Garuda - Garba Rujukan Digital

Helicobacter pylori Infection in Children with Recurrent Abdominal Pain and Positive Biopsy Findings Yusri Dianne Jurnalis; Yorva Sayoeti; Sari Dewi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 1, April 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Risk factors for Helicobacter pylori (H. pylori) infection include residence in a developing country, poor socio-economic status, overcrowding family, ethnic and genetic predisposition. The diagnosis and management H. pylori have not been satisfied yet; however, there is a problem of increasing H. pylori antibiotic resistance. We reported a case of 8 year-old girl who suffered from H. pylori infection. The diagnosis was made based on history, clinical findings, and laboratory work-up. Suspicion of H. pylori infection was started when she had recurrent abdominal pain. The result of serologic testing for H. pylori immunoglobulin G (IgG) was positive. Endoscopic biopsy revealed the presence of H. pylori. Patient received regimens for first line eradication of H. pylori, i.e. amoxicillin, clarithromycin and omeprazole for two weeks. Afterward, her condition improved markedly without any further complaint.Keywords: Helicobacter pylori, children, recurrent abdominal pain

The Effect of Pediococcus pentosaceus on Stool Frequency, TNF-α Level, Gut Microflora Balance in Diarrhea-induced Mice Yuliawati Yuliawati; Yusri Dianne Jurnalis; Endang Purwati; Gustina Lubis
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Enteropathogenic Escherichia coli (EPEC) are pathogenic microorganisms causing inflammation and imbalanced gut microflora that may result in diarrhea. Pediococcus pentosaceus (P. pentosaceus) isolated from “dadih” (milk curd) are used as probiotics containing lactic acid bacteria (LAB), which are useful to improve the balance of intestinal microflora and inhibit the growth of pathogenic microorganisms. This study was aimed to recognize the effect of P. pentosaceus supplementation on stool frequency, tumor necrosis factor-α (TNF-α) and gut microflora balance in experimental mice with EPEC-induced diarrhea. Method: The study was conducted in 60 white mice (Mus muscullus) at Biomedical Laboratory, Biotechnology/Production and Animal Husbandry Technology Institute, University of Andalas, Padang in April 2012. The frequency of stool, TNF-α level and microflora balance of the mice were measured before and after the EPEC-induced diarrhea and following the administration of antibiotics. Statistical analysis was performed using ANOVA and Duncan test. Results: The highest mean stool frequency was found in positive control group, i.e. 55 times, which was reduced significantly after 12-hour P. pentosaceus supplementation in a dose of 2 x 108 cfu/g into 18 times. The mean TNF-α level in positive control group was 128.17 pg/mL that lowered significantly to 48.0 pg/mL. The highest mean total number of LAB was 97.0 x 107 cfu/g, which was significantly different from positive control group of 7 x 107 cfu/g. Conclusion: P. pentosaceus supplementation in a dose of 2 x 108 cfu/g may reduce the stool frequency, lower TNF-α and improve the gut microflora balance following 12-hour supplementation in diarrhea-induced mice. Keywords: Pediococcus pentosaceus, TNF-α, diarrhea, EPEC, gut microflora

Hepatic Cirrhosis with Esophageal Varices: A Case Report Minanti, Nanda Anessa; Yusri Dianne Jurnalis
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1024

Background: In adults, portal hypertension is generally caused by hepatic cirrhosis, whereas in children it is more commonly caused by extrahepatic abnormalities with normal liver function. Portal hypertension causes hemodynamic abnormalities. Gastrointestinal bleeding is the most severe clinical manifestation of portal hypertension in both children and adults. Pathogenetically, increased pressure in the portal vein can be caused by increased vascular resistance and increased portal blood flow. The site of obstruction can be prehepatic (portal vein obstruction), intrahepatic (presinusoidal: eg congenital hepatic fibrosis; para sinusoidal: cirrhosis, hepatotoxic drug therapy, vitamin A hepatotoxicity; post sinusoidal: venocclusive disease) and/or post hepatic (Budd-Chiari syndrome, constrictive pericarditis). Case presentation: The study reports the results of observations of a case of a boy, FAA, aged 12 years and 2 months who came to the emergency room at Dr. M. Djamil General Hospital Padang with the main complaint of hematemesis and splenomegaly from physical examination. Non cirrhotic portal fibrosis is a cause that is not uncommon in the population in the early second decade of life. Some children with non-cirrhotic portal fibrosis as adults can end up with end stage liver disease. Conclusion: Patients with noncirrhotic or cirrhotic portal hypertension can be assessed using the Child Pugh instrument as an instrument that is still used to determine the survival rate if patients with portal hypertension.

