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All Journal International Journal of Integrated Health Sciences Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Jurnal Media Gizi Indonesia (MGI) Paediatrica Indonesiana Indian Journal of Forensic Medicine & Toxicology
Zahrah Hikmah, Zahrah
Allergy Immunology Division, Department Of Child Health, Faculty Of Medicine, Airlangga University-Dr. Soetomo General Hospital
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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The Use of Superoxide Dismutase in Accelerating Symptom Relief in Asthmatic and House Dust Mite Allergic Children Receiving House Dust Mite Immunotherapy: Double Blind Randomized Controlled Clinical Trial Endaryanto, Anang; Hikmah, Zahrah; Harsono, Ariyanto
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3133.931 KB)

Abstract

Objective: To evaluate the efficacy of superoxide dismutase (SOD) in lung function (FEV1 reversibility) and respiratory symptoms (drug scores, symptoms scores) in asthmatic and house dust mite allergic children receiving house dust mites immunotherapy.Methods: Forty subjects aged 6–17 years old with asthma and tested positive for house dust mite allergy on skin prick test, and received immunotherapy were enrolled in this study. All subjects completed clinical based assessments and diary-based assessments for drug and symptom scores. Following a four-week baseline assessment, all subjects were randomized to receive SOD or placebo. Respiratory symptoms (drug and symptoms score) and FEV1 were evaluated at the end of the 1st, 2nd, 3rd, and 4th weeks after randomization. Drug score, symptoms score and FEV1 reversibility test results were analyzed using a Paired t test and repeated measure of ANOVA. Results: There was a significant difference in drug scores, symptoms score and FEV1 reversibility test outcomes between SOD and placebo. SOD group showed a significant decrease in all outcome measures compared to those in placebo group. Conclusions: The use of SOD as antioxidants is effective in accelerating symptom relief for children with asthma and house dust mite allergy receiving house dust mite immunotherapy. Keywords: Allergic asthma, antioxidant, drug score, immunotherapy, symptoms score DOI: 10.15850/ijihs.v3n2.587
Immunotherapy Duration and Risk of Psychosocial Emotion and Risk of Attention Deficit Hyperactivity Disorder Prevalence and Relation in Allergic Rhinitis Children Dinda Anes Tunjungsari; Anang Endaryanto; Ahmad Suryawan; Ariyanto Harsono; Zahrah Hikmah; Azwin Mengindra Putera
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14707

Abstract

Background: Allergic rhinitis (AR) is the most common chronic disease in children. Allergic symptomsaffect daily activities and increase risk of psychosocial emotion and attention deficit hyperactivity disorder(ADHD). Immunotherapy has been proven in improving AR symptomsObjective: To identify prevalence of the risk of psychosocial emotion disorder and ADHD and its relationwith immunotherapy duration in AR children.Methods: A cross-sectional study was held in AR children aged 4-18 years at Allergy Immunology OutpatientClinic, Dr. Soetomo Hospital, during March 2017. Immunotherapy duration categorized into 0-6 months, 6months-1 year, 1-2 years, 2-3 years. Psychosocial emotion disorder risk assessed using Pediatric SymptomsChecklist 17 (PSC-17), scored into four different subscales: Internalizing, Externalizing, Attention, andTotal Score. ADHD risk was assessed using Abbreviated Conner’s Rating Scale (ACRS). Statistical analysisusing One-Way ANOVA and Eta test, with a value of p< 0.05 considered as significant.Results: Total of 37 children included. Based on immunotherapy duration 0-6 months, 6 months-1 year, 1-2years, and 2-3 years, prevalence risk of ADHD are 20.6%, 15.4%, 12.5%, and 12.5%, and prevalence ofpsychosocial emotion disorder risk are only in immunotherapy duration 6 months-1 year 12.5%. There wereno correlation between immunotherapy duration with risk of psychosocial emotion disorder (p = 0.945) andsignificantly correlated to ADHD (p = 0.049, r = 0.326).Conclusion: Prevalence risk of ADHD decrease as the immunotherapy duration increase and immunotherapyduration weakly correlated with risk of ADHD.
Nutrition Status And Neuropsychiatric Disorders In Indonesian Childhood Lupus: Experience At A Single Tertiary Referral Center Hikmah, Zahrah; Endaryanto, Anang; Sutawan, Ida Bagus Ramajaya; Wulandari, Desy
Media Gizi Indonesia Vol. 19 No. 1 (2024): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v19i1.40-48

