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All Journal Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Indonesian Journal of Cardiology
Mohd. Andalas
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Engineering Health Professions Medicine & Pharmacology Other

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Ketuban pecah dini dan tatalaksananya Mohd. Andalas; Cut Rika Maharani; Evans Rizqan Hendrawan; Muhammad Reva Florean; Zulfahmi Zulfahmi
Jurnal Kedokteran Syiah Kuala Vol 19, No 3 (2019): Volume 19 Nomor 3 Desember 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v19i3.18119

Abstract

Abstrak. Ketuban Pecah Dini (KPD) atau Premature rupture of Membranes (PROM) merupakan pecahnya ketuban yang terjadi sebelum proses persalinan. Ketuban pecah dini terjadi sekitar 1% dari seluruh kehamilan. Ketuban pecah dini menyebabkan terjadinya 1/3 persalinan preterm dan merupakan penyebab 18%-20% dari morbiditas dan mortalitas perinatal. Dalam laporan kasus ini kami melaporkan seorang ibu hamil berusia 35 tahun, gravida 3, hamil aterm dengan ketuban pecah dini, keluhan keluar air dari jalan lahir dan belum inpartu. Laporan kasus ini bertujuan untuk meningkatkan kualitas diagnosa dini serta penatalaksanaan ketuban pecah dini untuk mengurangi risiko bagi ibu dan janin. Abstract.Premature Rupture of Membranes (PROM) is the rupture of amniotic sac prior to the onset of labor beyond 37 week of gestation. Premature Rupture of Membranes occurs in 1% ofall pregnancies. Premature Rupture of Membranes causes 1/3 preterm delivery and a major  18%-20% cause of perinatal morbidity and mortality. In this case report we reported a 35 year old woman with pregnant 3rd child, aterm wiht Premateur rupture of Membrane (PROM) and prior to labor. This report aims to improve the quality of early diagnosis and management of premature rupture of membranes to reduce the risk for the mother and fetus. 
Molecular pathogenesis of preeclampsia: microRNA hypothesis Mohd. Andalas; H. Harapan; Diky Mudhakir; Muhammad Ichsan; Natalia C. Pedroza; Saurabh Laddha
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (143.314 KB)

Abstract

The discovery of micro RNA (miRNA) in 1993 by Ambros and colleagues has a huge influence in pathogenesis theory, diagnosis and treatment approach of some diseases. Some studies have conducted to seek the association alterations of miRNA expression to incidences and severity of preeclampsia (PE). We have reviewed some studies that conducted to seek the association of miRNA and PE and we discussed the role of various miRNAs in PE pathogenesis. In summary, we have shown that many researchers have given evident that the different placental and plasma miRNA expression is associated with PE. Some studies also identified the novel candidate of miRNAs (and their pathways) that may be of etiologic relevance in the pathogenesis of PE. Base on review, specific miRNA have a role to down regulate of anti apoptosis genes, regulate angiogenics growth factors such as angiogenin, vascular endothelial growth factor (VEGF) B (VEGF-β), cysteine-rich 61 (CYR61), Placental growth factor (PlGF) and VEGF-A that have a role in angiogenesis. miRNA also have a role in  survival, migration, and capillary tube formation of HUVEC by targeted of c-kit. Some miRNAs target genes that participate in immunologic dysfunction, cell adhesion, cell cycle, and signaling. miRNA also have a roles in endothelial cell response to hypoxia, cell differentiation, and survival. A miRNA influence calcium signaling through negative regulations of the calmodulin-coding mRNAs, Mef2a and Gata4, mainly in smooth muscle cells that contribute to PE pathogenesis. These investigations provide novel targets for further investigation of the pathogenesis of PE and these differential miRNAs may be potential markers for the diagnosis and provide a potential therapeutic target for PE. Further investigations on posttranscriptional regulation in PE to evaluate biologic effects of identified miRNAs (including confirmations of miRNA and target gene interactions) are needed
Cesarean myomectomy: A case report in Zainoel Abidin General Hospital, Banda Aceh, Indonesia Bram Pradipta; Mohd. Andalas
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

