be formulated in rectal gel dosage forms that their therapeutic effect can be achieved quickly and has a low solubility. Tween 80 is a surfactant that is used to improve the solubility of ketoprofen. The purposes of this study were to determine the effect of Tween 80 on the release of ketoprofen and the physical quality of rectal gel. Evaluation of physical quality of the preparation includes organoleptic test, homogeneity test, spreadability test, viscosity test and pH test. The release of ketoprofen determined by Franz diffusion cell using whatman membrane 0.45μm and a solution of pH 7.4 phosphate buffer as receptor media. The amount of ketoprofen pass in through the membrane was determined by UV-VIS spectrophotometer. The results showed that the release profile of ketoprofen was affected by the concentration of Tween 80, the greater the concentration of Tween 80 the greater the value of flux release. Tween 80 at the concentration 1%, 2.5%, 5%, 7.5% to produce release flux values of 111.660; 155.465; 449.648; 644.853μg/cm2/hour1/2. Statistical analysis by Anova of difference release flux values of each formula were significantly different (p
ANALGESIC ACTIVITY OF TRANSDERMAL PATCH ETHANOL EXTRACT PIPER NIGRUM L FRUCTUS WITH SOME ENHANCERS ON MICE Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Regiskha Hermandanie Surya; Alif Ekacahya Wahyudi; Dwi Damayanti Rasdianto
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4033

Abstract

Piper nigrum L fructus with active compound piperin had been known have an analgesic effect. Ethanol extract of Piper nigrum formulated to transdermal patch to reduce side effect of analgesic oral. The aim of this research was to know the effect of sodium lauryl sulphate, Tween 80, isopropyl myristate as enhancer of transdermal patch ethanolic extract of Piper nigrum L. Analgesic effect of Piper nigrum L. carried out by writhing method after acetic acid induction in mice. Parameters used were the number of writhing and macrophage from peritoneal fluid of mice at the end of this study. Based on this study, ethanol extract of Piper nigrum had an analgesic effect. The used of sodium lauryl sulphate 5%, Tween 80 5%, isopropyl myristate6% as enhancer increased the analgesic effect of Piper nigrum L.
Health education about COVID-19 pandemic through Youtube Channel Community Pharmacy News Lucia Hendriati; Galuh Nawang Pramesti; Ida Ayu Andri; Diga Albrian; Teguh Widodo
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol 7, No 4 (2022): November 2022
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v7i4.7776

Abstract

To meet information related to the COVID-19 pandemic, people usually search the internet, most of this is YouTube, which is the dominant source finding information. The purpose of this community service was to provide valid information in terms of pharmaceutical science, easy to understand by the public regarding the prevention and treatment of COVID-19 so that people can behave appropriately. The method was carried out by providing audiovisual information related to the COVID-19 pandemic through the “Pharmacy Community News” YouTube channel. The evaluation was measured by the number of viewers and the number of comments on the video. Educational videos made by students of the Faculty of Pharmacy UKWMS based on research journals under the guidance of lecturers. The information presented includes the themes: hand sanitizers and disinfectants; hoaxes related to COVID-19; vitamins and herbal as immunomodulators; guidelines of COVID-19 treatment and others related to COVID-19. For a year, these videos have been viewed 18,969 times and received 1490 times comments as responses from the public. Based on this data, we can conclude that health education related to COVID-19 during the pandemic through the Youtube channel can reach the wider community and can provide the valid information.
The Antigangrene Activity of Transdermal Patch of Insulin Leaves (Smallanthus Sonchifolius) to Diabetic Gangrene on White Rats: Aktivitas Antigangren Patch Transdermal Daun Insulin (Smallanthus sonchifolius) terhadap Gangrene Diabetik pada Tikus Putih Lucia Hendriati; Fecky Fernando Fredericktho; Iwan Sahrial Hamid; Teguh Widodo; Suryo Kuncorojakti
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 1 (2023): (March 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i1.16076