Abstract

NPSLE diagnosis is still challenging because of many SLE-related and non-SLE-related processes that can be presented in patient. The report of NPSLE in Indonesia is still limited. This study aim to describe the clinical features, nutrition status, and laboratory characteristics of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) and compared to non NPSLE case in Indonesian children. The study is a retrospective cohort study. Data were collected from the complete medical record of Juvenile Systemic lupus Erythematosus (jSLE) patients 2016 - 2020 at the Allergy Immunology Outpatient clinic at Dr. Soetomo General Academic Hospital. We include all patients with ages ranging from age 0-18 years old with a diagnosis of Systemic lupus Erythematosus (SLE). The diagnosis fo SLE based on American College of Rheumatology (ACR) criteria 1997 and Neuropsychiatric (NP) manifestations were classified using the standardized nomenclature and case definitions for the 19 NP manifestations linked to SLE developed in 1999 by the ACR ad hoc Committee. Disease activity SLE was defined according to the American Mexican-Systemic Lupus Erythematosus Disease Activity Index (Mex-SLEDAI) criteria. Statistical analysis conducted in this study was descriptive analysis, paired T-test (NPSLE vs. non-NPSLE as the dependent variable), Fischer exact test, and Pearson Chi-square test using SPSS ver. 21. A total of 90 patients with juvenile SLE were enrolled, but only 71 patients were eligible as participants with complete medical records obtained. Mex-SLEDAI score was significantly higher on NPSLE compared to non-NPSLE (p=0.001). 
Preliminary Investigation of Risk Factors for Food Allergies in the Pediatric Population: Observations from a Survey Utilizing a Simplified Questionnaire in Gresik, East Java, Indonesia Natalia Erica Jahja; Zahrah Hikmah; Azwin Mengindra Putera; Anang Endaryanto
Folia Medica Indonesiana Vol. 60 No. 1 (2024): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i1.53175

Abstract

Highlights:1. A questionnaire, comprising various risk factors associated with food allergies, is anticipated to provide reliable indications for determining the necessity of restrictive diets for patients within primary healthcare settings.2. Over time, the findings of this study can facilitate the development of a streamlined and cost-effective diagnostic tool, which will be particularly beneficial in remote regions due to its practical and efficient means of identifying food allergies. AbstractIn Gresik, Indonesia, limited resources have led to challenges in accurately diagnosing food allergies. This study aimed to identify risk factors for food allergies among children in Gresik using a questionnaire-based approach. The study's ultimate goal was to develop a simple diagnostic tool in primary healthcare settings. Conducted at Petrokimia Gresik Hospital, this cross-sectional study enrolled children aged ≥6 months experiencing respiratory symptoms or atopic dermatitis for ≥1 week. The subjects (n = 247) underwent a two- to four-week restrictive diet for diagnostic purposes. The questionnaire demonstrated validity and reliability. Bivariate statistical analyses were performed to examine the correlations between risk factors and the incidence of food allergies (p < 0.05). A receiver operating characteristic (ROC) curve analysis was used to establish the cut-off values for the number of food allergies and atopic family members. The majority of the 247 children enrolled in this study were 6 to 12 years old. Respiratory symptoms (56.3%) were more common than atopic dermatitis (38.1%). The significant risk factors for food allergies included atopic dermatitis (p = 0.001; R = 0.203), previous history of suspected food allergies (p < 0.001; R = 0.747), and atopy in the family (p = 0.013; R = 0.157). The ROC curve analysis established the cut-off values for the number of atopic family members at 1.5 (p = 0.005; 95% CI 0.53-0.67) and the number of food allergies at 0.5 (p = 0.000; 95% CI 0.85-0.94). In conclusion, children are considered at risk of food allergies if they display persistent respiratory symptoms or atopic dermatitis, considering the history of suspected food allergies even to only one specific type of food.
Successful management of a 7-year-old-female with juvenile dermatomyositis at a tertiary hospital in low-income country Wulandari, Desy; Lubis, Azwin Mengindra Putera; Hikmah, Zahrah; Endaryanto, Anang
Paediatrica Indonesiana Vol 64 No 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.551-8

