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Rasio Ostoklas dan Osteoblas pada Tulang Alveolar Model Tikus Diabetes dengan Aplikasi Gaya Ortodonti Hikmah, Nuzulul; Shita, Amandia Dewi Permana; Maulana, Hafiedz
Jurnal Kedokteran Brawijaya Vol 29, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2016.029.01.11

Pergerakan gigi secara ortodonti diperoleh melalui remodeling tulang alveolar dan jaringan periodontal sebagai respon terhadap adanya gaya ortodonti. Diabetes dapat mempengaruhi remodeling tulang alveolar. Remodeling tulang alveolar meliputi proses resobsi tulang yang diperankan oleh sel osteoklas, serta pembentukan tulang yang diperankan oleh sel osteoblas. Tujuan penelitian ini adalah untuk mengetahui rasio osteoklas dan osteoblas tulang alveolar pada model tikus diabetes oleh karena aplikasi gaya ortodonti. 24 ekor tikus Wistar dibagi menjadi 6 kelompok yang terdiri dari 3 kelompok kontrol dan 3 kelompok perlakuan diabetes dengan aplikasi gaya ortodonti yang berbeda (10, 20, dan 30 gramforce/grf). Hasil penelitian menunjukkan bahwa aplikasi gaya ortodonti pada model tikus diabetes menyebabkan peningkatan rasio osteoklas dan osteoblas tulang alveolar di daerah tekanan dan tarikan pada ligamen periodontal.

Diabetic Blood Glucose Level Profile with Stratified Dose Streptozotocin (SD-STZ) and Multi Low Dose Streptozotocin (MLD-STZ) Induction Methods Hikmah, Nuzulul; Shita, Amandia Dewi Permana; Maulana, Hafiedz
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

The prevalence of diabetes increased from year to year. Diabetic animal model was developed to study the pathogenesis and treatment in diabetes. The aim of this study was to determine the profile of diabetic blood glucose levels using a stratified dose streptozotocin (STZ-SD) and multi-low dose streptozotocin (MLD-STZ) induction methods. 27 Wistar rats were divided into three groups, control group, SD-STZ group, and MLD-STZ group. The induction of experimental animal was using the method of SD-STZ and MLD-STZ for 5 consecutive days intraperitoneally. SD-STZ method using stratified dose of 40, 35, 30, 25, and 20 mg/Kg of body weight, while MLD-STZ method using a dose of 20 mg/Kg of body weight for 5 times. The measurement of blood glucose level (BGL) and body weight (BW) in animal was made on 2, 4, 7, and 14 days after STZ induction. The results of this study indicate that the diabetic conditions (BGL â‰¥ 300 mg/dl) on the SD-STZ induction method was more stable, and no deaths occurred in experimental animals.Keywords: Streptozotocin (STZ), diabetes, blood glucose level (BGL).

The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model Maulana, Hafiedz; Hikmah, Nuzulul; Shita, Amandia Dewi permana; Permatasari, Nur; Widyarti, Sri
Journal of Tropical Life Science Vol 4, No 2 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment streptozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohistochemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t-test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides.

Evaluasi Kehilangan Gaya (Force Decay) Elastomeric Chain pada Perendaman Minuman Teh Kemasan (Evaluation of Force Decay Elastomeric Chain on The Immersion of Tea Packaging) Medina Nanda Utami; Hafiedz Maulana; Rudy Joelijanto
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Background : Force decay elastomeric chain can be caused by evironmental factors in the oral cavity suchas temperature,pH, saliva andalso drinks have been consumed. Tea beverage has an acidic pH which is suspected influencing force decay in elastomeric chain, so that tooth movement can not be optimal during orthodontic treatment. Objective : To analyze the loss of high force on elastomeric chain due to immersion of tea beverage. Method : Samples consisted of two groups, they are control group using artificial saliva and the treatment group using artificial saliva then added to the tea beverage. The trearment group were immersed in the solutions three times a day for 5 minutes every 24 hours. Force (grF) was measured using Autograph Machine, initially (0 hours), 0,5 hours, 1,5 hours, 3,5 hours, 7,5 hours, 24 hours and 48 hours. Result and Conclusion : The result showed no significant different between the groups of control and treatment groups. The conclusion from this research shown that elastomeric chain immersed in tea beverages packagingand saliva increased forcedecaygreater than the elastomeric chain that just immersedin saliva,but the difference was not significant. Keywords : elastomeric chain, force decay,tea beverage.

The RANKL expression and osteoclast in alveolar bone of rat diabetic model at different mechanical force application Nuzulul Hikmah; Amandia Dewi Permana Shita; Hafiedz Maulana
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 1 (2018): March 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Diabetes is a serious and important public health problem, especially in relation to dental treatment. Because of its complications in periodontal tissue, diabetes can be contraindicated in patients undergoing orthodontic treatment. The receptor activator of nuclear factor-κb ligand (RANKL) is an essential cytokine inducing osteoclastogenesis. Osteoblasts produce this cytokine which has been suggested to play an integral role in osteoclast activation during bone remodeling of orthodontic tooth movement. Purpose: The aim of this study was to determine the correlation between RANKL expression of osteoblast and the number of osteoclasts in the alveolar bone of diabetic rat models at different mechanical force application. Methods: This study used animal subjects, white rats (Rattus norvegicus) of the Wistar strain (n=24) divided into six groups. The mechanical force to which they were subjected ranged between 10, 20, and 30 gramforce (grf). The animal models with diabetes were injected with a stratified dose of Streptozotocin. An orthodontic appliance was inserted in both the maxillary incisors for seven days. The tissue was subjected to histological analysis of osteoclasts and immunohistochemistry analysis of RANKL expression on the pressure and tension side of the alveolar bone. Results: The results of this study showed that the increase in mechanical force produced a rise in RANKL expression and osteoclast number on the pressure and tension side of the alveolar bone of diabetic rat models. Conclusion: There was a correlation between the RANKL of osteoblast and osteoclast numbers in the alveolar bone of diabetic models with different mechanical force application.

