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All Journal Berkala Kedokteran Barigas: Jurnal Riset Mahasiswa
Agnes Frethernety Agnes Frethernety
Program Studi Ilmu Biomedik Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Potency of Swallow Nest Extract (Collocalia fuciphago) as Pancreaprotector Through Oxidative Mechanism in Rats (Rattus norvegicus) Induced by Streptozotocin Agnes Frethernety; Satriyandi M; Francisca Diana Alexandra
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.949 KB) | DOI: 10.20527/jbk.v14i1.4534

Abstract

Abstract: Diabetes mellitus is a clinical syndrome with characteristics of hyperglycemia. Hyperglycemia can lead to the formation of excessive free radical compounds that trigger oxidative stress, especially on pancreatic β cells. Swallow nest contains amino acids which are insulin-forming compounds and glutathione that can act as a major reducing agent and antioxidant defense. The purpose of this study is to analyze the effect of swallow’s nest water extract as a pancreaprotector through oxidative mechanism in rats (Rattus norvegicus) induced by streptozotocin. The rats induced by streptozotocin at a dose of 40 mg/kg BW and then randomly divided into 4 groups. Control groups were given aquades and 3 treatment groups, respectively were administered swallow’s nest water extract at doses of 1, 10, 100 mg/kg BW for 21 days. Fasting blood glucose levels were measured on 7, 14 and 21 day. MDA measured after  the animal is determined  at day 28th.Level of  fasting blood glucose and MDA were analyzed by statistic using Kruskal Wallis test followed by multiple comparisons Mann Whitney test. There was a significant decrease in fasting blood glucose level with p = 0.04 in all treatment groups compared the control group. The administration of swallow nest extract significantly decreased MDA pancreas with p value = 0.000 and dose 100 mg/kgBW extract of swallow’s nest significantly decrease pancreatic MDA level. The administration of swallow’s nest water extract shows decrease of fasting blood sugar and has a protective effect on the rats’ pancreas  through oxidative mechanism. Keywords: Swallow's nest extract, MDA
Influence of Extract Swiftlet Nest (Collocalia Fuciphago) as Antihyperglycemia to Circulating Endothelial Cells in Rat (Rattus novergicus) Induced by Streptozotocin Francisca Diana Alexandra; Satriyandi M; Agnes Frethernety; Triawanti Triawanti
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.021 KB) | DOI: 10.20527/jbk.v14i1.4528

Abstract

Abstract: Hyperglycemia could increase the oxidative stress by catalyzes the formation of free radical as anion superoxide(O2-). Oxidative stress will effect in endothelial damaged. This study aimed to evaluated the influence of  extract swiftlet nest  (Collocalia fuciphago) to glucose level and  CEC in rat (Rattus novergicus). Rats were classified into 4 groups, there were control group (K) and 3 treatments group (dose 1; 10 and 100 mg / kgBW) The seventh day  after induced by Streptozotozin (i.p),  the rats  had increased  glucose ± 102 – 108 mg/dL, then treated  with the  extract of   Swiftlet  nest for 28  days  by  oral.  The CEC was measured by Hladovec method. The results showed  the blood glucose level were significant differences ( p = 0.035). The number of CEC decrease significantly (p=0,002). In  conclusion  that extract of Swiftlet  nest  can effect  to decrease  glucose level and CEC number in plasma rat (Rattus novergicus) Keywords: Hyperglycemia, Circulating Endothelial Cells, Collocalia fuciphago
Gambaran berat badan dan kadar HBA1C pada tikus wistar (Rattus norvegicus) model diabetes melitus tipe 2 yang diinduksi streptozotocin dan sukrosa Saha, Daniel Setyawan; Agnes Frethernety; Ni Nyoman Sri Yuliani
Barigas: Jurnal Riset Mahasiswa Vol. 1 No. 3 (2023): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v1i3.8164

Abstract

The incidence of people with diabetes mellitus (DM) continues to increase over time. The World Health Organization (WHO) predicts a substantial increase in the number of people with Type 2 diabetes mellitus in the coming years. Patients with diabetes mellitus should be able to control their weight and blood glucose levels to reduce the risk of complications by performing glycemic control examinations such as HbA1c examination and managing a healthier lifestyle and regular exercise. The method used is true experimental design with the design used in this study is pre-posttest control group design to see the average weight and HbA1c levels of wistar rats before and after treatment. This study was divided into 2 research groups consisting of Normal group (KN), rats without streptozotocin induction and treatment group (KP), rats induced by streptozotocin that have met the inclusion and exclusion criteria. The conclusion of this study is that there is an increase in body weight and HbA1c levels in mice induced streptozotocin.
Co-Authors Angeline Novia Toemon Dian Tri Yeni Fatmaria Francisca Diana Alexandra Ni Nyoman Sri Yuliani Saha, Daniel Setyawan Satriyandi M Silvani Permatasari Triawanti Triawanti