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All Journal Jurnal Ilmiah Farmasi Indonesian Journal of Cancer Chemoprevention The Journal of Pure and Applied Chemistry Research Majalah Obat Tradisional JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat SEMAR Jurnal Pengabdian Masyarakat Bangsa Indonesian Journal of Pharmacology and Therapy
Rita Rakhmawati, Rita
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In vivo Wound Healing Activity of Tamanu Oil (Calophyllum inophyllum l.) Extracted by Cold-Pressed and Hot-Pressed Methods and Their Fatty Acids Composition Rakhmawati, Rita; Wahyuni, Dinar Sari Cahyaningrum; Ainurofiq, Ahmad; Hadi, Saptono; Choiri, Syaiful; Retnaningtyas, Estu; Pratama, Tiara Dewi Salindri
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97146

Abstract

Tamanu oil is a promising natural wound healer due to its chemical compounds, particularly fatty acids. Cold-pressed or hot-pressed methods are commonly used to obtain this oil from Calophyllum seed. However, there needs to be research documenting the impact of these two extraction methods on the fatty acid profile and wound healing activity. Therefore, the study aims to characterize the fatty acid profiles of cold-pressed and hot-pressed tamanu oils using Gas Chromatography and evaluate their wound healing activity in vivo. The fatty acid profiles were analyzed using GC, and the wound healing tests were conducted on animal subjects divided into four groups: negative control, positive control (Bioplacenton®), cold-pressed tamanu oil, and hot-pressed tamanu oil. Cold-pressed tamanu oil showed superior fatty acid characteristics with an acid value of 38,71 Mg KOH/g fat and a peroxide value of 3,0095 mEq O2/kg, indicating that oil is stable against oxidation.  The length of the wound was observed daily for up to 8 days to assess its effect. The parameters observed were the percentage of wound healing and the total AUC based on the average length of the wound. Cold-pressed tamanu oil demonstrated the highest wound healing efficacy compared to both the positive control and hot-pressed tamanu oils. Both cold (11,67± 0,78) and hot-pressed tamanu oil (11,87 ± 0,61) exhibited significant differences in AUC value compared to the negative control group (13,07 ± 0,38), highlighting the potential of tamanu oil as a wound healing agent.
Pemanfaatan Sumber Daya Alam Lokal dalam Peningkatan Produktivitas Industri Rumah Tangga di Ingasrejo, Gondangrejo, Kabupaten Karanganyar Ainurofiq, Ahmad; Hadi, Saptono; Rakhmawati, Rita; Choiri, Syaiful; Wahyuni, Dinar Sari C; Nugraheni, Estu Retnaningtyas; Pratama, Tiara Dewi Salindri
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 8 (2024): Oktober
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i8.1497

Abstract

Indonesia memiliki keanekaragaman hayati yang melimpah. Banyak tanaman di negara ini memiliki potensi besar untuk dimanfaatkan sebagai bahan baku produk bernilai ekonomi tinggi. Salah satunya adalah tanaman lerak (Sapindus rarak). Namun, tidak semua masyarakat mampu mengoptimalkan potensi tersebut karena kurangnya pengetahuan dan keterampilan mengenai pengolahan dan pemanfaatan bahan alam. Oleh karena itu, pengabdian ini ditujukan untuk memanfaatkan sumber daya alam lokal dalam meningkatkan produktivitas industri rumah tangga. Pengabdian ini dilakukan dengan metode sosialisasi, pendampingan, dan pelatihan untuk masyarakat Dusun Ingasrejo dalam mengoptimalkan buah lerak sebagai sabun cuci antiiritasi dan ramah lingkungan serta memilki nilai komersial. Dari hasil pengabdian didapatkan masyarakat memiliki pengetahuan lebih dan mendalam mengenai bahan alam khususnya buah lerak. Hal tersebut dibuktikan dengan adanya peningkatan pemahaman warga setelah dilakukan evaluasi, serta mengasah keterampilan baru yaitu pembuatan produk sabun cuci buah lerak. Selain itu juga memberikan manfaat ekonomi serta pelestarian lingkungan.
Standarisasi Proses Manufaktur Granul Jamu Instan Berbasis Kadar Fenolik Total, Aktivitas Antioksidan, dan Evaluasi Sifat Fisik Ainurofiq, Ahmad; Choiri, Syaiful; Hadi, Saptono; Wahyuni, Dinar Sari C.; Rakhmawati, Rita; Nugraheni, Estu Retnaningtyas; Pratama, Tiara Dewi S.; Azizah, Salma Nur
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 9 (2024): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i9.1551

