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Yuni Rukminiati
Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan
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Uji Kepekaan Obat Anti Tuberkulosis Lini Kedua Menggunakan BACTEC Mycobacterium Growth Indicator Tubes (MGIT) 960 Rukminiati, Yuni
Jurnal Kefarmasian Indonesia VOLUME 2 NOMOR 2, AGUSTUS 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

The emergence of Multidrug resistance tuberculosis (MDR TB) is a failure treatment caused by Mycobacterium tuberculosis is real threat for TB control program. Second line drugs were using for person who has MDR TB. The objective of this study was to evaluate the Mycobacterium Growth Indicator Tube (MGIT) 960 System as media for testing of Mycobacterium tuberculosis susceptibility to second line drugs. Levels of high sensitivity and specificity, and time of the testing time is the parameter being assessed. Thirty MDR TB isolates were tested for susceptibility to ofloxacin, amikacin, and kanamycin by MGIT 960, and the result were compared to those obtain with proportion method on Lowenstein Jensen media, considered a reference method. Results for ofloxacin showed sensitivity 100% and specificity 75%, whereas for amikacin sensitivity 96% and specificity 100%; kanamycin sensitivity showed both specificity of 100%. The time required to obtain result was faster compared to the reference method, with an average of 9 days by the MGIT960
Selektivitas Medium Cystine Tellurite Blood Agar (CTBA) terhadap Beberapa Isolat Bakteri Sariadji, Kambang; Sunarno, Sunarno; Puspandari, Nelly; Muna, Fauzul; Rukminiati, Yuni
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i1.3030

Abstract

Cystine tellurite blood agar (CTBA) medium is a selective medium for Corynebacterium diphtheriae culture. The presence of tellurite is a selectivity of this medium to inhibit the others bacteria. Others medium were used as a selective medium for the culture of Corynebacterium diphtheriae were tinsdale and Hoyle medium, but was recommended by the World Health Organization (WHO) were CTBA and hoyle medium. However, information about the selectivity of medium was recommended by WHO is still limited. The aims of study to determine the selectivity of medium against a number of others species bacteria on CTBA. A number of 24 isolates contains of different species Corynebacterium spp and others species were regrown, then all isolates were cultured in CTBA medium, incubated for 24 – 48 haours at 37°C. The growthing of colony in CTBA were observed. The results showed that 7 isolates for Corynebacterium species can grow well on medium CTBA, 5 isolates from different species showed growth in CTBA medium including Staphylococcus aureus, Streptococcus pneumoniae, Enterobacter sakazakii , Klebsiella pneumoniae and Candida albicans. Meanwhile the rest 12 isolates showed no growthing on CTBA medium. Therefore it can be concluded that the selectivity of the CTBA medium has limited capabilities
Co-Authors Fauzul Muna Kambang Sariadji Nelly Puspandari Sunarno Sunarno