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Abstract

The objective of the present study was to improve skill and knowledge in making a Cesarean myomectomy decision, its complications and its post operative care. Uterine myomas are the most common pelvic tumors over the age of 30. The incident of myomas in pregnancy are 0.05-5%.Myomas are now more frequently seen as many women delaying childbearing which is the time for greatest  risk of myoma growth. Also the use of ultrasonography has improved the diagnostic capability of detecting small myomas and has increased our knowledge of myomas in pregnancy. Myomectomy during cesarean section has traditionally been discouraged because of the risk of uncontrollable hemorrhage.  There are approximately 7 choices to be made according cesarean myomectomy such to leave it be, to leave it with Uterine artery ligation, to remove pedunculated fibroids only, to remove pedunculated, anterior subserous or lower uterine segment fibroids, to remove all anterior uterine fibroids, to remove all fibroids and selective removal of fibroids. A 32- year-old, gravida 3 para 2, Indonesian women presented with postterm-pregnancy and 20 cm intra mural- uterine myoma. Cesarean myomectomy was done to her with little to none intraoperative hemorrhage. Post C-section we found complications shown by uterine atony, profuse bleeding seen at the drainage through the peritoneum and marked changes in hemoglobin value. It is then carefully evaluated and managed using extensive follow up, high dose oxytocyin and blood transfusion. Cesarean myomectomy is now considered by many not always as a hazardous procedure and can be performed  in experienced hands, in a well equipped tertiary institution, with the advent of better anesthesia, with  availability of blood, in selected patients and according to site and size of myomas. It is always important to have a good informed consent beforehand and post operative care of cesarean myomectomy
Factors affecting the level of health care worker’s stigmatized and discriminatory attitude towards people living with HIV: A study at the Dr. Zainoel Abidin General Hospital, Banda Aceh, Indonesia H. Harapan; Syarifah Feramuhawan; Hendra Kurniawan; Mohd. Andalas; Mohammad Bellal Hossain
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (78.404 KB)

Abstract

The aim of this study was to identify the level of health care worker`s (HCW) stigmatized and discriminatory (SD) attitude towards people living with HIV (PLHIV) and the factors that influenced this attitude. This research was conducted at the Dr. Zainoel Abidin General Hospital (RSUDZA) in Banda Aceh province of Indonesia. A cross-sectional study design was adopted for this research. Eighty nine HCWs were included in this study and they were selected purposively. Pearson correlation analysis, analysis of variance or independent sample t test analysis was used according to the type of data. We found that the level of SD attitude towards PLHIV in RSUDZA is high. Based on the Least Significant Difference Test, the average score of the answers between nurses and general practitioners and between nurses and medical students was significantly different(p=0.05). Pearson correlation analysis showed that the levels of SD attitude towards PLHIV was positively correlated with age (r=0.219, p=0.04) and irrational fear of HIV transmission (r=0.352, p=0.001) and negatively correlated with knowledge about HIV/AIDS (r=-0.336, p=0.001). Pearson correlation analysis also found that knowledge of HIV/AIDS negatively correlated with the irrational fear of HIV transmission (r=0.382, p=0.000). In addition, the level of SD attitude towards PLHIV was also associated with marital status of HCWs (p=0.020). Gender, education level, religion and the importance of religion in HCW lives wasn`t significantly affect to the level of SD attitude towards PLHIV in HCW. We concluded that the factors that influence the level of SD attitude towards PLHIV among the HCW are age, marital status, knowledge of HIV/AIDS, irrational fear of HIV transmission and HCWs occupations. To reduce SD attitude towards PLHIV among the HCWs, we recommend introducing some program to increase knowledge of HIV/AIDS
Complete Heart Block In Pregnancy : A Case Report Dhanang Ali Yafi; Cloudia Noviani; Rahmi Eka Saputri; Adi Purnawarman; Mohd. Andalas; Yusmalinda Yusmalinda
Jurnal Kardiologi Indonesia Vol 42 No 1 (2021): Indonesian Journal of Cardiology: January - March 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1015

Abstract

Background: Complete heart block occurs due to various pathological conditions that cause an infiltration, fibrosis, or lose the connection from a part of the cardiac conduction system. Complete heart block in pregnancy is often caused by congenital anomalies. Around 30% cases, complete heart block remain asymptomatic and not detected until adulthood and may present in pregnancy state and puerperium. When the reversible cause of the AV Block cannot be found, the permanent pacemaker or temporary pacemaker may be indicated when the patients show the symptoms. Case Illusration: A-21 year old female, G2P0A1 preterm pregnancy (27-28 weeks) with bradycardia. From electrocardiograph examination revealed Total AV Block with junctional escape rhytym. Transthoracic echocardiogram shows massive tricuspid regurgitation, early phase of peripartum cardiomyopathy and ejection fraction 36-40%. Caesarean section was peformed due to PPROM. A male baby was born with birth weight of 1100 grams, 32 centimeters of body length and APGAR score of 7/9. The baby was died in NICU on day care 4th, with suspected respiratory problem. Conclusion: Complete heart block in pregnancy is a rare condition. This condition could remain asymptomatic and not detected until pregnancy. Multidisciplinary approach, close monitoring of the symptoms and cardiac functions are needed for patients with CHB.
Co-Authors Adi Purnawarman Bram Pradipta Cloudia Noviani Cut Rika Maharani Dhanang Ali Yafi Diky Mudhakir Evans Rizqan Hendrawan H. Harapan Hendra Kurniawan Mohammad Bellal Hossain Muhammad Ichsan Muhammad Reva Florean Natalia C. Pedroza Rahmi Eka Saputri Saurabh Laddha Syarifah Feramuhawan Yusmalinda Yusmalinda Zulfahmi Zulfahmi