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Saif Khan, Saif
Department of Periodontology, Dr ZA Dental College, Aligarh Muslim University, Aligarh 202001
Dentistry

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The Effect of Systemic Doxycycline and Mechanical Therapy on GCF β-Glucuronidase Leves in Chronic Periodontitis Patients Zia, Afaf; Gupta, Narendra; Bey, Afshan; Khan, Asad U; Khan, Saif; Andarabi, Syed Mukhtar Un Nisar; Khan, Rosina; Adil, Mohd
Journal of Dentistry Indonesia Vol. 24, No. 2
Publisher : UI Scholars Hub

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The goal of periodontal therapy includes management of bacterial pathogens to control the destruction of the periodontal tissue. A number of different nonsurgical and surgical therapies have been used in achieving this goal. Objective: To evaluate the effectiveness of doxycycline compared with nonsurgical therapy alone or in combination with nonsurgical therapy on gingival crevicular fluid β-Glucuronidase levels (ßG) and clinical parameters over a 20-week period in patients with chronic periodontitis. Methods: An interventional study comprising 60 patients with chronic periodontitis. They were divided into three groups of different treatment approach. The plaque index, gingival index, probing depth, and clinical attachment levels were recorded, and gingival crevicular fluid (GCF) samples were collected at 2, 6, 10, and 20 weeks, after treatment. Results: The levels of GCF βG and clinical parameters were higher when the treatment was initiated, and the levels decreased after treatment. No significant difference was found in the βG level when nonsurgical therapy and doxycycline were used alone. In comparison, when doxycyline and nonsurgical therapy were combined, the level of βG decreased significantly. Conclusion: The present study indicated the usefulness of doxycycline as an adjunct to nonsurgical periodontal therapy in lowering GFC βG levels and clinical parameters.
Endodontic Periodontic Lesions and Host Modulation – Case Series Zia, Afaf; Bey, Afshan; Andrabi, Syed MUN; Khan, Saif; Khan, Masood
Journal of Dentistry Indonesia Vol. 22, No. 1
Publisher : UI Scholars Hub

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Host modulation, includes inhibition of matrix metalloproteinases, blocking production of proinflammatory cytokines and inhibition of osteoclastic activity, has therapeutic value as adjunctive therapy in treating chronic periodontitis. This case series presented three patients with chief complaint of teeth mobility where endo perio involvement was diagnosed. The endo perio combined lesions generally shows the communication between pulp and periodontal tissues with the same origin of dental infection. Diagnosis in such cases is difficult and generally raising problem in the management. All of the cases were managed by non surgical endodontic therapy combined with host modulation. All local factors causing the lesion were removed. Clinical outcome after six and nine months were quite satisfactory. Combined endo perio cases are challenging to the dentists and involve multidisciplinary involvement. To manage such cases, dentists have to rely on the unconventional techniques.
Co-Authors Adil, Mohd Afaf Zia, Afaf Afshan Bey, Afshan Andarabi, Syed Mukhtar Un Nisar Andrabi, Syed MUN Gupta, Narendra Khan, Asad U Khan, Rosina Masood Khan, Masood