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All Journal International Journal of Integrated Health Sciences Paediatrica Indonesiana
Ariyanto Harsono, Ariyanto
Allergy Immunology Division, Department of Child Health, Faculty of Medicine, Airlangga University-Dr. Soetomo General Hospital
Health Professions Medicine & Pharmacology

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The Use of Superoxide Dismutase in Accelerating Symptom Relief in Asthmatic and House Dust Mite Allergic Children Receiving House Dust Mite Immunotherapy: Double Blind Randomized Controlled Clinical Trial Endaryanto, Anang; Hikmah, Zahrah; Harsono, Ariyanto
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
Publisher : International Journal of Integrated Health Sciences

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Objective: To evaluate the efficacy of superoxide dismutase (SOD) in lung function (FEV1 reversibility) and respiratory symptoms (drug scores, symptoms scores) in asthmatic and house dust mite allergic children receiving house dust mites immunotherapy.Methods: Forty subjects aged 6–17 years old with asthma and tested positive for house dust mite allergy on skin prick test, and received immunotherapy were enrolled in this study. All subjects completed clinical based assessments and diary-based assessments for drug and symptom scores. Following a four-week baseline assessment, all subjects were randomized to receive SOD or placebo. Respiratory symptoms (drug and symptoms score) and FEV1 were evaluated at the end of the 1st, 2nd, 3rd, and 4th weeks after randomization. Drug score, symptoms score and FEV1 reversibility test results were analyzed using a Paired t test and repeated measure of ANOVA. Results: There was a significant difference in drug scores, symptoms score and FEV1 reversibility test outcomes between SOD and placebo. SOD group showed a significant decrease in all outcome measures compared to those in placebo group. Conclusions: The use of SOD as antioxidants is effective in accelerating symptom relief for children with asthma and house dust mite allergy receiving house dust mite immunotherapy. Keywords: Allergic asthma, antioxidant, drug score, immunotherapy, symptoms score DOI: 10.15850/ijihs.v3n2.587
The Allergy Management of Bronchial Asthma in Children in Surabaya Harsono, Ariyanto; Partana, Js.; Partana, L.
Paediatrica Indonesiana Vol. 30 No. 9-10 (1990): September-October 1990
Publisher : Indonesian Pediatric Society

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The allergy management of bronchial asthma consists of avoidance of exposure to allergens either inhalant, or ingestant, hyposensitization in cases where complete avoidance is impossible and drug therapy is needed. The diet initiated in allergic children is principally a diagnostic tool. There are two important diet regimens. First, ''The Elimination Diet', indicated in patients to exclude major allergenic foods such as fruit, milk, egg, fish, and peanut Secondly, ''The Minimal Diet'' (Modified Rowe's Diet), consisting of several foods ''allowed'' such as water, rice, coconut, beef, soy-cake, soy sauce, spinach, carrot, garlic and onion, salt and sugar, while other foods are prohibited. To obtain clear improvement of symptoms, the diet must be continued for 3 weeks. If improvement occurs, a challenge can be performed. All previously excluded foods can be reinstituted one at a time in a sufficient amount, every day for one week. If no symptoms appear, the food can be considered as non allergenic to the patient. If symptoms reappear, the food should be suspected as causing the allergy. For diagnosis, three challenges are required. Pharmacologic therapy is initiated with ephedrine and chlortrimeton as needed. Aminophylline and beta 2 agonist may be given as a substitute if the former drugs fail to relieve the symptoms. Intravenous aminophylline and corticosteroid are used especially in ''status asthmaticus''.
Co-Authors Anang Endaryanto Partana, Js. Partana, L. Zahrah Hikmah, Zahrah