Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya El-Hayah : Jurnal Biologi STOMATOGNATIC- Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies
Nuzulul Hikmah
Biomedik Fakultas Kedokteran Gigi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 15 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Diabetic Blood Glucose Level Profile with Stratified Dose Streptozotocin (SD-STZ) and Multi Low Dose Streptozotocin (MLD-STZ) Induction Methods Hikmah, Nuzulul; Shita, Amandia Dewi Permana; Maulana, Hafiedz
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

The prevalence of diabetes increased from year to year. Diabetic animal model was developed to study the pathogenesis and treatment in diabetes. The aim of this study was to determine the profile of diabetic blood glucose levels using a stratified dose streptozotocin (STZ-SD) and multi-low dose streptozotocin (MLD-STZ) induction methods. 27 Wistar rats were divided into three groups, control group, SD-STZ group, and MLD-STZ group. The induction of experimental animal was using the method of SD-STZ and MLD-STZ for 5 consecutive days intraperitoneally. SD-STZ method using stratified dose of 40, 35, 30, 25, and 20 mg/Kg of body weight, while MLD-STZ method using a dose of 20 mg/Kg of body weight for 5 times. The measurement of blood glucose level (BGL) and body weight (BW) in animal was made on 2, 4, 7, and 14 days after STZ induction. The results of this study indicate that the diabetic conditions (BGL ≥ 300 mg/dl) on the SD-STZ induction method was more stable, and no deaths occurred in experimental animals.Keywords: Streptozotocin (STZ), diabetes, blood glucose level (BGL).
The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model Maulana, Hafiedz; Hikmah, Nuzulul; Shita, Amandia Dewi permana; Permatasari, Nur; Widyarti, Sri
Journal of Tropical Life Science Vol 4, No 2 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment streptozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohistochemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t-test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides.
The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model Hafiedz Maulana; Nuzulul Hikmah; Amandia Dewi permana Shita; Nur Permatasari; Sri Widyarti
Journal of Tropical Life Science Vol. 4 No. 2 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment streptozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohistochemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t-test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides.
Diabetic Blood Glucose Level Profile with Stratified Dose Streptozotocin (SD-STZ) and Multi Low Dose Streptozotocin (MLD-STZ) Induction Methods Nuzulul Hikmah; Amandia Dewi Permana Shita; Hafiedz Maulana
Journal of Tropical Life Science Vol. 5 No. 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

The prevalence of diabetes increased from year to year. Diabetic animal model was developed to study the pathogenesis and treatment in diabetes. The aim of this study was to determine the profile of diabetic blood glucose levels using a stratified dose streptozotocin (STZ-SD) and multi-low dose streptozotocin (MLD-STZ) induction methods. 27 Wistar rats were divided into three groups, control group, SD-STZ group, and MLD-STZ group. The induction of experimental animal was using the method of SD-STZ and MLD-STZ for 5 consecutive days intraperitoneally. SD-STZ method using stratified dose of 40, 35, 30, 25, and 20 mg/Kg of body weight, while MLD-STZ method using a dose of 20 mg/Kg of body weight for 5 times. The measurement of blood glucose level (BGL) and body weight (BW) in animal was made on 2, 4, 7, and 14 days after STZ induction. The results of this study indicate that the diabetic conditions (BGL ≥ 300 mg/dl) on the SD-STZ induction method was more stable, and no deaths occurred in experimental animals.Keywords: Streptozotocin (STZ), diabetes, blood glucose level (BGL).
Co-Authors Adinda Febriyanti Amandia Dewi Permana Shita Dwi Kartika Apriyono Hafiedz Maulana I Dewa Ayu Ratna Dewanti Indonesia Koes Wijayaningrat Nadie Fatimatuzzahro Nur Permatasari Nur Permatasari Rendra Chriestedy Prasetya Sri Widyarti