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All Journal Indonesian Journal of Cancer Majalah Patologi Indonesia Ophthalmologica Indonesiana
Evelina Kodrat Evelina Kodrat
Department Of Anatomic Pathology, Cipto Mangunkusumo Hospital Faculty Of Medicine Universitas Indonesia
Health Professions Medicine & Pharmacology Public Health

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A Modified Buttockectomy as a Limb Salvage Procedure in Ischium Osteosarcoma: A Case Report KAMAL, ACHMAD FAUZI; DJAJA, YOSHI PRATAMA; KODRAT, EVELINA; SALAMAH, THARIQAH
Indonesian Journal of Cancer Vol 9, No 2 (2015): April-Juni 2015
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3225.388 KB)

Abstract

Osteosarcoma, which rarely originates from the axial bones such as pelvis, presents a major challenge in limb preservation. We report a 9-year-old girl with osteosarcoma on her buttock. She underwent wide excision “modified buttockectomy” to resect the tumour with sciatic nerve involvement. One year after surgery, she was able to walk and no recurrence was found. Keywords: buttockectomy, osteosarcoma ABSTRAKOsteosarkoma, tulang aksial seperti pelvis jarang sekali ditemukan, dan menjadi tantangan besar dalam upaya penyelamatan ekstremitas. Kami laporkan satu kasus osteosarkoma pada tulang panggul-daearah bokong pada seorang anak perempuan berusia 9 tahun. Pasien menjalani eksisi luas “buttockectomy” yang dimodifikasi untuk mengangkat tumor beserta nervus ischiadikus yang terlibat. Pada pengamatan satu tahun pasca pembedahan, pasien dapat berjalan dan tidak ditemukan tanda-tanda rekurensi. Kata Kunci: buttockectomy, osteosarkoma
Ekspresi New York Esophageal Squamous Cell Carcinoma-1 (NYESO-1) pada Sarkoma Sinovial dan Non Sarkoma Sinovial Lainnya Sebagai Dasar Pemilihan Pemberian Imunoterapi Ros Nirmawati,; Nurjati Chairani Siregar; Evelina Kodrat
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (660.98 KB) | DOI: 10.55816/mpi.v30i3.483

Abstract

BackgroundSynovial sarcoma is a rare high grade soft tissue sarcoma. Nowdays, the available therapeutic modalities has not given asatisfactory result yet. Currently, there is a promising therapeutic strategy through immunotherapy targeting NY-ESO-1 which isexpressed on tumor. The aim of this study was comparing NY-ESO-1 immunoexpression between synovial sarcoma and itshistologic mimics i.e. malignant peripheral nerve sheath tumor (MPNST) and dermatofibrosarcoma protuberans (DFSP)MethodsA cross sectional study was done in 28 cases of synovial sarcoma, 10 cases of MPNST and 17 cases of DFSP from archievalmaterial in Department Anatomical Pathology, FMUI/RSCM from January 2013 to June 2019. Immunohistohemical stainning wasperformed using an antibody NY-ESO-1 and it was described positive if it was expressed in more than 50% of tumor with moderateto strong positive intensity.ResultsThere is a significant difference (p<0.001) in NY-ESO-1 immunoexpression among synovial sarcoma (18/28), MPNST (2/10) andDFSP (1/17). Furthermore, synovial sarcoma showed a significantly higher immunoexpression compared to MPNST (OR 7.2;p=0.016; power 68.7%) and DFSP (OR 28.8; p<0.001; power 98.9%).ConclusionSynovial sarcoma showed a higher expression of NY-ESO-1 thus makes it as a good candidates for immunotherapy. There aredifferences in the expression of NY-ESO-1 in synovial sarcoma against MPNST and DFSP.
Case Series of Two Patients with Primary Malignant Melanoma of the Lacrimal Sac Tessa H Anindya; Neni Anggraini; Evelina Kodrat
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.194

Abstract

Background: To demonstrate two rare case of primary malignant melanoma of lacrimal sac. Case Illustration: Patients were both female, 38-year-old and 46-year-old, with lacrimal sac mass,bloody discharge and epiphora. The first patient was previously diagnosed with chronic dacryocystitisand treated with antibiotics and anti-inflammation for two months which resulted in worsen conditionand enlarged swelling. Computed tomography scan revealed solid mass at lacrimal sac 13 x 12 x 7.4millimeters in size with no bone destruction. Patient underwent total mass removal surgery, whichrevealed solid highly pigmented mass. The second patient also had enlarged mass within two months.Other complaints include obstructed left nose and epistaxis. Computed tomography scan revealed solidmass at left medial canthal region involving inferior orbit, nasolacrimal duct, left nose cavity, andmaxillary sinus. Incisional biopsy revealed a malignant melanoma. Patient underwent eye exenteration,maxilectomy, and radical neck dissection. Conclusion: Primary malignant melanoma of the lacrimal sac is a rare case and often mimics chronicdacryocystitis. It’s imporant to understand this disease entity to make accurate diagnosis and managementwith the help of imaging modality.
Extensive Primary Orbital Malignant Melanoma Associated with Nevus of Ota Mutmainah Mutmainah; Neni Anggraini; Evelina Kodrat
Majalah Oftalmologi Indonesia Vol 47 No 2 (2021): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v47i2.100299

Abstract

Primary orbital malignant melanoma is an extremely rare condition to present alone without previous extension of choroidal or conjunctival involvement. We reported the first case of malignant orbital melanoma without ocular involvement in a patient with nevus of Ota. A 52-year-old man presented with left proptosis and extensive bluish black pigmentation on left side of the face classified as Tanino type II of nevus of Ota and left ocular melanocytosis from birth. CT scan imaging showed extensive orbital mass occupying most of the orbital space. Transconjunctival biopsy was performed and a very pigmented mass was discovered, confirming the histopathology result of malignant melanoma. The patient was given up to five cycles of chemotherapy regimen. On serial orbital CT Scan, 33% of the tumor mass has disappeared after completing three cycles.
Co-Authors Achmad F. Kamal Achmad Fauzi Kamal Adrian Situmeang Anggraini, Neni Tri Marcel Prasetyo Mutmainah Mutmainah Nurjati Chairani Siregar Ros Nirmawati, Tessa H Anindya THARIQAH SALAMAH, THARIQAH Wahyu Widodo YOSHI PRATAMA DJAJA, YOSHI PRATAMA