Concurrent Hiatal Hernia, Gastric Polyp, and Lupus Nephritis in an Adolescent: A Case Report Yugatama, Andyan; Yusri Dianne Jurnalis; M. Iqbal Rivai; Irwan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1125

Background: The coexistence of hiatal hernia (HH), gastric polyp, and lupus nephritis in an adolescent patient presents a unique clinical challenge, demanding a multidisciplinary approach to diagnosis and management. This case report aims to highlight the complexities involved in addressing these concurrent conditions and their implications for patient care. Case presentation: A 16-year-old girl with a history of systemic lupus erythematosus (SLE) and lupus nephritis presented with recurrent abdominal pain. Esophagogastroduodenoscopy (EGD) revealed a hiatal hernia and an esophageal polyp. The patient underwent laparoscopic gastrofundoplication for the hiatal hernia, and the polyp was subsequently removed via polypectomy. Histopathological examination confirmed a hyperplastic gastric polyp. The patient's postoperative course was complicated by electrolyte imbalances and dysphagia, which were managed successfully. Conclusion: This case underscores the importance of a thorough diagnostic workup in adolescents with SLE presenting with gastrointestinal symptoms. The concurrent presence of HH, gastric polyp, and lupus nephritis necessitates a multidisciplinary approach involving gastroenterologists, surgeons, rheumatologists, and other specialists. Careful attention to potential complications, such as electrolyte imbalances and dysphagia, is crucial for optimal patient outcomes.

Challenges in the Management of Hypertrophic Pyloric Stenosis in a Malnourished Infant with Pulmonary Tuberculosis: A Case Report Basri Hadi; Yusri Dianne Jurnalis; Mayetti Akmal; Didik Hariyanto; Yuanico Lirauka
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1194

Background: Hypertrophic pyloric stenosis (HPS) is a common cause of gastric outlet obstruction in infants, but its management can be challenging in the presence of comorbidities like malnutrition and pulmonary tuberculosis (PTB). This case report highlights the complexities and considerations in managing an infant with HPS, PTB, and severe malnutrition. Case presentation: A 6-month-old male infant presented with lethargy, recurrent vomiting, and failure to thrive. He had a history of PTB on anti-tuberculosis treatment and was severely malnourished. Investigations revealed HPS, and he underwent a pyloromyotomy. Postoperatively, he required careful fluid management, nutritional support, and continued anti-tuberculosis therapy. Conclusion: This case highlights the challenges in managing HPS in an infant with PTB and severe malnutrition. It underscores the importance of a multidisciplinary approach involving pediatricians, surgeons, and nutritionists to ensure optimal outcomes in such complex cases.

A Rare Presentation of Choledochal Cyst in a Six-Month-Old Infant: Diagnostic and Surgical Challenges Dita Novia Wulansari; Yusri Dianne Jurnalis; Jon Efendi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1300

Background: Choledochal cysts (CCs) are rare congenital anomalies of the biliary tree, characterized by cystic dilation of the intrahepatic and/or extrahepatic bile ducts. While the classic triad of abdominal pain, jaundice, and a palpable abdominal mass is well-described, the presentation in infants can be subtle and often involves diagnostic and surgical challenges. This case report describes a rare presentation of a Todani Type 1 choledochal cyst in a six-month-old infant who presented primarily with abdominal distension, highlighting the diagnostic pathway and surgical management. Case presentation: A six-month-old female infant presented with a two-month history of progressive abdominal distension. There was a history of pale stools at two months of age that lasted for one week. Physical examination revealed a well-nourished infant with icteric skin and sclera and a distended abdomen with a palpable, mobile mass measuring 7x5 cm. Laboratory investigations revealed hyperbilirubinemia and elevated liver enzymes. Abdominal ultrasound and subsequent CT scan with contrast confirmed the presence of a Todani Type 1 choledochal cyst. The infant underwent successful surgical excision of the cyst and Roux-en-Y hepaticojejunostomy. The postoperative period was uneventful, and the patient was discharged in stable condition. Follow-up at one month showed good recovery and no signs of complications. Conclusion: This case highlights an atypical presentation of a Todani Type 1 choledochal cyst in a young infant, where the primary symptom was abdominal distension rather than the classic triad. Early diagnosis through imaging modalities like ultrasound and CT scan, followed by complete surgical excision and Roux-en-Y reconstruction, resulted in a favorable outcome. This case underscores the importance of considering choledochal cysts in the differential diagnosis of abdominal distension in infants, even in the absence of jaundice or pain.

