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All Journal MANDALA of Health Mandala of Health : A Scientific Journal Medical and Health Journal
Kamal Agung Wijayana, Kamal Agung
FK UNSOED
Dentistry Health Professions Medicine & Pharmacology Public Health

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FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN TINGKAT DEPRESI PADA PASIEN KANKER PAYUDARA YANG SUDAH MENDAPATKAN TERAPI DI RUMAH SAKIT MARGONO SOEKARJO PURWOKERTO Wijayana, Kamal Agung; ., Suharmilah; Budi Setyaningsih, Tri Rini
MANDALA of Health Vol 6, No 1 (2013): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Prevalence of depression in Indonesia is currently quite high. Depression is caused by internal and external factors. External factors that can cause depression for example, medical disease . One of the medical illnesses associated with the incidence of depression is breast cancer. Depression in breast cancer can occur because of the sense of loss such as loss of body shape. The purpose of the research was to discover the factors associated with level of depression in breast cancer patients who had therapy at Margono Soekarjo Hospital Purwokerto. The subjects of the research was breast cancer outpatient who had therapy at Margono Soekarjo Hospital Purwokerto in 2011. The dependent variable in this research was level of depression which measured by the BDI questionnaire (Beck Depression Inventory). The independent variables in this research was term of diagnosis, disease stage and therapy in breast cancer patients who had therapy. The Method of this research was an observational analytic with cross sectional design. The sampling technique used consecutive sampling with 66 samples. Univariate analysis was used to see the frequency distribution of variables and Spearman test and the Contingency Coefficient test for bivariate analysis. The result of the statistical analysis revealed that there was no relationship between the term of diagnosis p = 0,289 (p> 0,05) and stage of disease p = 0,354 (p> 0,05) with level of depression, but there was a relationship between therapy with level of depession p = 0,001 (p< 0,05). The conclusion of the research was there was significant correlation between negative direction and therapy with level of depression in breast cancer patients who had therapy at Margono Soekarjo Hospital Purwokerto.
PEMBERIAN ANTIBIOTIK PADA SEPSIS NEONATORUM Hapsari, Ariadne; Wijayana, Kamal Agung
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11437

Abstract

Neonatal sepsis is still an unsolved problem in newborn baby services and care. In developing countries, almost the majority of newborn baby treated are related to sepsis. The same thing was found in developed countries in babies treated in newborn baby intensive care units. In addition to morbidity. High mortality was also found in BBL sepsis sufferers. Neonatal sepsis is a clinical syndrome of systemic disease accompanied by bacteremia that occurs in the first 28 days of life. Bacterial, viral or fungal invasion into the blood before or after birth can spread to other organs/systems causing meningitis, pneumonia, osteomyelitis and pyelonephritis. Patient treatment usually involves giving a combination of antibiotics which aims to expand the range of pathogenic microorganisms that the patient may be suffering from. It is hoped that the combination of antibiotics will have good sensitivity to both Gram-positive and Gram-negative germs. Depending on the pattern and resistance of germs in each hospital, usually the antibiotics chosen are the ampicillin/ cloxacillin/ vancomycin group and the aminoglycoside/cephalosporin group. The length of treatment depends on the type of germ causing it. In patients with gram-positive bacteria, antibiotics are recommended for 10-14 days, while for patients with gram-negative bacteria, treatment can be continued for 2-3 weeks.
RELATIONSHIP BETWEEN MMP14 +7096 GENETIC VARIATION WITH CHILD TURCOTTE PUGH (CTP) SCORE IN HEPATIC CIRRHOSIS Wijayana, Kamal Agung; Siswandari, Wahyu; Hapsari, Ariadne; Yudha, Paskalis Bhaskara Unggul
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11438

