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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Chemistry
Pinandi Sri Pudyani
Universitas Gadjah Mada
Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions

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Effects of soy isoflavone genistein on orthodontic tooth movement in guinea pigs Sri Suparwitri; Pinandi Sri Pudyani; Sofia Mubarika Haryana; Dewi Agustina
Dental Journal (Majalah Kedokteran Gigi) Vol. 49 No. 3 (2016): September 2016
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.189 KB) | DOI: 10.20473/j.djmkg.v49.i3.p168-174

Abstract

Background: Osteoblast and osteoclast are the important factor in periodontal tissue remodeling for the orthodontic treatment success. Resorption process takes place in compression area by osteoclast and apposition in the tension area by osteoblast. In general hormone condition and age affect remodeling process. Estrogen has a high contribution in remodelling process and decreased in elderly individual such as menopausal women. Soybean contains isoflavone genistein which has similar structure and activity to estrogen. Many researchers indicate that isoflavone genistein not only has an inhibitor effect in osteoporosis but also has estrogenic and antiestrogenic effect as well. Purpose: The study aimed to investigate the effect of soybean isoflavone genistein administration on osteoblast and osteoclast cells number in orthodontic tooth movement of young and old guinea pigs. Method: The research was quasi-experimental study with post test only with control design. The experimental animals were 24 male guinea pigs that divided into: young guinea pigs (±4 months old) and old guinea pigs (±2.5 years old). Each group was divided into 4 subgroups for receiving the treatment namely; control, orthodontic treatment, genistein treatment and orthodontic+genistein treatment. All of the subjects were sacrificed at day 7 and the specimens were histologically analyzed using tartrate resistance acid phosphatase (TRAP) and hematoxylin eosin (HE) staining and observed using microscope that connected to obtilab and an image raster program. Result: U Mann-Whitney statistical analysis showed there were significant differences in osteoblast cell numbers; between orthodontic treatment and orthodontic+genistein treatment in the old guinea pigs (p=0.004); between orthodontic treatment in the young guinea pig and orthodontic+genistein treatment in the old guinea pig (p=0.016); between orthodontics treatment and orthodontic+genistein treatment in the young guinea pigs (p=0.025). U Mann-Whitney statistical analysis showed there were significant differences in osteoclast cell numbers: between the orthodontic treatment in the old guinea pig and orthodontics+genistein treatment in the young guinea pigs (p=0.007); between orthodontic treatment group in the young guinea pigs and orthodontics+genistein treatment in the old guinea pigs; between orthodontic treatment and orthodontic+ genistein treatment in the young guinea pigs (p=0.007). All groups administered by genistein the numbers of osteoblast in the surrounding of the tension sites increased, while in the surrounding of the compression sites had less osteoclasts; even, there were no osteoclasts found in some samples. Conclusion: Soybean isoflavone genistein administration on orthodontic tooth movement increased osteoblast numbers in the tension sides and decreased osteoclast numbers in the compression sides.
Effect of caffeine in chocolate (Theobroma cacao) on the alveolar bone mineral density in guinea pigs (Cavia cobaya) with orthodontic tooth movement Bramita Beta Arnanda; Sri Suparwitri; Pinandi Sri Pudyani
Dental Journal (Majalah Kedokteran Gigi) Vol. 53 No. 3 (2020): September 2020
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v53.i3.p164-169

Abstract

Background: The benefits of chocolate have attracted significant attention from clinicians, especially the active compound of caffeine on bone metabolism. The bone density significantly affected the rate of tooth movement. Purpose: This study aims to analyse the effect of the dose and the duration of caffeine consumption in chocolate on alveolar bone mineral density in orthodontic tooth movement. Methods: Forty-eight male guinea pigs (Cavia cobaya) aged between 3-4 months and weighing 300-350 grams were divided into four groups (group A control, group B caffeine dose of 2.3 mg, group C caffeine dose of 3.45 mg, and group D caffeine dose of 4.6 mg). An open coil spring was applied to the mandibular inter-incisor with an orthodontic force of 35 grams. Guinea pigs were sacrificed using lethal doses of anaesthetics on days 0, 1, 7, and 14 after an orthodontic appliance installation. Mandibular alveolar bone mineral density in compression sites was analysed with an atomic absorption spectrophotometer (AAS). Experiment data results were analysed using two-way ANOVA with a 95% degree of confidence. Results: Caffeine consumption with a dose of 4.6 mg on day 7 had the lowest alveolar bone mineral density and the highest was at a dose of 2.3 mg on day 14, but there were no differences between the dose groups, the duration groups and interactions between both of them (p>0.05). Conclusion: The consumption of caffeine in chocolate did not decrease the bone mineral density in the compression site of orthodontic tooth movement.
The effect of fixed orthodontic treatment with Edgewise and Straightwire techniques on white spot lesions incidence and accumulation of Streptococcus mutans bacteria Elfira Maharani; Dyah Karunia; Pinandi Sri Pudyani
Dental Journal (Majalah Kedokteran Gigi) Vol. 53 No. 3 (2020): September 2020
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v53.i3.p170-174

