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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Mahasiswa Ilmu Kesehatan Jurnal Sains Farmasi dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Yuliarni Syafrita
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Relationship between Serum p-Tau Levels and Impaired Cognitive Function in Type 2 Diabetes Mellitus Riandini, Isnu Lucky; Yuliarni Syafrita; Restu Susanti; Syarif Indra; Lydia Susanti; Fanny Adhy Putri; Reno Bestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1041

Abstract

Background: Type 2 diabetes mellitus (Type 2 DM) is a metabolic disease that causes a global crisis that threatens health and the world economy. Impaired cognitive function is a key factor in reducing health-related quality of life in type 2 DM patients. Phosphorylated Tau (p-Tau) is a microtubule protein that functions in cell signaling, synaptic plasticity, and regulation of genome stability. A malfunction of p-Tau will cause disruption of cell signaling, which can result in impaired cognitive function. This study aims to assess the relationship between serum p-Tau levels and impaired cognitive function in type 2 diabetes mellitus patients. Methods: This research is an observational study, comparative analysis with a cross-sectional design with a sample of 60 type 2 diabetes mellitus patients who sought treatment at the endocrine polyclinic at Dr. M. Djamil General Hospital Padang. Cognitive function was assessed using MoCa-Ina. Serum p-Tau levels were measured using the ELISA method. Data analysis was carried out using SPSS. Results: The average serum p-Tau level in type 2 diabetes mellitus patients with impaired cognitive function was 542.9 pg/ml. The cut-off point for serum p-Tau levels which is associated with impaired cognitive function in type 2 diabetes mellitus patients is 517.2 pg/ml. There was a significant relationship between serum p-Tau levels and impaired cognitive function in type 2 diabetes mellitus patients (p=0.039). Conclusion: There is a significant relationship between serum p-Tau levels and impaired cognitive function in type 2 diabetes mellitus patients.
PENGARUH TRIGLISERIDA TERHADAP KADAR LEPTIN PADA USIA LANJUT DENGAN GANGGUAN KOGNITIF Yuliarni Syafrita; Lusi Eryanti
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.425

Abstract

There are some relationships between cognitive impairment with elevation of triglycerides and reduction of leptin concentration in elderly. The elevation of serum triglycerides concentration leads to leptin resistance resulting in impairment of leptin ability to cross blood brain barrier and decrease leptin concentration in brain. The aim of this study is to determine the correlation between triglycerides serum concentration towards leptin concentration in elderly with cognitive impairment. This was a cross sectional study conducted at Neurology Clinic Dr. M. Djamil Hospital. Cognitive function was assessed by using MoCA-Ina, concentration of triglycerides was measured by using enzymatic GPO-PAP method and concentration of leptin was measured by using ELISA. The correlation between two variables was analyzed by using Mann-Whitney test and correlation between triglycerides concentration with leptin was analyzed by using Spearman test. The p value ≤ 0.05 was statistically significant. There are mean triglycerides differences between elderly groups with cognitive impairment (160 (54 – 397)) and elderly groups with normal cognitive function (107 (53 – 249)) with p= 0.005. There are no leptin concentration differences between elderly with cognitive impairment (8,6 (0,96-36,92)) and elderly with normal cognitive function (11,73 (0,71 -36,66 )) with p= 0.45. There are negative correlations between triglycerides concentration with leptin concentration in groups with cognitive impairment, but the correlation is weak (r=0,347, p=0,134). There is negative correlation between triglycerides concentration with cognitive function. There is no correlation between leptin concentration in elderly with cognitive impairment.
Co-Authors Almurdi Almurdi Aulia Noza Fanny Adhy Putri Ida Rahmah Burhan Isnindiah Koerniati Isnu Lucky Riandini, Isnu Lucky Lusi Eryanti Lydia Susanti Natasya Alamanda Martias Rachmat Saleh Eka Putra Reno Bestari Restu Susanti Rifki Irsyad Roza Mulyana Salsabilah Firdausiah Syarif Indra Syofiadi, Dhiang Mulia