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All Journal VALENSI Alchemy Jurnal Penelitian Kimia Indonesian Journal of Chemical Science Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia Molekul: Jurnal Ilmiah Kimia
Fajar Rakhman Wibowo
Departmen of Chemistry, Faculty of Mathematics and Natural Sciences, Sebelas Maret State University, Surakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology

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ISOLASI DAN IDENTIFIKASI KOMPONEN PRODUK UTAMA REAKSI ADISI β-KARIOFILENA DENGAN MENGGUNAKAN BF3.CH3OH Marliana, Soerya Dewi; Wibowo, Fajar Rakhman; Prayoga, Teddy
Alchemy Jurnal Penelitian Kimia Vol 3, No 2 (2004)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

Telah dilakukan isolasi dan identifikasi komponen produk utama dari reaksi adisi ?-kariofilena dengan menggunakan BF3.CH3OH. Kondisi reaksi dilakukan pada suhu 65o dan waktu refluk selama 9 jam. Isolasi produk komponen utama dilakukan dengan metoda kromatografi kolom sedangkan identifikasinyadilakukan dengan kromatografi gas (GC), spektometer inframerah (IR) dan kromatografi gas-spektrometri massa (GC-MS).Hasil isolasi diperoleh cairan berwarna coklat kekuningan dengan aroma woody. Analisis produk utama dari hasil isolasi dengan menggunakan GC diperoleh konsentrasi relatif sebesar 36,24%, sedangkan spektrum IR menunjukkan adanya serapan pada daerah 2866-2927,7cm-1, 1458 cm-1, 1377,1 cm-1 dan 1076,6 cm-1 yang masing-masing merupakan serapan dari gugus fungsi hidrokarbon (C-H, -CH3 dan –CH2-) dan eter (C-O-C). Hasil analisis spektra GC-MS menunjukkan ion molekuler (m/e) sebesar   236 dan mempunyai puncak dasar 125. Berdasarkan ketiga analisis tersebut maka produk utama diduga senyawa kariolana metil eter.
REAKSI ADISI METANOL TERHADAP β-KARIOFILENA DENGAN KATALIS AlCl3 Kusumaningsih, Triana; Wibowo, Fajar Rakhman; Triambodo, Ali
Alchemy Jurnal Penelitian Kimia Vol 3, No 1 (2004)
Publisher : Alchemy Jurnal Penelitian Kimia

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Telah dilakukan reaksi adisi methanol terhadap ? -karioflena dengan menggunakan katalis asam lewis AlCl3. Hasil yang diharapkan dari reaksi ini adalah diperoleh senyawa ? -kariofilena yaitu ?-kariofilena metal eter yang bermanfaat dalam industri obat dan parfum.Reaksi adisi metanol tehadap ?-kariofilena dilakukan pada variasi suhu 27oC, 50oC dan 62,5oC serta variasi waktu refluks selam 2 jam, 4 jam dan 6 jam. Produk dominan yang dihasilkan dari reaksi ini berupa senyawa kariofilena metal eter. Hasil analisis dengan kromatografi gas menunjukkan bahwa produk kariofilena metil eter terbanyak pada suhu 62,5oC dalam waktu 6 jam yaitu sebesar 25,22%. Produk samping yang menarik untuk dianalisis adalah produk berupa kariofilena alkohol. Hail kromatografi kolom yang diikuti analisis dengan kromatografi gas dan spektrofotometer IR diperoleh dua produk kariofilena alkohol yang berebtuk cairan berwarna kuning bening dan Kristal berbentuk jarum yang berwarna putih. Struktur kariofilena alkohol belum dapat ditentukan karena keterbatasan dat-data yang ada.
MODIFIKASI Y220C PADA RESIDU 220 OLEH ADDUCT PRIMA-SISTEIN MERESTORASI Y220C PADA RESIDU 120 C, Angeline Prita; Wibowo, Fajar Rakhman
Indonesian Journal of Chemical Science Vol 3 No 2 (2014)
Publisher : Indonesian Journal of Chemical Science

