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All Journal Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Yustini Alioes
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Health Professions Medicine & Pharmacology Public Health

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Clinical Manifestations, TSH and FT4 Levels During Initiation and Maintenance Therapy in Patients with Graves’ Disease at Dr. M. Djamil General Hospital, Padang, 2017–2022 Rahmat, Nia Aulia; Dinda Aprilia; Dian Pertiwi; Rudy Afriant; Elfira Yusri; Yustini Alioes
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.996

Abstract

Background: Graves’ disease is an autoimmune cause of hyperthyroidism marked by characteristic symptoms and abnormalities in TSH and FT4 levels. Management consists of an initial treatment phase followed by long-term maintenance, and variability in immune responsiveness may influence therapeutic outcomes. This study aimed to describe clinical manifestations and thyroid hormone profiles during initial and maintenance therapy among patients treated at Dr. M. Djamil General Hospital, Padang, from 2017 to 2022. Method: A descriptive cross-sectional design with total sampling was applied. Forty patients diagnosed with Graves’ disease were included. Clinical and laboratory variables were extracted from medical records, and univariate analysis was performed using SPSS v26. Results: The majority of patients were women aged 40–60 years. Palpitations were the most frequent symptom in both treatment phases, followed by excessive sweating, tremor, and exophthalmos. Treatment duration exceeded 24 months for the majority. Mean TSH increased from 0.11±0.17 µIU/mL in the initial phase to 0.62±1.03 µIU/mL during maintenance, while mean FT4 decreased from 47.09±32.79 pmol/L to 21.73±13.10 pmol/L. Discussion: The observed rise in TSH and decline in FT4 indicate biochemical improvement consistent with antithyroid drug responsiveness. The reduction in symptom frequency parallels hormonal stabilization, supporting the clinical utility of long-term therapy. The extended duration of treatment aligns with standard recommendations that emphasize sustained disease control to minimize the risk of relapse. Conclusion: Transition from initial to maintenance therapy was associated with symptomatic improvement and progressive normalization of thyroid function, emphasizing the importance of prolonged and well-supervised treatment in Graves’ disease.
Factors Associated with the Incidence of Hand Dermatitis Among Car and Motorcycle Wash Workers in East Padang District Shafiqah Zawira; Gardenia Akhyar; Selfi Renita Rusjdi; Ennesta Asri; Biomechy Oktomalio Putri; Yustini Alioes
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.997

Abstract

Introduction: Hand dermatitis is a common occupational skin disorder caused by repeated exposure to irritants or allergens. Workers in car and motorcycle wash services are particularly vulnerable due to their frequent contact with detergents and cleaning agents, as well as prolonged exposure to wet work. This study aimed to identify factors associated with hand dermatitis among workers in East Padang District. Methods: A quantitative analytical observational study with a cross-sectional design was conducted among 32 workers selected through simple random sampling. Data were collected through direct interviews using a validated questionnaire. Univariate and bivariate analyses were performed, with chi-square tests used to evaluate associations between hand dermatitis and variables including working period, duration of contact, age, atopic history, personal hygiene, and use of personal protective equipment (PPE). Results: Hand dermatitis was identified in 65.6% of respondents. Bivariate analysis revealed significant associations between duration of contact (p = 0.020), personal hygiene (p = 0.027), and PPE use (p < 0.000) and the incidence of hand dermatitis. No significant associations were found for working period (p = 0.798), age (p = 0.211), or atopic history (p = 0.637). Discussion: Prolonged exposure to irritants, inadequate hygiene practices, and non-use of PPE likely heighten skin barrier disruption, predisposing workers to dermatitis. Conversely, factors such as age and atopic predisposition may play a minor role in this occupational group. Conclusion: Duration of contact, personal hygiene, and the use of PPE are significantly associated with hand dermatitis among car and motorcycle wash workers. In contrast, working period, age, and atopic history show no meaningful relationship. Strengthening preventive practices, remarkably consistent PPE use, is essential.
Gambaran Kadar Pepsin pada Saliva Pasien Refluks Laringofaring di RSUP Dr. M. Djamil Padang Mutiara Adinda Rahma; Ade Asyari; Yustini Alioes
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.38

Abstract

Laryngopharyngeal reflux (RFL) is a condition of tissue inflammation in the upper aerodigestive tract due to the reflux of gastric and duodenal contents, the symptoms such as post-nasal drip, globus sensation, and heartburn which decrease quality of life. RFL was diagnosed subjectively using the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). The pepsin levels in saliva that were detected by ELISA can be a sensitive and objective diagnostic marker for RFL because pepsin was only produced by chief cells in the stomach. The purpose of this study was to determine the characteristics of RFL patients based on age, sex, features of complaints in RSI, features of anatomic abnormalities in RFS, and salivary pepsin levels. This study was a descriptive observational retrospective design. From September to October 2022, this study was carried out at the Medical Record Department of RSUP Dr. M. Djamil Padang. The Lemeshow formula was used as the minimum number sampling in this study, 22% was the value of the proportion of events. The findings of this study revealed that 20 patients with RFL were tested for pepsin levels in saliva at Dr. RSUP. M. Djamil Padang, with nearly the same total number of RFL patients in each age group. The majority of RFL patients (60.0%) were female, and the most common complaint felt by RFL sufferers was post-nasal drip (90.00%). The most common anatomic abnormality was diffuse laryngeal edema (100%), and the mean pepsin levels in saliva was 15.863 ng/mL. Pepsin was found in all samples. Keywords: laringofaringeal reflux, pepsin, saliva
Co-Authors Ade Asyari Dian Pertiwi Dinda Aprilia Elfira Yusri Ennesta Asri Gardenia Akhyar Mutiara Adinda Rahma Putri, Biomechy Oktomalio Rahmat, Nia Aulia Rudy Afriant Selfi Renita Rusjdi Shafiqah Zawira