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Kurniawan, Mohammad
Divisi Neurovaskular Dan Neurosonologi, Departemen Neurologi, RSUPN Dr. Cipto Mangunkusumo, Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia
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Permanent flame-blunted monofilament of middle cerebral artery occlusion technique for ischemia stroke induction in animal models Ramli, Yetty; Alwahdy, Ahmad S.; Kurniawan, Mohammad; Juliandi, Berry; Wuyung, Puspita E.; Susanto, Yayi D.B.
Medical Journal of Indonesia Vol 26, No 3 (2017): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (564.83 KB) | DOI: 10.13181/mji.v26i3.1645

Abstract

Background: Rat is the most frequently used animal for ischemic stroke studies. Recently, middle cerebral artery occlusion (MCAO) by introducing various types of surgical monofilament intraluminally has been widely used, with their advantages and disadvantages. For permanent occlusion, problems with mortality in rats are higher than transient. In this study, we used permanent occlusion using modified monofilament by flaming on its tip which may reduce mortality rate, so that chronic phase of stroke can be learned extensively.Methods: Three male Sprague-Dawley rats underwent permanent MCAO. The flame-blunted monofilament was introduced through common carotid artery. Hematoxylin eosin histopathology confirmation and functional assessment post-stroke induction were then evaluated.Results: Evaluation was conducted on 3 rats in different time post-stroke induction (48 hours, 72 hours, and 3 weeks). Using histopathological examination, the infarction was proved in all 3 rats showing red neurons, perivascular edema and neutrophil spongiosis, in infarct and peri-infarct area. The changes in histopathology showed spongiosis were more dominant in 3 week-post-MCAO rats. On the other hand, red neurons and perivascular edema were less compared to 48 and 72-hour-post-MCAO rats.Conclusion: Flame–blunted monofilament showed its efficacy in producing infarct area. The advantages of this technique are easy to perform with simple and less expensive modification of the monofilament. Conducting successful permanent occlusion with less mortality rate will give chances to do further research on stroke in chronic phase and its effect on novel treatment.
ANALISIS TINGKAT KEBUGARAN PADA PEGAWAI PUSKESMAS KURNIAWAN, MOHAMMAD; SUDIJANDOKO, ANDUN
Jurnal Kesehatan Olahraga Vol 7, No 2 (2019): Edisi Juli 2019
Publisher : Jurnal Kesehatan Olahraga

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Abstract

ABSTRAK Tujuan dalam penelitian ini adalah Untuk mengetahui seberapa besar tingkat kebugaran jasmani pada pegawai puskesmas bulangan hajiKabupaten Pamekasan. Jenis penelitian ini adalah penelitian non-eksperimen dengan menggunakan pendekatan deskripsi kuantitatif. jumlah sampel penelitian ini adalah 17 laki-laki pegawai puskesmas bulangan haji kabupaten pamekasan. Penelitian ini menggunakan instrument tes Multi Fitness Test (MFT) yang di lakukan 1 kali pertemuan. Hasil analisis data menggunakan Statistical Program For Social Science (SPSS) 22.0 di ketahui bahwa persentase hasil tingkat kebugaran jasmani pada pegawai puskesmas bulangan haji Kabupaten Pamekasan termasuk dalam berkategori kurang sekali dengan persentase dibawah rata-rata. Maka dapat di simpulkan bahwa tingkat kebugaran jasmani pada pegawai puskesmas laki laki bulangan haji memiliki tingkat kebugaran jasmani yang masih berkategori dibawah rata-rata. Kata Kunci:Kebugaran jasmani, Multi Fitness TestABSTRACT The purpose of this research is to learn the level of fitness of the employees of Puskesmas Bulangan haji, in the kabupaten of Pamekasan. This research is a non-experimental research with a descriptive quantitative approach. The number of samples in this research is 17 male employees of Bulangan haji Puskesmas. This research utilizes a Multi Fitness Test as a test instrument which is used in one meeting. The analysis of the data uses Statistical Program For Social Science (SPSS) 22.0.it is known that the percentage of the physical fitness of the employees of Bulangan haji puskesmas is in the physical conditions of the employees are in the very poor category with a below average percentage. It can be concluded that level of physical fitness of the male employees is categorized as below average. Keywords: Physical Fitness, Multi Fitness Test
Intravenous Versus Intraarterial Transplantation of Human Umbilical Cord Blood Mononuclear Cells for Brain Ischemia in Rats Yetty Ramli; Ahmad Sulaiman Alwahdy; Mohammad Kurniawan; Berry Juliandi; Puspita Eka Wuyung; Yayi Dwina Bilianti Susanto
HAYATI Journal of Biosciences Vol. 24 No. 4 (2017): October 2017
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1838.272 KB) | DOI: 10.4308/hjb.24.4.187

