Garuda - Garba Rujukan Digital

p-Index From 2021 - 2026

1.037

P-Index

This Author published in this journals

All Journal JURNAL KIMIA SAINS DAN APLIKASI Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Chimica et Natura Acta Pharmacoscript Jurnal Ilmiah Farmako Bahari

Fajar Fauzi Abdullah

Program Studi Kimia Fakultas Matematikan Dan Ilmu Pengetahuan Alam Universitas Garut

Author-ID : 5301197

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 6 Documents Claim Missing Document

Claim Missing Document

Articles

Analisa Karakteristik Simplisia Buah Andaliman (Zanthoxyllum acanthopodium) Serta Aktivitas Penghambatan Xantin Oksidase Dhini Anisa; Fajar Fauzi Abdullah; Riza Apriani; Gun Gun Gumilar; Iqbal Musthapa
Chimica et Natura Acta Vol 7, No 3 (2019)
Publisher : Departemen Kimia

Gout atau hiperurisemia adalah keadaan dimana terjadinya peningkatan kadar asam urat dalam darah. Xantin oksidase berperan dalam oksidasi xantin dan hipoxantin menjadi asam urat. Salah satu pengobatan kelebihan asam urat adalah menghambat aktivitas enzim xantin oksidase. Penelitian ini menguji aktivitas anti asam urat ekstrak etanol dari buah andaliman kemudian dan menentukan nilai persentase penghambatannya. Hasil pengujian menunjukkan bahwa ekstrak buah andaliman memiliki potensi yang baik untuk menjadi kandidat antihiperurisemia, dengan nilai persentase penghambatannya sebesar 70,67% pada konsentrasi ekstrak sebesar 100 µg/mL.

Cytotoxic Activity of Ethyl-para-methoxycinnamate from Kaempferia galanga L. on A549 Lung Cancer and B16 Melanoma Cancer Cells Riza Apriani; Fajar Fauzi Abdullah
Jurnal Kimia Sains dan Aplikasi Vol 24, No 1 (2021): Volume 24 Issue 1 Year 2021
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Kaempferia galanga L. belongs to the family of Zingiberaceae, an endangered medicinal plant with pharmacology activities. Ethyl-p-methoxycinnamate (EPMC) is an essential phytoconstituent of K. galanga rhizomes. Several studies have reported that EPMC has anticancer activities in several cancer cells, including CL-6 gallbladder cancer cells, HepG2liver cancer cells, MCF-7 breast cancer cells, and Raji lymphoma cancer cells. However, studies on A549 lung cancer and B16 melanoma cancer cells have not been reported. This study aimed to determine the anticancer activity of EPMC against A549 lung cancer and B16 melanoma cancer cells. EPMC was obtained by extraction using n-hexane, then recrystallized with chloroform. The isolate was then analyzed by thin-layer chromatography (TLC), and the structure was characterized by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy. Cytotoxic activity was determined under Presto Blue assay. Based on the result, EPMC from K. galanga showed the cytotoxic effect on B16 cells with an IC50 value of 97.09 μg/mL, whereas EPMC showed no significant cytotoxic effect on A549 with an IC50 value of 1407.75 μg/mL. It was concluded that EPMC has potential cytotoxic on B16 melanoma cancer cells, but it showed inactive activity against A549 lung cancer cells. Further molecular mechanism underlying EPMC cytotoxic activity needs to be conducted.

AKTIVITAS ANTIKANKER KURKUMINOID TERHADAP SEL MELANOMA B16-F10 Sandra Amalia Riyadi; Fajar Fauzi Abdullah; Fitri Fadhilah; Nurul Assidiqiah
Jurnal Ilmiah Farmako Bahari Vol 13, No 2 (2022): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v13i2.1458

