Garuda - Garba Rujukan Digital

Hubungan Usia, Jenis Kelamin Dan Gejala Dengan Kejadian COVID-19 di Sumatera Barat Nia Ayuni Putri; Andani Eka Putra; Rinang Mariko
Majalah Kedokteran Andalas Vol 44, No 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i2.p104-111.2021

Latar Belakang : Pandemi COVID-19 menjadi masalah global. Di Indonesia angka prevalensi COVID-19 terus meningkat. COVID-19 merupakan penyakit yang disebabkan oleh virus SARS-CoV-2. SARS-CoV-2 menggunakan ACE2 sebagai reseptornya untuk masuk ke dalam sel. Maka dari itu, penelitian ini bertujuan untuk melihat hubungan karakteristik berupa usia, jenis kelamin dan gejala dengan kejadian COVID-19 di Sumatera Barat Metode : Case Control Study dengan sampel berupa spesimen swab nasofaring Laboratorium Pusat Diagnostik dan Riset Penyakit Infeksi (LPDRPI) yang diisolasi dan diperoleh isolat RNA virus. Isolat yang diperoleh kemudian diamplifikasi dengan metode qRT-PCR. Hasil : Tidak ada hubungan antara karakteristik jenis kelamin dengan kejadian COVID-19 dimana nilai P value yaitu 0,485 dan lebih besar dari 0,05 (Ho ditolak). Sedangkan terdapat hubungan antara karakteristik usia dan gejala terhadap kejadian COVID-19 dimana nilai P value yaitu 0,000 dan 0,036 yang lebih kecil dari 0,05 (Ho diterima). Kesimpulan : Laki-laki maupun perempuan memiliki probabilitas yang sama untuk terinfeksi COVID-19. Kelompok usia <50 tahun lebih berisiko terinfeksi COVID-19 daripada kelompok usia ≥50 tahun. Lebih banyak orang tanpa gejala daripada orang dengan gejala yang terinfeksi COVID-19.

EKSFRESI GEN SUPEROXIDE DISMUTASE 1 SERTA I{UBUNGANNYA DENGAN FUNGSI TIMUS PENDERITA SINDROMA DOWN Siti Nurhajjah; Rinang Mariko; Raysa Ramayumi
Majalah Kedokteran Andalas Vol 37 (2014): Supplement 2 | Published in December 2014
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3403.28 KB)

lnfeksi merupakan masalah kesehatan pada penderita sindroma Down (SD), sehingga tinggiangka kesakitan dan kematian. Peningkatan ekspresi SOD1 1,5 kali pada penderita SDyang berefek terhadap peningkatan peroksidasi (Hr0r), sehingga diperkirakan sebagai faktorpenyebab apoptosis timus. Tujuan penelitian ini untuk mengetahui ekspresi gen SOD1 danhubungannya dengan sel timus pada penderita SD. Penelitian ini nnengunakan desain crosssectionalcomparative sfudydengan jumlah sampelsebanyak 50 orang (25 orang penderita SDdan 25 orang kontrol). Darah vena diambil sebanyak 5 cc setiap sampel untuk isolasi RNAdanDNA, ekspresi gen SODl dengan teknik Real Time PCR, sedangkan fungsi timus dilihat dariprensentas TREC. Analisis statistik untuk ekspresi gen dan hubungan antar variabel denganmengunakan uji t. Penelitian ini ditemukan log copy nurnber SOD 1 pada kelompok penderita$D adalah 11,10T t0,44lng cDNA, sedangkan pada kontrol 10,501 t 0,48/ng cDNA,secarastatistik terdapat perbedaan bermakna (P=0,000). Presentase TREC adalah 44,7 + 7,4o/opada kelompok penderita SD dan 57,9t5,4% pada kelompok kontrol. secara st-atistik terdapatperbedaan bermakna p<0,05. Penelitian ini dapat disimpulkan bahwa terdapat peningkatanekspresi gen SOD 1 pada penderita SD dibandingkan kontrol dan rendahnya prensentasiTREC pada penderita SD dibandingkan kontrol, hal ini mungkin disebabkan terjadi penurunanfungsi timus akibat peningkatan ekspresi gen SOD1.Kata Kunci: sindrom Down, ekspresi gen SOD 1, prensentasi TREC