Abstract

Cerebral ischemia is among the most common type of stroke seen in patient. Regeneration of death neurons remains questionable. Human umbilical cord blood mononuclear cell(cbMNC) is one of the treatment options for ischemia stroke through their various advantages; availability, pluripotency, and immaturity. One group of healthy rats and three groups (n = 6 per group) of male Wistar rats undergone permanent middle cerebral artery occlusion (MCAO). Rats were allowed to recover for 7 days before intraarterial and intravenous injection of 1 × 106 cells/kg of human cbMNC. Behavioral tests were performed before the MCAO, 1 week after MCAO, and at 3, 9, and 14 days after cbMNC injection. Brain infarct area and neurons in hippocampus were evaluated. Spontaneous activity was much significantly improved compared with the placebo group (p < 0.05). Comparing the neuron cells in hippocampus, intraarterial and intravenous have more changes in neurons morphology. No effect of cbMNC implantation in decreasing infarct area. Safety of xenogenic was confirmed by this study when the dosage of 1 × 106 cells/kg was used and showed their beneficial effects.
INDONESIAN VERSION OF THE PAINDETECT QUESTIONNAIRE IN THE ASSESSMENT OF NEUROPATHIC PAIN: A VALIDITY AND RELIABILITY STUDY Karolina Margareta; Manfaluthy Hakim; Mohammad Kurniawan; Tiara Anindhita; Herqutanto
Jurnal Sinaps Vol. 4 No. 2 (2021): Volume 4 Nomor 2, Juni 2021
Publisher : Neurologi Manado

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Objective: To develop an Indonesian version of PainDETECT Questionnaire (PDQ-Ina) and assess itsvalidity and reliability. Methode: The validity and reliability study was conducted at the Neurology ClinicCipto Mangunkusumo General Hospital, Jakarta from March 2014 until May 2014 using cross sectionaldesign. Sample of the research was done by non random consecutive sampling method. and were takenfrom each participant who met the inclusion criteria, measuring reliability of painDETECT Questionnaires(PDQ) using statistical analysis and retest test method within 24-48 hours interval. Result:There were150 subjects with chronic pain. Divided in to 3 types of group based on Indonesian version PDQ scoring,75 patients having nociceptive pain, 42 were mixed pain and 33 patients having neuropathic pain. Withinvalidation criteria analysis there were high correlation between PDQ-Ina with LANSS instrument as goldstandard (r= 0,082,p<0,001), AUC 85,5%, sensitivity 78,3% and specificity 78,7% with the optimal cut offpoint ≥17. The reliability of internal consistency Cronbach’s Alpha value were 0,710 and the test retestrealibility were 0,96. Conclusion :The Indonesian version of the PDQ is a valid and reliable scale andhave a good sensitivity and specificity to be used to determine neuropathic component of chronic pain.
PREDIKTOR SYMPTOMATIC INTRACEREBRAL HEMORRHAGE PASCATROMBOLISIS INTRAVENA PADA STROKE ISKEMIK AKUT Al Rasyid; Salim Harris; Mohammad Kurniawan; Rakhmad Hidayat; Taufik Mesiano
NEURONA Vol 35 No 3 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i3.12

