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All Journal Paediatrica Indonesiana Indonesian Journal of Cancer
Antony Abel Adibrata
Medical Education Program, Faculty of Medicine, Padjadjaran University, Bandung
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Profile of Soft Tissue Sarcoma Patients who Undergo Radiotherapy in Dr. Hasan Sadikin General Hospital Bandung Antony Abel Adibrata; Marhendra Satria Utama; Adji Kusumadjati
Indonesian Journal of Cancer Vol 16, No 1 (2022): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.561 KB) | DOI: 10.33371/ijoc.v16i1.856

Abstract

Background: Soft Tissue Sarcoma is one of the rare cancers that increased in number in the last few years, but information about soft tissue sarcoma patients was still limited, especially in West Java, Indonesia. This study aimed to find out the patient profile and the histopathological cell distribution of soft tissue sarcoma patients who undergo radiotherapy. Methods: The study design was retrospective descriptive quantitative with the total sampling method. This study was done by observing all patients’ medical records registered from January 1, 2018, until December 31, 2019, in the Hospital-Based Cancer Registry of Radiology Department of Dr. Hasan Sadikin General Hospital Bandung, with the inclusion criterion of patients diagnosed with soft tissue sarcoma.  Results: A total of 5% (n = 75) from 1,388 cases registered were soft tissue sarcoma. The most common patient profile was female (57.3%) and age group 45–54 years (21.3%). The chief complaint was dominated by a painless mass (56.0%) at the lower limb (37.8%) with the most frequent cell of fibrosarcoma (17.3%), the most intention of the radiotherapy of curative adjuvant (78.7%). Conclusions: The number of soft tissue sarcoma is small compared to other malignancies. It is more common in women, the most age group is from 45 to 54 years with the median of 47 years old, ranging from 9 to 90 years, it tends to occur in the lower limb with a chief complaint of a painless mass, and the most frequent cell is fibrosarcoma. The common treatment combination is surgery with radiotherapy
Profile of Nasopharyngeal Cancer Patients who Underwent Radiotherapy in Dr. Hasan Sadikin General Hospital Bandung Indira Meidina Nafisa; Marhendra Satria Utama; Mas Adi Sunardi; Antony Abel Adibrata
Indonesian Journal of Cancer Vol 16, No 2 (2022): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.867 KB) | DOI: 10.33371/ijoc.v16i2.869

Abstract

Background: Nasopharyngeal cancer (NPC) is a malignant epithelial tumor located in the nasopharynx and is the most common head and neck malignancy. This study aimed to find and describe the profile of NPC patients who undergo radiotherapy at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This study was a descriptive study conducted at the Department of Radiology of Dr. Hasan Sadikin General Hospital, Bandung. This study employed a total sampling method and was done by observing patients’ status/medical records from January 1, 2018, to December 31, 2019, which was registered based on the Hospital-Based Cancer Registry (HBCR). The inclusion criteria were all patients diagnosed with NPC and undergone radiotherapy.Results: There were 274 records (19.74%) included as NPC from 1,388 records. This cancer was more frequent in men (70.4%), in the age group of 45–54 years (35.0%), non-active smokers (58.8%), entrepreneurs (23.0%), and those who came from West Priangan (36.1%). The most common chief complaint was an enlargement of neck lymph nodes (55.1%) at stage IVB (42.8%). Histopathological findings were dominated by undifferentiated squamous cell carcinoma (WHO III) (74.4%). Most of the patients were treated with chemoradiation (64.3%).Conclusions: NPC could happen to anyone with different background. This study found it was more frequent in men than women (2.3:1), in the fourth and fifth decade of life, in entrepreneurs followed by housewives, and even in non-active smokers. It also could happen in children to the elderly. Most patients came with an enlargement of neck lymph nodes as their chief complaint in the advanced stage and need chemoradiation as their treatment.
Antibody-synthesizing lymphocytes (AS-LYMP) and reactive lymphocytes (RE-LYMP): novel predictors of severe dengue Saputra, I M Yullyantara; Gustawan, I Wayan; Utama, Made Gede Dwilingga; Lestari, AA Wiradewi; Adibrata, Antony Abel; Dewi, Eleonora Anindya Tiara
Paediatrica Indonesiana Vol. 66 No. 2 (2026): March 2026
Publisher : Indonesian Pediatric Society

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Abstract

Background Dengue fever is a major public health problem in Indonesia, where children are particularly at risk of severe disease. Early recognition of severe dengue is critical to reduce morbidity and mortality. Novel lymphocyte activation markers, such as antibody-synthesizing lymphocytes (AS-LYMP) and reactive lymphocytes (RE-LYMP), may improve risk stratification. Objective To evaluate antibody-synthesizing lymphocytes (AS-LYMP) and reactive lymphocytes (RE-LYMP) as potential diagnostic risk stratification markers for severe dengue fever. Methods This cohort retrospective study was conducted at Ngoerah General Hospital, Denpasar, Bali, and included children under 18 years with confirmed dengue infection. AS-LYMP and RE-LYMP counts were obtained using a Sysmex XN-3000 analyzer. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis, and optimal cut-off points were identified using the Youden index. Results Seventy-nine dengue patients were analyzed: 15 without warning signs, 39 with warning signs, and 25 with severe dengue. Both AS-LYMP and RE-LYMP counts were significantly elevated in severe dengue (P<0.001) compared to other two groups. The ROC analysis showed acceptable accuracy for AS-LYMP (AUC 0.749; cut-off 0.83 × 10³/μL; sensitivity 80.0%; specificity 63.0%) and RE-LYMP (AUC 0.729; cut-off 1.04 × 10³/μL; sensitivity 80.0%; specificity 59.3%). Hemoglobin level and leukocyte count demonstrated predictive value, but with lower accuracy. Conclusion AS-LYMP and RE-LYMP are promising biomarkers for early identification of severe dengue in children. Integration into routine hematology testing may support timely clinical decision-making.
Co-Authors Adji Kusumadjati Anak Agung Wiradewi Lestari Dewi, Eleonora Anindya Tiara I Made Gede Dwi Lingga Utama I Wayan Gustawan Indira Meidina Nafisa Marhendra Satria Utama Mas Adi Sunardi Saputra, I M Yullyantara