A Rare Presentation of Choledochal Cyst in a Six-Month-Old Infant: Diagnostic and Surgical Challenges Dita Novia Wulansari; Yusri Dianne Jurnalis; Jon Efendi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1300

Background: Choledochal cysts (CCs) are rare congenital anomalies of the biliary tree, characterized by cystic dilation of the intrahepatic and/or extrahepatic bile ducts. While the classic triad of abdominal pain, jaundice, and a palpable abdominal mass is well-described, the presentation in infants can be subtle and often involves diagnostic and surgical challenges. This case report describes a rare presentation of a Todani Type 1 choledochal cyst in a six-month-old infant who presented primarily with abdominal distension, highlighting the diagnostic pathway and surgical management. Case presentation: A six-month-old female infant presented with a two-month history of progressive abdominal distension. There was a history of pale stools at two months of age that lasted for one week. Physical examination revealed a well-nourished infant with icteric skin and sclera and a distended abdomen with a palpable, mobile mass measuring 7x5 cm. Laboratory investigations revealed hyperbilirubinemia and elevated liver enzymes. Abdominal ultrasound and subsequent CT scan with contrast confirmed the presence of a Todani Type 1 choledochal cyst. The infant underwent successful surgical excision of the cyst and Roux-en-Y hepaticojejunostomy. The postoperative period was uneventful, and the patient was discharged in stable condition. Follow-up at one month showed good recovery and no signs of complications. Conclusion: This case highlights an atypical presentation of a Todani Type 1 choledochal cyst in a young infant, where the primary symptom was abdominal distension rather than the classic triad. Early diagnosis through imaging modalities like ultrasound and CT scan, followed by complete surgical excision and Roux-en-Y reconstruction, resulted in a favorable outcome. This case underscores the importance of considering choledochal cysts in the differential diagnosis of abdominal distension in infants, even in the absence of jaundice or pain.

Histamine-2 Receptor Antagonist for Gastric Bleeding Prophylaxis in Low-Risk Critically Ill Children: A Randomized Trial of Ranitidine Sylvetri Lestari; Mayetti; Yusri Dianne Jurnalis; Eva Chundrayetti; Rusdi; Rahmi Lestari; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1397

Background: The utility of stress ulcer prophylaxis (SUP) in critically ill children is a subject of ongoing debate, particularly in patients who do not present with classic high-risk features for stress-related mucosal disease (SRMD). This study aimed to evaluate the efficacy of ranitidine for preventing gastric bleeding in a heterogeneous cohort of critically ill children. Methods: A single-center, prospective, open-label, randomized controlled trial was conducted in a tertiary Pediatric Intensive Care Unit (PICU) in Indonesia. Children aged 1 month to 18 years admitted to the PICU were randomized to receive either intravenous ranitidine (1 mg/kg/dose twice daily) or standard care without prophylaxis for five days. The primary outcome was the incidence of overt gastric bleeding. Post-hoc power analysis and multivariable logistic regression were performed to contextualize the findings. Results: From 243 patients screened, 60 were randomized (30 per group). The cohort was predominantly composed of infants (60.0%) with respiratory distress. Overt gastric bleeding occurred in 1 of 30 patients (3.3%) in the ranitidine group versus 3 of 30 patients (10.0%) in the control group. This difference was not statistically significant (Relative Risk [RR] 0.33; 95% CI 0.04–3.11; p=0.612). After adjusting for a baseline imbalance in age, the odds of bleeding remained non-significantly lower in the ranitidine group (Adjusted Odds Ratio [aOR] 0.29; 95% CI 0.03–3.20). The study was found to be severely underpowered (16% power), and none of the bleeding events were clinically significant. Conclusion: In this small, underpowered trial of predominantly low-risk critically ill children, ranitidine did not significantly reduce the incidence of overt gastric bleeding. These findings, while limited by significant methodological weaknesses, do not support the routine use of SUP in similar pediatric populations and underscore the critical need for larger, more definitive trials to inform evidence-based risk-stratification strategies.

