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CHAIDIR A MOCHTAR
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Internal Genital Organ-preserving Radical Cystectomy: A Case Report FINA WIDIA; GERHARD R SITUMORANG; AGUS RIZAL A.H HAMID; CHAIDIR A MOCHTAR
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.53 KB) | DOI: 10.33371/ijoc.v10i2.429

Abstract

ABSTRACTAdenocarcinoma of the bladder is usually managed by radical cystectomy. However, recent literature shows that internal genital organ-preserving radical cystectomy is feasible in selected cases in order to get a better impact on patient’s psychology, sexuality and potential fertility. Here, we report a 32-year-old woman with adenocarcinoma of the bladder who was managed with internal genital organ-preserving radical cystectomy. The patient was never had any child and the radiologic examination (MRI) showed no involvement of internal genitalia organ. This procedure aims to maintain fertility potential of the patient. Intraoperatively, no adhesion was found between the tumor and internal genitalia organ. The internal genitalia organ was successfully preserved during the radical cystectomy. ABSTRAKTata laksana adenokarsinoma kandung kemih umumnya berupa sistektomi radikal. Akan tetapi, penelitian terbaru menunjukkan bahwa preservasi organ internal genitalia dapat diterapkan pada kasus-kasus tertentu dengan tujuan untuk mempertahankan potensi seksual dan fertilitas pasien. Saat ini kami melaporkan seorang perempuan berusia 32 tahun dengan adenokarsinoma kandung kemih yang menjalani sistektomi radikal dengan tetap mempertahankan organ genitalia interna. Pasien merupakan nulipara dan pada pemeriksaan radiologi MRI tidak didapatkan infiltrasi tumor pada organ genitalia interna. Prosedur operasi dilakukan dengan tujuan mempertahankan potensi fertilitas. Intraoperatif, tidak didapatkan perlengketan antara tumor dan organ genitalia interna. Organ genitalia interna berhasil dipreservasi selama prosedur sistektomi radikal.
Karsinoma Pelvis Renis dan Ureter di Jakarta: Karakteristik dan Faktor Risiko YEVRI ZULFIKAR; RAINY UMBAS; CHAIDIR A MOCHTAR
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v4i2.89

Abstract

To study the characteristics,diagnosis and role of upper urinary tract stone as risk factors of renal pelvis and ureter malignancy. Data were collected from medical record of Urology Clinic Ciptomangunkusumo Hospital and Dharmais Cancer Hospital, Jakarta during the period between January 1995 and December 2009. The clinical factors which were studied are age, gender, symptoms, history of stone disease, imaging, histopathology , primary lesions of the tumor, and stage. There were 42 renal pelvis and ureter carcinoma patients during 15 years period. With mean age of 53.5 years (range 33 74). There were 54.8% cases associated with stone disease. The most common histopatology was Transitional Cell Carcinoma (TCC) (47.6%). Ninety two point nine percent cases with Squamous Cell Carcinoma (SCC) are associated with stone or history of operation for stone removal. Symptom of flank tumor occurred in 61.0 % patients, flank pain 58.5 %, and hematuria 53.7 %. Only 71.4 % of cases were detected pre operatively. Pre operative imaging detection were 89.3%, 53.8%, 20.7% for CT Scan USG and IVU respectively . Fifty two point five percents of patients were found on Stage IV and 47.8 % of these patients were associated with stone disease. Most of patients with renal pelvis and ureter carcinoma were associated with stone disease, especially in patients with SCC tumors. There are still some problems in detecting these tumors especially in early stage.
Sistem Skoring Nefrometri R.E.N.A.L: Sistem Berstandar yang Komprehensif Dalam Menilai Ukuran, Lokasi, dan Kedalaman Tumor Ginjal MOCHAMMAD REZA; ARIEF RAKHMAN; CHAIDIR A MOCHTAR
Indonesian Journal of Cancer Vol 8, No 2 (2014): April-Juni 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v8i2.301

Abstract

The treatment of localized renal cell carcinoma remains subjective.The R.E.N.A.L.- Nephrometry Score quantifies the characteristics of renal mass anatomy based on radiologic findings to provide a standardized objective descriptive system in an reproducible manner. We evaluate the utility of this system in predicting tumor resectability, operative approach and risk of complication, and their relevance to clinical practice.Electronic literature research was performed to access the main series of literature in the past 4 years since the scoring system developed. The articles were then analyzed and selected to address these issues. Fifteen peer-reviewed publications (2009 to 2012) were selected. Most of the studies were analyzed using the prospective acquired database. Increasing tumor complexity was asscociated with greater overall nephrometry score in patient underwent renal neprectomy and partial neprectomy. Compared with patients who underwent partial nephrectomy, the patients treated with radical nephrectomy had a significantly greater size (R), central proximity (N), and location (L) component scores. There were more complications among patients with higher R.E.N.A.L scores who underwent partial nechrectomy (PN) thanin patients with PN who did not developcomplications. The R.E.N.A.L nephrometry scoring system has good interobserver reliability showed by the similar sum of nephrometry score concordance to the R, E, N, A, and L components among surgeons in different centre. The R.E.N.A.L nephrometry standardize the reporting of solid renal masses and appears to effectively stratify the treatment choice for patients. Nephrometry aids in objectifying previously subjective measure and provide more meaningful comparison of treatment recommendation or results in published series.
Terapi Radikal pada Penderita Kanker Prostat: Tindak Lanjut Jangka Panjang dan Faktor Prediksi Survival RAINY UMBAS; CHAIDIR A MOCHTAR; RIZAL A HAMID
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v4i2.87

Abstract

Radical treatment in the form of radical prostatectomy (PR) or external beam radiotherapy (EBRT) considered as gold standard in the management of localized and in some selected cases of locally advanced prostate cancer patients. Aim of this study is to know the treatment results of RP and EBRT in prostate cancer patients with T1-3 at Cipto Mangunkusumo Hospital and Dharmais Cancer Hospital, Jakarta. Analysis to the prediction factors in those two treatment modalities was also done. There were 110 patients among 610 prostate cancer patients in those two hospitals between January 1995 and December 2007 who received radical treatment. Radical prostatectomy was done to 43 patients with median age of 63 years (range: 50-74 years), and the other 67 patients with median age of 70 years (range: 50-82 years) were treated by EBRT. Median survival was 101 months and 85 months for patients treated with RP and EBRT respectively while 5-year survival rate was 68.4% and 69.2% for those respective groups. There was no clinical parameter in the group of patients who underwent PR which significantly correlated with survival. In the EBRT group, low grade tumor was significantly correlated with better survival. In conclussion, less than 20% of prostate cancer patients in those two hospitals underwent radical treatment in form of PR or EBRT. Median survival for patients treated with PR was better than those who received EBRT. Tumor grade was the only survival predictor factor in the EBRT group.
Co-Authors AGUS RIZAL A.H HAMID ARIEF RAKHMAN FINA WIDIA GERHARD R SITUMORANG MOCHAMMAD REZA Rainy Umbas RIZAL A HAMID YEVRI ZULFIKAR