GAMBARAN TINGKAT PENGETAHUAN PERAWATAN DENTAL BLEACHING PADA PETUGAS TELLER DAN CUSTOMER SERVICE BANK DI KOTA PADANG Deli Mona; Rinang Mariko; Dina Wardaningsih
HUMAN CARE JOURNAL Vol 7, No 3 (2022): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v7i3.2067

Dental bleaching is an aesthetic dental care that popular in the society. Public interest in the dental bleaching increase as the increasing the need of aesthetic itself, especially in those who work as teller and customer service who always interacts with people and need to look good. Dental bleaching uses chemical material which has side effects for the consumer, if it is being used freely without awareness about its procedures and a dentist’s supervision. The aim of study is to know the description about teller and customer service knowledge on dental bleaching. This study uses descriptive method. The sample of study is 65 tellers and customer services of BNI, Nagari, CIMB Niaga, Bukopin, Kesejahteraan, Maybank, and Pundi in Padang. The sampling technique is probability proportional to size. There are 26 (40%) respondent had high level knowledge about dental bleaching and 39 (60%) respondent had low level knowledge about dental bleaching. The conclusion of this study is most of the tellers and customer services had low level knowledge about dental bleaching care, that is 39 (60%) respondent.

Differences in Mean Anti-Pertussis Antibody Levels in Children with Acellular Pertussis Immunization and Whole Pertussis Without Booster Rezki, Wenny Rahmalia; Rinang Mariko; Rizanda Machmud; Rusdi; Asrawati; Indra Ihsan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1022

Background: The incidence of pertussis is increasing every year, especially in developing countries. Low immunization coverage and decreased immunity are some of the factors causing the re-increase in pertussis cases. The protection provided by the pertussis vaccine whole and acellular pertussis given as a baby will decrease with age. This study aims to determine the difference in mean levels of anti-pertussis antibodies in children who received acellular pertussis and whole pertussis immunization without a booster. Methods: A cross-sectional study was carried out at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from December 2022 to December 2023. Research subjects were children aged 5-9 years with a history of whole pertussis immunization (DPwT) 3 times or acellular pertussis immunization (DPaT) 3 times. The research subjects were examined for anti-pertussis antibody titers using the ELISA technique. Results: Thirty-four children with a history of DPwT immunization 3 times and 34 children with a history of DPwT immunization 3 times were research subjects, with mean age 6.94±1.49 in the DPwT group and 6.88 ±1.61 in the DPaT group. The mean anti-pertussis antibody level in the DPwT group (9.54 IU/mL) was higher than the DPaT group (6.96 IU/mL) but was not statistically significant (p>0.05). The average antibody results showed that the antibody levels in both groups were below the antibody titer threshold that provides protection against pertussis. The results of the analysis showed that there was a significant difference in the incidence of AEFI between the DPwT and DPaT immunization groups (p<0.05). Conclusion: There was no difference in anti-pertussis antibody levels in children who received DPwT and DPaT immunization 3 times. Pertussis immunization is a required booster so that antibody levels are sufficient to provide protection against pertussis.

