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All Journal VALENSI Jurnal Kimia dan Kemasan Jurnal Litbang Industri Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Jurnal Kefarmasian Indonesia
Etik Mardliyati, Etik
Pusat Pengkajian dan Penerapan Teknologi Farmasi dan Medika BPPT
Chemistry Industrial & Manufacturing Engineering Medicine & Pharmacology

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Ekstraksi Dan Karakterisasi Serbuk Nano Pigmen Dari Daun Tanaman Jati (Tectona Grandis Linn. F) Kembaren, Riahna br; Putriliniar, Sesotya; Maulana, Nurwenda Novan; Yulianto, Kiki; Ikono, Radyum; Rochman, Nurul Taufiqu; Mardliyati, Etik
Jurnal Kimia dan Kemasan Vol. 36 No. 1 April 2014
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (626.466 KB)

Abstract

Tanaman Jati (Tectona grandis linn. F) umumnya hanya dimanfaatkan bagian kayunya untuk industri meubel, namun bagian lain seperti daun kurang dimanfaatkan. Daun jati terutama bagian pucuk daun muda dapat menghasilkan pigmen. Produksi serbuk nano pigmen dari daun jati dan karakterisasi serbuk nano pigmen tersebut belum dilakukan. Tujuan penelitian ini adalah menghasilkan nano pigmen dari pucuk daun jati muda dalam bentuk serbuk dengan menggunakan persentase filler yang berbeda dan melakukan karakterisasi serbuk nano pigmen jati tersebut. Pucuk daun jati muda diberi perlakuan mekanik dengan penggerusan kemudian disaring, larutan yang diperoleh diukur partikelnya dengan Particle Size Analyzer (PSA), dan dikeringkan dengan penambahan filler maltodekstrin 5% dan 10%. Serbuk yang diperoleh dihitung rendemen, ukuran partikel, dan kelarutan dalam air. Warna merah yang dihasilkan dari filtrat pucuk daun jati muda berasal dari zat warna antosianin yang terkandung dalam daun jati muda. Ekstrak dari pucuk daun jati muda memiliki ukuran dengan kisaran 87,8- 318,1 nm dengan ukuran rata-rata 109,2 nm. Hal ini menunjukkan bahwa ekstrak tersebut merupakan produk nano di alam. Penambahan filler dengan konsentrasi berbeda berpengaruh terhadap warna, rendemen, ukuran partikel serbuk, dan kelarutan pigmen serbuk dalam air. 
Penentuan Teknologi Proses Pembuatan Gambir Murni dan Katekin Terstandar dari Gambir Asalan Yeni, Gustri; Syamsu, Khaswar; Mardliyati, Etik; Muchtar, Hendri
Jurnal Litbang Industri Vol 7, No 1 (2017)
Publisher : Institution for Industrial Research and Standardization of Industry - Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (528.758 KB) | DOI: 10.24960/jli.v7i1.2846.1-10