Abstract

Background: Diabetic gangrene is a chronic complication of diabetes mellitus caused by neuropathy, blood vessel disorders, and infection by Staphylococcus aureus. S.sonchifolius leaves contains flavonoid as hypoglycemic agents and sesquiterpene lactones as antibacterial. Unfortunately, oral administration of S. sonchifolius leaves infusion causes kidney toxicity. Objective: The aimed of the study was to determine the effectiveness of the transdermal patch of S. sonchifolius leaves ethanol extract on gangrene wound healing with macroscopic parameters and neoangiogenesis of gangrenous wounds in white rats that have been induced by diabetes mellitus. Material and Methods: This study used 4 treatment groups: positive control (Bevalex® cream), negative control (patch without S. sonchifolius leaves extract), F1 (S. sonchifolius leaves patch without enhancer), and F2 (S. sonchifolius leaves patch with Tween 60 as enhancer). The dose of S. sonchifolius leaves given was 400 mg/kg BW. Alloxan-induced diabetic rat feet were injected with S. aureus to form gangrene. Observations were made on the 7th and 14th days. Results: Based on the Wagner-Meggit scale on macroscopic observations, administration of a transdermal patch of S. sonchifolius leaves accelerates gangrene healing. The statistical results of neoangiogenesis on the 7th and 14th days showed a significant difference (p<0.05) between the positive control, F1, and F2 to the negative control. F2 showed the highest angiogenesis on day 7 (114.00 ± 5,00) and 14 (161.00 ± 5.29) compared to all groups. Tween 60 as enhancer increase the number of angiogenesis. Both F1 and F2 did not show a significant difference to the positive control. Conclusion: S. sonchifolius leaves ethanol extract patch accelerated the diabetic gangrene healing process based on macroscopic and neoangiogenesis observation on the 7th and 14th days. Toxicity examination in white rats are needed before clinical study in human.
Efektivitas Patch Transdermal Ekstrak Etanol Daun Insulin (Smallanthus sonchifolius) Terhadap Kadar Glukosa Darah dan Histopatologi Pankreas Tikus Putih Ni Putu Pirna Wijayanti; Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Suryo Kuncorojakti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 2 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i2.59508

Abstract

Diabetes melitus adalah penyakit metabolik yang ditandai dengan hiperglikemia akibat kelainan sekresi insulin, kerja insulin atau keduanya. Salah satu permasalahan yang dihadapi dalam pengobatan pasien diabetes adalah kepatuhan terhadap terapi obat. Daun insulin (Smallantus sonchifolius) memiliki efek menurunkan kadar gula darah, tetapi pada penggunaan jangka panjang per oral dapat menimbulkan efek samping terbentuknya lesi ginjal. Rute penghantaran alternatif untuk meningkatkan kepatuhan pasien dan menurunkan efek samping adalah penghantaran transdermal. Tujuan penelitian ini untuk mengetahui efek patch transdermal ekstrak etanol daun insulin terhadap kadar gula darah dan gambaran histopatologi pankreas tikus. Tikus putih yang telah diinduksi aloksan dibagi menjadi 6 kelompok perlakuan yaitu: kontrol positif (metformin per oral), patch tanpa ekstrak daun insulin dengan peningkat penetrasi Tween 60, patch tanpa ekstrak daun insulin dengan peningkat penetrasi Span 80, patch ekstrak daun insulin dengan Tween 60, dan patch ekstrak daun insulin dengan Span 80.  Dosis ekstrak etanol daun insulin yang digunakan sebesar 400 mg/kgBB. Pengamatan terhadap kadar gula darah dan gambaran histopatologi pankreas dilakukan selama 14 hari. Analisis data menggunakan Anova satu jalan. Penggunaan patch transdermal ekstrak daun insulin menurunkan gula darah tikus sejak hari ke-1 dan pada hari ke-9 menghasilkan kadar gula darah tikus lebih rendah dibandingkan metformin per oral. Penambahan peningkat penetrasi Tween 60 dan Span 80 meningkatkan penurunan kadar gula darah. Hasil yang sama juga didapatkan pada parameter gambaran histopatologi pankreas tikus.  Berdasar hasil penelitian, pemberian patch transdermal ekstrak etanol daun insulin (Smallanthus sonchifolius) dapat menurunkan kadar glukosa darah dan mempengaruhi gambaran hispatologi pankreas pada tikus putih. 
Co-Authors Alif Ekacahya Wahyudi Diga Albrian Dwi Damayanti Rasdianto Fecky Fernando Fredericktho Galuh Nawang Pramesti Ida Ayu Andri Iwan Sahrial Hamid Iwan Sahrial Hamid Iwan Sahrial Hamid Kuncorojakti, Suryo Ni Putu Pirna Wijayanti Regiskha Hermandanie Surya Sulfia Imami Teguh Widodo Teguh Widodo Teguh Widodo Teguh Widodo Teguh Widodo