Garuda - Garba Rujukan Digital

Bacterial Patterns and Sensitivity to Antibiotics in Neonatorum Sepsis Patients at Dr. M. Djamil Padang General Hospital in the Period 2018–2021 Fenty Primadhani; Linosefa, Linosefa; Fitrisia Amelin; Almurdi, Almurdi; Elly Usman; Rahmi Lestari
Jurnal EduHealth Vol. 16 No. 02 (2025): Jurnal EduHealt, Edition April - June , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Neonatal sepsis is one of the leading causes of morbidity and mortality in neonates. Bacteria are the most common cause of neonatal sepsis. The appropriate empirical therapy is given based on the bacterial pattern and sensitivity at the site. The appropriate use of empirical antibiotics can help reduce the neonatal mortality rate. This study aimed to evaluate bacterial patterns and antibiotic sensitivity in neonatal sepsis patients at RSUP Dr. M. Djamil Padang period 2018-2021. This study is a descriptive study that used a total sampling method with 63 samples that met the inclusion criteria. The results showed that neonatal sepsis was most commonly found in neonates aged 4-28 days, which were mostly male, had a birth weight < 2500 grams, had a mortality rate of 25.4%, and neonatal pneumonia was the most comorbid disease. The most common causative bacteria were Klebsiella pneumoniae and Staphylococcus haemolyticus. Klebsiella pneumoniae is sensitive to amikacin, tigecycline, meropenem, and ertapenem. Staphylococcus haemolyticus was sensitive to tigecycline, nitrofurantoin, vancomycin, linezolid, and quinupristin / dalfopristin. This study concluded that the most common bacteria causing neonatal sepsis were Klebsiella pneumoniae and Staphylococcus haemolyticus. Klebsiella pneumoniae was sensitive to amikacin, tigecycline, meropenem, and ertapenem. Staphylococcus haemolyticus was sensitive to tigecycline, nitrofurantoin, vancomycin, linezolid, and quinupristin / dalfopristin. Clinicians are expected to review the clinical practice guidelines for neonatal sepsis to suit bacterial patterns and their sensitivity to antibiotics.

Histamine-2 Receptor Antagonist for Gastric Bleeding Prophylaxis in Low-Risk Critically Ill Children: A Randomized Trial of Ranitidine Sylvetri Lestari; Mayetti; Yusri Dianne Jurnalis; Eva Chundrayetti; Rusdi; Rahmi Lestari; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1397

Background: The utility of stress ulcer prophylaxis (SUP) in critically ill children is a subject of ongoing debate, particularly in patients who do not present with classic high-risk features for stress-related mucosal disease (SRMD). This study aimed to evaluate the efficacy of ranitidine for preventing gastric bleeding in a heterogeneous cohort of critically ill children. Methods: A single-center, prospective, open-label, randomized controlled trial was conducted in a tertiary Pediatric Intensive Care Unit (PICU) in Indonesia. Children aged 1 month to 18 years admitted to the PICU were randomized to receive either intravenous ranitidine (1 mg/kg/dose twice daily) or standard care without prophylaxis for five days. The primary outcome was the incidence of overt gastric bleeding. Post-hoc power analysis and multivariable logistic regression were performed to contextualize the findings. Results: From 243 patients screened, 60 were randomized (30 per group). The cohort was predominantly composed of infants (60.0%) with respiratory distress. Overt gastric bleeding occurred in 1 of 30 patients (3.3%) in the ranitidine group versus 3 of 30 patients (10.0%) in the control group. This difference was not statistically significant (Relative Risk [RR] 0.33; 95% CI 0.04–3.11; p=0.612). After adjusting for a baseline imbalance in age, the odds of bleeding remained non-significantly lower in the ranitidine group (Adjusted Odds Ratio [aOR] 0.29; 95% CI 0.03–3.20). The study was found to be severely underpowered (16% power), and none of the bleeding events were clinically significant. Conclusion: In this small, underpowered trial of predominantly low-risk critically ill children, ranitidine did not significantly reduce the incidence of overt gastric bleeding. These findings, while limited by significant methodological weaknesses, do not support the routine use of SUP in similar pediatric populations and underscore the critical need for larger, more definitive trials to inform evidence-based risk-stratification strategies.

