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All Journal HAYATI Journal of Biosciences Paediatrica Indonesiana Majalah Kedokteran Neurosains Journal of Stem Cell Research and Tissue Engineering Narra J The Indonesian Journal of Community and Occupational Medicine Journal of Global Pharma Technology Neurona Acta Neurologica Indonesia Folia Medica Indonesiana
Yetty Ramli
Department Of Neurology, Faculty Of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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HUBUNGAN MODEL PROGNOSTIK PASIEN CEDERA OTAK TRAUMATIK TERTUTUP SEDANG DAN BERAT DENGAN GOS 3 BULAN Aida Fithrie*, Mursyid Bustami*, Yetty Ramli*, Joedo Prihartono**
NEURONA Vol 27 No. 2 Januari 2010
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION ESTABLISHING A RELIABLE PROGNOSIS EARLY AFTER INJURY IS NOTORIOUSLY DIFFICULTFOR ACCURATE OUTCOME PREDICTION MULTIPLE RISK FACTORS NEED TO BE CONSIDERED JOINTLY IN A PROGNOSTIC MODEL BECAUSE SINGLE FACTOR HAVE INSUFFICIENT PREDICTIVE VALUE TO DISTINGUISH PATIENTS WHO WILL DO WELL FROM THOSE WHO WILL DO POORLY
MONTREAL COGNITIVE ASSESSMENT VERSI INDONESIA MoCAIna UNTUK SKRINING GANGGUAN FUNGSI KOGNITIF Nadia Husein*, Silvia Lumempouw*, Yetty Ramli*, Herqutanto**
NEURONA Vol 27 No. 4 Juli 2010
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION MOCA TEST IS VERY SENSITIVE IN MCI SCREENING THIS MOCA TEST ORIGINATED FROM CANADA WHICH IS DIFFERING IN TERMS OF CULTURE AND LANGUAGE FROM INDONESIA IN ORDER TO BE APPLICABLE IN INDONESIA MOCA TEST HAVE TO GO THROUGH VALIDITY AND RELIABILITY EXERCISES
PROFIL SEKUELE GANGGUAN NEUROBEHAVIOUR PADA PASIENdashPASIEN TRAUMA KEPALA POLIKLINIK FUNGSI LUHUR RSCM NOVEMBER 2008dashJUNI 2010 Winnugroho Wiratman*,Sheila Agustini*, Yetty Ramli*, Silvia Lumempouw*
NEURONA Vol 28 No. 1 Oktober 2010
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION TRAUMATIC BRAIN INJURY COULD CAUSE ATTENTION DEFICIT DISORIENTATION CONCENTRATION DISORDER DUE TO DIFFUSE INJURY AND ALSO COULD CAUSE IMPAIRED LANGUAGE SKILLS AND VISUOSPATIAL DISORDER DUE TO FOCAL LESION OTHER COGNITIVE DISORDERS CAUSED BY TRAUMATIC BRAIN INJURY ARE ALTERED ACADEMIC ABILITIES EXECUTIVE AND DECREASED MEMORY FUNCTIONING
NILAI NORMAL PEMERIKSAAN STATUS MENTAL NEUROLOGI STRUB DAN BLACK VERSI INDONESIA Nastiti Widyarini, Silvia F. Lumempouw, Yetty Ramli, Herqutanto
NEURONA Vol 30 No. 3 Juni 2013
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION STRUB AND BLACK MENTAL STATUS EXAMINATION OF NEUROLOGY SBMSEN IS AN INSTRUMENT THAT CAN BE USED TO DETECT COGNITIVE IMPAIRMENT THE INDONESIAN VERSION OF THIS EXAM HAS BEEN DEVELOPED BUT ITS NORMAL VALUES FOR NORMAL COGNITIVE INDONESIAN PEOPLE ARE STILL UNKNOWN
NILAI NORMAL PEMERIKSAAN NEUROPSIKOLOGI CERAD DI JAKARTA Abdul Wahid Indrajaya, Silvia Francina Lumempouw, Yetty Ramli, Joedo Prihartono
NEURONA Vol 30 No. 3 Juni 2013
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION CERAD NEUROPSYCHOLOGY EXAMINATION IS AN INSTRUMENT THAT CAN BE USED TO DETECT COGNITIVE IMPAIRMENT ESPECIALLY DETERMINING THE TYPE OF DEMENTIA TO DATE NORMATIVE VALUE OF THAT EXAMINATION HAS NOT BEEN KNOWN
TERAPI HIPEROSMOLAR SEBAGAI TATA LAKSANA EDEMA SEREBRI PASCACEDERA KEPALA LAPORAN KASUS BERBASIS BUKTI Ramdinal Aviesena Zairinal,* Irma Savitri Madjid,* Yetty Ramli,* Diatri Nari Lastri,* Adre Mayza*
NEURONA Vol. 36 No. 1 Desember 2018
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