Kurkuminoid berasal dari rimpang kunyit (Curcuma Longa L.) yang memiliki ketiga komponen utama penyusunnya diantaranya kurkumin, demetoksikurkumin dan bisdemetoksikurkumin. Secara struktur ketiganya hanya berbeda pada subtituen gugus metoksi, namun mampu memberikan efek biologis yang berbeda. Kurkumin dalam beberapa tahun kebelakang menjadi salah satu target pengembangan penelitian sebagai agen antikanker yang dilakukan terhadap beberapa sel kanker. Namun, kemampuan kurkumin sebagai antikanker menjadi sangat terbatas akibat rendahnya kelarutan kurkumin dalam air, yang mempengaruhi rendahnya penyerapan senyawa kurkumin oleh sel dalam tubuh. Maka dari itu menjadi sangat perlu dilakukannya penelitian lebih lanjut untuk melihat aktivitas antikanker dari senyawa kurkumin lainnya yaitu demetoksikurkumin dan bisdemetoksikurkumin. Rimpang kunyit yang telah dikeringkan kemudian dimaserasi dengan etanol selama 3x24 jam kemudian maserat yang diperoleh diuapkan dengan rotary evaporator sehingga didapatkan ekstrak pekat etanol kunyit. Selanjutnya dilakukan partisi dengan pelarut n-heksan, etil asetat, dan n-butanol. Fraksi etil asetat kemudian dipekatkan dan dilakukan berbagai jenis metode pemisahan sehingga didapatkan ketiga senyawa kurkuminoid. Selanjutnya, isolat yang sudah terkarakterisasi di lakukan uji sitotoksik terhadap sel B16-F10 dengan menggunakan Metode Reduksi Resazurin. Hasil penelitian menunjukkan adanya perbedaan aktivitas penghambatan yang signifikan diantara ketiga isolat. Bisdemetoksikurkumin memiliki aktivitas penghambatan tertinggi dengan nilai IC50 16,20 µg/mL. Setelah itu, demetoksikurkumin dengan nilai IC50 22,59 µg/mL dan yang terakhir adalah kurkumin dengan nilai IC50 152,71 µg/mL.

Isolation and Structure Determination of Stigmaterol from the Stem Bark of Lansium domesticum Corr. Cv. Kokossan Siska Elisahbet Sinaga; Fajar Fauzi Abdullah; Unang Supratman; Tri Mayanti; Rani Maharani
Chimica et Natura Acta Vol 10, No 3 (2022)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v10.n3.39240

Indonesia is a tropical country with biodiversity and a source of natural compounds such as terpenoids, phenolic, flavonoids, and alkaloid groups. The steroid is one of the large groups of terpenoid compounds with various structures and bioactivities. The steroid was also commonly found in the Meliaceae family. One species of this family is Lansium domesticum Corr. which has been studied to have various activities from isolated compounds (limonoids, sesquiterpenoids, onoceranoids, cycloartanoids, and steroids) as well as from their extracts such as antidiarrheal, antimalarial, antimicrobial, antiinsecticide, antifeedant and were used as traditional medicine such as eye drops and scorpion stings. The n-hexane fraction from the bark of L. domesticum Cor. cv. Kokosan produced steroid compounds whose structure is determined by IR, 1H-NMR, 13C-NMR, and DEPT spectroscopy methods and compared with the literature. It was concluded that the steroid isolated was (22E)-stigmasta-5,22-dien-3ol and was first isolated from this genus. This compound was inactive against MCF-7 breast cancer cells with an IC50 value of 832.14 µM.

Pelatihan Pembuatan Lotion Antinyamuk Berbasis Minyak Atsiri untuk Meningkatkan Pengetahuan Siswa SMAN 30 Garut Aika Latifah Alawiyah; Fajar Fauzi Abdullah; Ruchiyat; Farid Perdana; Isye Martiani; Jasminum Sambact; Rahma Mekar Muharram
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 12 No. 2 (2026): Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.12.2.367-375

