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All Journal Alchemy Jurnal Penelitian Kimia
Nestri H, Nestri
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Chemical Engineering, Chemistry & Bioengineering Energy Environmental Science Materials Science & Nanotechnology

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CYTOTOXICITY EXTRACT OF RED FRUIT (Pandanus Conoideus Lamk.) WITH BRINE SHRIMP LETHALITY TEST Marliyana, Soerya D.; W, Fajar Rakhman; H, Nestri; Rakhmawati, Rita
Alchemy Jurnal Penelitian Kimia Vol 8, No 1 (2012)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

The cytotoxicity with Brine Shrimp Lethality Test (BSLT) extract of red fruit (Pandanus conoideus Lamk.) have been done. The ethanol and n-hexana extracts were evaluated for cytotoxicities. The n-hexane extract demonstrated higher cytotoxic activity than the ethanol extract, with 54% death in concentration 400 ?g/mL. The n-hexane extract was separated by column chromatography, eluting with a gradient of n-hexane-EtOAc to had an active fraction. The cytotoxicity of an active fraction showed with LC50 values of 138,05 µg/mL. Identification of this fraction exhibited three compounds of fatty acid were palmitic acid, oleic acid, and miristic acid
Co-Authors Fajar Rakhman W, Fajar Rakhman Rita Rakhmawati, Rita Soerya Dewi Marliyana