Bram Pradipta
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Ovarian cryopreservation and transplantation: A preserving fertility procedure Bram Pradipta; . Rajuddin; Mohd Andalas
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 2, No 1 (2012): Life Sciences
Publisher : Syiah Kuala University

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Abstract

Cancer is a major health problem in both developed and developing countries. In women, cancer incidence rates increased every year. Developments in treatment modalities and the ability to detect tumours in the early stages increased their survival rate but also raise fertility problems. Those problems are the fertility preservation for patient who have to endure gonadotoxic chemotherapy and or radiation even though they still need their fertility functions. Ovarian cryopreservation and autotransplantation were initially designed to protect and restore reproductive function in patients receiving sterilizing chemotherapy and/or radiotherapy. Other indications including patients undergoing haematopietic stem cell transplantation, autoimmune diseases and those undergoing oophorectomy for non-cancer conditions. Options in cryopreserved ovarian tissues include autotransplantation and xenotransplantation. An orthotopic site or a heterotopic site can be considered for autotransplantation. Xenotransplantation of human ovarian tissue into immunodeficient animals can prevent immunological rejection.  The theoretical advantage of orthotopic grafts is the restoration of normal reproductive function and natural conception after transplantation but application for cancer patients is problematic because of the potential risk of transmission of microscopic metastatic disease. With Xenotransplantantion, the possibility of cancer transmission and relapse can be eliminated because cancer cells cannot penetrate the zona pellucida, and some technical difficulties of in vitro growth and maturation of primordial follicles can be bypassed. But it is still unknown whether conditions for the growth and maturation of human oocytes in an animal host are comparable to those in situ and whether animal pathogens can be transmitted to human tissue with it. Ovarian tissue cryopreservation is the fertility preservation option for prepubertal girls and for women who face thehigh likelihood of diminished ovarian reserve requiring immediate treatment. Its procedure are still within improvement and also in the study of understanding its mechanism. In the future, studies and large clinical trials are still needed to develop better cryoprotectants and cryopreservation protocols and also standardization - optimization transplantation techniques
Cesarean myomectomy: A case report in Zainoel Abidin General Hospital, Banda Aceh, Indonesia Bram Pradipta; Mohd. Andalas
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

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The objective of the present study was to improve skill and knowledge in making a Cesarean myomectomy decision, its complications and its post operative care. Uterine myomas are the most common pelvic tumors over the age of 30. The incident of myomas in pregnancy are 0.05-5%.Myomas are now more frequently seen as many women delaying childbearing which is the time for greatest  risk of myoma growth. Also the use of ultrasonography has improved the diagnostic capability of detecting small myomas and has increased our knowledge of myomas in pregnancy. Myomectomy during cesarean section has traditionally been discouraged because of the risk of uncontrollable hemorrhage.  There are approximately 7 choices to be made according cesarean myomectomy such to leave it be, to leave it with Uterine artery ligation, to remove pedunculated fibroids only, to remove pedunculated, anterior subserous or lower uterine segment fibroids, to remove all anterior uterine fibroids, to remove all fibroids and selective removal of fibroids. A 32- year-old, gravida 3 para 2, Indonesian women presented with postterm-pregnancy and 20 cm intra mural- uterine myoma. Cesarean myomectomy was done to her with little to none intraoperative hemorrhage. Post C-section we found complications shown by uterine atony, profuse bleeding seen at the drainage through the peritoneum and marked changes in hemoglobin value. It is then carefully evaluated and managed using extensive follow up, high dose oxytocyin and blood transfusion. Cesarean myomectomy is now considered by many not always as a hazardous procedure and can be performed  in experienced hands, in a well equipped tertiary institution, with the advent of better anesthesia, with  availability of blood, in selected patients and according to site and size of myomas. It is always important to have a good informed consent beforehand and post operative care of cesarean myomectomy
Late post partum hemorrhage - causes and defining aspects: Case series in Zainoel Abidin General Hospital, Banda Aceh, Indonesia Bram Pradipta; Cut Meurah Yeni
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

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Abstract

Improving skill and knowledge in making a diagnosis and management of late post partum hemorrhage.Globally, more than half a million women die annually due to pregnancy and childbirth. Bleeding causes 28% of the direct causes of maternal deaths and remains the most common cause of maternal death. In developing countries, several countries have maternal mortality ratio over 1000 women per 100,000 live births, and WHO statistics illustrates that 25% of maternal deaths resulting from post partum hemorrhage, which counted more than 100,000 maternal deaths per year. Postpartum hemorrhage can be divided into 2 types: early postpartum hemorrhage, which occurs within 24 hours of delivery, and late postpartum hemorrhage, which occurs 24 hours to 6 weeks after delivery. Most cases of postpartum hemorrhage, greater than 99%, are early postpartum hemorrhage. Notably, most women are still under the care of their delivering provider during this time. But a few are considered late postpartum hemorrhage. Here we presented case series consisted of two cases with late postpartum hemorrhage. Both of them enrolled in Zainoel Abidin General Hospital OBGYN emergency ward as an outpatient post c-section patient. The first case was a 38 years old Indonesian women, Parity 4, post-cesarean section that comes with hypovolemic shock and post partum hemorrhage and foul smelling lochia. Six days after treatment the patient is discharged with good condition with abnormalities found in the form of disturbances of uterine contractions and uterine infection. The second case was a 19 years old, parity 1, post-Caesarean section 120 days ago for CPD indication that comes with recurrent bleeding after the operation. Curettage of the endometrium was then done to the patient in Bireun Hospital prior to the Zainoel Abidin General Hospital, but the bleeding persisted. Patients were then treated for 10 days and discharged with good condition with a diagnosis of abnormal uterine bleeding. With many women delivering outside of hospitals and early postpartum hospital discharge being a growing trend, postpartum hemorrhage that presents to the emergency department may be either early or late. Late post partum hemorrhage though a minority still poses great risk to maternal health. Key management of both early and late HPP are rapid assesment and diagnosis of conditions, restoration of blood volume and simultaneously search for the cause. HPP diagnosis is confirmed by observing the amount of bleeding and the patient's clinical symptoms. Management of HPP requires teamwork and a systematic yet comprehensive management