Mosquitoes are considered vectors responsible for dengue fever, malaria, and chikungunya. Applying anti-mosquito lotion is a precaution to avoid mosquito bites. Certain commercial items contain diethyltoluamide (DEET), which can be harmful to health and contaminate the environment when used for extended periods. Utilizing essential oils in a anti-mosquito lotion is more eco-friendly. This community service aimed to improve students’ understanding and ability to produce anti-mosquito lotion using essential oils. The training took place at SMAN 30 Garut, involving 35 students from classes X and XII. The training approach involves preparation; implementation (pre-test and post-test to evaluate participants’ knowledge levels, delivering material interactively, and practicing); and evaluating activities through satisfaction questionnaires. A paired t-test analysis of the pre-test and post-test results showed that a t-value of 3,25 with a p-value of 0,012 (< 0,05), indicating a significant improvement in the pupils’ knowledge of the subject matter and their skills in making mosquito-repellent lotion. The percentage of correct answers has increased from 68,57% (pre-test) to 86,35% (post-test). The results indicated that participants responded positively to the activities conducted. The results of the training showed an improvement in students’ understanding of the subjectand their ability to make anti-mosquito lotions. This activity not only provides insight into the use of natural products but also raises students’ interest in entrepreneurial oppoturnities and innovation within schools and the community.

AKTIVITAS INHIBISI α-AMILASE EKSTRAK ETANOL DAN BERBAGAI FRAKSI KULIT BATANG MAHONI (Swietenia mahagoni (L.) Jacq) Qowiyyah Atun; Kartika Dita; Febriani Deswita; Haq Fikri Rijalul; Abdullah Fajar Fauzi
Pharmacoscript 2025: Special Issue Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v1iSpecial.2492

Diabetes Mellitus (DM) ialah penyakit yang dicirikan hiperglikemia kronis akibat sekresi dan/atau kerja insulin yang tidak adekuat. Salah satu strategi pengendalian kadar glukosa darah adalah melalui penghambatan enzim pencerna karbohidrat seperti α-amilase. Studi literatur menunjukkan tumbuhan mahoni memiliki aktivitas antidiabetes in vitro maupun in vivo. Tujuan penelitian ini adalah mengetahui aktivitas inhibisi enzim α-amilase ekstrak etanol dan berbagai fraksi kulit batang mahoni (Swietenia mahagoni (L.) Jacq.) dan menentukan nilai IC₅₀-nya. Metode maserasi digunakan untuk mengekstraksi simplisia kulit batang mahoni dengan etanol 96%, kemudian fraksinasi dengan metode ekstraksi cair–cair menggunakan etil asetat, n-heksan, n-butanol, serta air. Uji inhibisi α-amilase dilakukan dengan metode kolorimetri menggunakan reagen 3,5-dinitrosalisilat untuk mengukur produk gula pereduksi yaitu maltosa. Akarbose digunakan sebagai pembanding. Hasil penelitian menunjukkan adanya aktivitas inhibisi α-amilase dari ekstrak etanol maupun fraksi kulit batang mahoni dengan IC₅₀ fraksi etil asetat sebesar 0,68 µg/mL; diikuti oleh ekstrak etanol (IC₅₀ = 9,02 µg/mL); fraksi air (IC₅₀ = 9,36 µg/mL); fraksi n-butanol (IC₅₀ = 16,59 µg/mL); dan fraksi n-heksan (IC₅₀ = 379,035 µg/mL); dibandingkan dengan akarbose (IC₅₀ = 1,896 µg/mL). Fraksi etil asetat kulit batang mahoni menunjukkan aktivitas inhibisi α-amilase yang paling tinggi dibanding ekstrak etanol atau fraksi lainnya. Hasil ini menunjukkan bahwa fraksi etil asetat kulit batang mahoni berpotensi sebagai inhibitor α-amilase alami untuk pengendalian kadar glukosa darah.

Co-Authors Aika Latifah Alawiyah Dhini Anisa Febriani Deswita Fitri Fadhilah Gun Gun Gumilar Haq Fikri Rijalul Iqbal Musthapa Isye Martiani Jasminum Sambact Kartika Dita Nurul Assidiqiah Perdana, Farid Qowiyyah Atun Rahma Mekar Muharram Rani Maharani Riza Apriani Ruchiyat Sandra Amalia Riyadi Siska Elisahbet Sinaga Tri Mayanti Unang Supratman

Title

Found 6 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 6 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 6 Documents
Search