Abstract

Jamu merupakan warisan budaya Indonesia yang telah digunakan secara turun menurun oleh nenek moyang. Penggunaan jamu dalam pengobatan hanya didasarkan pada data empiris yang diturunakan terus menerus antar generasi. Pembuktian khasiat dan kemanan jamu secara ilmiah telah diatur dalam Peraturan Menteri Kesehatan Republik Indonesia Nomor : 003/MENKES/PER/I/2010 dalam bentuk saintifikasi jamu. Saintifikasi produk jamu industri perlu dilakukan untuk mempertahankan eksistensi produk jamu di masyarakat. Tujuan pengabdian ini yaitu untuk meningkatkan penyediaan jamu berkhasiat melalui pembuktian khasiat jamu secara ilmiah. Standarisasi proses manufaktur granul jamu instan dilakukan sebagai bentuk saintifikasi jamu di industri. Standarisasi proses dilakukan berdasarkan penetapan kadar fenolik total dan nilai aktivitas antioksidan. Kadar fenolik total dianalisis dengan teknik Folin-Ciocalteu menggunakan asam galat sebagai senyawa pembanding. Aktivitas antioksidan dianalisis berdasarkan reaksi transfer electron senyawa antioksidan dengan •ABTS. Hasil penetapan menunjukkan adanya penurunan kadar fenolik total dari rimpang (0.1% GAE/g), hasil penyarian (0.065% GAE/g), dan hasil ruahan (0.057% GAE/g). Hasil penetapan aktivitas antioksidan menunjukkan adanya penurunan aktivitas antioksidan dari rimpang (29.79 IC50 mg/mL) ke hasil penyarian (34.62 IC50 mg/mL) serta terdapat peningkatan pada hasil ruahan (17.18 IC50 mg/mL) karena adanya bahan tambahan.
Review: Isolasi, Peningkatan Kadar, dan Analisis Calophyllolide dalam Minyak Calophyllum inophyllum Linn. serta Potensinya untuk Terapi Luka Bakar Herawati, Zainab; Rakhmawati, Rita
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art10