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Abstract

Mutasi tirosin pada residu 220 menjadi sistein (Y220C) dapat menginduksi cavity pada residu 220 sebagai pusatnya. Mutasi ini dapat menurunkan kestabilan termal dan menyebabkan adanya sedikit perubahan pada bagian kontak DNA. p53 reactivation and induction of massive apoptosis-1 (PRIMA-1) terbukti dapat mereaktivasi p53, namun mekanisme dan target residunya belum cukup jelas. Fakta eksperimen menunjukkan PRIMA-1 dapat modifikasi sistein dengan membentuk adduct. Penelitian ini ditujukan untuk mengamati efek dinamis modifikasi sistein menggunakan PRIMA-1, yang disebut adduct PRIMA-sistein pada residu 220 untuk mereaktivasi p53. Modifikasi Y220C dilakukan dengan memaksa adduct PRIMA-sistein masuk ke dalam cavity yang berukuran lebih kecil dibanding struktur adduct tersebut. Pengamatan stabilitas pada level molekuler dilakukan dengan cara simulasi dinamika molekuler (DM). Trajektori-Trajektori yang dihasilkan simulasi dinamika molekul selama 100ns menunjukkan perubahan  dinamika karena adanya modifikasi Y220C pada residu nomor 220. Data Backbone B-factor dan order parameter menunjukkan bahwa  adanya modifikasi Y220C sebagian mampu menyerupai wild type pada residu 120 yang merupakan daerah yang berfungsi untuk interaksi dengan DNA. Selain itu, pada residu 155 yang berinteraksi langsung dengan residu 220 juga terdapat peningkatan fleksibilitas residu 155 setelah adanya modifikasi Y220C.
Cation Sensing Capabilities of A Nitrophenyl Cinnamaldehyde Derivative Suryanti, Venty; Wibowo, Fajar Rakhman; Marzuki, Ahmad; Sari, Meiyanti Ratna Kumala
Molekul Vol 15, No 3 (2020)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.005 KB) | DOI: 10.20884/1.jm.2020.15.3.654

Abstract

The cationic chemosensor based on organic compound bearing an aminophenol moiety as a receptor for metal analyte and a cinnamaldehyde moiety as chromophoric fragment has been developed. In this work, we report the colorimetric sensing of nitrophenyl cinnamaldehyde derivative, namely methyl-3-(2-hidroxy-5-nitrophenyl amino)-3-phenylpropanoate, towards a variety of metal cations, such as Cu2+, Fe3+, Ni2+ and Zn2+. The cation sensing abilities of the sensor were observed for Cu2+and Fe3+ with a color change from colorless to pink and faint yellow, respectively, The characteristic UV-Vis spectra changes were observed upon addition of Cu2+and Fe3+ cations. The hypsochromic absorption spectra shifts were obtained, indicating the cations and sensor complexations had formed. A metal-to-ligand-charge-transfer (MLCT) had occurred and the charge density of the sensor changed resulting in appearance of new absorption peaks in the UV-Vis spectra and color changes of the sensor solution upon addition of the Cu2+and Fe3+.  
Synthesis and Characterization of Anethole-lauryl Methacrylate Copolymer via Cationic Polymerization Handayani, Desi Suci; Tahara, Alfia Uke; Firdaus, Maulidan; Suryanti, Venty; Kusumaningsih, Triana; Marliyana, Soerya Dewi; Wibowo, Fajar Rakhman; Wartono, Muhammad Widyo
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.7078

Abstract

The synthesis of anethole-lauryl methacrylate (LMA) copolymer had been carried out by cationic polymerization using BF3O(C2H5)2 as the initiator without the use of solvent at room temperature (28-30 °C) over atmospheric N2 conditions. Polymerization was conducted by varying LMA concentration i.e. 2%, 4%, and 6%, (w/w) with respect to the anethole weight. Structural determination of co-poly(anethole-LMA) was done using FTIR and 1H-NMR spectrophotometer. The relative molecular weight (Mv) of co-poly (anethole-LMA) was measured by an Ostwald Viscometer at room temperature. Morphological characterization and surface area analysis of co-poly(anethole-LMA) was performed using SEM and SAA, respectively. The successful synthesis of co-poly(anethole-LMA) was proven by the disappearance of vinyl group absorption at 1696, 1638, 965, and 938 cm-1 of the FTIR spectra, as well as the loss of vinyl group proton signals at 6.4-5.5 ppm in the 1H-NMR spectra. Increasing the weight of the LMA affected the characteristics of co-poly(anethole-LMA). The relative molecular weight of co-poly(anethole-LMA) was found to rise by increasing the weight of LMA. The Mv of co-poly(anethole-LMA) 2%, 4%, and 6% were 32378.62, 50611.05, and 65133.79 g/mol, respectively. The morphology of co-poly(anethole-LMA) showed that the surface distance between particles was getting tighter and the highest surface area in co-poly(Anethole-LMA) 6% was 233.80 m2/g.
Advances in Mesoporous Silica Nanoparticles: Synthesis, Characterization, and Biomedical Uses Saputra, Ozi Adi; Safitriono, Wahyu Nur; Istiqomah, Annisa; Kumalasari, Meiyanti Ratna; Irmawan, Muhammad; Wibowo, Fajar Rakhman
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 2 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss2.art9