Abstract

PREDICTORS OF SYMPTOMATIC INTRACEREBRAL HEMORRHAGE FOLLOWING INTRAVENOUS THROMBOLYSIS IN ACUTE ISCHEMIC STROKEABSTRACTDespite its effectiveness, the percentage of ischemic stroke patients who received definitive treatment, thrombolysis, never went above 10%, due to one of the reason is the occurrence of severe, post-therapeutic complications, such as symptomatic intracerebral hemorrhage (sICH). Several factors contribute to sICH occurrence are age, severity of stroke, early changes of ischemic sign, hyperglycemia, blood pressure, antiplatelet use and its interval. Patients with highest risk of sICH has been shown to have the greatest benefits from thrombolysis among other subgroup patients, therefore withholding therapy is not a choice. Compliance to the stroke’s guidelines could reduce the risk of complications as well as boost effectiveness of treatment.Keywords: Safety predictors, acute ischemic stroke, thrombolysis, sICH ABSTRAK Walau terbukti efektif, persentase pasien yang dapat dilakukan tindakan definitif stroke iskemik akut berupa trombolisis  tidak  pernah  mencapai  angka  10%,  salah  satunya  disebabkan  pertimbangan  terhadap  komplikasi  berat, seperti symptomatic intracerebral hemorrhage (sICH). Beberapa faktor yang berpengaruh terhadap kejadian sICH antara lain usia, derajat stroke, perubahan tanda iskemik dini, hiperglikemia dan diabetes melitus, tekanan darah, penggunaan antiplatelet, serta waktu pemberian. Pasien dengan risiko sICH tertinggi memiliki keuntungan terbesar dari trombolisis sehingga menunda tindakan bukanlah suatu opsi. Kepatuhan terhadap panduan tindakan dapat mengurangi angka kejadian komplikasi berat.Kata kunci: Prediktor keamanan, stroke iskemik akut, trombolisis, sICH
PERDARAHAN INTRASEREBRAL SEBAGAI KOMPLIKASI NEUROLOGI EMBOLI SEPTIK PADA ENDOKARDITIS INFEKTIF: SEBUAH LAPORAN KASUS Mohammad Kurniawan; Salim Harris; Al Rasyid; Taufik Mesiano; Rakhmad Hidayat; Yesi Astri
NEURONA Vol 36 No 4 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i4.93

Abstract

      INTRACEREBRAL HEMORRHAGE AS A NEUROLOGICAL COMPLICATION OF SEPTIC EMBOLISM IN INFECTIVE ENDOCARDITIS: A CASE REPORTABSTRACTInfective endocarditis (IE) is a life-threatening disease. The incidence of IE in developing countries is reported at 1.7-6.2 per 100,000 individuals per year. IE is also known as a potential condition for embolization, especially septic embolism to the brain. Septic embolism results in various neurological complications and manifestations due to vascular occlusion, aneurysm formation and rupture of the aneurysm. We report a case of 34-year-old male with definitive IE based on Duke criteria who experienced neurological complications of intracerebral bleeding. Patient was given pharmacological treatment according to the guidelines of the American Heart Association (AHA)with improvement in clinical symptoms.Keywords: Infective endocarditis, intracerebral hemorrhage, septic embolismABSTRAKEndokarditis infektif (EI) merupakan penyakit yang mengancam nyawa, walaupun angka kejadiannya kecil, yaitu 1,7-6,2 per 100.000 individu per tahun di negara berkembang. EI juga sangat potensial menyebabkan embolisasi, khususnya emboli septik ke otak. Emboli ini mengakibatkan manifestasi gangguan neurologis yang disebabkan karena oklusi pembuluh pembentukan dan ruptur aneurisma. Dilaporkan kasus seorang laki-laki 34 tahun dengan EI definitif berdasarkan kriteria Duke yang mengalami komplikasi neurologis perdarahan intraserebral. Pasien ditatalaksana sesuai panduan American Heart Association (AHA) dengan perbaikan gejala klinis.Kata kunci: Endokarditis infektif, emboli septik, perdarahan intrakranial  
MEMBANGUN SISTEM CODE STROKE PADA DUA RUMAH SAKIT PENDIDIKAN DI INDONESIA Rakhmad Hidayat; Hirari Fattah Yasfi; Dinda Diafiri; Reyhan Eddy Yunus; Andi Ade Wijaya Ramlan; Taufik Mesiano; Mohammad Kurniawan; Al Rasyid; Salim Harris
NEURONA Vol 37 No 3 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.165