Abstract

Background: Calophyllolide is a dipyranocoumarin compound found in Calophyllum inophyllum L., known for its antimicrobial and anti-inflammatory properties, which are beneficial for burn wound healing. However, variability in its content and lack of standardized methods remain challenges.Objective: This review aims to present a literature study on calophyllolide, including its sources, isolation techniques, bioactive content optimization, analytical methods, and pharmacological potential in burn wound healing.Method: Data were retrieved from Scopus and PubMed using predefined keywords. Articles published in English between 2001 and 2021 and classified as original research were selected. Relevant studies were assessed for quality using the SYRCLE tool (animal studies) and the Young & Solomon checklist (non-clinical research).Results: Seeds harvested in September had the highest calophyllolide content (0.23%). Enhancement through tissue culture using 2 mg/L IBA yielded up to 45.23 mg/100 g callus. Among analytical techniques, a validated GC-MS method showed high precision and recovery. Pharmacological studies confirmed its activity against Staphylococcus aureus and its ability to modulate inflammatory responses.Conclusion: Calophyllolide shows strong potential as a natural agent for burn wound therapy. Standardized extraction, quantification, and production approaches are essential for further development.
Analyzing Curcumin Content using UV-Vis Spectrophotometry and TLC-Densitometry Methods: A Case Study in Curcuma Capsule Commercial Products Rakhmawati, Rita; Anastacia, Laura; Hadi, Saptono
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Curcuma is a genus of plants commonly used in herbal medicine due to its benefits, primarily from the active compound curcumin. Accurate analytical methods are necessary to identify and quantify curcumin for quality control, especially in small-scale industries. This study compares spectrophotometry UV-visible and TLC-densitometry methods for analyzing Curcuma capsules from PT Rachmasari Group, a small-scale traditional medicine industry (UKOT) in Sukoharjo. The methods were evaluated based on linearity, LOD, LOQ, repeatability, intermediate precision, and accuracy. TLC-densitometry used a mobile phase of chloroform: methanol (95:5 v/v) and silica plates F254, while spectrophotometry used ethanol as the solvent. Both methods used a wavelength of 420 nm. Spectrophotometry showed better linearity (r2 = 0.9985) than TLC (r2 = 0.9847), while TLC-densitometry demonstrated higher sensitivity with lower LOD and LOQ values (1.2853 and 4.2845 μg/mL) compared to spectrophotometry (13.9261 and 46.4203 μg/mL). UV-Visible spectrophotometry exhibited superior repeatability (0.33 ± 0.02%) and intermediate precision (0.34 ± 0.01%) than TLC (1.86 ± 0.12% and 1.02 ± 0.88%). Accuracy ranged from 98.45–105.90% for spectrophotometry and 98.81–115.82% for TLC-densitometry. In conclusion, UV-Visible spectrophotometry is more precise, linear, and reliable overall, making it more suitable for curcumin quality control in small-scale herbal product industries.
Synergistic Cytotoxicity Effect by Combination of Methanol Extract of Parijoto Fruit (Medinilla speciosa Reinw. ex. Bl) and Cisplatin Against Hela Cell Line Artanti, Anif Nur; Pujiastuti, Umi Hanik; Prihapsara, Fea; Rakhmawati, Rita
Indonesian Journal of Cancer Chemoprevention Vol 11, No 1 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss1pp16-21

Abstract

As one of the leading causes of death in worldwide, cervical cancer requires the effective therapies to reduce its mortality rate. One of the chemotherapy agents that frequently used in the treatment is cisplatin. However, due to drug resistance and its side effects, an agent that can be combined with cisplatin is needed. Parijoto fruit (Medinilla speciosa Reinw.ex.Bl) contains secondary metabolites compounds that have potential as anticancer. The study aims to determine the cytotoxic effect of methanol extract of Parijoto fruit calculated from the IC50 value and the synergicity of the combinational treatment with cisplatin evaluated from the Combination Index (CI) value and its cell viability by using MTT assay. Results showed that methanol extract of Parijoto fruit (MEP) performed cytotoxic effect on HeLa cell line with IC50 of 209.6 μg/mL while the value of IC50 of cisplatin against HeLa cells amounted to 12.8 μg/mL. The combination of 26.205 ppm (1/8 IC50) of MEP and 1.601 ppm (1/8 IC50) of Cisplatin performed synergistic effect on HeLa cell line with the CI value of 0.69. From the above results, it can be concluded that MEP is potential as co-chemotherapy agent based on the synergistic cytotoxicity effect with cisplatin.Keyword: cytotoxic, Medinilla speciosa, cisplatin, co-chemotherapy, MTT
Tamarindus indica increases the stability of jamu kunyit-asam herbal suspension over Citrus aurantifolia wicaksono, arko jatmiko; Rakhmawati, rita; Wahyuningsih, Mae Sri Hartati; Syarif, Rul Afiyah; Prasetyo, Yacobus Christian
Indonesian Journal of Pharmacology and Therapy Vol 5 No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11818