Histamine-2 Receptor Antagonist for Gastric Bleeding Prophylaxis in Low-Risk Critically Ill Children: A Randomized Trial of Ranitidine Sylvetri Lestari; Mayetti; Yusri Dianne Jurnalis; Eva Chundrayetti; Rusdi; Rahmi Lestari; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1397

Background: The utility of stress ulcer prophylaxis (SUP) in critically ill children is a subject of ongoing debate, particularly in patients who do not present with classic high-risk features for stress-related mucosal disease (SRMD). This study aimed to evaluate the efficacy of ranitidine for preventing gastric bleeding in a heterogeneous cohort of critically ill children. Methods: A single-center, prospective, open-label, randomized controlled trial was conducted in a tertiary Pediatric Intensive Care Unit (PICU) in Indonesia. Children aged 1 month to 18 years admitted to the PICU were randomized to receive either intravenous ranitidine (1 mg/kg/dose twice daily) or standard care without prophylaxis for five days. The primary outcome was the incidence of overt gastric bleeding. Post-hoc power analysis and multivariable logistic regression were performed to contextualize the findings. Results: From 243 patients screened, 60 were randomized (30 per group). The cohort was predominantly composed of infants (60.0%) with respiratory distress. Overt gastric bleeding occurred in 1 of 30 patients (3.3%) in the ranitidine group versus 3 of 30 patients (10.0%) in the control group. This difference was not statistically significant (Relative Risk [RR] 0.33; 95% CI 0.04–3.11; p=0.612). After adjusting for a baseline imbalance in age, the odds of bleeding remained non-significantly lower in the ranitidine group (Adjusted Odds Ratio [aOR] 0.29; 95% CI 0.03–3.20). The study was found to be severely underpowered (16% power), and none of the bleeding events were clinically significant. Conclusion: In this small, underpowered trial of predominantly low-risk critically ill children, ranitidine did not significantly reduce the incidence of overt gastric bleeding. These findings, while limited by significant methodological weaknesses, do not support the routine use of SUP in similar pediatric populations and underscore the critical need for larger, more definitive trials to inform evidence-based risk-stratification strategies.

Histamine-2 Receptor Antagonist for Gastric Bleeding Prophylaxis in Low-Risk Critically Ill Children: A Randomized Trial of Ranitidine Sylvetri Lestari; Mayetti; Yusri Dianne Jurnalis; Eva Chundrayetti; Rusdi; Rahmi Lestari; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1397

Background: The utility of stress ulcer prophylaxis (SUP) in critically ill children is a subject of ongoing debate, particularly in patients who do not present with classic high-risk features for stress-related mucosal disease (SRMD). This study aimed to evaluate the efficacy of ranitidine for preventing gastric bleeding in a heterogeneous cohort of critically ill children. Methods: A single-center, prospective, open-label, randomized controlled trial was conducted in a tertiary Pediatric Intensive Care Unit (PICU) in Indonesia. Children aged 1 month to 18 years admitted to the PICU were randomized to receive either intravenous ranitidine (1 mg/kg/dose twice daily) or standard care without prophylaxis for five days. The primary outcome was the incidence of overt gastric bleeding. Post-hoc power analysis and multivariable logistic regression were performed to contextualize the findings. Results: From 243 patients screened, 60 were randomized (30 per group). The cohort was predominantly composed of infants (60.0%) with respiratory distress. Overt gastric bleeding occurred in 1 of 30 patients (3.3%) in the ranitidine group versus 3 of 30 patients (10.0%) in the control group. This difference was not statistically significant (Relative Risk [RR] 0.33; 95% CI 0.04–3.11; p=0.612). After adjusting for a baseline imbalance in age, the odds of bleeding remained non-significantly lower in the ranitidine group (Adjusted Odds Ratio [aOR] 0.29; 95% CI 0.03–3.20). The study was found to be severely underpowered (16% power), and none of the bleeding events were clinically significant. Conclusion: In this small, underpowered trial of predominantly low-risk critically ill children, ranitidine did not significantly reduce the incidence of overt gastric bleeding. These findings, while limited by significant methodological weaknesses, do not support the routine use of SUP in similar pediatric populations and underscore the critical need for larger, more definitive trials to inform evidence-based risk-stratification strategies.

Title

Found 6 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 6 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 6 Documents
Search