Abstract

Background: Hepatic cirrhosis is chronic hepatic damage followed by structural change and decreased function of hepar. Child Turcotte Pugh (CTP) score is used to assess the severity of hepatic cirrhosis. Genetic variation of MMP14 has a role in the progressivity of liver diseases. Relationship between MMP14 +7096 genetic variation and Child Turcotte Pugh score in hepatic cirrhosis was not well known.Aim: To determine the relationship between MMP14 +7096 genetic variation with Child Turcotte Pugh score in hepatic cirrhosis patients in Prof. Dr. Margono Soekarjo General Hospital Purwokerto.Methods: Analytical observational study with cross-sectional design was conducted among 30 patients who were diagnosed hepatic cirrhosis in Prof. Dr. Margono Soekarjo General Hospital Purwokerto. Data collection was performed by total samping of blood laboratory test and PCR-RFLP. Data was analysed using Kruskal-Wallis test and Mann-Whitney post hoc test.Results: Kruskal-Wallis test shows relationship between genetic variation of MMP14 +7096 with Child Turcotte Pugh (CTP) score (p=0,024). Mann-Whitney post hoc test shows significant relationship between CC and TT genotype (p=0,02).Conclusions: There is a significant relationship between CC and TT genotype MMP14 +7096 genetic variation with Child Turcotte Pugh score in hepatic cirrhosis patients in Prof. Dr. Margono Soekarjo General Hospital Purwokerto.
KADAR ALPHA FETOPROTEIN (AFP) DENGAN PROFIL HbsAg PADA PASIEN KARSINOMA HEPATOSELULER DI RSUD PROF. DR. MARGONO SOEKARJO: SEBUAH STUDI CROSS SECTIONAL Yudiananda, Domas Shifa; Sulistyo, Hidayat; Wijayana, Kamal Agung
Medical and Health Journal Vol 4 No 1 (2024): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.4.1.12894

Abstract

Background: Hepatocellular carcinoma is 10-20% of all liver diseases in Indonesia. Detect the emergence of hepatocellular carcinoma in the early phase are needed, especially in patients with high risk, such as chronic hepatitis and cirrhosis of the liver by performing regular investigations (USG, CT Scan) and laboratory examinations (AFP, PIVKA II). Aim: To determine the correlation between AFP levels and HbsAg profile in Hepatocellular Carcinoma patients at Regional Public Hospital of Prof. Dr. Margono Soekarjo. Methods: The research method was analytic observational with cross sectional approach. This research uses samples from January-December in 2020. The sampling method of this research is Total sampling. Retrospective data retrieval of secondary data in the form of medical records of the research sample. The research subjects were Hepatocellular Carcinoma patients at Prof. Dr. Margono Soekarjo, totaling 30 people. Result: The mean of people with hepatocarcinoma was 22 men with a percentage of 73.33%, while 8 people were female with a percentage of 26.67%. The mean age of the subjects of this study was 49.5 years. Subjects who had reactive results on HBsAg examination were 21 people with a percentage of 70%. The mean AFP level of the subjects was 17379.37 with a standard deviation of 25968.78. Results of the Fisher test for the correlation between AFP and HbsAg profile in hepatocellular carcinoma patients had a significance value of 0.032 (p <0.05). Conclution: that there is a correlation between AFP levels and HBsAg profile in Hepatocellular Carcinoma patients at Regional Public Hospital Prof. Dr. Margono Soekarjo.
PENYAKIT HIRSCHSPRUNG: SEBUAH TINJAUAN PUSTAKA TENTANG PATOFISIOLOGI, DIAGNOSA, DAN TERAPI Wijayana, Kamal Agung
Mandala Of Health Vol 16 No 2 (2023): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2023.16.2.9602

Abstract

Penyakit Hirschsprung merupakan kelainan bawaan pada sistem pencernaan yang ditandai oleh ketiadaan sel ganglion di sebagian atau seluruh segmen usus besar. Gangguan ini menghambat pergerakan normal usus, yang berakibat pada akumulasi tinja di bagian usus yang terkena, menyebabkan gejala seperti konstipasi berat, kembung, muntah, dan distensi perut. Etiologi Penyakit Hirschsprung atau megakolon bawaan disebabkan karena kelainan perkembangan yang disebabkan oleh kegagalan migrasi sel crest neural. Ketika sel- sel neurogenik primitif ini gagal untuk mengambil posisi dalam Submucosal usus dan pleksus intermyenteric dari bibir ke anus, maka terjadi gangguan motilitas, yang paling sering muncul sebagai konstipasi kronis pada anak yang baru lahir. Hirschsprung dikategorikan berdasarkan seberapa banyak colon yang terkena meliputi: Ultra short segment, Short segment, Long segment, Very longs segment. Gejala kardinalnya yaitu gagalnya pasase mekonium pada 24 jam pertama kehidupan, distensi abdomen dan muntah. Pemeriksaan penunjang diantaranya Barium enema, Anorectal manometry dan Biopsy rectal sebagai gold standard. Tatalaksana operatif dengan cara tindakan bedah sementara dan bedah definitive (Prosedur Swenson, Duhamel, Soave dan Rehbein). Komplikasi utama adalah enterokolitis post operatif, konstipasi dan striktur anastomosis
Co-Authors Hapsari, Ariadne Hidayat Sulistyo Suharmilah ., Suharmilah Tri Rini Budi Setyaningsih, Tri Rini Wahyu Siswandari Yudha, Paskalis Bhaskara Unggul Yudiananda, Domas Shifa