Abstract

Rapid shelf-life of traditional supplementary drink still becomes major issue for herbal production in household industries. In this study the stability formula of an herbal suspension, so called as jamu kunyit-asam, was investigated. The jamu kunyit-asam Formula-1 (F1) contains combination of Citrus aurantifolia and Curcuma longa. While the Formula-2 (F2) is consisted by mixture of Tamarindus indica and C. longa. The two formulas were compared to justify better stability between preparations. No preservatives were added, in order to comply with the local regulation. To simulate the real situation, all samples were stored in 4 different conditions: opened bottle (room temperature), closed bottle (room temperature), closed bottle (refrigerator), and freeze-thaw condition. To evaluate the stability profile, an organoleptic testing and pH alteration were frequently checked for 12 consecutive days. Several parameters including color changing, sting odor, and microscopic appearance were looked over. As the results, mold, precipitation and pungent odor were formed faster from the F1 (C. aurantifolia combined with C. longa). These findings indicates that jamu kunyit-asam herbal drink suspensions containing C. longa has less stability in combination with the C. aurantifolia (F1) compared to the T. indica (F2).
Upaya Peningkatan Kesejahteraan Masyarakat melalui Pemanfaatan Bahan Alam di Randusari, Mojosongo, Surakarta: Improving Community Welfare through the Utilization of Natural Resources in Randusari, Mojosongo, Surakarta Wahyuni, Dinar Sari Cahyaningrum; Handayani, Nestri; Rakhmawati, Rita; Nugraheni, Estu Retnaningtyas; Pribadi, Fitrawan Hernuza
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 11 No. Suppl-1 (2026): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v11iSuppl-1.10434

Abstract

Randusari Hamlet, located in Mojosongo Village, Jebres District, Surakarta City, faces environmental and health problems due to its location close to the Putri Cempo Final Disposal Site (TPA). To address social and health issues, the Natural Product Pharmacy Research Group, Pharmacy Department, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, conducted educational activities on the utilization of natural materials, namely citronella (Cymbopogon nardus L.). The activity was carried out on May 4, 2025, and involved 75 participants from PKK RW 30 in Randusari Hamlet. It included preparation, presentation, leaflet distribution, demonstration of simple extraction of essential oils from citronella, and evaluation through pre- and post-tests. It led to various understandings of the applications of herbal medicine. The average increase in the pre-test and post-test study was 8.4%. It showed that the activity has successfully increased public knowledge and understanding regarding the use of herbal medicines. This activity is expected to increase the knowledge of the benefits, methods, and processing of medicinal plants into valuable products.
Uji Aktivitas Afrodisiaka Ekstrak Sambiloto (Andrographis Paniculata) pada Tikus Jantan Galur Wistar Pratama, Tiara Dewi Salindri; Wahyuni, Dinar Sari Cahyaningrum; Ainurofiq, Ahmad; Hadi, Saptono; Choiri, Syaiful; Rakhmawati, Rita; Nugraheni, Estu Retnaningtyas
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 11, No 1 (2026)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v11i1.94957