Abstract

Code stroke system is rapid respond system for ischemic stroke patient’s care to have immediate therapy in order to increase effectiveness and achieve maximum outcome. Cipto Mangunkusumo Hospital and Universitas Indonesia Hospital are educational hospitals with different background, resources, facilities, and conditions in code stroke system implementation. This paper compares the code stroke system between both hospitals from some aspects, such as emergency unit health care providers, cost and facility, diagnostic imaging, initiator of code stroke system, observation room, availability of catherization lab, and communication within code stroke team. Code stroke system can be implemented in many hospitals correspondingly adjusting each of hospital conditions by maximizing advantages to cover the hospital’s shortcomings. Keywords: Code stroke, hospital, ischemic stroke, thrombectomy, thrombolysis
KEJADIAN STROKE ISKEMIK PADA PASIEN POSITIF COVID-19 TERKONFIRMASI DI RUMAH SAKIT UNIVERSITAS INDONESIA Rakhmad Hidayat; Gemia Clarisa Fathi; Ramdinal Aviesena Zairinal; Raden Rara Diah Handayani; Mohammad Kurniawan; Taufik Mesiano; Al Rasyid; Salim Harris
NEURONA Vol 38 No 2 (2021)
Publisher : PERDOSNI

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Abstract

Coronavirus disease 2019 (COVID-19) is not only disrupts the respiratory system, it can disrupt various organ systems, one of which is the central nervous system. Indonesia still has a little literature that discusses COVID-19 and its relation to ischemic stroke. This study aims to report the course of ischemic stroke cases in patients who have been confirmed positive for COVID-19. A 56 year old man presented with confirmed COVID-19, the patient had a history of type 2 diabetes mellitus and also a history of dyslipidemia. At initial presentation the patient did not complain of neurological symptoms, but after 12 days of treatment the patient complained of weakness in the left side of the upper leg. The CT scan of the head with contrast revealed an infarction in the peripheral area, perfusion CT found that the patient was hypoperfused in the right cerebral hemisphere area without the presence of a large core infarction or a clear perfusion mismatch defect. CT angiography did not reveal stenosis or occlusion of the large vessels. It can be concluded that ischemic stroke in COVID-19 patients can occur due to various underlying factors, one of which is hypercoagulability. Keywords: COVID-19, Stroke, Universitas Indonesia Hospital
PROFIL KLINIS DAN LUARAN STROKE ISKEMIK AKUT DENGAN TROMBEKTOMI MEKANIK BERDASARKAN LOKASI OKLUSI DI RSUPN DR. CIPTO MANGUNKUSUMO Kevin Kevin; Taufik Mesiano; Mohammad Kurniawan; Rakhmad Hidayat; Affan P. Permana; Al Rasyid; Salim Harris
NEURONA Vol 38 No 3 (2021)
Publisher : PERDOSNI