IS AN AGENT WIDELY USED TO TREAT HYPEROSMOLARITY IN CASES OF INCREASED INTRACRANIAL PRESSURE AFTER ACUTE TRAUMATIC BRAIN INJURY TBI HYPERTONIC SALINE IS AN ALTERNATIVE AGENT IN SUCH CASES BUT IS STILL NOT WELLRECOGNIZED IN DAILY PRACTICE THUS A LITERATURE SEARCHING WAS CONDUCTED TO SEE WHETHER MANNITOL IS MORE EFFECTIVE AND SAFER THAN HYPERTONIC SALINE IN REDUCING INTRACRANIAL PRESSURE IN PATIENTS WITH CEREBRAL EDEMA POST TBI
Intravenous Versus Intraarterial Transplantation of Human Umbilical Cord Blood Mononuclear Cells for Brain Ischemia in Rats Yetty Ramli; Ahmad Sulaiman Alwahdy; Mohammad Kurniawan; Berry Juliandi; Puspita Eka Wuyung; Yayi Dwina Bilianti Susanto
HAYATI Journal of Biosciences Vol. 24 No. 4 (2017): October 2017
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1838.272 KB) | DOI: 10.4308/hjb.24.4.187

Abstract

Cerebral ischemia is among the most common type of stroke seen in patient. Regeneration of death neurons remains questionable. Human umbilical cord blood mononuclear cell(cbMNC) is one of the treatment options for ischemia stroke through their various advantages; availability, pluripotency, and immaturity. One group of healthy rats and three groups (n = 6 per group) of male Wistar rats undergone permanent middle cerebral artery occlusion (MCAO). Rats were allowed to recover for 7 days before intraarterial and intravenous injection of 1 × 106 cells/kg of human cbMNC. Behavioral tests were performed before the MCAO, 1 week after MCAO, and at 3, 9, and 14 days after cbMNC injection. Brain infarct area and neurons in hippocampus were evaluated. Spontaneous activity was much significantly improved compared with the placebo group (p < 0.05). Comparing the neuron cells in hippocampus, intraarterial and intravenous have more changes in neurons morphology. No effect of cbMNC implantation in decreasing infarct area. Safety of xenogenic was confirmed by this study when the dosage of 1 × 106 cells/kg was used and showed their beneficial effects.
Detecting neurodevelopmental problems in children aged 1-5 years using the simple parent-reported screening tool in combination with primitive reflex assessment Nicholas Calvin; Yetty Ramli
Paediatrica Indonesiana Vol 60 No 1 (2020): January 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.375 KB) | DOI: 10.14238/pi60.1.2020.31-6

Abstract

Background The Kuesioner Pra Skrining Perkembangan/DPsQ (Developmental Pre-screening Questionnaire/DPsQ) is a series of questions and instructions used as a developmental screening tool for children aged 3 months to 6 years. However, the DPsQ cannot fully detect the soft signs of future neurological disorders. However, the retained primitive reflex assessment as an adjunct to the DPsQ may be useful for such detection. Objective To determine whether assessing for retained primitive reflexes can add to the usefulness of DPsQ as a neurodevelopmental screen in children aged 1 to 5 years. Methods This cross-sectional study included children aged 1-5 years. Developmental screening was done using the DPsQ and retained primitive reflex assessment was performed using the Institute for Neuro-Physiological Psychology (INPP) screening and scoring guideline. Results Of 46 subjects, 56.8% of children with normal DPsQ scores had not retained primitive reflexes, while 88.9% of children with suspect DPsQ score had retained primitive reflexes. Hence, children with suspect DPsQ score had a 10.5 times higher chance of retaining primitive reflexes (OR 10.50; 95%CI 1.19 to 92.73; P=0.034). Furthermore, 66.7-77.8% of children with suspect DPsQ score had retained the Moro reflex, asymmetrical tonic neck reflex (ATNR), and symmetrical tonic neck reflex (STNR). Neither gender nor age were significantly associated with either suspect DPsQ score or the presence of retained primitive reflexes. Conclusion The DPsQ results correlate to integration of primitive reflexes, with 10.50 greater odds of children with ‘suspect’ DPsQ scores to have retained primitive reflexes. As such, retained primitive reflexes is not useful as a primary screen for future neurological problems. However, a high percentage of children (43.2%) with normal DPsQ scores also have retained primitive reflexes.
Interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) as proinflammatory cytokines in traumatic brain injury (TBI) of rat (Sprague-Dawley) : A study of propofol administration Riyadh Firdaus; Franciscus Dhyana Giri Suyatna; Aida Rosita Tantri; Yetty Ramli; Ekowati Handharyani; Arni Diana Fitri
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