Evaluasi Pergerakan Gigi Insisif Menggunakan Desain Alat Ortodonsi Terbaru dengan Gaya Mekanis yang Berbeda Hafiedz Maulana
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 13 No 1 (2016)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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The purpose of orthodontic treatment is to correct dental malocclusion, which involved periodontal tissue remodeling process. Removable orthodontic appliance application was resulted a tipping tooth movement. Therefore, this research will develop a new orthodontic appliance design which is expected to generate closely to bodily tooth movement. The aim of this study was to evaluate the incisor tooth movement using a new orthodontic appliance design with different mechanical force applications. 28 Wistar rats were divided into 4 groups, a control group without orthodontic appliances (K), experimental group with 10 grams force (grf) of orthodontic appliances (P1), 20 grf (P2), and 30 grf (P3). Incisor distance measurement and roentgenogram evaluation were performed after seven days of orthodontic appliances application. The results of this study showed that the largest distance of incisor seen in P3 group and there is not a statistically significant difference between P1 and P2. Roentgenogram evaluation shows that all of orthodontic appliance force produced a bodily tooth movement.

The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model Hafiedz Maulana; Nuzulul Hikmah; Amandia Dewi permana Shita; Nur Permatasari; Sri Widyarti
Journal of Tropical Life Science Vol. 4 No. 2 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment streptozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohistochemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t-test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides.

Diabetic Blood Glucose Level Profile with Stratified Dose Streptozotocin (SD-STZ) and Multi Low Dose Streptozotocin (MLD-STZ) Induction Methods Nuzulul Hikmah; Amandia Dewi Permana Shita; Hafiedz Maulana
Journal of Tropical Life Science Vol. 5 No. 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

The prevalence of diabetes increased from year to year. Diabetic animal model was developed to study the pathogenesis and treatment in diabetes. The aim of this study was to determine the profile of diabetic blood glucose levels using a stratified dose streptozotocin (STZ-SD) and multi-low dose streptozotocin (MLD-STZ) induction methods. 27 Wistar rats were divided into three groups, control group, SD-STZ group, and MLD-STZ group. The induction of experimental animal was using the method of SD-STZ and MLD-STZ for 5 consecutive days intraperitoneally. SD-STZ method using stratified dose of 40, 35, 30, 25, and 20 mg/Kg of body weight, while MLD-STZ method using a dose of 20 mg/Kg of body weight for 5 times. The measurement of blood glucose level (BGL) and body weight (BW) in animal was made on 2, 4, 7, and 14 days after STZ induction. The results of this study indicate that the diabetic conditions (BGL â‰¥ 300 mg/dl) on the SD-STZ induction method was more stable, and no deaths occurred in experimental animals.Keywords: Streptozotocin (STZ), diabetes, blood glucose level (BGL).

MANDIBULAR RADIOGRAPHIC ANALYSIS FOR GENDER DETERMINATION OF DOWN SYNDROME SUFFERERS Rendra Chriestedy Prasetya; Amandia Dewi Permana Shita; Nadie Fatimatuzzahro; Nuzulul Hikmah; Hafiedz Maulana; Indonesia Koes Wijayaningrat; Adinda Febriyanti; Dwi Kartika Apriyono
Journal of Vocational Health Studies Vol. 9 No. 2 (2025): November 2025 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V9.I2.2025.130-138

Background: Natural disasters frequently occur in Indonesia, creating a need for effective victim identification. Gender identification is a crucial initial step, as it can narrow the search space by 50% during individual identification. The corpus and ramus mandible are an organ that plays an important role in gender prediction with a high predictive accuracy. However, the Down syndrome mandibular size is different from that of normal people. Purpose: To analyze the difference in corpus length and total height of the mandibular ramus between individuals with down syndrome and those without, as a step to gender determination. Method: This observational cross-sectional study involved 12 individuals with down syndrome and 12 individuals without, aged 10 – 17 years. The mandibular corpus length was measured through panoramic radiography from the gonion to the menton point. The mandibular ramus was measured from the apex of the condyle to the gonion point using the Clinicview application. Data were analyzed using the T-test with SPSS Ver. 26 software. Result: The length of the mandibular corpus differs significantly (p-value = 0.000) between Down syndrome with normal people. The length of the mandibular corpus in down syndrome does not differ significantly (p-value > 0.000) between males and females. The total height of the mandibular ramus does not differ significantly between down syndrome and non-down syndrome groups, both in males and females. Conclusion: The corpus length and the mandibular ramus's total height cannot be used as indicators of gender determination in down syndrome.

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