Abstract

Mesoporous silica nanoparticles (MSNs) have drawn significant attention due to their exceptional properties and diverse range of applications, particularly in nanomedicine. The distinctive properties of MSNs, such as their high surface area, tunable pore size, and versatile surface chemistry, make them ideal candidates for various biomedical applications. This review aims to present a detailed understanding of MSNs, from synthesis and characterization to their versatile applications in biomedicine, highlighting their significant potential in advancing healthcare technologies. The synthesis methods for MSNs were comprehensively discussed, emphasizing the influence of parameters like solvent, base, alkoxysilane concentrations, and template surfactants on the size and shape of the nanostructures. Different types of MSNs, including MCM-41, SBA-15, KIT-6, and hollow MSNs, are discussed, along with their synthesis protocols and unique characteristics. The review also covers various spectroscopic techniques, such as XRD, XPS, FTIR, NMR, and fluorescence spectroscopy, which are crucial for characterizing MSNs. Furthermore, the biomedical applications of MSNs are highlighted, demonstrating their potential in drug delivery systems, imaging, and diagnostics. The review concludes with a discussion of the future perspectives and challenges in the field, providing insights into potential developments and the prospects for clinical translation.
Search for SARS-CoV-2 Inhibitors. Is it still needed?Molecular Docking Study of Teicoplanin Derivatives and Vancomycin against SARS-CoV-2 Mpro Mulyani, Sri; Lestari, Nova Dwi; Samodra, Imam; Wibowo, Fajar Rakhman; VH, Elfi Susanti; Ardyanto, Tonang Dwi
Jurnal Kimia Valensi Vol. 11 No. 1 (2025): Jurnal Kimia VALENSI
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.44709

Abstract

Coronaviruses have been known since 2002 in the case of SARS (Severe Acute Respiratory Syndrome). SARS-CoV-2, the cause of the COVID-19 pandemic, is believed to be an evolution of the SARS-causing coronavirus (SARS-CoV). This evolution shows the complex interaction dynamics between the virus and the host, which have characterized the emergence of new SARS-CoV-2 strain variations until now. Therefore, the search for these antiviral drugs is still critical. MPro is one of the important proteins for the life cycle of pathogenic coronaviruses, so it is an attractive target for developing drugs that inhibit this virus. This study examined the interaction of teicoplanin derivatives and vancomycin as SARS-CoV-2 MPro (6LU7) inhibitors through molecular docking with Autodock Vina. The smallest RMSD value was selected and stored to calculate the energy value. The image of atoms in the ligand and receptor was processed with Autodock Tools, LigPlus, and PyMOL. The study showed that teicoplanin derivatives such as teicoplanin aglycone, teicoplanin-A3-1, and vancomycin had the potential as SARS-CoV-2 Mpro inhibitors. Based on the interaction at the active site and the obtained ΔG values, even the teicoplanin aglycon had a more significant inhibitory potential than other potent inhibitors such as N3.
Co-Authors Ali Triambodo, Ali Angeline Prita C, Angeline Prita Annisa Istiqomah, Annisa Desi Suci Handayani Elfi Susanti V. H. Elfrida Ratnawati Irmawan, Muhammad Lestari, Nova Dwi Maulidan Firdaus Muhammad Widyo Wartono, Muhammad Widyo Ozi Adi Saputra, Ozi Adi Safitriono, Wahyu Nur Samodra, Imam Sari, Meiyanti Ratna Kumala Soerya Dewi Marliana, Soerya Dewi Soerya Dewi Marliyana Sri Mulyani Tahara, Alfia Uke Teddy Prayoga, Teddy Tonang Dwi Ardyanto Triana Kusumaningsih Venty Suryanti