The increase in the prevalence of traumatic brain injury (TBI) followed by increased morbidity and mortality challenges anesthetists to perform the treatment patients with TBI. Menwhile, interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) are the first pro-inflammatory markers expressed after secondary injury occurs. In addition, propofol (2,6-disopropylphenol) is a short-acting intravenous agent that reported to play role in inflammatory process. This study aims to determine the effects of propofol administration on the neuroinflammatory pathway. Thirty adult female Sprague Dawley rats were randomly assigned as TBI rats (T), rats that received propofol infusion (P), or TBI rats that received propofol infusion (TP). The rat model of TBI was developed using the Marmarou Weight Drop method. Clinical assessment was performed using the Neurobehavioral Severity Score-Revised (NSS-R). Brain tissues were taken 24 h after TBI and the levels of interleukin-1 (IL-1) and interleukin-6 (IL-6) mRNA expression levels were examined using qRT-PCR, while the concentration were examined using ELISA and immunohistochemistry. On clinical examination, a decrease in the median value of NSS-R in the TP group was found from 30th minute to 120th minute. 24 hours after the occurrence of TBI, there was a decrease in both the TP and T groups. However, the NSS-R values in the TP group were lower than those in the T group. The expression of IL-1β was found in the nuclei and cytosol, while IL-6 was found in the axons and cytosol. The expression and concentration of IL-1β and IL-6 were the highest in the TP group, followed by the P and then the T group. Propofol can improve neurological function in rats with TBI, probably through the mechanism involves neuroinflammatory pathways, particularly IL-1β and IL-6.
Factors associated with cognitive and communication delay in children aged 0 to 3 years using the Battelle-Developmental Inventory, 2nd edition Florentina Febrina; Veronika Cendana Pinasthika Lawalata; Yetty Ramli
Paediatrica Indonesiana Vol 63 No 4 (2023): July 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.4.2023.282-9

Abstract

Background The first years of life are crucial in cognitive and communication development. Delayed functional development impedes children’s future academic and occupational performance. Therefore, early detection is important for effective resolution in order to minimize further impairment. Objective To evaluate cognitive and communication developmental delay in children under 3 years of age in Jakarta using the Battelle Developmental Inventory, 2nd edition (BDI-2). Methods A cross-sectional study was conducted in Jakarta in 2020, including children aged under 3 years of age without chronic medical conditions that hinder cognitive and speech function. We collected subjects’ demographic characteristics, evaluated their communication and cognitive development using the BDI-2, and analyzed for risk factors of delays. Results Of 121 children, 34 (28.1%) had cognitive delay and 21 (17.4%) had communication delay. Bivariate analysis revealed that male gender (P=0.048) and non-exclusive breastfeeding (P=0.003) were significantly associated with communication delay, while only male gender was associated with cognitive delay (P=0.015). Multivariate analysis revealed that significant risk factors for communication delay were male gender (P=0.043) and non-exclusive breastfeeding (P=0.023). Conclusion Male gender and non-exclusive breastfeeding are significant risk factors for delayed communication development, and only male gender was a significant risk factor for cognitive delay. Socioeconomic status, primary caregiver, and breastfeeding duration, were not found to be risk factors for delays.
Co-Authors Adre Mayza Adre Mayza Adre Mayza Adrian Cristianto Yusuf Agus Sugiharto Ahmad Sulaiman Alwahdy Alwahdy, Ahmad S. Amanda Soebadi Andira Larasari Arni Diana Fitri Astri Budikayanti Berry Juliandi Chandrika Najwa Malufti Dewi Friska Dyah Tunjungsari, Dyah Ekowati Handharyani Florentina Febrina Franciscus D. Suyatna Irma Savitri Madjid Jeanne A. Pawitan Kartika Maharani Kurniawan, Mohammad Lastri, Diatri Nari Malufti, Chandrika Najwa Nicholas Calvin Pukovisa Prawiroharjo Pukovisa Prawiroharjo, Pukovisa Puspita E. Wuyung Puspita Eka Wuyung Pusponegoro, Hardiono Djuned Ramdinal Aviesena Zairinal Riyadh Firdaus Susanto, Yayi D.B. Tantri, Aida Rosita Taufik Mesiano Tiara Aninditha Tiara Aninditha Urfianty, Urfianty Veronika Cendana Pinasthika Lawalata Widaja, Edhijanto Yayi Dwina Bilianti Susanto