Abstract

Uncaria gambir Roxb. is an industrial crop commodity that has a high economic value and good prospect for farmers and exporter. Gambier of traditional processed products (raw gambier) generally have various catechin content, so it is required further handling to increase the purity of catechins from raw gambier. The research was aimed to get a process technology on the making of pure gambier and standardized catechins. Sources of raw materials was obtained from extraction process through steaming leaves and twigs of gambier (KA) using equipment from aluminum (RA) and from iron (RF). Purification of raw gambier through repeated extraction with water could decrease tannin content from 24% to 2.4% and increase catechin levels between 40% to 74%. Gambier with a low tannin content (catechin KA) through re-extraction using water had the highest increase of catechin content with a color of yellowish white product. The iron-containing equipment affected the color of the pure gambier produced, which was reddish-brown. The effect of solvent on further extraction using ethyl acetate solvent resulted in higher catechin content (up to 99%) compare to ethanol (95%). The catechin purity of KA samples was tested by looking at its stability at varying levels of acidity, showing catechins of gambier was stabile at pH 6.ABSTRAK Uncaria gambir Roxb. merupakan komoditas tanaman industri yang memiliki nilai ekonomi tinggi serta mempunyai prospek cukup baik bagi petani dan pemasok negara-negara asing. Gambir hasil olahan tradisional (gambir asalan), umumnya memiliki kandungan katekin yang beragam, sehingga diperlukan penanganan lebih lanjut untuk meningkatkan kemurnian katekin dari gambir asalan. Tujuan penelitian adalah untuk mendapatkan teknologi proses pembuatan gambir murni dan katekin terstandar. Sumber bahan baku diperoleh dari proses ekstraksi melalui pengukusan daun dan ranting tanaman gambir (KA) menggunakan peralatan dari aluminium (RA) dan dari besi (RF). Pemurnian gambir asalan melalui ekstraksi berulang dengan air dapat menurunkan kadar tanin, yaitu dari 24% sampai 2,4% dan meningkatkan kadar katekin, yaitu antara 40% sampai 74%. Gambir dengan kandungan tanin rendah (katekin KA) melalui ekstraksi ulang menggunakan air memiliki peningkatan kadar katekin tertinggi dengan warna produk putih kekuningan. Peralatan mengandung besi berpengaruh terhadap warna dari gambir murni yang dihasilkan, yaitu berwarna coklat kemerahan. Pengaruh pelarut terhadap ekstraksi lanjut menggunakan pelarut etil asetat menghasilkan kadar katekin lebih tinggi (sampai 98%) dibandingkan etanol (95%). Kemurnian katekin sampel KA diuji dengan melihat stabilitasnya pada berbagai tingkat keasaman, menunjukkan katekin dari gambir stabil pada pH 6.
Pembuatan dan Mikroenkapsulasi Ekstrak Etanol Biji Jinten Hitam Pahit (Nigella sativa Linn.) Sugindro, Sugindro; Mardliyati, Etik; Djajadisastra, Joshita
Majalah Ilmu Kefarmasian Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

The aim of this study is to convert Nigella sativa black seed extract from liquid phase into solid phase by microencapsulation using spray drying method. The benefits hoped from this research are obtaining the dry extract to be formulated into pharmaceutical variable dosage forms in order to increase the usefulness and variability products of Nigella sativa black seed extract. The spray drying method was done by adding Nigella sativa black extract into the gum arabic and maltodextrin solution. The evaluation of microencapsulated extract is including drug content, encapsulation efficiency, flow properties, compressibility, angle of repose, moisture content, particel size distribu-tion and microstructure of microcapsules. The result showed that microencapsula-tion of Nigella sativa black seed extract can be produced by spray drying method. The highest microencapsulation efficiency is at the coating solution concentration of 20% (gum arabic : maltodextrin = 50 : 50) and Nigella sativa black extract percentage of 30%.
Effect of Mechanical Milling on the Total Phenolic Content and Antioxidant Activity of Garcinia mangostana Pericarp Nugroho, Dwi Wahyu; Daratika, Dyah Ayu; Kamila, Muthia; Togatorop, Lusiana; Rifada, Mohammad Aulia; Widayatno, Wahyu Bambang; Maulana, Syahrizal; Setyawati, Damai Ria; Mardliyati, Etik; Rochman, Nurul Taufiqu
Makara Journal of Science Vol. 24, No. 2
Publisher : UI Scholars Hub

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Abstract

This study aimed to identify the effect of mechanical milling on the total phenolic content and antioxidant activity of mangosteen pericarp. Mangosteen pericarp was milled under different milling times (30, 90, 150, and 210 min). The particle morphology before and after milling was observed by scanning electron microscopy (SEM), and the average particle size was obtained from SEM images and analyzed statistically. The antioxidant activity was measured through the 2,2-diphenyl-1-picrylhydrazyl method. The total phenolic content for the non-milling sample was 14.52 × 104 µg GAE/g sample, and the highest total phenol content was 17.44 × 104 µg GAE/g sample for the sample milled for 210 min. The IC50 value decreased for samples with milling 150 and 210 min, which showed strong antioxidant activity, whereas the value of gallic acid equivalent increased. SEM observations showed the presence of agglomeration in the morphology of mangosteen pericarp samples. The average particle size of the mangosteen pericarp decreased as the milling time increased (up to 4499 nm for samples milled for 210 min). Therefore, mechanical milling had a significant effect on the phenolic content and antioxidant activity, which indicated an increase in the bioavailability of mangosteen pericarp.
Flavonoid Concentration and Tyrosinase Inhibition Activity of Ethanol Extract of Piper crocatum (Piper crocatum var. Ruiz & Pav) from Various Regions in Indonesia and Their Correlations Irsal, Riyan Alifbi Putera; Safithri, Mega; Andrianto, Dimas; Mardliyati, Etik
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.31426

