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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Asvin nurulita, Asvin
Bagian Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin, Makassar/RS. Dr. Wahidin Sudirohusodo, Makassar
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Correlation Analysis between Platelet Aggregation and Neurological Outcomes in Ischemic Stroke Patients Nurindar, Muyadhil; Muhiddin, Rachmawati A.; Muhadi, Darwati; Muis, Abdul; Nurulita, Asvin; Patellongi, Ilham Jaya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i1.2336

Abstract

Ischemic stroke is a condition triggered by cerebral perfusion disorders with the risk factor of blood clotting disorders that can cause neurological deficits through a complex pathophysiological process of thrombus formation. The role of platelet aggregation as a blood clotting parameter has the potential to be used as a marker for the level of neurological deficit in patients with ischemic stroke in conjunction with the National Institutes of Health Stroke Scale (NIHSS). The study aimed to observe the correlation between platelet aggregation and the degree of neurological deficit calculated using NIHSS. The study utilized a cross-sectional design with 51 research subjects diagnosed with ischemic stroke based on CT Scan results, followed by platelet aggregation testing. Patients with a diagnosis of hemorrhagic stroke and cardiogenic ischemic stroke were excluded from this study. This study found variations in platelet aggregation among groups with different degrees of stroke severity. However, it was not statistically significant (p=0.427). Correlation analysis showed a mild positive correlation between platelet aggregation and the degree of neurological deficit (r=0.157), although it was not statistically significant (p=0.270). There are variations in platelet aggregation in assessing neurological deficits using NIHSS. There is a positive correlation between the percentage of platelet aggregation and the level of neurological deficit in patients with ischemic stroke.
Platelet Limphocyte Ratio and Procalcitonin in Survivor and Non-Survivor Sepsis Patients at Dr. Wahidin Sudirohusodo Hospital Makassar Fitriana, Astri Yul; Nurulita, Asvin; Bahrun, Uleng; Arifin Seweng
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2396

Abstract

 Sepsis is a life-threatening organ dysfunction caused by dysregulation in the host's response to infection and is a major cause of global morbidity and mortality.The platelet-to-lymphocyte ratio (PLR) is considered a prognostic marker of sepsis. Another inflammatory marker, procalciton in which is secreted in response to bacterial endotoxin can also serve as a biomarker for diagnosis, prognosis and monitoring of sepsis patients. Analysis of platelet lymphocyte ratio and procalcitonin levels may therefore be useful for predicting survival outcomes in sepsis. This retrospective observational study included 276 patients diagnosed with sepsis, consisting of 128 survivors and 148 non-survivors. Statistical analysis was performed using the Kolmogorov-Smirnov test, Mann-Whitney test, Spearman correlation test, and Friedman test, with significance defined as p <0.05. No significant differences in mean platelet-to lymphocyte ratio between a survivors and non-survivors on day 1 (200.59 vs 233.91, p >0.05), day 3 (191.58 vs 238.74, p >0.05), or day 5 (210.42 vs 208.62, p >0.05). Similarly, no significant difference in mean procalcitonin levels was found on day 1 (20.18 ng/mL vs 16.20 ng/mL, p >0.05). However, mean procalcitonin levels were significantly lower in survivors compared with non-survivors on day 3 (14.04 ng/mL vs 17.48 ng/mL, p <0.05) and day 5 (7.78 ng/mL vs 23.06 ng/mL, p <0.05). In survivors, procalcitonin levels showed a significant decreasing trend across days 1, 3, and 5 (p <0.05). There was no difference in platelet-to-lymphocyte ratio values between survivors and non-survivors. There was a significant difference in procalcitonin levels between survivors and non-survivors on the third and fifth days.
Co-Authors Abdul Muis Arifin Seweng Fitriana, Astri Yul Muhadi, Darwati Muhiddin, Rachmawati A. Nurindar, Muyadhil Patellongi, Ilham Jaya Uleng Bahrun, Uleng