Abstract

Background: Fixed orthodontic appliances, such as Edgewise and Straightwire techniques, can increase the amount of plaque retention containing Streptococcus mutans (S. mutans), which can lead to white spot lesions. Purpose: The aim of this study is to analyse the correlation of fixed orthodontic treatment with Edgewise and Straightwire techniques on the incidence of white spot lesions and accumulation of S. mutans. Methods: The samples consisted of three groups: control group (n=8), Edgewise technique group, and Straightwire technique group. We observed the samples at the sixth month and eighth month of the treatment, after the installation of the fixed orthodontic appliances. The observation of white spot lesions with caries detector was applied in all regions. Bacterial swabs were acquired in the lateral incisor region, then a bacterial culture procedure was carried out on selective media of S. mutans, and then a bacterial count was performed. The data was analysed using two-way ANOVA, the post-hoc least square differences test, and the Pearson’s correlation test. Results: The number of white spot lesions in the Edgewise group was higher than in the Straightwire group in the sixth and eighth month of treatment with insignificant difference (p>0.05). The number of S. mutans bacteria increased in all groups, but there were no significant differences (p>0.05). There was no significant relationship between the number of white spot lesions with the accumulation of S. mutans between groups (p>0.05). Conclusion: The Edgewise and Straightwire techniques increase the incidence of white spot lesions but accumulation of S. mutans with the incidence of white spot lesions has no relationship.
Solubility Enhancement of Simvastatin through Surfactant Addition for Development of Hydrophobic Drug-Loaded Gelatin Hydrogel Niswati Fathmah Rosyida; Pinandi Sri Pudyani; Akhmad Kharis Nugroho; Ika Dewi Ana; Teguh Ariyanto
Indonesian Journal of Chemistry Vol 19, No 4 (2019)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.913 KB) | DOI: 10.22146/ijc.38153

Abstract

This study aims to synthesize simvastatin hydrogel as drug delivery system with surfactant addition for improving solubility of simvastatin. Surfactants used in the study were the zwitterionic amino acid of arginine and nonionic surface-active agent of polysorbate 80. The solubility study was conducted by pouring of an excess mass of simvastatin into the solution of a surfactant in a conical flask. The sample was shaken up to 72 h in a mechanical water bath shaker at a varied temperature of 25, 40, and 50 °C. The amount of drug dissolved in solution was analyzed by UV/Visible spectrophotometer at 238 nm. The results showed that the simvastatin solubility is profoundly influenced by the surfactant type, surfactant concentration, and temperature. Polysorbate 80 exhibited as a better surfactant than arginine and an enhancement up to 1400 times, in respect of without any addition of a surfactant, was observed. Based on the solubility study, simvastatin-loaded gelatin hydrogel composite was formulated and the characterization (FTIR and SEM) showed the successful impregnation. The hydrogel microparticles of featured swelling indexes in the range of 2–6 for every patch and presented a sustained release profile.
Increased TGF-β1 level after cocoa administration during orthodontics tooth movement in Cavia cobaya Fikri, Annisa Nurul; Farmasyanti, Cendrawasih Andusyana; Pudyani, Pinandi Sri
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 2 (2024): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i2.p118-123

Abstract

Background: Orthodontic tooth movement (OTM) is a process of tooth movement in the alveolar socket through a bone remodeling process. Cocoa contains caffeine as a bioactive component. The number of studies on the effects of caffeine on orthodontic tooth movement is rising. Purpose: This study aimed to determine the effect of caffeine in cocoa administration on TGF-β1 levels in the pressure side during orthodontic tooth movement. Methods: Twelve Cavia cobaya were divided into 4 groups: control group (ONC), treatment group with 2.3 mg caffeine in cocoa (OWC1), 3.45 mg dose (OWC2) and 4.6 mg dose (OWC3) (n=3). A NiTi open coil spring with light force was applied to two lower incisors tooth of Cavia cobaya. TGF-β1 level in GCF of the pressure side was analyzed using ELISA on days 0, 1, 7, and 14. Data were analyzed using the Two-way ANOVA test (p<0.05) and the LSD Post-Hoc test. Results: Research indicated improvement of TGF-β1 level from the control group with the least average followed group caffeine in cocoa 2.3 mg (OWC1), 3.45 mg (OWC2), and 4.6 mg (OWC3) (p<0.05). Conclusion: This study confirmed that caffeine in cocoa administration increase TGF-β1 level during orthodontics tooth movement on Cavia cobaya in the pressure side.
Co-Authors Akhmad Kharis Nugroho Andi Triawan Ardianysah, M. Shulchan Ardianysah, M. Shulchan Bramita Beta Arnanda Darmawan Sutantyo Darmawan Sutantyo Darmawan Sutantyo Darmawan Sutantyo, Darmawan Dewi Agustina Dyah Karunia Elfira Maharani Farmasyanti, Cendrawasih Andusyana Fikri, Annisa Nurul Heri Susilo Winarti Heri Susilo Winarti, Heri Susilo Ika Dewi Ana Ika Dewi Ana Indra Sari JCP Heryumani Nolista Indah Rasyid Novarini Prahastuti Novarini Prahastuti, Novarini Rosyida, Niswati Fathmah Setiarini Widiarsanti Setiarini Widiarsanti Sismindari - Siti Sunarintyas Soekarsono Hardjono Soekarsono Hardjono Soekarsono Hardjono, Soekarsono Soesatyo Marsetyawan HNE Sofia Mubarika Haryana Sri Suparwitri Teguh Ariyanto Tita Ratya Utari Widya Asmara Yenni Hanimastuti Yenni Hanimastuti Yenni Hanimastuti, Yenni