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Abstract

Introduction: Occlusion in anterior circulation gives variable clinical manifestations. Mechanical thrombectomy promises almost two times higher recanalization rate as opposed to thrombolysis. Aim: To evaluate the clinical and outcome profile of acute ischemic stroke patients who underwent mechanical thrombectomy based on the occlusion site. Methods: This was a retrospective cohort conducted at Cipto Mangunkusumo National Referral Hospital from May 2017 to January 2020. All acute ischemic stroke patients in anterior circulation who underwent mechanical thrombectomy with or without bridging intravenous thrombolysis were analyzed. Occlusion site and recanalization rate were scored based on arteriogram. Results: Sixteen patients had occlusion in ICA-M1 segment, while ten others were in the M2 segment. NIHSS value was two points higher in ICA-M1 occlusion (p>0.05), which further analysis found that the proportion of aphasia manifestation was higher in the ICA-M1 segment (50.0% vs 20.0%; p=0.218). Demographical and clinical characteristics were similar between the two groups. Thrombolysis did not modify the occlusion site on thrombectomy (p>0.05). Despite statistical insignificancy, ICA-M1 occlusion showed an earlier time trend from admission to recanalization. The M2 segment had a higher proportion of mTICI 2b/3 recanali????ation (50.0% vs 70.0%; p=0.428) and mRS 0-2 on discharge (12.5% vs 50.0%; p=0.053). Discussion: Aphasia was more common in proximal occlusion???? which drove family members to bring patients earlier to the hospital. The functional outcome on discharge was lower in proximal occlusion due to more extensive and permanent brain tissue loss. Future coordination is warranted to improve the therapeutic time from admission to recanalization. Keywords: functional outcome, ischemic stroke, mechanical thrombectomy, occlusion site
Pengaruh Kompetensi dan Disiplin Kerja Terhadap Kinerja Pegawai Pada Dinas Kebudayaan Kota Palembang Afif, M. Bariq Naufal; Kurniawan, Mohammad; Veronica, Meilin
Jurnal EMT KITA Vol 7 No 4 (2023): OCTOBER 2023
Publisher : Lembaga Otonom Lembaga Informasi dan Riset Indonesia (KITA INFO dan RISET) - Lembaga KITA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/emt.v7i4.1687

Abstract

The purpose of this study was to determine the effect of competence and work discipline on the performance of employees at the Palembang city cultural service. This study used quantitative and primary data by distributing questionnaires to employees of the cultural office of the city of Palembang. The population in this study were 60 respondents with a sampling technique using the slovin formula with ordinal scale measurements. The data were processed through the SPSS version 24 program with multiple linear regression analysis techniques. The results of this study indicate that competence has a positive and significant effect on employee performance, while work discipline has no effect on employee performance. From the results of the t test proves that competence has a partial effect on employee performance, work discipline has a partial effect on employee performance. Then the results of the f test prove competence and work discipline simultaneously affect employee performance by looking at the Fcount value that isgreater than Ftable, namely (44.985 > 3.16) with a significance value of 0.000 <0.05. The competency variable is the variable that has the greatest influence on employee performance at the Palembang city cultural service.
Co-Authors Affan P. Permana Afif, M. Bariq Naufal Agiska, Bella Putri Ahmad Sulaiman Alwahdy Al Rasyid Aldina, Rizky Alexander, Fooann Alwahdy, Ahmad S. Andi Ade Wijaya Ramlan ANDUN SUDIJANDOKO Aris Munandar Berry Juliandi Dinda Diafiri Eka Agustina, Eka Fritz Sumantri Usman, Fritz Sumantri Gemia Clarisa Fathi Herqutanto Hirari Fattah Yasfi Intan, Amelia Nur Karolina Margareta Kevin Kevin Khalily, Muhammad Naufal Marnisah, Luis Masawir, Bambang Moh Hasan Machfoed, Moh Hasan Pukovisa Prawiroharjo, Pukovisa Puspita E. Wuyung Puspita Eka Wuyung Putri Putri, Putri Raden Rara Diah Handayani Rakhmad Hidayat Rakhmad Hidayat Rakhmad Hidayat Rakhmad Hidayat Rakhmad Hidayat Ramdinal Aviesena Zairinal Ramli, Yetty Reyhan Eddy Yunus Roswaty Salim Harris Salim Harris Salim Harris Salim Harris Saputri, Efrillia Missel Susanto, Yayi D.B. Taufik Mesiano Taufik Mesiano Taufik Mesiano Taufik Mesiano Tiara Anindhita Veronica, Meilin Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yayi Dwina Bilianti Susanto Yesi Astri