Histamine-2 Receptor Antagonist for Gastric Bleeding Prophylaxis in Low-Risk Critically Ill Children: A Randomized Trial of Ranitidine Sylvetri Lestari; Mayetti; Yusri Dianne Jurnalis; Eva Chundrayetti; Rusdi; Rahmi Lestari; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1397

Background: The utility of stress ulcer prophylaxis (SUP) in critically ill children is a subject of ongoing debate, particularly in patients who do not present with classic high-risk features for stress-related mucosal disease (SRMD). This study aimed to evaluate the efficacy of ranitidine for preventing gastric bleeding in a heterogeneous cohort of critically ill children. Methods: A single-center, prospective, open-label, randomized controlled trial was conducted in a tertiary Pediatric Intensive Care Unit (PICU) in Indonesia. Children aged 1 month to 18 years admitted to the PICU were randomized to receive either intravenous ranitidine (1 mg/kg/dose twice daily) or standard care without prophylaxis for five days. The primary outcome was the incidence of overt gastric bleeding. Post-hoc power analysis and multivariable logistic regression were performed to contextualize the findings. Results: From 243 patients screened, 60 were randomized (30 per group). The cohort was predominantly composed of infants (60.0%) with respiratory distress. Overt gastric bleeding occurred in 1 of 30 patients (3.3%) in the ranitidine group versus 3 of 30 patients (10.0%) in the control group. This difference was not statistically significant (Relative Risk [RR] 0.33; 95% CI 0.04–3.11; p=0.612). After adjusting for a baseline imbalance in age, the odds of bleeding remained non-significantly lower in the ranitidine group (Adjusted Odds Ratio [aOR] 0.29; 95% CI 0.03–3.20). The study was found to be severely underpowered (16% power), and none of the bleeding events were clinically significant. Conclusion: In this small, underpowered trial of predominantly low-risk critically ill children, ranitidine did not significantly reduce the incidence of overt gastric bleeding. These findings, while limited by significant methodological weaknesses, do not support the routine use of SUP in similar pediatric populations and underscore the critical need for larger, more definitive trials to inform evidence-based risk-stratification strategies.

Gambaran Kejadian Infeksi STH Pada Murid SDN 33 Ikur Koto Kecamatan Koto Tangah Padang Ramadani, Indah; Eka Nofita; Rahmi Lestari; Elly Usman; Ulya Uti Fasrini
Majalah Kedokteran Andalas Vol. 48 No. 4 (2025): MKA October 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i4.p390-399.2025

Latar Belakang: Infeksi cacing usus atau yang lebih dikenal dengan kecacingan masih menjadi masalah kesehatan masyarakat global. Pada saat awal terinfeksi, penyakit ini sering tidak menimbulkan gejala sehingga kurang mendapat perhatian dari masyarakat. Jenis yang paling sering menginfeksi manusia berasal dari kelompok soil transmitted helminth. Infeksi ini lebih banyak menginfeksi anak usia sekolah. Objektif: Mengetahui gambaran kejadian infeksi pada murid SDN 33 Ikur Koto, Kecamatan Koto Tangah, Kota Padang. Metode: Penelitian deskriptif dengan melibatkan 33 murid dari kelas I-VI. Pemeriksaan tinja dilakukan dengan menggunakan metode langsung. Data sosiodemografi dan faktor risiko kecacingan dikumpulkan melalui kuesioner, sedangkan status gizi dinilai berdasarkan IMT/U. Hasil: Menunjukkan 3,0 % (1 orang) murid terinfeksi dengan tipe infeksi tunggal oleh spesies Trichuris Trichiura. Anak yang terinfeksi umumnya memiliki kebiasaan menggigit kuku, bermain di tanah, dan tidak selalu memakai alas kaki saat keluar ruangan. Umur orang tua responden terinfeksi berada direntang 39-48 tahun, tamatan SLTA, tidak bekerja, dan memiliki pendapatan keluarga yang tergolong tinggi. Status gizi anak terinfeksi tergolong normal. Kesimpulan Hanya satu anak yang ditemukan terinfeksi soil transmitted helminth.

Title

Found 4 Documents
Search

Abstract

Abstract

Abstract

Abstract

Title Search

Found 4 Documents Search

Abstract

Abstract

Abstract

Abstract

Title

Found 4 Documents
Search