Abstract

Hyperpigmentation is a condition of darkening of the skin which is generally caused by an increase in melanin production. Melanin is produced in melanocytes by the enzyme tyrosinase. Piper crocatum contains flavonoid compounds that are known from previous research to inhibit tyrosinase. The goals of this study were to determine the tyrosinase inhibitory activity and total flavonoid content of seven accessions, as well as look at the Pearson’s correlation and clustering PCA (principal component analysis). The method used was water content analysis, extraction yield measurement, total flavonoids analysis, and in vitro tyrosinase inhibition. Based on the results, P. crocatum from Kendari had the best yield and total flavonoid content of 24.07% and 5.10 mg QE g-1, while P. crocatum from Bogor had the lowest water content with a value of 6.21% and the best in tyrosinase inhibition of 13.77. The correlation between total flavonoid content and percent inhibition showed a very weak correlation. The results of clustering formed four clusters of seven accessions based on total flavonoids and percent inhibition. The cluster was divided into Malang (506mDPL) and Jayapura (287mDPL), Banda Aceh (0.80mDPL) and Bandung (670mDPL), Samarinda (8mDPL) and Bogor (190-350m DPL), and Kendari (14mDPL). In conclusion, the correlation between total flavonoid levels and percent inhibition is very weak and regional diversity had a significant effect on total flavonoids and total inhibition.
Preparation of Curcumin-Liposomes using pH-Driven Method to Enhance Stability and Encapsulation Efficiency Sekaringtyas, Fransiska Christydira; Purwajanti, Suwasmi; Mardliyati, Etik; Ningsih, Sri
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2728

Abstract

Curcumin, a hydrophobic polyphenol, derived from turmeric, has numerous pharmacological activities, including hepatoprotective, antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic. However, the therapeutic efficacy of curcumin is limited due to its poor oral bioavailability and high susceptibility to degradation. The poor oral bioavailability of curcumin has been attributed to its poor aqueous solubility and extensive first past metabolism. Curcumin dissolves in alkaline conditions but it is highly unstable undergoing rapid hydrolytic degradation in neutral or alkaline condition. To solve these problems, liposome-based encapsulation technology is applied to improve the bioavailability of curcumin. The existing method to prepare curcumin-liposome, thin-film method, is complex and usually required the use of organic solvents. In this study, pH-driven method, an organic solvent-free and easily encapsulation technique utilizing the pH-dependent solubility of curcumin was proposed to improve the stability and bioavailability. Curcumin-liposomes were prepared using phospholipon 90 H and soya lecithin as phospholipid sources. The characterizations of curcumin-liposomes include particle size, microstructure, encapsulation efficiency, infrared spectra, salt stability and storage stability. The particle size measured was 77.85 ± 0.39 nm. It was found that curcumin-liposomes prepared by the pH-driven method was stable during storage for 30 days and gave encapsulation efficiency of 60.71 ± 0.20%, higher as compared to the ones prepared by thin-film method. In conclusion, pH-driven is a promising method for the preparation of curcumin-liposomes to enhance stability and encapsulation efficiency
Co-Authors Daratika, Dyah Ayu DIMAS ANDRIANTO Dwi Wahyu Nugroho Hendri Muchtar, Hendri Irsal, Riyan Alifbi Putera Joshita Djajadisastra, Joshita Kamila, Muthia Khaswar Syamsu Kiki Yulianto Maulana, Syahrizal Mega Safithri Nurul Taufiqu Rochman Nurwenda Novan Maulana, Nurwenda Novan Purwajanti, Suwasmi Radyum Ikono Riahna br Kembaren Rifada, Mohammad Aulia Sekaringtyas, Fransiska Christydira Sesotya Putriliniar, Sesotya SETYAWATI, DAMAI RIA Sri Ningsih Sugindro, Sugindro Togatorop, Lusiana Wahyu Bambang Widayatno, Wahyu Bambang Yeni, Gustri