Abstract

Salah satu obat tradisional yang sudah digunakan sejak zaman dahulu secara turun menurun di Indonesia adalah sambiloto.  Permasalahan disfungsi seksual, terutama pada pria, dapat berdampak signifikan terhadap kualitas hidup dan kesehatan mental. Pemilihan sambiloto sebagai bahan baku karena tanaman sambiloto memiliki aktifitas sebagai afrodisiak melalui pengaturan kadar hormon atau efek langsung pada jaringan seksual. Penelitian ini memiliki tujuan untuk mengkaji aktivitas seksual hewan uji tikus jantan galur Wistar pada efek pemberian ekstrak etanol sambiloto. Selama tujuh hari, hewan uji akan diberikan ekstrak setiap hari, dan perilaku seksualnya akan diamati 30 menit setelah pemberian terakhir. Kelompok perlakuan pada penelitian ini dibagi menjadi 5 yaitu perlakuan kontrol negatif yang diberikan aquades, perlakuan kontrol positif yang menerima ekstrak pasak bumi dengan dosis sebanyak 7,5 mg/kgBB, serta kelompok perlakuan dengan ekstrak sambiloto, kelompok perlakuan dosis pertama (26,5 mg/kgBB), dosis kedua (50,5 mg/kgBB), dan dosis ketiga (100,5 mg/kgBB). Setiap kelompok terdiri dari tujuh tikus jantan. Dilakukan pengamatan setelah 30 menit pemberian ekstrak dengan memasukkan tikus jantan ke dalam chamber tikus betina dan diamati selama 30 menit. Parameter yang diamati meliputi Frekuensi pemasangan (Mounting Frequency), frekuensi intromisi (Intromission Frequency), latensi pemasangan (Mounting Latency), dan latensi intromisi (Intromission Latency). Hasil dari penelitian menunjukkan jika pemberian ekstrak etanol sambiloto pada dosis 26,5 mg/kgBB, 50,5 mg/kgBB, dan 100,5 mg/kgBB memengaruhi aktivitas seksual hewan uji yang dilihat dari parameter frekuensi pemasangan (Mounting Frequency), frekuensi intromisi (Intromission Frequency), latensi pemasangan (Mounting Latency), dan latensi intromisi (Intromission Latency).
Tamanu Oil (Calophyllum inophyllum L.) Promotes Wound-Healing Activity in Alloxan-Induced Diabetic Rats, and Its Fatty Acids Profile Rakhmawati, Rita; Hadi, Saptono; Ainurofiq, Ahmad; Nugraheni, Estu Retnaningtyas; Choiri, Syaiful; Pratama, Tiara Dewi Salindri
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.80107

Abstract

Diabetes Mellitus (DM) is a metabolic disease and is a severe threat because it causes diabetic wounds. Treating injuries in patients with DM is dominated by synthetic chemicals such as anti-inflammatory, corticosteroids, and antibacterial. It has side effects, so further exploration of natural ingredients is needed. One plant that has the potential to heal wounds is tamanu oil or nyamplung oil. This study aimed to investigate the effect of tamanu oil on the healing of diabetic wounds and the fatty acid composition profile. Male rats of the Wistar strain (Ratus novergius) were given incision wounds along a 2 cm depth of 2 mm, randomly divided into three groups, by applying topically twice a day. We are profiling fatty acids using gas chromatography-mass spectrometry (GC-MS). As far as we know, this is the first study showing that tamanu oil can speed up the healing of diabetic wounds in rats. The Tamanu oil containing oleic acid (42.65%), linoleic acid (25.69%), stearic acid (16.50%), and palmitic acid (12,93) had better effectiveness than other groups, demonstrated by wound closure exceeding 50% on day six and wound closure by 100% on day nine.
Co-Authors Ahmad Ainurofiq, Ahmad Anastacia, Laura Anif Nur Artanti, Anif Nur Arko Jatmiko Wicaksono, Arko Jatmiko Azhari, Fauziyah Azizah, Salma Nur Danarto, Y. Calasanctius Desi Suci Handayani Dinar Sari Cahyaningrum Wahyuni Dwi Ardiana Setyawardhani, Dwi Ardiana Ermaningsih, Yeni Esti Suryani ESTU RETNANINGTYAS N Fajar Rakhman Wibowo Farida, Yeni Fea Prihapsara, Fea Herawati, Zainab Islah, Siti Baroroh Zakiyatul Lestari, Witri Wahyu Mae Sri Hartati Wahyuningsih Mujtahid Kaavessina, Mujtahid Nestri H, Nestri Nestri Handayani, Nestri Pratama, Tiara Dewi S. Pratama, Tiara Dewi Salindri Pribadi, Fitrawan Hernuza Pujiastuti, Umi Hanik Rasmaya Niruri Rul Afiyah Syarif Saptono Hadi, Saptono Saputri, Rani Nurindah Soerya Dewi Marliyana Syaiful Choiri Wahyuni, Dinar Sari C Wahyuni, Dinar Sari C. Wahyuni, Titi WIDYA MUDYANTINI Yacobus Christian Prasetyo Zikri, Fahrul