Abstract

Juvenile dermatomyositis (JDM) is a rare chronic autoimmune disease belonging to idiopathic inflammatory myopathies. Pathological skin lesions and proximal weakness primarily characterize this entity, but clinical symptoms can be heterogeneous. Children are more likely to have long-term complications such as lipodystrophy, calcinosis, and vasculopathy. Calcinosis is one of the characteristic sequelae of JDM, despite recent advances in the treatment of JDM, about one-third of patients still develop dystrophic calcinosis. In low-income countries, the availability of medicines is very limited. In our case, a 7-year-old female diagnosed with JDM presented with calcinosis. Aggressive and adequate treatment with steroids, methotrexate, hydroxychloroquine, and aluminium hydroxide can treat the complications. It is challenging to establish an early diagnosis, treatment, prevention of long-term complications, and improved prognosis of JDM, which then will improve the patient’s quality of life, especially in low income countries with limited drug availability.
Correlation between Allergic Rhinitis and History of Infantile Atopic Dermatitis Mutiara Arikah Balqis; Hikmah, Zahrah; Indramaya, Diah Mira; Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 1 (2025): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V37.1.2025.15-20

Abstract

Background: Atopic march is one of the global health problems that is commonly found in children. The prevalence of allergic rhinitis in Indonesia reaches to 1.5% to 12.4% and continues to increase every year. Allergic reactions can affect all tissues and organs in the body. Some clinical manifestations of allergies are allergic rhinitis, atopic dermatitis, and asthma (atopic march). Atopic march often begins in infancy with the development of atopic dermatitis later in life. Purpose: To analyze the correlation between the prevalence of allergic rhinitis and history of infantile atopic dermatitis in children. Methods: This research used an observational analytic design with a cross-sectional approach. Result: The data were categorized based on a history of atopic dermatitis and the diagnosis of allergic rhinitis. The statistical tests revealed a relationship between the incidence of allergic rhinitis and history of infantile AD in children. The chi-square test yielded a p-value of 0.014 and a contingency coefficient value of 0.213. The odd ratio (OR) value at a confidence level (CL) of 95% and a limit of 1.312 – 6.256 is 2.865, which means that patients who have a history of AD have a 2.8 times higher risk of experiencing AR. Conclusion: The conclusion of this study is that there is a correlation between the incidence of allergic rhinitis and history of infantile atopic dermatitis.
THE ZINC STATUS IN CHILDREN WITH ALLERGIES: A SYSTEMATIC REVIEW AND META-ANALYSIS Ningsih, Rusdian; Hikmah, Zahrah; Endaryanto, Anang
Media Gizi Indonesia Vol. 20 No. 3 (2025): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v20i3.234-244

Abstract

Allergies pose significant health concerns, particularly in children, where they can adversely affect growth and quality of life. Recent studies have suggested that zinc deficiency may play a critical role in the immune dysregulation associated with allergies. The method used in This systematic review followed the PRISMA guidelines and analyzed studies on the relationship between zinc levels and allergies in children, using data from PubMed, Science Direct, EBSCO, and Cochrane Library, and a meta-analysis was conducted to evaluate the effect size and risk of bias assessed using the Newcastle-Ottawa Scale to examine the relationship between zinc levels and allergies in children. Our findings indicate that children with allergies may exhibit different zinc levels compared to healthy controls, with a pooled effect size of -0.56 (95% CI: [-0.99, -0.13]). The analysis revealed significant heterogeneity (Tau² = 0.39; Chi² = 79.41, df = 8, p < 0.00001; I² = 90%), highlighting the variability across studies and the necessity for further research to standardize the methodologies. These results were statistically significant (Z = 2.54, p = 0.01), suggesting a potential association between zinc levels and allergies in children. Further investigations are needed to explore whether zinc supplementation can support immune function and alleviate allergic symptoms.
Co-Authors Ahmad Suryawan Anang Endaryanto Ariyanto Harsono Ariyanto Harsono, Ariyanto Azwin Mengindra Putera Damayanti desy wulandari Diah Mira Indramaya Dinda Anes Tunjungsari Ida Bagus Ramajaya Sutawan, Ida Bagus Ramajaya Mutiara Arikah Balqis Natalia Erica Jahja Ningsih, Rusdian