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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Teguh Widodo

Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya

Author-ID : 4417488

Medicine & Pharmacology

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Articles

Formulasi Sediaan Gel Rektal Ketoprofen dengan Peningkat Kelarutan Tween 80 Sulfia Imami; Lucia Hendriati; Teguh Widodo
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Ketoprofen is a non steroidal anti-inflammatory drugs,often used as a post operative analgesic for the patient which is oral drug delivery, so ketoprofen should be formulated in rectal gel dosage forms that their therapeutic effect can be achieved quickly and has a low solubility. Tween 80 is a surfactant that is used to improve the solubility of ketoprofen. The purposes of this study were to determine the effect of Tween 80 on the release of ketoprofen and the physical quality of rectal gel. Evaluation of physical quality of the preparation includes organoleptic test, homogeneity test, spreadability test, viscosity test and pH test. The release of ketoprofen determined by Franz diffusion cell using whatman membrane 0.45μm and a solution of pH 7.4 phosphate buffer as receptor media. The amount of ketoprofen pass in through the membrane was determined by UV-VIS spectrophotometer. The results showed that the release profile of ketoprofen was affected by the concentration of Tween 80, the greater the concentration of Tween 80 the greater the value of flux release. Tween 80 at the concentration 1%, 2.5%, 5%, 7.5% to produce release flux values of 111.660; 155.465; 449.648; 644.853μg/cm2/hour1/2. Statistical analysis by Anova of difference release flux values of each formula were significantly different (p

Uji Antipiretik Patch Ekstrak Etanol Bawang Merah (Allium ascalonicum L.) dengan Matriks Chitosan dan Enhancer Tween-80 Jennifer Rachel Willyanto; Iwan Sahrial Hamid; Teguh Widodo
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Onion is a traditional medicine that has a lot of pharmacological potential. Flavanoid compounds found in onions have an antipyretic effect that acts as an inhibitor of cyclooxygenase (COX) enzymes that play a role in the formation of prostaglandins. In this study red onion is formulated into a patch because of its practical use and can avoid the first metabolic pathway. This study aims to analyze the effect of onion ethanol extract patch (Allium ascalonicum L.) on the decrease of body temperature and the number of monocytes in white rats induced by DPT vaccine. This study used 4 treatment groups: positive controls administered paracetamol syrup, negative controls given placebo patch, treatment group 1 treated with red onion ethanol extract without enhancers and treatment group 2 treated with an red onion ethanol extract with enhancers. Rats adapted for 7 days before temperature being measured and the blood being collected from the rat tail in order to calculate the number of monocytes. The animal temperature was measured after injected with vaccine DPT at 15, 30, 45, 60, 75, 90, 105, 120, 150, 180 minutes meanwhile number of monocyte were calculated every 15 minutes for 120 minutes. The results showed that there was no significant difference in monocyte count of treatment group with positive control but there were significant differences in temperature. The use of onion ethanol extract patch may decrease the temperature and number of monocytes in white mice induced by DPT vaccine.

Co-Authors Iwan Sahrial Hamid Jennifer Rachel Willyanto Lucia Hendriati Sulfia Imami

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