Histamine-2 Receptor Antagonist for Gastric Bleeding Prophylaxis in Low-Risk Critically Ill Children: A Randomized Trial of Ranitidine Sylvetri Lestari; Mayetti; Yusri Dianne Jurnalis; Eva Chundrayetti; Rusdi; Rahmi Lestari; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1397

Background: The utility of stress ulcer prophylaxis (SUP) in critically ill children is a subject of ongoing debate, particularly in patients who do not present with classic high-risk features for stress-related mucosal disease (SRMD). This study aimed to evaluate the efficacy of ranitidine for preventing gastric bleeding in a heterogeneous cohort of critically ill children. Methods: A single-center, prospective, open-label, randomized controlled trial was conducted in a tertiary Pediatric Intensive Care Unit (PICU) in Indonesia. Children aged 1 month to 18 years admitted to the PICU were randomized to receive either intravenous ranitidine (1 mg/kg/dose twice daily) or standard care without prophylaxis for five days. The primary outcome was the incidence of overt gastric bleeding. Post-hoc power analysis and multivariable logistic regression were performed to contextualize the findings. Results: From 243 patients screened, 60 were randomized (30 per group). The cohort was predominantly composed of infants (60.0%) with respiratory distress. Overt gastric bleeding occurred in 1 of 30 patients (3.3%) in the ranitidine group versus 3 of 30 patients (10.0%) in the control group. This difference was not statistically significant (Relative Risk [RR] 0.33; 95% CI 0.04–3.11; p=0.612). After adjusting for a baseline imbalance in age, the odds of bleeding remained non-significantly lower in the ranitidine group (Adjusted Odds Ratio [aOR] 0.29; 95% CI 0.03–3.20). The study was found to be severely underpowered (16% power), and none of the bleeding events were clinically significant. Conclusion: In this small, underpowered trial of predominantly low-risk critically ill children, ranitidine did not significantly reduce the incidence of overt gastric bleeding. These findings, while limited by significant methodological weaknesses, do not support the routine use of SUP in similar pediatric populations and underscore the critical need for larger, more definitive trials to inform evidence-based risk-stratification strategies.

High-Dose Sucralfate as a Mucosal-Protective Cornerstone in the Organ-Sparing Management of Pediatric Grade 2A Corrosive Gastroduodenitis: A Case Report and Pathophysiological Review Wely Wahyura; Yusri Dianne Jurnalis; Ade Nofendra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1416

Background: Accidental corrosive ingestion is a formidable pediatric emergency that can lead to severe gastrointestinal injury and long-term sequelae. Sulfuric acid, a common agent, induces coagulative necrosis, primarily affecting the stomach. The optimal management for moderate-grade injuries (Zargar Grade 2A) is debated, with a focus on preventing stricture formation. This report details a case managed with an aggressive pharmacotherapeutic protocol centered on high-dose sucralfate. Case presentation: A 2-year-10-month-old boy was admitted following accidental ingestion of battery acid. His presentation was atypical, with vomiting but no oropharyngeal lesions. Initial investigations revealed a significant systemic inflammatory response (leukocytosis: 19,220/mm³; thrombocytosis: 581,000/mm³) and aspiration pneumonitis. Despite a 12-day delay in endoscopy due to parental refusal, an aggressive conservative regimen was initiated upon admission. This protocol included high-dose, frequent-interval sucralfate (80 mg/kg every 2 hours), intensive intravenous acid suppression (omeprazole and ranitidine), and prophylactic antibiotics. The endoscopy on day 12 confirmed Zargar Grade 2A burns in the gastric fundus, pylorus, and proximal duodenum, with the esophagus spared. The patient improved rapidly, tolerated an oral diet by day 11, and was discharged on day 14. Conclusion: Follow-up endoscopy at 6 weeks and 6 months confirmed complete mucosal healing without any evidence of stricture or gastric outlet obstruction. This case suggests that an immediate, aggressive, non-surgical protocol featuring high-dose sucralfate can be effective in managing pediatric Grade 2A corrosive gastroduodenal burns, promoting complete healing and preventing long-term complications. The findings underscore the potential of this pharmacotherapeutic strategy and warrant further investigation.

Title

Found 11 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 11 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 11 Documents
Search